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Books in Toxicology

Elsevier's Toxicology collection provides essential insights for researchers and scientists into mitigating the adverse effects of contaminants on organisms, covering research, analysis, risk assessment, detection, prevention, diagnosis, and treatment of toxic exposure. Including toxicity testing, environmental toxicology it offers valuable knowledge for addressing public health and safety challenges by examining the adverse effects of contaminants on human health, animals, and the environment.

  • Drugs and Enzymes

    Proceedings of The Second International Pharmacological Meeting, Vol. 4
    • 1st Edition
    • Bernard B. Brodie + 1 more
    • English
    Second International Pharmacological Meeting, Volume 4: Drugs and Enzymes is a collection of papers presented at the Second International Pharmacological Meeting on August 20-23, 1963. This volume is organized into two sections encompassing 41 chapters. The first section discusses the relationship between biochemical effects of drugs in vitro and their pharmacological effect in vivo. This section specifically examines the correlation between the action of substances on isolated smooth muscle and on the central nervous system, as well as the behavior of a centrally-acting drug and enzyme in the ion movement in the system. The second section surveys the biochemical mechanisms of drug toxicity. Considerable chapters in this section are devoted to the effect of drug toxicity, such as altered drug metabolism, enzyme induction, morphological changes, hepatic effects, and photosensitivity. This book will prove useful to pharmacologists, neurologists, biochemists, and researchers who are interested the fields of drugs and drug toxicity.

  • Pharmacological Control of Heart and Circulation

    Proceedings of the 3rd Congress of the Hungarian Pharmacological Society, Budapest, 1979
    • 1st Edition
    • L. Tardos + 2 more
    • English
    Pharmacological Control of Heart and Circulation, Volume 1, documents the proceedings of the 3rd Congress of the Hungarian Pharmacological Society held in Budapest, 1979. Because the papers published in this volume cover diverse areas of the cardiovascular field, they had to be arranged into several smaller symposia. The common thread running through these symposia is their focus on some pathological condition of the heart and circulation as well as on their control by drugs. The first symposium is devoted to the pharmacological control of the adverse effects of coronary insufficiency including disturbances in rhythm. The second symposium is dedicated to cardiac hypertrophy; to the action of cardiac hypertrophy on the sensitivity of the heart to drugs; and to the changes in the biochemical parameters of the myocardium due to cardiomegaly. The third symposium deals with hypertension and its pharmacological control. Two separate symposia are devoted to new drugs, namely the fourth symposium to the cerebrovascular activity of Cavinton—a synthetic Vinca-derivative; and the fifth to a newly developed beta-adrenergic blocking agent, Tobanum, to its anti-arrhythmic action, its effect in myocardial ischemia and in hypertension. Finally, a short symposium on serotonin and serotonin antagonists, both of great importance in cardiovascular pharmacology, is included.

  • Male Reproductive Toxicology

    • 1st Edition
    • Robert E. Chapin + 1 more
    • English
    Methods in Toxicology, Volume 3: Male Reproductive Toxicology, Part A, deals with the male reproductive system and discusses methods that will help identify toxicant-induced changes at all levels in living organisms. It is important to realize that a toxic effect does not occur in a vacuum. All work in toxicology must be predicated on a demonstrated adverse effect in vivo. If good toxicology cannot exist in a vacuum, then there must be a structure. Thus, the book begins by presenting a few models as examples of the ways experiments could be grouped to define the toxicity of a chemical. This is followed by separate chapters on methods such as male mouse sexual behavior test; in vitro techniques for assessing pituitary secretory function; histological methods for preservation of the rat testis; procedures for assessing testicular sperm head counts in mice, rats, and dogs; and guidelines for conducting rodent dominant lethal tests. Subsequent chapters cover topics such as methods for the isolation and purification of Leydig cells from rat and mouse testes, and techniques used in semen analysis and fertility assessment in the rabbit.

  • Annual Review of Chronopharmacology

    Volume 2
    • 1st Edition
    • A. Reinberg + 2 more
    • English
    Annual Review of Chronopharmacology, Volume 2 presents a scholarly means of rapidly communicating findings and developments in chronopharmacology, which is considered a quickly emerging field. This text first discusses aspects and statistical procedures in chronobiology and chronopharmacology. This book then explains circadian and circannual changes in nephrotoxic effects of heavy metals and antibiotics; chronotoxicology and chronopharmacology with emphasis on carcinostatic agents; and chronopharmacology of cardiovascular medications. The chronopharmacology and chronotherapy of asthma are also tackled. This book concludes by explaining the chronopharmacology of antidepressant drugs and of the inflammatory process. This publication will be invaluable to those interested in the field of chronopharmacology.

  • Mode of Action, Metabolism and Toxicology

    Pesticide Chemistry: Human Welfare and the Environment
    • 1st Edition
    • S. Matsunaka + 2 more
    • English
    Pesticide Chemistry: Human Welfare and the Environment, Volume 3: Mode of Action, Metabolism and Toxicology covers the proceeding of the Fifth International Congress of Pesticide Chemistry. This book is organized into three parts that tackle relevant issues regarding the use of pesticide. The opening part tackles topics relevant to the biochemistry of pests and mode of action of pesticides, such as influence of chlorinated and parathyroid insecticide on cellular calcium regulatory mechanisms; behavioral and lethal actions of amidines on invertebrates; and insect chitin synthetase as biochemical probe for insecticidal compounds. The second part encompasses metabolism and degradation of pesticides and xenobiotics and includes topics on propesticides; selective toxicity conferred by activation; and comparative biochemistry of animal, plant, and microorganism oxidases. The last part covers the toxicology of pesticides and xenobiotics, including the role of biochemical studies in modern toxicological assessment of pesticides; neurophysiological and behavioral assessment of pesticide toxicity; and genetic toxicology applied to the assessment of mutagenic, carcinogenic, and teratogenic action of pesticides and related compounds. This book will be of great interest to chemists, biologists, botanists, and entomologists or professionals whose line of work involves the use of pesticides and who are concerned with pesticide side-effects to the users and the environment.

  • Keep off the Grass

    A Scientific Enquiry Into the Biological Effects of Marijuana
    • 1st Edition
    • Gabriel G. Nahas
    • English
    Keep Off the Grass is a scientific inquiry into the scientific effects of marijuana. Marijuana, like most drugs ingested by man, gives the user the impression that his senses are enhanced, when in fact they have been distorted and impaired. This book is composed of 27 chapters, and starts with a brief introduction to the history of marijuana, the properties of its chemical components, called cannabinoids, and its widespread use and abuse. The succeeding chapters deal with the first scientific meetings on marijuana, social impact of marijuana, and its widespread use in some countries, such as in Morocco and Egypt. These topics are followed by discussions on the immunological and DNA effects of marijuana. The remaining chapters highlight the legal issues and government policies concerning the utility of this plant.

  • The Hallucinogens

    • 1st Edition
    • A. Hoffer + 1 more
    • English
    The Hallucinogens attempts to provide a detailed description of the hallucinogens in a single volume. Hallucinogens are chemicals which in nontoxic doses produce changes in perception, in thought, and in mood, but which seldom produce mental confusion, memory loss, or disorientation for person, place, and time. These latter changes are characteristic of organic brain reactions following intoxications with alcohol, anesthetics, and other toxic drugs. The book covers the following hallucinogens: plant ß-phenethylamines, d-lysergic acid diethylamide, ololiuqui, indole hallucinogens derived from tryptophan, and taraxein. The discussions include their chemistry, biochemistry, and neurophysiological effects. The final chapter deals with animal studies with hallucinogenic drugs. This work has been written for chemists, biochemists, psychologists, sociologists, and research physicians. While it cannot satisfy each group fully, it is sufficiently comprehensive and well documented so that each group can use it as a springboard for future enquiry into these fascinating chemicals.

  • Toxicology

    Mechanisms and Analytical Methods
    • 1st Edition
    • C. P. Stewart + 1 more
    • English
    Toxicology: Mechanisms and Analytical Methods, Volume II provides an account of the general methods of chemical analysis available to the toxicologist, discussion of the principles on which they are based, and a survey of the material to which they are applied. The volume supplements the methods presented in the first volume. It provides specific examples of general procedures; considers the important groups of poisons; arranges the order of extraction from biological material; and discusses the methods for identifying and determining the members of each poison group. The book will be invaluable to toxicologists, clinical chemists, and biochemists.

  • Prostaglandins-Immunopharmacology

    Proceedings of the 7Th International Congress of Pharmacology, Paris 1978
    • 1st Edition
    • B. B. Vargaftig
    • English
    Advances in Pharmacology and Therapeutics, Volume 4: Prostaglandins-Immun... contains the proceedings of the 7th International Congress of Pharmacology held in Paris, France, in 1978. The papers explore advances in the understanding of prostaglandins, their immunopharmacology, and their therapeutic applications. Topics covered range from the biochemistry of prostaglandins, thromboxanes, and prostacyclin to the pharmacology of blood platelets and pharmacological approaches to enhancement of immunity. This volume is comprised of 23 chapters and opens with a discussion on the discovery of prostaglandins and their possible biological functions, including platelet aggregation and adrenergic neurotransmission. The reader is then introduced to unstable metabolites of arachidonic acid in relation to thrombosis; pharmacological interference in biotransformation of arachidonic acid; participation of prostaglandins in inflammatory pain; and factors affecting the formation and actions of cyclic AMP in blood platelets. The following chapters explore the role of thymosin and the endocrine thymus in the maintenance of immune balance; effects of thymosin fraction 5 in cancer patients; and the immunoregulatory activities of non-toxic synthetic polyribonucleotides. This book will be of interest to practitioners in biosciences, pharmacology, physiology, and medicine.

  • Drugs in Cerebral Palsy

    Based on a Symposium Held at Dallas, 24-26 November, 1963
    • 1st Edition
    • Eric Denhoff + 2 more
    • Eric Denhoff
    • English
    Clinics in Developmental Medicine No. 16: Drugs in Cerebral Palsy: Based on a Symposium held at Dallas, 24-26 November, 1963 is a collection of papers of the 1963 Symposium on Drugs in Cerebral Palsy, arranged by the American Academy. This book is composed of nine chapters that cover the various components and treatment options involved in cerebral palsy. This text begins with a presentation of the many problems of drug evaluation, with an emphasis on the issue that human responses to a drug cannot be predicted from those of animals and that the response of one human to a drug may differ quite sharply from that of another. The next chapters deal with the historical developments and pharmacology of drugs in cerebral palsy, as well as the two aspects of drug evaluation, namely, the immediate or direct effects of the drug on patients and the double-blind test. The discussion the shifts to the pharmacological capacity of muscle relaxants and anti-convulsant drugs. The last chapter considers the possible toxic drug reactions, which are the result of individual idiosyncrasy and may occur regardless of drug dosage. This book will be of value to pharmacologists, neurologists, clinicians, and researchers who are interested in drug evaluation in cerebral palsy.

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