Books in Toxicology

Antibiotics

1st Edition
September 3, 2013
Tadeusz Korzybski + 2 more
English
eBook
9 7 8 1 4 8 3 2 2 3 0 4 9

Antibiotics; Origin, Nature and Properties, Volume II focuses on the principles of the classification of antibiotic substances. This volume is divided into four main topics—antibiotics produced by Fungi imperfecti, antibiotics produced by fungi belonging to the basidiomycetes and ascomycetes, antibiotics produced by lichens and algae, and antibiotics from higher plants. The antibiotics covered in this book include penicillin, viridicatin, cyclopaldic acid, cephalosporin P, bongkrek acid, chlamydosporine, and flammulin. The diploicin, chlorellin, chlorophorin, ethyl gallate, anacardic acid, and echinacosid are also described. Other antibiotics include the tuberosine, antifungal substance from field corn, fulvoplumerin, plumericin, and chinoc acid. This publication is recommended for pharmacists and specialists interested in the classification of antibiotics.

Antibiotics

1st Edition
September 3, 2013
Tadeusz Korzybski + 2 more
English
eBook
9 7 8 1 4 8 3 2 2 3 0 5 6

Antibiotics: Origin, Nature and Properties, Volume I is a systematic coverage of the sources, varieties, and properties of the antibiotics. This book is organized into two main parts encompassing 13 chapters. This book considers the antibiotics according to their sources. It describes the antibiotics produced by bacteria, Actinomycetes,Fungi imperfecti, Basidiomycetes, algae, lichens and green plants, and those from animal sources. This group of antibiotics includes, streptomycin, the tetracyclines, chloromycetin, the macrolide family of compounds of which erythromycin, magnamycin and spiramycin are members, and the antifungal polyene compounds. The members of each group are arranged according to their chemical and biological similarity. Sections on each antibiotic present complete information, including the name, description of the producing strains, composition of the media, methods of culture, isolation and purification of the antibiotic principle, its physical and chemical properties, antibiotic spectrum, toxicity for laboratory animals, results of treatment of experimental infections, and possible clinical applications. This book is of value to researchers and workers in various medical fields.

Nonclinical Development of Novel Biologics, Biosimilars, Vaccines and Specialty Biologics

1st Edition
June 27, 2013
Lisa M. Plitnick + 1 more
English
Hardback
9 7 8 0 1 2 3 9 4 8 1 0 6
eBook
9 7 8 0 1 2 3 9 4 8 2 3 6

Nonclinical Development of Novel Biologics, Biosimilars, Vaccines and Specialty Biologics is a complete reference devoted to the nonclinical safety assessment of novel biopharmaceuticals, biosimilars, vaccines, cell and gene therapies and blood products. This book compares and contrasts these types of biologics with one another and with small molecule drugs, while incorporating the most current and essential international regulatory documents. Each section discusses a different type of biologic, as well as early characterization strategies, principles of study design, preclinical pharmacokinetics and pharmacodynamics and preclinical assays. An edited book that is authored by leading experts in the field, this comprehensive reference provides critical insights to all researchers involved in early through late stage biologics.

Haschek and Rousseaux's Handbook of Toxicologic Pathology

3rd Edition
May 1, 2013
Brad Bolon + 4 more
English
Hardback
9 7 8 0 1 2 4 1 5 7 5 9 0
eBook
9 7 8 0 1 2 4 1 5 7 6 5 1

Haschek and Rousseaux's Handbook of Toxicologic Pathology is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. The 3e has been expanded by a full volume, and covers aspects of safety assessment not discussed in the 2e. Completely revised with many new chapters, it remains the most authoritative reference on toxicologic pathology for scientists and researchers studying and making decisions on drugs, biologics, medical devices and other chemicals, including agrochemicals and environmental contaminants. New topics include safety assessment, the drug life cycle, risk assessment, communication and management, carcinogenicity assessment, pharmacology and pharmacokinetics, biomarkers in toxicologic pathology, quality assurance, peer review, agrochemicals, nanotechnology, food and toxicologic pathology, the environment and toxicologic pathology and more.

Nonclinical Study Contracting and Monitoring

1st Edition
December 31, 2012
William F. Salminen + 2 more
English
Paperback
9 7 8 0 1 2 3 9 7 8 2 9 5
eBook
9 7 8 0 1 2 3 9 7 8 3 1 8

Nonclinical Study Contracting and Monitoring: A Practical Guide offers a systematic and straightforward handbook for obtaining high quality preclinical Good Laboratory Practice (GLP) studies. This book is full of real-world examples, processes, procedures, useful templates, checklists and sample reports to provide readers with a better understanding of exactly what happens during all stages of a GLP study and the critical aspects of GLP study design and conduct. Designed for both the novice and experienced scientist, this book covers the GLP regulations and how they impact preclinical studies, the differences between GLP, non-GLP and peer-reviewed studies, preclinical GLP study design, laboratory selection, contracts and business ethics, how to obtain test material for the study, animal sourcing and release for study, preparation of a draft report and much more. By illustrating the overall big picture and tying it together with the individual steps, this book is an essential resource to help scientists ensure a high quality GLP study that passes both scientific and regulatory scrutiny.

Enzymatic Basis of Detoxication Volume 1

1st Edition
December 2, 2012
William B. Jakoby
English
eBook
9 7 8 0 3 2 3 1 3 7 9 8 0

Enzymatic Basis of Detoxication, Volume I focuses on the catalytic mechanisms and physiological expression of the enzymes that are involved in the detoxication of foreign compounds. The book explores foreign compound metabolism at the level of what specific enzymes can do. This book is organized into three sections and comprised of 17 chapters. The discussion begins with an overview of detoxication and covers both catalytic and non-catalytic removal of foreign substances, along with the general properties of the enzymes that are active in detoxication. The reader is then introduced to the physiological aspects of detoxication, paying particular attention to the kinetic aspects of metabolism and elimination of foreign compounds in animals, human genetic variation in detoxication enzymes, and how such enzymes are induced. The next section focuses on mixed function oxygenase systems and includes chapters on cytochrome P-450 and the detoxication reactions it catalyzes. The book also considers other oxidation-reduction systems, with reference to alcohol dehydrogenase, aldehyde reductase, aldehyde oxidizing enzymes, ketone reductases, xanthine oxidase and aldehyde oxidase, glutathione peroxidase, and superoxide dismutases. The final chapter is devoted to monoamine oxidase, its properties, substrate specificity, inhibitors, kinetics and mechanism, and multiple forms. Pharmacologists, toxicologists, and biochemists will find this book extremely helpful.

Enzymatic Basis of Detoxication Volume 2

1st Edition
December 2, 2012
William B. Jakoby
English
eBook
9 7 8 0 3 2 3 1 3 8 2 0 8

Enzymatic Basis of Detoxication, Volume II, reviews the state of knowledge on foreign compound metabolism at the level of what specific enzymes can do. The book attempts to provide a holistic view of the information gleaned from work with specific, purified enzymes encompassing as many mammalian sources as have been studied. The book is organized into two parts. Part I on conjugation reactions and related systems includes studies on the properties of glucuronide formation; the physiological function, assay, and purificatgion of function of bilirubin-glucuronos... glucuronosyltransfer... the roles of N- and O-methylation reactions and glutathione transferases in detoxication; and amino acid conjugation. Part II presents studies on hydrolytic systems, covering the role of epoxide hydrolase, carboxylesterases, and amidases in detoxication and the regulatory effects of these enzymes. This book provides pharmacologists and toxicologists with the biochemical view of detoxication, and biochemists with the corresponding pharmacological and toxicological aspects.

Halogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Products

2nd Edition
December 2, 2012
R.D. Kimbrough + 1 more
English
eBook
9 7 8 0 4 4 4 5 9 8 9 2 9

The chemical industry is increasingly faced with problems arizing from chemicals produced during the manufacture of halogenated biphenyls or phenols. Knowledge of these chemicals and their destructive properties is sporadic, and the acute toxicity of this group varies widely. This informative revised edition presents the chemistry, environmental pollution problems, animal toxicology and information about structure-activity relationships. A brief overview is given of worker exposure and occupational illness. The book is divided into three parts: chemistry and environmental contamination; experimental toxicology; and human exposure and effects. Because of the great deal of interest in these compounds much new research work has been conducted since the first edition of this book was published. This revised edition has retained the effectiveness and clarity of the first edition, while being supplemented with new information, condensed old information, and examples of recent incidents.

Advances in Molecular Toxicology

1st Edition
Volume 6
August 1, 2012
James C. Fishbein
English
eBook
9 7 8 0 4 4 4 5 9 4 0 2 0

Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons, and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced by the human body itself manifest themselves as toxins. Not strictly limited to documenting these examples, the series is also concerned with the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field. Advances in Molecular Toxicology will report progress in all aspects of these rapidly evolving molecular aspects of toxicology with a view toward detailed elucidation of both progress on the molecular level and on advances in technological approaches employed.

Current Concepts in Drug Metabolism and Toxicology

1st Edition
Volume 63
June 12, 2012
Gabrielle M. Hawksworth
English
Hardback
9 7 8 0 1 2 3 9 8 3 3 9 8
eBook
9 7 8 0 1 2 3 9 8 3 5 9 6

This new volume of Advances in Pharmacology explores the current concepts in drug metabolism and toxicology. Chapters cover the Keap1-Nrf2 cell defense pathway, animal models of drug-induced idiosyncratic toxicity and the use of human embryonic and induced pluripotent stem cells for modeling metabolism and toxicity. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike.

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Social Sciences & Humanities

Health

Books in Toxicology

Antibiotics

Antibiotics

Nonclinical Development of Novel Biologics, Biosimilars, Vaccines and Specialty Biologics

Haschek and Rousseaux's Handbook of Toxicologic Pathology

Nonclinical Study Contracting and Monitoring

Enzymatic Basis of Detoxication Volume 1

Enzymatic Basis of Detoxication Volume 2

Halogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Products

Advances in Molecular Toxicology

Current Concepts in Drug Metabolism and Toxicology