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Books in Life sciences

  • Neuroglia in Neurologic and Psychiatric Disorders, Part II

    • 1st Edition
    • Volume 210
    • English
    Neuroglia in Neurologic and Psychiatric Disorders, Part II discusses glia relative to neurologic and psychiatric disorders, emphasizing cross-disease-glial cell dysfunctions. Driven by advances in genetics, transcriptomics, electrophysiologic and imaging techniques, as well as by the increase in knowledge on neuropathologic features and underlying disease mechanisms, this book bridges the gap between neuroglia basic science and neuroglia clinical research.

  • Aquatic Biomes

    Global Biome Conservation and Global Warming Impacts on Ecology and Biodiversity
    • 1st Edition
    • Germano Leão Demolin-Leite
    • English
    Aquatic Biomes: Global Biome Conservation and Global Warming Impacts on Ecology and Biodiversity explores the effects of anthropogenic activities on Earth’s aquatic biomes, species, and climate. It summarizes operational and potential monitoring tools to conserve or recover aquatic biomes at global scale. Written by international experts in ecology and biodiversity conservation, this book identifies the challenges and threats to aquatic organisms and connects them to real cases of conservation.Aquatic Biomes: Global Biome Conservation and Global Warming Impacts on Ecology and Biodiversity is an important resource for students, professors, researchers, governmental and non-governmental organizations active in biodiversity conservation and climate change mitigation seeking guidance on the best practices for aquatic biome conservation.

  • Agriculture Toward Net Zero Emissions

    • 1st Edition
    • Sandeep Kumar + 1 more
    • English
    Agriculture Toward Net Zero Emissions explores how agriculture has historically contributed to carbon emissions and then takes the reader forward, offering insights into an integrated approach to reducing those emissions toward the COP26 goal. The dual challenge of increasing production to meet population and nutrition food demands while reducing the traditional emissions generated by production practices is significant. It requires understanding the foundation of current practices and then revising those underlying principles to reflect the resources and greater insights of today.This book provides an overview of the current state of the science, explores the development of policies and plans to improve carbon management, and provides examples of technology and agroecosystem management practices. It includes the latest updates in carbon neutral farming, carbon and energy management, and addresses the knowledge gap between input management, livestock management and agroecosystem management.Advancing agroecosystem science through a roadmap for improving capacity, Agriculture Toward Net Zero Emissions is a valuable resource for those seeking to develop and apply new agricultural best practices.

  • An Overview of FDA Regulated Products

    From Drugs and Cosmetics to Food and Tobacco
    • 2nd Edition
    • Eunjoo Pacifici + 1 more
    • English
    An Overview of FDA Regulated Products: From Drugs and Cosmetics to Food and Tobacco, Second Edition is fully updated to reflect recent advances in science and technology and new laws and regulations. Breakthroughs in cellular and gene therapy, immunotherapy, precision medicine, and digital health are changing the face of healthcare and regulation. The updates brought about by the 21st Century Cures Act and subsequent PDUFA Reauthorizations, as well as signing into law the “Modernization of Cosmetic Regulation Act of 2022,” which will transform FDA’s oversight of cosmetics, are fully reflected in all chapters of the book.This book provides graduate students and industry professionals with comprehensive information on approval processes with the FDA and other country regulation organizations. Regulatory science professionals working with not only drugs, but biologics, medical devices, food and additives, cosmetics, veterinary products, and tobacco will benefit from this comprehensive overview of the regulatory environment.

  • Early Detection of Alzheimer’s Disease

    Biological and Technological Advances
    • 1st Edition
    • Dennis Chan
    • English
    Early Detection of Alzheimer’s Disease: Biological and Technological Advances aims to introduce to a wide audience the high global priority problem of detecting AD prior to dementia onset. According to the Alzheimer’s Association, 5.8 million Americans are living with Alzheimer’s and care costs will cost the nation approximately $290 billion (2019 Alzheimer’s Disease Facts and Figures). With the failure of recent AD drug trials, many hypothesize that by the time symptoms appear, it is too late to be treated. Early detection can offer benefits such as more choice of medications, ability to participate in clinical trials, more time for family and for care planning. This book outlines potential solutions to the above problem using opportunities arising from the technology revolution, advances in neuroscience, and molecular biology. Most importantly, it discusses a paradigm shift from a reactive to a proactive diagnostic approach, aiming to detect disease before occurrence of symptoms. Topics covered include the use of sensing technologies (e.g. smartphones, smartwatches, Internet of Things) to detect early disease-related changes, the application of data science (machine learning/AI) to extract otherwise invisible disease features from these datasets and the potential to personalize diagnosis based on tracking changes in individual behaviours. Advances in blood-based biomarkers, brain imaging, and the potential for early diagnosis to aid interventions (lifestyle, dietary, pharmacological) to delay future development of dementia are also discussed.

  • CRISPR-Cas Systems for RNA and Genome Editing

    • 1st Edition
    • Volume 712
    • English
    CRISPR-Cas Systems for RNA and Genome Editing, Volume 711 in this ongoing series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as Massively parallel genomic perturbations with multi-target CRISPR interrogates Cas9 activity and DNA repair at endogenous sites, Genome oligopaint via local denaturation fluorescence in situ hybridization, Biochemical reconstitution of a type I-B CRISPR-associated transposon, Visualizing the conformational landscape of CRISPR-Cas9 through kinetics-informed structural studies, and much more.Additional sections cover Analysis of metal-dependent DNA nicking activities by Cas endonucleases, Biochemically characterizing the accessory proteins and ribonucleoprotein complexes of Type IV CRISPR systems, Prime editing in bacteria with BacPE, Preparation of high-purity CRISPR-based DNA base editor RNPs, Bacterial directed evolution of CRISPR base editors, Cloning and validating systems for high throughput molecular recording, Using CRISPR-Cas13 for viral nucleic acid detection, and more.

  • Viral Hepatitis in Asia and the Pacific

    Towards Elimination as a Public Health Threat
    • 1st Edition
    • Jing Sun + 2 more
    • English
    Viral Hepatitis in Asia and the Pacific: Towards Elimination as a Public Health Threat documents the narratives, innovations, and scope of work in the Asia-Pacific region in starting, consolidating, and moving towards the elimination of viral hepatitis. The Asia-Pacific region is disproportionately affected by viral hepatitis, accounting for two-thirds of the global burden. Countries from low-, middle- and high-income economies have adopted different strategies to address combating and eliminating viral hepatitis. The successful experiences of the Asia-Pacific region are valuable for other regions, especially the middle- and low-income countries moving towards the achievement of the 2030 goal of elimination.Strategi... discussed include integrated approaches, negotiating universal access to diagnostics, and treatment options, including vaccines. Content further covers the critical barriers to achieve the 2030 targets for elimination of viral hepatitis and how to overcome them. This is the perfect reference for all hepatology researchers and elimination policy advocates who are dedicated to joining the fight for the 2030 goal of the elimination of viral hepatitis as a public health threat.

  • Protein and Peptide Therapeutics

    • 1st Edition
    • Volume 212
    • English
    Progress in Molecular Biology and Translational Science series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Encyclopedia of Bioinformatics and Computational Biology

    • 2nd Edition
    • Shoba Ranganathan + 2 more
    • English
    Bioinformatics and Computational Biology (BCB) combine elements of computer science, information technology, mathematics, statistics, and biotechnology, providing the methodology and in silico solutions to mine biological data and processes, for knowledge discovery.In the era of molecular diagnostics, targeted drug design, translational medicine and Big Data for personalized medicine, computational methods for data analysis are essential tools for biochemistry, biology, biotechnology, pharmacology, biomedical and computer science, as well as mathematics and statistics. New areas are emerging, and relatively isolated fields are becoming current hot research areas in BCB, such as Artificial Intelligence, Quantitative Biology, Computational Vaccinology, Epidemiology and Infection Diffusion, Synthetic Biology, and Phenomics. The role of BCB in characterizing SARS-CoV-2 variants and facing the COVID-19 pandemic is just one example of how these tools can help us better prepare for such future events.This Encyclopedia comprises three sections, covering Methods, Topics, and Applications. The methodologies and algorithms underpinning BCB are described in the Methods section; Topics covers traditional areas such as phylogeny, as well as more recent areas such as translational bioinformatics, cheminformatics and environmental informatics; Applications provides guidance for commonly asked “how to” questions.Navigating the maze of confusing jargon and the plethora of software tools is often confronting for students and researchers alike. This comprehensive and unique resource provides up-to-date theory and application content to address molecular data analysis requirements, with precise definitions of terminology and lucid explanations by field experts.

  • Clinical Landscape in Cancer Research

    • 1st Edition
    • Ranjita Shegokar + 1 more
    • English
    Cancer, a multifaceted disease, remains the leading cause of death worldwide. Ongoing research and technological advancements are continually improving the human understanding of newer treatment options. This book series aims to provide wide-ranging insights into the current landscape of cancer research, highlighting the recent advancements, current challenges, and future directions. Cancer varies widely in its formation, microenvironment, location in the body, associated risk factors, detection methodology, and treatment approaches. Early detection and prevention through lifestyle changes, regular screenings, and the awareness of symptoms are crucial for improving outcomes and survival rates. In this book series, the main focus is on trending topics, like new drug delivery, diagnostics, biomarkers, and preclinical and clinical developments in cancer research. Nanotechnology has emerged as a transformative approach in medicine, particularly in the areas of targeted drug delivery systems, imaging, and diagnostics to enhance the therapeutic efficacy and minimize adverse effects in cancer therapy. Advances in pharma, medical device, and diagnostic research, including the development of Trojan-horse therapies and precision treatments/assay kits, continue to enhance the effectiveness of cancer care over the past few decades. A total of five books are covered in this series: Drug Delivery Landscape in Cancer Research (Vol. 1)Biomarker Landscape in Cancer Research (Vol. 2)Diagnostic Landscape in Cancer Research (Vol. 3)Preclinical Landscape in Cancer Research (Vol. 4)Clinical Landscape in Cancer Research (Vol. 5) By integrating basic, applied, and innovative science concepts, this book series fosters a deeper understanding of the disease and paves the way for the development of more effective strategies. This book series serves as a valuable resource for students, researchers, regulators, and clinicians interested in understanding the complexities of cancer and the innovative approaches researched to combat this deadly disease. Nonetheless, continuous interdisciplinary, cross-country collaborations and cross-science innovation strategies are essential to further reduce the global cancer burden.

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