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Books in Life sciences

Elsevier's Life Sciences collection helps researchers get comprehensive coverage and up-to-date information on the study of living organisms, their processes, and interrelationships, spanning disciplines like biology, genetics, and biochemistry, and addressing emerging trends such as genomics, biotechnology, and sustainability, essential for advancing knowledge and driving innovation in the field.

BooksJournals

    • 100 Years of Human Chorionic Gonadotropin

      • 1st Edition
      • February 7, 2020
      • Laurence A. Cole + 1 more
      • English
      • Paperback
        9 7 8 0 1 2 8 2 0 0 5 0 6
      • eBook
        9 7 8 0 1 2 8 2 1 6 0 9 5
      100 years of Human Chorionic Gonadotropin: Reviews and New Perspectives is a collection of articles written by some of the world’s leading experts on the pregnancy hormone and cancer marker hCG. In 2019 it is difficult to ignore the effect that our understanding of hCG has had on the lives of millions of people worldwide. The hCG immunoassay, in one form or another, is now one of the most common medical tests conducted and is often the first indication that a mother-to-be is pregnant. Not only a marker of pregnancy, hCG is utilized in the diagnosis and monitoring in oncology and presents a potential target for novel cancer therapeutics. 100 years ago, in 1919, Hirose was demonstrating gonadotropic functions which resulted from a chorionic factor. Over the last century this factor has become defined as hCG and more recently explored as not one molecule but a group of molecules with variable structure and variable functions in both pregnancy and cancer. hCG is a multi-faceted molecule that has clinical and therapeutic implications but can be a challenging topic for researchers and physicians alike. This text covers the different structures and functions of hCG exploring the genes and evolution of the molecule, the different protein and glycosylation structures which can exist and their effect on structure, detection and quantification. 100 Years of hCG is not an attempt to recount the history of every publication on hCG, but rather a collection of reviews and new perspectives by "hCG-ologists", the term used by Hussa to describe biochemists working on HCG in the first book written on the topic over 30 years ago. Some of the authors have been around a while, some not so long, but others are just beginning their journey with a most beguiling molecule.

    • Advanced Methods in Molecular Biology and Biotechnology

      • 1st Edition
      • October 28, 2020
      • Khalid Z. Masoodi + 2 more
      • English
      • Paperback
        9 7 8 0 1 2 8 2 4 4 4 9 4
      • eBook
        9 7 8 0 1 2 8 2 4 4 5 0 0
      Advanced Methods in Molecular Biology and Biotechnology: A Practical Lab Manual is a concise reference on common protocols and techniques for advanced molecular biology and biotechnology experimentation. Each chapter focuses on a different method, providing an overview before delving deeper into the procedure in a step-by-step approach. Techniques covered include genomic DNA extraction using cetyl trimethylammonium bromide (CTAB) and chloroform extraction, chromatographic techniques, ELISA, hybridization, gel electrophoresis, dot blot analysis and methods for studying polymerase chain reactions. Laboratory protocols and standard operating procedures for key equipment are also discussed, providing an instructive overview for lab work. This practical guide focuses on the latest advances and innovations in methods for molecular biology and biotechnology investigation, helping researchers and practitioners enhance and advance their own methodologies and take their work to the next level.

    • Protocols in Biochemistry and Clinical Biochemistry

      • 1st Edition
      • November 12, 2020
      • Shweta Pandey + 2 more
      • English
      • Paperback
        9 7 8 0 1 2 8 2 2 0 0 7 8
      • eBook
        9 7 8 0 1 2 8 2 2 0 0 8 5
      Protocols in Biochemistry and Clinical Biochemistry offers clear, applied instruction to fundamental biochemistry methods and protocols, from buffer preparation to nucleic acid purification, protein, lipid, carbohydrate, and enzyme testing, and clinical testing of vitamins, glucose and cholesterol levels, among other diagnostics. Each protocol is illustrated with step-by-step instructions, labeled diagrams, and color images, as well as a thorough overview of materials and equipment, precursor techniques, safety considerations and standards, analysis and statistics, alternative methods and troubleshooting.

    • Novel Therapies in Head and Neck Cancer: Beyond the Horizon

      • 1st Edition
      • Volume 9
      • June 29, 2020
      • Maie A. St. John + 1 more
      • English
      • Hardback
        9 7 8 0 1 2 8 2 0 6 7 9 9
      • eBook
        9 7 8 0 1 2 8 2 0 9 2 9 5
      Novel Therapies in Head and Neck Cancer: Beyond the Horizon, Volume Twelve, provides a high-level synthesis of the latest treatments and outcomes relating to head and neck cancer. Chemotherapy and immunotherapy for those cancer types are rapidly evolving, and an updated source based on the expertise of internationally renowned researchers is necessary. This book discusses the outcome of recent trials using chemotherapy, novel approaches for HPV+ SCCA, cases in which immunotherapy is more likely to be successful, and precision medicine based on target therapies. Additionally, new approaches for rare diseases in head and neck and novel drug delivery platforms are presented. This book will be a very useful source so that students, scientists and clinicians who can be facile with the data, build on what is known, and continue to offer cutting-edge, validated therapies to all patients.

    • Stem Cell Epigenetics

      • 1st Edition
      • Volume 17
      • August 5, 2020
      • English
      • Hardback
        9 7 8 0 1 2 8 1 4 0 8 5 7
      • eBook
        9 7 8 0 1 2 8 1 4 0 8 6 4
      Growing evidence suggests that epigenetic mechanisms play a central role in stem cell biology and are vital for determining gene expression during cellular differentiation and governing mammalian development. In Stem Cell Epigenetics, leading international researchers examine how chromatin regulation and bona fide epigenetic mechanisms underlie stem cell renewal and differentiation. Authors also explore how the diversity of cell types, including the extent revealed by single cell omic approaches, is achieved, and how such processes may be reversed or managed via epigenetic reprogramming.Topics discussed include chromatin in pluripotency, stem cells and DNA methylation, histone modifications in stem cells and differentiation, higher-order chromatin conformation in pluripotent cells, stem cells and cancer, epigenetics and disease modeling, brain organoids from pluripotent cells, transcriptional regulation in stem cells and differentiation, non-coding RNAs in pluripotency and early differentiation, and diseases caused by epigenetic alterations in stem cells. Additionally, the book discusses the potential implementation of stem cell epigenetics in drug discovery, regenerative medicine, and disease treatment. Stem Cell Epigenetics will provide researchers and physicians with a state-of-the-art map to orient across the frontiers of this fast-evolving field.

    • Integrative Pancreatic Intervention Therapy

      • 1st Edition
      • September 12, 2020
      • Ligong Lu + 4 more
      • English
      • Hardback
        9 7 8 0 1 2 8 1 9 4 0 2 7
      • eBook
        9 7 8 0 1 2 8 1 9 4 0 3 4
      Integrative Pancreatic Intervention Therapy: A Holistic Approach summarizes, in a systematic manner, the diagnosis and treatment of late, critical pancreatic diseases. The book gives insights into each interventional technique, with an ultimate goal of improving survival rates for late stage pancreatic cancer patients. Six sections cover basic and transformation research on pancreatic diseases, interventional therapy for benign pancreatic disease, interventional therapy for malignant pancreatic diseases, interventional therapy for pancreative cancer-related lesions, stem cell and targeted molecular therapy for pancreative carcinoma, and combined interventional therapy for pancreative carcinoma. This book will be useful for those looking to understand how best to apply interventional therapy for the improvement of late state pancreatic cancer treatment.

    • Mitochondrial Disease Genes Compendium

      • 1st Edition
      • April 28, 2020
      • Marni J. Falk
      • English
      • Paperback
        9 7 8 0 1 2 8 2 0 0 2 9 2
      • eBook
        9 7 8 0 1 2 8 2 0 0 3 0 8
      The field of Mitochondrial Medicine has been dominated by symptom constellation-based diagnostic categorization since the first clinical syndrome was described three decades ago. Now, as rapidly expanding knowledge has revealed that mitochondrial diseases may result from several hundred distinct gene disorders with extensive clinical and mutation heterogeneity, the most useful guide for clinical care and research embraces a gene-centric approach to each individual’s disorder. Together with international colleagues, Dr. Marni Falk has developed the Mitochondrial Disease Sequence Data Resource (MSeqDR), an online, community curated, centralized data resource of mitochondrial disease data from a genomic perspective. Here, in the Mitochondrial Disease Genes Compendium, Dr. Marni Falk and a team of international experts have built off their work on MSeqDR to provide an all-in-one, readily accessible, and easy-to-use at point of care reference on 256 mitochondrial disease genes from a gene-based perspective. In this book, clinicians and researchers will find a complete overview of mitochondrial disease genes relevant across all specialties, cataloging and building context around clinical features and the genetic basis of each condition. Within, each "gene page" offers an in-depth, referenced view of the relevant clinical disease spectrum, including gene and protein descriptions, year discovered, inheritance pattern(s), age ranges affected, major clinical features and severity range, clinical pearls, known therapies, available support groups, animal models, and gene-specific basic, translational, or clinical research activities now underway. Links provided on each gene page direct readers to MSeqDR for new findings, up-to-date genomic variant data, and user friendly informatics tools accessible to general clinicians and sophisticated geneticists or bioinformaticians alike, ensuring access to updated information on each condition.

    • Microbiomics

      • 1st Edition
      • February 21, 2020
      • English
      • Paperback
        9 7 8 0 1 2 8 1 6 6 6 4 2
      • eBook
        9 7 8 0 1 2 8 1 7 2 8 2 7
      Microbiomics: Dimensions, Applications, and Translational Implications of Human and Environmental Microbiome Research describes a new, holistic approach to microbiomics. International experts provide in-depth discussion of current research methods for studying human, environmental, viral and fungal microbiomes, as well as the implications of new discoveries for human health, nutrition, disease, cancer research, probiotics and in the food and agricultural industries. Distinct chapters covering culturomics and sub-microbiomes, such as the viriome and mycetobiome, provide an integrative framework for the expansion of microbiomics into new areas of application, as well as crosspollination between research areas. Detailed case studies include the use of microbiomics to develop natural products with antimicrobial properties, microbiomic enhancements in food and beverage technology, microbes for bioprotection and biopreservation, microbial tools to reduce antibiotic resistance, and maintenance and cultivation of human microbial communities.

    • Data Deduplication Approaches

      • 1st Edition
      • November 25, 2020
      • Tin Thein Thwel + 1 more
      • English
      • Paperback
        9 7 8 0 1 2 8 2 3 3 9 5 5
      • eBook
        9 7 8 0 1 2 8 2 3 6 3 3 8
      In the age of data science, the rapidly increasing amount of data is a major concern in numerous applications of computing operations and data storage. Duplicated data or redundant data is a main challenge in the field of data science research. Data Deduplication Approaches: Concepts, Strategies, and Challenges shows readers the various methods that can be used to eliminate multiple copies of the same files as well as duplicated segments or chunks of data within the associated files. Due to ever-increasing data duplication, its deduplication has become an especially useful field of research for storage environments, in particular persistent data storage. Data Deduplication Approaches provides readers with an overview of the concepts and background of data deduplication approaches, then proceeds to demonstrate in technical detail the strategies and challenges of real-time implementations of handling big data, data science, data backup, and recovery. The book also includes future research directions, case studies, and real-world applications of data deduplication, focusing on reduced storage, backup, recovery, and reliability.

    • Phenotypic Switching

      • 1st Edition
      • June 8, 2020
      • Herbert Levine + 3 more
      • English
      • Paperback
        9 7 8 0 1 2 8 1 7 9 9 6 3
      • eBook
        9 7 8 0 1 2 8 1 7 9 9 7 0
      Phenotypic Switching: Implications in Biology and Medicine provides a comprehensive examination of phenotypic switching across biological systems, including underlying mechanisms, evolutionary significance, and its role in biomedical science. Contributions from international leaders discuss conceptual and theoretical aspects of phenotypic plasticity, its influence over biological development, differentiation, biodiversity, and potential applications in cancer therapy, regenerative medicine and stem cell therapy, among other treatments. Chapters discuss fundamental mechanisms of phenotypic switching, including transition states, cell fate decisions, epigenetic factors, stochasticity, protein-based inheritance, specific areas of human development and disease relevance, phenotypic plasticity in melanoma, prostate cancer, breast cancer, non-genetic heterogeneity in cancer, hepatitis C, and more. This book is essential for active researchers, basic and translational scientists, clinicians, postgraduates and students in genetics, human genomics, pathology, bioinformatics, developmental biology, evolutionary biology and adaptive opportunities in yeast.

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Biochemistry biophysics

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