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Books in Toxicology

Elsevier's Toxicology collection provides essential insights for researchers and scientists into mitigating the adverse effects of contaminants on organisms, covering research, analysis, risk assessment, detection, prevention, diagnosis, and treatment of toxic exposure. Including toxicity testing, environmental toxicology it offers valuable knowledge for addressing public health and safety challenges by examining the adverse effects of contaminants on human health, animals, and the environment.

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371-380 of 389 results in All results

The Nervous System

  • 1st Edition
  • January 1, 1967
  • Walter S. Root + 1 more
  • English
  • eBook
    9 7 8 - 1 - 4 8 3 2 - 7 2 9 5 - 5
Physiological Pharmacology: A Comprehensive Treatise, Volume IV: The Nervous System — Part D: Autonomic Nervous System Drugs focuses on the effects of drugs on the nervous system, including how adrenergic drugs affect the heart and systemic circulation, metabolism, and adrenergic compounds. The selection first offers information on the effects of adrenergic drugs on the heart and systemic circulation. Topics include actions of adrenergic drugs, possible drug actions on the heart, epinephrine and arterenol, and other sympathomimetic drugs. The book then examines the effects of adrenergic compounds on pulmonary circulation, including physiologic considerations and general considerations of adrenergic compounds. The manuscript ponders on the effects of adrenergic agents on smooth muscles other than those of the vascular system and the effects of sympathomimetic amines and adrenergic blocking agents on metabolism. The book also touches on veratrum alkaloids and neurotoxins, as well as botulism, tetanus, therapeutic use, and chemistry of veratrum alkaloids. The selection is a dependable reference for readers interested in the effects of drugs on the nervous system.

The Hallucinogens

  • 1st Edition
  • January 1, 1967
  • A. Hoffer + 1 more
  • English
  • eBook
    9 7 8 - 1 - 4 8 3 2 - 6 1 6 9 - 0
The Hallucinogens attempts to provide a detailed description of the hallucinogens in a single volume. Hallucinogens are chemicals which in nontoxic doses produce changes in perception, in thought, and in mood, but which seldom produce mental confusion, memory loss, or disorientation for person, place, and time. These latter changes are characteristic of organic brain reactions following intoxications with alcohol, anesthetics, and other toxic drugs. The book covers the following hallucinogens: plant ß-phenethylamines, d-lysergic acid diethylamide, ololiuqui, indole hallucinogens derived from tryptophan, and taraxein. The discussions include their chemistry, biochemistry, and neurophysiological effects. The final chapter deals with animal studies with hallucinogenic drugs. This work has been written for chemists, biochemists, psychologists, sociologists, and research physicians. While it cannot satisfy each group fully, it is sufficiently comprehensive and well documented so that each group can use it as a springboard for future enquiry into these fascinating chemicals.

The Lung Circulation

  • 1st Edition
  • January 1, 1965
  • Domingo M. Aviado
  • English
  • eBook
    9 7 8 - 1 - 4 8 3 1 - 6 5 5 7 - 8
The Lung Circulation deals with important aspects of the lung circulation, with emphasis on the physiology of the pulmonary and bronchial circulation and autonomic pharmacology. Topics covered range from the role of anoxia in pulmonary circulation to reflexes arising from the pulmonary circulation and neighboring structures. The release of chemical substances from the pulmonary and bronchial circulation is also discussed. This volume is comprised of 10 chapters and begins with a review of the influence of anoxia on pulmonary circulation as well as four pertinent effects of anoxemia, namely, respiratory stimulation; cardiac stimulation; systemic vasoconstriction and vasodilatation; and pulmonary vasoconstriction and vasodilatation). The following chapters focus on the regulation of bronchial circulation; autonomic nervous control of pulmonary circulation involving acetylcholine, anticholinesterases, and atropine; and the pharmacology of sympathomimetic drugs, sympathetic blocking drugs, ganglion stimulants, and blocking drugs. The final chapter is devoted to the pharmacology of the autonomic nervous system and considers drugs that stimulate chemoreflexes arising from the lung circulation, including veratrum alkaloids. This book will appeal to physiologists and pharmacologists.

Sterilisation and Disinfection

  • 1st Edition
  • January 1, 1965
  • T. D. Whittet + 2 more
  • J. B. Stenlake
  • English
  • eBook
    9 7 8 - 1 - 4 8 3 1 - 9 6 1 3 - 8
Pharmaceutical Monographs, Volume 3: Sterilisation and Disinfection provides a strong foundation for the proper use of disinfectants in practice. This monograph surveys the types of preparations required to be produced in a sterile condition and explains in detail the methods available for sterilization. This monograph is comprised of four parts. Part 1 discusses the purposes of sterilizing pharmaceutical preparations to prevent the infection of body tissues, fluids, or cavities with organisms that may produce damage or disease. Part 2 provides information concerning the extent of contamination of pharmaceutical materials, which is obtained by means of sterility tests. Part 3 focuses on autoclave design and an explanation is offered of the background against which sterilizers have been developed and the method in which their major components operate. Part 4 describes the various types of disinfectants, including halogens, phenols, alcohols, aldehydes, dyes, furan derivatives, amidines, surface-active compounds, and derivatives of quinolone and isoquinoline. This monograph is a valuable resource for undergraduate students of pharmacy and allied subjects.

Pharmacology of Conditioning, Learning and Retention

  • 1st Edition
  • January 1, 1965
  • M. Ya. Mikhel'son + 1 more
  • English
  • eBook
    9 7 8 - 1 - 4 8 3 2 - 2 3 5 0 - 6
Proceedings of the Second International Pharmacological Meeting, Volume 1: Pharmacology of Conditioning, Learning and Retention is a collection of papers presented at the Second International Pharmacological Meeting on August 20-23, 1963. This book is organized into two sections encompassing 28 chapters. The first section defines the main problem in psychopharmacology, which is the establishment of methods that will enable to appreciate in animals the value of psychotropic drugs in the therapy of human mental diseases. This section also describes the specific activation of the central nervous system and its significance in psychopharmacological research. The second section explores the electrophysiological phenomena observed during pharmacological conditioning, with emphasis on the modifications of electrical activity during the establishment and the performance of the conditioned responses. This section also deals with the electrical correlated of various kinds of conditioned behavior in animals and the alterations of spontaneous rhythm and evoked potentials. This book is of value to psychopharmacologists and electrophysiologists.

Progress in Chemical Toxicology

  • 1st Edition
  • January 1, 1965
  • Abraham Stolman
  • English
  • eBook
    9 7 8 - 1 - 4 8 3 2 - 2 4 9 0 - 9
Progress in Chemical Toxicology, Volume 2 reviews significant developments in chemical toxicology, with particular reference to the mode of absorption, distribution, excretion, and metabolism of drugs and poisons in both humans and animals. Some of the techniques for the rapid infrared analysis and identification of gases in human breath are also discussed, along with rapid drug analysis by ion-exchange paper chromatography and ionophoresis. Comprised of six chapters, this volume first deals with the absorption, distribution, and excretion of poisons and their metabolites, including drugs extractable by organic solvents from aqueous acid and alkaline solutions. Subsequent chapters focus on the use of rapid infrared techniques in the detection of volatile organic compounds and toxic gases in humans; rapid methods of toxicological analysis by ion-exchange paper chromatography and ionophoresis; sample preparation and techniques for concentration of metal poisons for increased sensitivity of spectrographic analysis; and application of thin layer chromatography in toxicology. An approach to the analysis of biological specimens for basic drugs is also described. This book will be of interest to chemists and toxicologists.

Screening Methods in Pharmacology

  • 1st Edition
  • January 1, 1965
  • Robert Turner
  • English
  • eBook
    9 7 8 - 1 - 4 8 3 2 - 6 1 6 0 - 7
Screening Methods in Pharmacology focuses on the methods for screening substances for pharmacological activities and discussions of organization of screening programs. The manuscript first offers information on the biochemistry of the nervous system and organization of screening, as well as mechanisms of drug effects within the autonomic system; mechanisms within the parasympathetic and symphatetic systems; and neuropharmacological tests in blind screening. The book also takes a look at general and quantal responses. The publication reviews depressants of the central nervous system and ataractic (tranquillizing, neuroleptic) agents. Topics include natatory exhaustion, motor deficit, righting reflex, pentylenetetrazol (metrazol) antagonism, head-withdrawal reflex, and avoidance of electrical shock. The book also ponders on analgesics and oxytoxic, antiserotonin, and anti-inflammatory agents. Discussions focus on narcotic and nonnarcotic analgesics, erythema, inhibition of ascites, and pleural fluid. The manuscript is a valuable reference for readers interested in the screening methods in pharmacology.

Pharmacology of Cardiac Function

  • 1st Edition
  • January 1, 1964
  • Otto Krayer
  • English
  • eBook
    9 7 8 - 1 - 4 8 3 1 - 6 4 5 2 - 6
Pharmacology of Cardiac Function brings together the proceedings of the Second International Pharmacological Meeting of the International Union of Physiological Sciences, held in Prague, Czechoslovakia, on August 20-23, 1963. The meeting provided a forum for discussing advances in the understanding of the pharmacology of cardiac function and addressed topics ranging from the link between muscle physiology and the heart to the development of tension in cardiac muscle. This volume is comprised of 21 chapters and begins with an overview of the structural aspects of contraction in cardiac and skeletal muscle, followed by a description of muscle physiology and its effect on the heart. The next section deals with the effects of drugs on the interval-strength relationship of heart muscle, paying particular attention to acetylstrophanthidin, levarterenol, and carbacliol as well as metabolic inhibitors. The nature of the restitution process occurring between beats in cardiac muscle is also considered. Subsequent chapters explore how the heart is affected by the action of the vagus and of acetylcholine and other parasympathomimetic drugs; membrane effects of epinephrine and digitalis; and the mode of action of antifibrillatory drugs. This book will be of particular value to pharmacologists and physiologists.

Insecticides

  • 1st Edition
  • January 1, 1964
  • Gunter Zweig
  • English
  • eBook
    9 7 8 - 1 - 4 8 3 2 - 2 1 7 7 - 9
Analytical Methods for Pesticides, Plant Growth Regulators, and Food Additives, Volume II: Insecticides contains detailed analytical procedures for analysis of 47 widely used insecticides. This volume is composed of 47 chapters that cover the history, biological and chemical properties, and physical constants of these insecticides. Each chapter presents first the general information, followed by intensive discussion of the methods of occurrence and residue analysis of the insecticide. Methods of analysis covered in each chapter include chemical methods, gas-liquid chromatography, colorimetry, and enzymatic techniques. Each chapter also provides analysis of phosphorus and acetylcholinesterase inhibition of the insecticide, which is classified into two groups, namely, organochlorine and organophosphorus. Agriculturists, analytical chemists, and toxicologists will find this book rewarding.

Drugs in Cerebral Palsy

  • 1st Edition
  • January 1, 1964
  • Eric Denhoff + 2 more
  • Eric Denhoff
  • English
  • eBook
    9 7 8 - 1 - 4 8 3 2 - 2 1 8 4 - 7
Clinics in Developmental Medicine No. 16: Drugs in Cerebral Palsy: Based on a Symposium held at Dallas, 24-26 November, 1963 is a collection of papers of the 1963 Symposium on Drugs in Cerebral Palsy, arranged by the American Academy. This book is composed of nine chapters that cover the various components and treatment options involved in cerebral palsy. This text begins with a presentation of the many problems of drug evaluation, with an emphasis on the issue that human responses to a drug cannot be predicted from those of animals and that the response of one human to a drug may differ quite sharply from that of another. The next chapters deal with the historical developments and pharmacology of drugs in cerebral palsy, as well as the two aspects of drug evaluation, namely, the immediate or direct effects of the drug on patients and the double-blind test. The discussion the shifts to the pharmacological capacity of muscle relaxants and anti-convulsant drugs. The last chapter considers the possible toxic drug reactions, which are the result of individual idiosyncrasy and may occur regardless of drug dosage. This book will be of value to pharmacologists, neurologists, clinicians, and researchers who are interested in drug evaluation in cerebral palsy.

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