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Books in Neurology

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Genetic Aberrancies and Neurodegenerative Disorders

  • 1st Edition
  • Volume 3
  • January 28, 2000
  • M.P. Mattson
  • English
  • eBook
    9 7 8 - 0 - 0 8 - 0 8 7 6 7 3 - 3
Genetic Aberrancies and Neurodegenerative Disorders presents critical reviews and emerging findings concerning the roles of genetic mutations and polymorphisms in the pathogenesis of a range of neurological disorders including Alzheimer's and Parkinson's diseases, trinucleotide repeat disorders, stroke, epilepsy and others. This volume, written by leading experts, brings together fundamental information concerning the roles of inherited traits in the pathogenesis of different neurodegenerative disorders. In addition to providing a catalogue of the known genetic alterations that are linked to specific neurodegenerative disorders, the chapters detail the current state of understanding of the cellular and biochemical mechanisms whereby the genetic aberrancies lead to neuronal dysfunction and degeneration. The emerging picture of each disorder, painted by pathological, biochemical and molecular brushes, suggests that they share key mechanisms including increased levels of oxidative stress, perturbed ion homeostasis, mitochondrial dysfunction and apoptotic proteolytic cascades. The existence of specific molecular defects provides the opportunity to design experiments that can establish the precise pathogenic mechanism of a specific mutation or genetic risk factor. The value of this approach is exemplified by recent studies of how mutations in Cu/Zn-superoxide dismutase cause amyotrophic lateral sclerosis and how presenilin mutations result in early-onset Alzheimer's disease. A theme developed among the different chapters is that events that occur during aging predispose neurons to genetic aberrancies that promote degenerative cascades, and that specific genetic defects exert their influence on particular populations of neurons in a disorder-specific manner. The chapters in this volume will stimulate readers to generate new hypotheses concerning the pathogenic mechanisms of genetic aberrancies that can be experimentally tested.

Neuronal Processing of Optic Flow

  • 1st Edition
  • Volume 44
  • November 22, 1999
  • Robert Adron Harris + 3 more
  • English
  • Hardback
    9 7 8 - 0 - 1 2 - 3 6 6 8 4 4 - 8
  • eBook
    9 7 8 - 0 - 0 8 - 0 8 5 7 7 8 - 7
When we walk, drive a car, or fly an airplane, visual motion is used to control and guide our movement. Optic flow describes the characteristic pattern of visual motion that arises in these situations. This book is the first to take an in-depth look at the neuronal processing strategies that underlie the brain's ability to analyze and use optic flow for the control of self-motion. It does so in a variety of species which use optic flow in different behavioral contexts. The spectrum ranges from flying insects to birds, higher mammals and man. The contributions cover physiological and behavioral studies as well as computational models. Neuronal Processing of Optic Flow provides an authoritative and comprehensive overview of the current state of research on this topic written by a group of authors who have made essential contributions to shaping this field of research over the last ten years.

Disorders of Brain, Behavior, and Cognition: The Neurocomputational Perspective

  • 1st Edition
  • Volume 121
  • September 16, 1999
  • J.A. Reggia + 2 more
  • English
  • eBook
    9 7 8 - 0 - 0 8 - 0 8 6 2 4 6 - 0
This book contains selected contributions of papers, many presented at the Second International Workshop on Neural Modeling of Brain Disorders, as well as a few additional papers on related topics, including a wide range of presentations describing computational models of neurological, neuropsychological and psychiatric disorders. It is a unique, comprehensive review of the state-of-the-art of modeling cognitive and brain disorders, appealing to a multidisciplinary audience of clinicians, psychologists, neuroscientists, cognitive scientists, computer scientists, and other neural network researchers. The rest of the book is organized along four main themes, involving memory, neuropsychological, neurological and psychiatric disorders. In general, the cognitive disorders and these psychiatric diseases traditionally regarded as "functional" were modeled along functional lines, while those disorders traditionally viewed as "organic" neurological diseases generally drew more from knowledge of the underlying neurobiology and pathophysiology.

The Histamine H<INF>3</INF> Receptor

  • 1st Edition
  • Volume 30
  • December 9, 1998
  • R. Leurs + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 4 4 4 - 8 2 9 3 6 - 8
  • eBook
    9 7 8 - 0 - 0 8 - 0 5 3 4 0 0 - 8
In the early eighties when the H3 receptor was identified, many thought that an H3 ligand, an agonist or an antagonist, would become available as a therapeutic agent. This has not occurred. The reason for this could be the fact that many investigators consider histamine mainly, if not only, as a mediator present in for example mast cells being released during allergic events. However, it has become apparent that histamine is an important neurotransmitter. Its role in the nervous system, especially in the central part of it, is rather extensive.The H3 receptor is mainly found as a presynaptic one, both on histaminergic neurons (the auto-type) and on other neuronal systems (the hetero-type). Both the H3 agonist and the H3 antagonist cause important pharmacological effects. Several ligands have become available now, including radiolabelled analogues.In this book, the current state of affairs with regards to the medicinal chemistry and pharmacology of the H3 receptor and the several ligands available are presented by a number of experts in the field. The book presents an extended review of what has happened since the first H3 paper appeared. The editors hope that publication of this work will lead to an increase in interest of both academia and industry for the H3 receptor, especially as a target for drug development.

Quantitative Functional Brain Imaging with Positron Emission Tomography

  • 1st Edition
  • August 28, 1998
  • Richard E. Carson + 2 more
  • English
  • Hardback
    9 7 8 - 0 - 1 2 - 1 6 1 3 4 0 - 2
  • eBook
    9 7 8 - 0 - 0 8 - 0 5 4 0 1 1 - 5
This book presents the latest scientific developments in the field of positron emission tomography (PET) dealing with data acquisition, image processing, applications, statistical analysis, tracer development, parameter estimation, and kinetic modeling. It covers improved methodology and the application of existing techniques to new areas. The text also describes new approaches in scanner design and image processing, and the latest techniques for modeling and statistical analyses. This volume will be a useful reference for the active brain PET scientist, as well as a valuable introduction for students and researchers who wish to take advantage of the capabilities of PET to study the normal and diseased brain.

The Comprehensive Evaluation and Treatment of Epilepsy

  • 1st Edition
  • April 22, 1997
  • Steven C. Schachter + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 1 2 - 6 2 1 3 5 5 - 3
  • eBook
    9 7 8 - 0 - 0 8 - 0 5 2 9 4 6 - 2
Epilepsy is, after headache, the second most common neurological disorder. This book clarifies the many courses of action to take in treating patients with epilepsy. It presents current knowledge about seizures and epilepsy in a comprehensive, socially conscious, and clear manner. The editors have provided this information in a comprehensive, easy-to-use, and practical form. This short, simple pedagogical guide to the diagnosis and management of epilepsy is an important reference work for all medical schools, hospitals, clinics, and primary care centers.

Excitatory Amino Acids

  • 1st Edition
  • January 10, 1997
  • Paul L. Herrling
  • English
  • Hardback
    9 7 8 - 0 - 1 2 - 5 4 6 8 2 0 - 6
  • eBook
    9 7 8 - 0 - 0 8 - 0 5 3 1 3 4 - 2
Glutamate is the major excitatory neurotransmitter in the brain and dysfunction of glutamate transmission is the likely cause of a variety of diseases including neurodegeneration following cerebral ischemia, Huntington's chorea, amyotrophic lateral sclerosis, epilepsy, spasticity, emesis, chronic pain, and schizophrenia. Excitatory amino acid receptor agonists and antagonists are therefore of major interest as potential drugs for central nervous system disorders. Excitatory Amino Acids is the first book entirely dedicated to the results of human testing of modulators of excitatory amino acid neurotransmitters.

Neurodegeneration and Neuroprotection in Parkinson's Disease

  • 1st Edition
  • Volume .
  • April 17, 1996
  • C. W. Olanow + 2 more
  • English
  • eBook
    9 7 8 - 0 - 0 8 - 0 5 3 7 4 1 - 2
Neuroscience Perspectives provides multidisciplinary reviews of topics in one of the most divers and rapidly advancing fields in the life sciences. Whether you are a new recruit to neuroscience, or an established expert, look to this series for 'one-stop' sources of the historical, physiological, pharmacological, biochemical, molecular biological, and therapeutic aspects of chosen research areas.

Eye Movement Research

  • 1st Edition
  • Volume 6
  • February 3, 1995
  • J.M. Findlay + 2 more
  • English
  • eBook
    9 7 8 - 0 - 0 8 - 0 5 3 1 5 4 - 0
This volume contains selected and edited papers from the 7th European Conference on Eye Movements (ECEM 7) held in Durham, UK on August 31-September 3 1993. The volume is organized as follows:- Invited Lectures, Pursuit and Co-Ordination, Saccade and Fixation Control, Oculomotor Physiology, Clinical and Medical Aspects of Eye Movements, Eye Movements and Cognition, Eye Movements and Language and finally, Displays and Applications.

The Visually Responsive Neuron

  • 1st Edition
  • Volume 95
  • March 18, 1993
  • T.P. Hicks + 2 more
  • English
  • eBook
    9 7 8 - 0 - 0 8 - 0 8 6 2 2 0 - 0
This timely new volume presents broad-based and wide-ranging contributions on all aspects of vision. The material is grouped for presentation in a logical fashion in five main themes: peripheral processing; sensory integration in superior colliculus; organization of visual projections; development and plasticity; and neuronal encoding and visually guided behavior.The material spans from molecules to cognition, including overt behavior, and synaptic and membrane levels of analysis. The species studied also range over diverse phyla, while contributors too form a diverse group representing Europe, North America, and Asia. The Visually Responsive Neuron is an exciting and informative addition to the well known Progress in Brain Research series.

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