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Books in Toxicology

Elsevier's Toxicology collection provides essential insights for researchers and scientists into mitigating the adverse effects of contaminants on organisms, covering research, analysis, risk assessment, detection, prevention, diagnosis, and treatment of toxic exposure. Including toxicity testing, environmental toxicology it offers valuable knowledge for addressing public health and safety challenges by examining the adverse effects of contaminants on human health, animals, and the environment.

    • Venoms of the Hymenoptera

      • 1st Edition
      • October 22, 2013
      • Tom Piek
      • English
      • Hardback
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      • Paperback
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      Venoms of the Hymenoptera: Biochemical, Pharmacological, and Behavioral Aspects contains papers that deals with the study of the venoms and toxins produced by insects belonging to the order of the Hymenoptera. The book provides a considerable amount of information in the study of the venoms of the Hymenoptera. There are chapters that focus on the history of the research made on the order of the Hymenoptera; the stinging apparatus; venom collection; physiological effects of venoms produced by particular insects belonging to the order; and the pharmacological uses of the venoms and toxins. Entomologists, physiologists, pharmacologists, biochemists, and researchers developing drugs and pesticides will find this text extremely useful.
    • Marijuana

      • 1st Edition
      • October 22, 2013
      • Loren L. Miller
      • English
      • Paperback
        9 7 8 1 4 8 3 2 4 3 5 7 3
      • Hardback
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      Marijuana: Effects on Human Behavior attempts to synthesize much of the existing experimentation concerning the acute and chronic effects of marijuana and its derivatives on human behavior. The book opens with a chapter on the strategies for conducting research on marijuana. It also describes a clinical study at the University of British Columbia. The next chapter discusses the issues that have beclouded the question of legalization of marijuana in the United States. This is followed by separate chapters on the effects of marijuana on motor and mental performance; marijuana-memory research; a model of attention which can be used to describe the effects of marijuana use on cognition; and the effects of marijuana on neuropsychological functioning and learning. Subsequent chapters examine the behavioral actions of cannabis in man; compare the behavioral actions of cannabinoids in humans with those found in infrahumans, with special reference to acquisition and retention processes, timing behavior, state-dependent learning, and attention; and investigate the long-term effects of cannabis use.
    • Neurotransmitters

      • 1st Edition
      • October 22, 2013
      • P. Simon
      • English
      • Hardback
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      Advances in Pharmacology and Therapeutics, Volume 2: Neurotransmitters contains the proceedings of the 7th International Congress of Pharmacology held in Paris, France, in 1978. The papers explore advances in the understanding of neurotransmitters, their pharmacology, and their therapeutic applications. Topics covered range from the functions of GABA to the interdependence of neurotransmitter systems in the central nervous system (CNS). This volume is comprised of 24 chapters and opens with a discussion on the role of GABA systems in Huntington's disease and schizophrenia. The reader is then introduced to the stereospecific actions of GABA analogues; interactions between serotonin and noradrenalin containing neurons; immunofluorescent staining of serotonin in the CNS; and plasticity of transmitter functions in sympathetic neurons developing in cell culture. The following chapters explore the molecular mechanisms underlying the modulation of catecholamine release from the adrenal medulla; pre-and postsynaptic regulation of catecholamine neurotransmitters; the role of GABA-ergic component in the mechanism of action of neurotropic drugs; and pre-and postsynaptic action of GABA in the mammalian spinal cord. This book will be of interest to practitioners in biosciences, pharmacology, physiology, and medicine.
    • Opiate Receptors and the Neurochemical Correlates of Pain

      • 1st Edition
      • October 22, 2013
      • Susanna Fürst
      • English
      • Paperback
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      Opiate Receptors and the Neurochemical Correlates of Pain, Volume V, documents the proceedings of the 3rd Congress of the Hungarian Pharmacological Society held in Budapest, 1979. The congress offered a good opportunity to stimulate discussions and exchange of ideas between scientists from various countries who approach the problem of narcotics and pain mechanisms in different ways. The 27 contributions in this volume have enriched knowledge in this rapidly expanding field of pharmacology. This volume begins with a discussion of opiate receptors. The results suggest the interaction of various morphine-like drugs with different opiate receptor populations. The existence in nerve tissue of specific opiate receptors binding morphine and other opioids has led to the assumption of endogenous ligand for opiate receptors. One section of the present volume is devoted to enkephalins and endorphins, their structure-activity relationships, interactions with transmitter and other systems, their behavioral effects, and to factors controlling their release. Some other aspects of nociception; the pathways involved in the mode of action of different types of analgesics, e.g. narcotics and non-narcotics; and their relations to inflammation and active substances, such as prostaglandins and substance P, are discussed from various aspects.
    • The Nervous System

      • 1st Edition
      • October 22, 2013
      • Walter S. Root + 1 more
      • English
      • Hardback
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      Physiological Pharmacology: A Comprehensive Treatise, Volume I: The Nervous System — Part A, Central Nervous System Drugs focuses on the influence of drugs on the functions of the central nervous system. The selection first offers information on absorption, distribution, and elimination and effects upon physiological systems. Discussions focus on factors that disturb normal sequence of uptake and elimination of volatile drugs; variations in distribution due to systemic effects of anesthetics; factors influencing the uptake of gases by tissues; and theories of general anesthesia. The book also ponders on alcohols, including alcohols acting on the central nervous system; effect of alcohols on and outside the central nervous system; and synergisms and antagonisms between alcohols and other drugs. The publication takes a look at sedatives and hypnotics, effects upon physiological systems, and analgesics and antipyretic drugs. The text also examines non-narcotic analgesics, tranquilizers, and diphenylmethane derivatives. The selection is a vital source of data for readers interested in the effects of drugs on the central nervous system.
    • Computational Toxicology

      • 1st Edition
      • June 4, 2013
      • Bruce A. Fowler
      • English
      • Hardback
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      Computational Toxicology: Methods and Applications for Risk Assessment is an essential reference on the translation of computational toxicology data into information that can be used for more informed risk assessment decision-making. This book is authored by leading international investigators who have real-world experience in relating computational toxicology methods to risk assessment. Key topics of interest include QSAR modeling, chemical mixtures, applications to metabolomic and metabonomic data sets, toxicogenomic analyses, applications to REACH informational strategies and much more. The examples provided in this book are based on cutting-edge technologies and set out to stimulate the further development of this promising field to offer rapid, better and more cost-effective answers to major public health concerns.
    • Advances in Molecular Toxicology

      • 1st Edition
      • Volume 7
      • August 7, 2013
      • English
      • Hardback
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      Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons, and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced by the human body itself manifest themselves as toxins. Not strictly limited to documenting these examples, the series is also concerned with the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field. Advances in Molecular Toxicology will report progress in all aspects of these rapidly evolving molecular aspects of toxicology with a view toward detailed elucidation of progress on the molecular level and on advances in technological approaches employed.
    • Annual Review of Chronopharmacology

      • 1st Edition
      • October 22, 2013
      • A. Reinberg + 2 more
      • English
      • Paperback
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      Annual Review of Chronopharmacology, Volume 2 presents a scholarly means of rapidly communicating findings and developments in chronopharmacology, which is considered a quickly emerging field. This text first discusses aspects and statistical procedures in chronobiology and chronopharmacology. This book then explains circadian and circannual changes in nephrotoxic effects of heavy metals and antibiotics; chronotoxicology and chronopharmacology with emphasis on carcinostatic agents; and chronopharmacology of cardiovascular medications. The chronopharmacology and chronotherapy of asthma are also tackled. This book concludes by explaining the chronopharmacology of antidepressant drugs and of the inflammatory process. This publication will be invaluable to those interested in the field of chronopharmacology.
    • Routes of Drug Administration

      • 1st Edition
      • October 22, 2013
      • A. T. Florence + 1 more
      • English
      • Paperback
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      Routes of Drug Administration covers topics about parenteral and enteral routes of drug administration. The book discusses the anatomy and physiology of administration sites; the formulation and design of delivery systems; and other relevant aspects of biopharmaceutics. The text describes pulmonary delivery, nasal, buccal, and transdermal routes of administration for systemic delivery, as well as a number of systems for more localized therapy with antibiotics. Innovative methods of antibiotic administration, such as continuous and intermittent infusion, endotracheal installation, aerosol delivery, antibiotic-impregnat... catheters, antibiotic-containin... bone cement, and beads, are also considered. Senior undergraduate and postgraduate students in pharmacy, medicine, nursing and allied health sciences and practitioners in these fields, as well as other professionals concerned with the preparation and administration of medicines and the monitoring of drug therapy will find the book useful.
    • Biological Response Mediators and Modulators

      • 1st Edition
      • October 22, 2013
      • J. Thomas August
      • English
      • Paperback
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      Biological Response Mediators and Modulators explains that the behavior of a cell depends upon the absorption of the ligand, the quantity of functional receptors existing for ligand recognition and binding, and the transduction of the signal through successive intercellular events. The book presents such model systems as the low-density lipoprotein (LDL) receptor, the epidermal growth factor receptor, and the insulin receptor. The LDL receptor is a model for a class of surface receptors that facilitate the cellular application of macromolecules through the process of receptor-mediated endocytosis. The book discusses the general characteristics of receptor-mediated endocytosis. Another topic of interest is the property of growth-related cell surface receptors. The section that follows describes the function of these receptors as tyrosine-specific protein kinases, which is related to the protein yields of some viral oncogenes. The amount of receptors in a cell depends upon the rates of synthesis and inactivation. The book will provide valuable insights for scientists, cytologists, students, and researchers in the field of chemistry.