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Elsevier

Books in Human physiology

  • Implications of Artificial Intelligence in Next Generation Physiotherapy

    • 1st Edition
    • Manpreet Kaur + 3 more
    • English
    Implications of Artificial Intelligence in Next Generation Physiotherapy explores how artificial intelligence is transforming the future of physiotherapy across the entire continuum of rehabilitation. Covering musculoskeletal, neurological, cardiopulmonary, sports, paediatric, geriatric, women's health, and community-based physiotherapy, the book highlights how AI is reshaping clinical practice through intelligent assessment, precision rehabilitation, personalized treatment planning, predictive analytics, remote monitoring, and data-driven clinical decision-making.The book presents comprehensive coverage of emerging AI technologies, including machine learning, deep learning, computer vision, wearable sensors, robotics, virtual and augmented reality, digital twins, tele-rehabilitation, and intelligent clinical decision support systems. It also discusses workload monitoring, movement analysis, biomechanical assessment, functional outcome prediction, patient engagement, and continuous recovery tracking, supported by current research, real-world applications, and clinical case studies.Designed for researchers, clinicians, educators, students, and healthcare innovators, this book bridges the gap between cutting-edge artificial intelligence and evidence-based physiotherapy practice. By examining both current applications and future directions, it provides readers with the knowledge required to implement AI-driven innovations that enhance diagnostic accuracy, optimize rehabilitation outcomes, improve healthcare accessibility, and advance patient-centred care in the next generation of physiotherapy.

  • Biomechanics of the Human Spine

    Basic Concepts, Spinal Disorders and Treatments
    • 2nd Edition
    • Fabio Galbusera + 1 more
    • English
    Biomechanics of the Human Spine: Basic Concepts, Spinal Disorders and Treatments, Second Edition is an essential resource for both biomedical engineers and spinal surgeons. The book is divided into four key sections, each building on the previous to offer a thorough understanding of spine biomechanics. It starts with the functional anatomy of the spine, emphasizing often overlooked aspects of clinical literature. The second section details the mechanics of spinal tissues, including testing setups and mathematical models. The third section explores contemporary spine research methods, while the final section addresses biomechanical aspects of spinal pathologies and their surgical treatments.Contribut... from leading institutions worldwide ensure the inclusion of the latest research and expertise in spine biomechanics. Highlights include in-depth experimental testing, numerical simulation, and in vivo studies, such as imaging and motion analysis. The book stands out for its comprehensive approach, bridging the gap between biomechanical knowledge and clinical application. It is indispensable for professionals in the field, offering valuable insights and practical guidance for understanding and treating spinal disorders.

  • Cell Physiology Sourcebook

    • 5th Edition
    • F. Javier Alvarez-Leefmans + 1 more
    • English
    Written by leading experts in the field, the fifth edition of the Cell Physiology Sourcebook, Fifth Edition offers a critical, comprehensive, and multidisciplinary overview of essential aspects of cell physiology and biophysics, spanning from bacterial and archaeal cells to mammalian cells and tissues. The present edition incorporates new molecular insights without losing the integrative perspective of cell physiology and biophysics, as well as its foundational concepts. Our target readers are advanced students and researchers interested in understanding how cells work.The history of this book goes back to Hugh Davson’s classic A Textbook of General Physiology, which reached its fourth and last edition in 1970. The successor of this influential work was Cell Physiology Sourcebook, first published in 1995 and edited by the late Professor Nicholas Sperelakis, with a foreword written by Davson. At that time, the knowledge of molecular and cell physiology became so vast that a single author's work, like its predecessor, was materially impossible. Professor Sperelakis, for whom we dedicate the present edition, put together an impressive volume with the contribution of various experts in fundamental areas of the field until the 4th edition, published in 2012, one year before his death. This book's success and the gap it fills motivated the present editors to continue this project, updating the entire book to reflect new developments.

  • The Human Body

    Linking Structure and Function
    • 2nd Edition
    • Bruce M. Carlson
    • English
    The Human Body: Linking Structure and Function, Second Edition offers a comprehensive and accessible exploration of the human anatomy, making it an invaluable resource for students and professionals alike. Each chapter delves into a specific organ system, elaborating on how the unique structures within the body contribute to its overall functionality.Organi... by organ system, this succinct publication presents the functional relevance of developmental studies and integrates anatomical function with structure. A new chapter presents the functional anatomy of a joint, including the skeleton, muscles, connective tissues, nerves and vessels.Written by a leader in the field for upper undergraduate, graduate and postdoc market, as well as professors and researchers studying functional anatomy, developmental biology, physiology and across the life sciences, dentistry, and nursing.

  • Unveiling the History of Transplantation

    An Illustrated Review of the Boundaries, Fantasies and Realities
    • 1st Edition
    • Shi Chen
    • English
    Unveiling the History of Transplantation: An Illustrated Review of the Boundaries, Fantasies and Realities covers the key international figures involved in organ transplantation and related fields. It includes a discussion of the contributions of many Nobel Prize winners in Physiology and Medicine. The book introduces the whole process of transplantation and the latest research progress of cell, tissue, and organ transplantation: from initial exploration to maturity and on to widespread application. A key feature of this resource is that it includes a large number of unique historical photos and material related to organ transplantation as collected by the author from libraries worldwide.

  • Joint Replacement in the Human Body

    • 1st Edition
    • Thomas J Joyce
    • English
    Joint Replacement in the Human Body provides a comprehensive exploration of artificial joint designs. The book's primary focus is to introduce readers to the diverse landscape of artificial joint technologies while offering insights into their historical development. This book is divided into three sections, each addressing specific aspects of joint replacements. The first section delves into artificial joints of the lower limb, including the hip, knee, and ankle. In the subsequent section, the book explores upper limb replacements, covering joints such as the shoulder, elbow, wrist, finger, and thumb.The third section tackles broader themes like biotribology, regulatory aspects of joint replacements, examines noteworthy case studies like metal-on-metal hips, and addresses joint replacements not easily categorized in the previous sections, such as spinal total disc replacements. This book offers a critical assessment of the diverse and evolving design concepts currently in use, ranging from established metal-on-polymer joints to innovative biomimetic solutions. This book is designed to swiftly equip readers with a deep understanding of contemporary joint replacements and the immediate and long-term challenges they present.

  • Early Vascular Aging (EVA)

    New Directions in Cardiovascular Protection
    • 2nd Edition
    • Pedro Guimarães Cunha + 4 more
    • English
    Early Vascular Aging (EVA): New Directions in Cardiovascular Protection, Second Edition continues to be the most comprehensive and authoritative resource on premature alterations in artery structure and function. The book presents a novel approach to the problem of cardiovascular disease, showing it in relation to great vessels disease and revealing a comprehensive approach to the problem of increased rigidity of the great vessels, its causes, and further consequences. This second edition contains completely updated content with expanded coverage of basic and translational research, systematic reviews of the most prominent literature, discussion of applicability of new evidence and more. Written by an international team of clinicians and researchers, this is a valuable resource to basic and translational scientists, clinical researchers and clinicians in the cardiovascular field interested in prevention, diagnosis and treatment of EVA.

  • Diagnostic Molecular Pathology

    A Guide to Applied Molecular Testing
    • 2nd Edition
    • William B. Coleman + 1 more
    • English
    Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing, Second Edition assembles a group of experts to discuss the molecular basis and mechanisms of major human diseases and disease processes and how the molecular features of disease can be harnessed to develop practical molecular tests for disease detection, diagnosis and prognosis. The book explains how molecular tests are utilized in the treatment of patients in personalized medicine, highlights new technologies and approaches of applied molecular pathology, and discusses how this discovery-based research yields new and useful biomarkers and tests. As it is essential to stay up-to-date on new molecular diagnostics in this changing field, this book covers critically important areas in the practice of personalized medicine and reflects our understanding of the pathology, pathogenesis and pathophysiology of human disease.

  • Venous Ulcers

    • 2nd Edition
    • Cynthia K. Shortell + 1 more
    • English
    Venous Ulcers, Second Edition, provides a comprehensive synthesis of evidence-based recommendations and the highest level of expertise from a leading group of doctors, which is a fundamental constituent for the appropriate management of nonhealing venous wounds in everyday practice. This book offers a fertile environment for a complete understanding of genetics and molecular and biochemical mechanisms that lead to the development and progression of venous ulcers, which is essential for elucidating the underlying pathophysiology and can be utilized for developing novel therapies and accessing previously inaccessible areas of research. Socioeconomic impact, impact on health-related quality of life, the clinical course of the disease, and diagnostic algorithms are elaborated in detail. All currently available treatment modalities are explained in a clinically applicable approach with particular emphasis on operative technique, technical feasibility, success rates (both clinical and technical), and side effects. Lastly, this book elaborates on special diagnostic considerations and management of the most complex patients, often requiring the highest level of expertise for successful treatment.

  • Aging

    From Fundamental Biology to Societal Impact
    • 1st Edition
    • Paulo J. Oliveira + 1 more
    • English
    Aging: From Fundamental Biology to Societal Impact examines the interconnection of the cellular and molecular basis of aging and societal-based challenges and innovative interventions. Sections take a societal-based angle on aging, describing several flagship initiatives for healthy living and active aging in different regions, cover the biology of aging which includes the hallmarks of aging, explain the pathophysiology of aging, describing different comorbidities associated with aging and possible interventions to decrease the impact of aging, and envision future and innovative measures to tackle aging-related morbidities.Contribu... from an interdisciplinary panel of experts cover such topics as the biology of aging to physical activity, nutrition, psychology, pharmacology, health care, social care and urban planning.

  • Beauty, Aging and AntiAging

    • 1st Edition
    • Ibrahim Vargel + 1 more
    • English
    Beauty, Aging and AntiAging covers novel and updated research and treatment options regarding the effects of aging on human physiology. Beauty perception and related molecular pathways are reviewed, along with current medical and surgical approaches to aging. The first part of the book focuses on beauty, youth, aging and its effects on the human body. In the second part, various restorative treatment approaches are reviewed in detail. Particularly, invasive treatment options and molecular pathophysiology of aging are covered in this book.

  • Textbook of Arterial Stiffness and Pulsatile Hemodynamics in Health and Disease

    • 1st Edition
    • Julio A. Chirinos
    • English
    Textbook of Arterial Stiffness and Pulsatile Hemodynamics in Health and Disease, Two Volume Set covers the principles, physiology, biologic pathways, clinical implications and therapeutics surrounding arterial stiffness and pulsatile hemodynamics, along with a thorough overview of the field. The book presents complex engineering concepts in a way that those in science and medicine can more easily understand. It includes detailed illustrations. Additionally, it presents advanced bioengineering concepts in boxes for readers who wants more in-depth biophysical knowledge. This is a must-have reference for students, researchers and clinicians interested in learning more about this field.

  • Cardiovascular Pathology

    • 5th Edition
    • L. Maximilian Buja + 1 more
    • English
    Cardiovascular Pathology, Fifth Edition provides a comprehensive treatise on the pathology of cardiovascular diseases, combining presentations of detailed pathology of cardiovascular diseases coupled with contemporary insights into etiology and pathogenesis. Twenty-two chapters cover general topics, including cardiovascular genetics, heart failure, and transplantation, and specific congenital and acquired cardiovascular diseases, therapeutic interventions, and forensic aspects. New chapters address the scope of practice and training in cardiovascular pathology, with a focus on major diagnostic approaches used in contemporary practice and research in cardiovascular pathology, and a perspective on the field of cardiovascular regenerative medicine linked to the basic pathobiology of cell-based therapy. The book provides a unique combination of details of pathological anatomy essential for pathologists involved in the evaluation of cardiovascular specimens and cardiovascular diseases, and is an excellent reference for anyone interested in the natural history and therapeutic advances in the cardiovascular field.

  • Muscle Biology

    The Life History of a Muscle
    • 1st Edition
    • Bruce M. Carlson
    • English
    Muscle Biology: The Life History of a Muscle looks at the story of a muscle from its embryonic beginnings, through its growth and ability to adapt to changing functional circumstances during adult life, to its eventual decline in both structure and function as old age progresses. Injury occurs to muscle during normal activity, after trauma, and during the source of certain diseases. Chapters on both muscle regeneration and muscle diseases emphasize the possibilities and limitsations of the healing capacity of muscle fibers. Muscle Biology begins with a brief review about the structure and function of a normal mature muscle and then proceeds to follow the developmental history of a muscle from the embryo to old age in a manner that gives the reader a perspective about not only developmental controls but also how at any stage of development a muscle is able to adapt to its functional environment. The book discusses both normal and abnormal changes in the muscle, the mechanisms behind those changes and how to mitigate deleterious changes from disease, 'normal' aging, and disuse/lack of physical activity. This is a must-have reference for students, researchers and practitioners in need of a comprehensive overview of muscle biology.

  • Human Biochemistry

    • 2nd Edition
    • Gerald Litwack
    • English
    **Selected for Doody’s Core Titles® 2024 in Biochemistry**Human Biochemistry, Second Edition provides a comprehensive, pragmatic introduction to biochemistry as it relates to human development and disease. Here, Gerald Litwack, award-wining researcher and longtime teacher, discusses the biochemical aspects of organ systems and tissue, cells, proteins, enzymes, insulins and sugars, lipids, nucleic acids, amino acids, polypeptides, steroids, and vitamins and nutrition, among other topics. Fully updated to address recent advances, the new edition features fresh discussions on hypothalamic releasing hormones, DNA editing with CRISPR, new functions of cellular prions, plant-based diet and nutrition, and much more.Grounded in problem-driven learning, this new edition features clinical case studies, applications, chapter summaries, and review-based questions that translate basic biochemistry into clinical practice, thus empowering active clinicians, students and researchers.

  • Human Growth and Development

    • 3rd Edition
    • Noel Cameron + 1 more
    • English
    Human Growth and Development, Third Edition provides a comprehensive volume covering the biology of human growth and the genetic, endocrine, environmental, nutritional, and socio-economic factors that contribute towards its full expression. Human Growth and Development continues to be a valuable resource for researchers, professors and graduate students across the interdisciplinary area of human development. For the new edition, updates are made to all fourteen of the "core chapters" of the book which form the essential reading for a comprehensive understanding of human growth and development. Additionally, new special topics are covered including the interpretation of recently found sub-adult fossils that expand our understanding of the evolution of human growth and a discussion of the early pattern of growth and development as the developmental origins of risk for non-communicable diseases of adulthood. Human Growth and Development, Third Edition includes contributions from the well-known experts in the field and is the most reputable, comprehensive resource available.

  • Recent Trends in Computer-aided Diagnostic Systems for Skin Diseases

    Theory, Implementation, and Analysis
    • 1st Edition
    • Saptarshi Chatterjee + 2 more
    • English
    Recent Trends in Computer-aided Diagnostic Systems for Skin Diseases: Theory, Implementation, and Analysis provides comprehensive coverage on the development of computer-aided diagnostic (CAD) systems employing image processing and machine learning tools for improved, uniform evaluation and diagnosis (avoiding subjective judgment) of skin disorders. The methods and tools are described in a general way so that these tools can be applied not only for skin diseases but also for a wide range of analogous problems in the domain of biomedical systems. Moreover, quantification of clinically relevant information that can associate the findings of physicians/experts is the most challenging task of any CAD system. This book gives all the details in a step-by-step form for different modules so that the readers can develop each of the modules like preprocessing, feature extraction/learning, disease classification, as well as an entire expert diagnosis system themselves for their own applications.

  • Lahita's Systemic Lupus Erythematosus

    • 6th Edition
    • Robert G. Lahita
    • English
    Systemic lupus erythematosus (SLE), commonly called lupus, is a chronic autoimmune disorder that can affect virtually any organ of the body. In lupus, the body's immune system, which normally functions to protect against foreign invaders, becomes hyperactive, forming antibodies that attack normal tissues and organs, including the skin, joints, kidneys, brain, heart, lungs, and blood. Lupus is characterized by periods of illness, called flares, and periods of wellness or remission. Because its symptoms come and go and mimic those of other diseases, lupus is difficult to diagnose. There is no single laboratory test that can definitively prove that a person has the complex illness.To date, lupus has no known cause or cure. Early detection and treatment are the key to a better health outcome and can usually lessen the progression and severity of the disease. Anti-inflammatory drugs, antimalarials, and steroids (such as cortisone and others) are often used to treat lupus. Cytotoxic chemotherapies, like those used in the treatment of cancer, are also used to suppress the immune system in lupus patients. A new edition of this established and well-regarded reference combines basic science with clinical science to provide a translational medicine model. Systemic Lupus Erythematosus, Sixth Edition, is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease, and a reference work for hospital libraries.

  • Human Aging

    From Cellular Mechanisms to Therapeutic Strategies
    • 1st Edition
    • Calogero Caruso + 1 more
    • English
    Human Aging: From Cellular Mechanisms to Therapeutic Strategies offers an exhaustive picture of all the biological aspects of human aging by describing the key mechanisms associated with human aging and covering events that could disrupt the normal course of aging. Each chapter includes a summary of the salient points covered, along with futures prospects. The book provides readers with the information they need to gain or deepen the skills needed to evaluate the mechanisms of aging and age-related diseases and to monitor the effectiveness of therapies aimed at slowing aging. The book encourages PhD and Postdoc students, researchers, health professionals and others interested in the biology of aging to explore the fascinating and challenging questions about why and how we age as well as what can and cannot be done about it.

  • In Situ Molecular Pathology and Co-expression Analyses

    • 2nd Edition
    • Gerard J. Nuovo
    • English
    Major advancements in the field of in situ molecular pathology have occurred since publication of the first edition. In Situ Molecular Pathology and Co-expression Analyses, Second Edition, continues to teach both the molecular basis for the improvements and the actual protocols. This is the unique feature that separates it from the pack of other "cook-book" type approaches. The fields of in situ hybridization and immunohistochemistry have expanded rapidly where computer-based analyses systems have greatly expanded the power of these methods. Further, knowledge of the marked improvements in the reagents themselves since the first edition can make the difference of excellent versus misleading data. The automated platforms require that researchers and diagnostic biomedical investigators have a good understanding of the basics of in situ based tests, protocols, and biochemistry for troubleshooting in order to maximize the use of these platforms. This second edition focuses attention on straightforward protocols used to simultaneously detect two or more proteins/nucleic acids within intact tissue by doing co-expression analyses. Practicing molecular pathologists, diagnostic pathologists, laboratory directors, and toxicologists, as well as clinicians and researchers in training, will benefit from this clear presentation of protocols and theoretical framework. Data derived from in situ hybridization and immunohistochemistry...

  • Tantalizing Therapeutics in Bronchopulmonary Dysplasia

    • 1st Edition
    • Vineet Bhandari
    • English
    Tantalizing Therapeutics in Bronchopulmonary Dysplasia is a concise reference that provides an overview of emerging concepts in the understanding of lung development and injury from a molecular and cellular point-of-view, including exciting pathways that are paving the way for new options to prevent or treat Bronchopulmonary Dysplasia (BPD). The book's chapters are written by experts who are at the forefront of BPD research. Coverage includes chapters on exosomes, stem cells and miRs, as well as a section on new discoveries in BPD research with translational potential. This is a must-have reference for researchers, physicians and trainees working on BPD, lung developmental biology, and more.

  • Comparative Kinesiology of the Human Body

    Normal and Pathological Conditions
    • 1st Edition
    • Salih Angin + 1 more
    • English
    Comparative Kinesiology of the Human Body: Normal and Pathological Conditions covers changes in musculoskeletal, neurological and cardiopulmonary systems that, when combined, are the three pillars of human movement. It examines the causes, processes, consequences and contexts of physical activity from different perspectives and life stages, from early childhood to the elderly. The book explains how purposeful movement of the human body is affected by pathological conditions related to any of these major systems. Coverage also includes external and internal factors that affect human growth patterns and development throughout the lifespan (embryo, child, adult and geriatrics). This book is the perfect reference for researchers in kinesiology, but it is also ideal for clinicians and students involved in rehabilitation practice.

  • Functional and Clinical Neuroanatomy

    A Guide for Health Care Professionals
    • 1st Edition
    • Jahangir Moini + 1 more
    • English
    Functional and Clinical Neuroanatomy: A Guide for Health Care Professionals is a comprehensive, yet easy-to read, introduction to neuroanatomy that covers the structures and functions of the central, peripheral and autonomic nervous systems. The book also focuses on the clinical presentation of disease processes involving specific structures. It is the first review of clinical neuroanatomy that is written specifically for nurses, physician assistants, nurse practitioners, medical students and medical assistants who work in the field of neurology. It will also be an invaluable resource for graduate and postgraduate students in neuroscience. With 22 chapters, including two that provide complete neurological examinations and diagnostic evaluations, this book is an ideal resource for health care professionals across a wide variety of disciplines.

  • Atlas of the Morphology of the Human Cerebral Cortex on the Average MNI Brain

    • 1st Edition
    • Michael Petrides
    • English
    Atlas of the Morphology of the Human Cerebral Cortex on the Average MNI Brain provides a comprehensive identification of the sulci and gyri of the human brain on a series of coronal sections of the average MNI brain and identifies the likely location of the cytoarchitectonic areas of the cerebral cortex. Presentation in MNI Stereotaxic Space enables the atlas to serve as a useful working tool for structural/functiona... neuroimagers attempting to identify the sulcus or gyrus and the likely cytoarchitectonic area within which a functional activation or a structural change has occurred. A brief introductory section discusses the history and current state of studies of the sulcal and gyral morphology and cytoarchitecture of the human cerebral cortex.

  • Encyclopedia of Reproduction

    • 2nd Edition
    • Michael K. Skinner
    • English
    Encyclopedia of Reproduction, Second Edition, Six Volume Set comprehensively reviews biology and abnormalities, also covering the most common diseases in humans, such as prostate and breast cancer, as well as normal developmental biology, including embryogenesis, gestation, birth and puberty. Each article provides a comprehensive overview of the selected topic to inform a broad spectrum of readers, from advanced undergraduate students, to research professionals. Chapters also explore the latest advances in cloning, stem cells, endocrinology, clinical reproductive medicine and genomics. As reproductive health is a fundamental component of an individual’s overall health status and a central determinant of quality of life, this book provides the most extensive and authoritative reference within the field.

  • Conn's Handbook of Models for Human Aging

    • 2nd Edition
    • Jeffrey L. Ram + 1 more
    • English
    Conn's Handbook of Models for Human Aging, Second Edition, presents key aspects of biology, nutrition, factors affecting lifespan, methods of age determination, use in research and the disadvantages/advant... of use. Using a multidisciplinary approach, this updated edition is designed as the only comprehensive, current work that covers the diversity in aging models. Chapters on comparative models explore age-related diseases, including Alzheimer's, joint disease, cataracts, cancer and obesity. Also included are new tricks and approaches not available in primary publications. This must-have handbook is an indispensable resource for researchers interested in the mechanisms of aging, gerontologists, health professionals, allied health practitioners and students.

  • Research in the Biomedical Sciences

    Transparent and Reproducible
    • 1st Edition
    • Michael Williams + 2 more
    • English
    Research in the Biomedical Sciences: Transparent and Reproducible documents the widespread concerns related to reproducibility in biomedical research and provides a best practices guide to effective and transparent hypothesis generation, experimental design, reagent standardization (including validation and authentication), statistical analysis, and data reporting. The book addresses issues in the perceived value of the existing peer review process and calls for the need for improved transparency in data reporting. It reflects new guidelines for publication that include manuscript checklists, replication/reproduc... initiatives, and the potential consequences for the biomedical research community and societal health and well-being if training, mentoring, and funding of new generations of researchers and incentives for publications are not improved. This book offers real world examples, insights, and solutions to provide a thought-provoking and timely resource for all those learning about, or engaged in, performing and supervising research across the biomedical sciences.

  • Biomechanics of Living Organs

    Hyperelastic Constitutive Laws for Finite Element Modeling
    • 1st Edition
    • Yohan Payan + 1 more
    • English
    Biomechanics of Living Organs: Hyperelastic Constitutive Laws for Finite Element Modeling is the first book to cover finite element biomechanical modeling of each organ in the human body. This collection of chapters from the leaders in the field focuses on the constitutive laws for each organ. Each author introduces the state-of-the-art concerning constitutive laws and then illustrates the implementation of such laws with Finite Element Modeling of these organs. The focus of each chapter is on instruction, careful derivation and presentation of formulae, and methods. When modeling tissues, this book will help users determine modeling parameters and the variability for particular populations. Chapters highlight important experimental techniques needed to inform, motivate, and validate the choice of strain energy function or the constitutive model. Remodeling, growth, and damage are all covered, as is the relationship of constitutive relationships of organs to tissue and molecular scale properties (as net organ behavior depends fundamentally on its sub components). This book is intended for professionals, academics, and students in tissue and continuum biomechanics.

  • Alpha-1-antitrypsin Deficiency

    Biology, Diagnosis, Clinical Significance, and Emerging Therapies
    • 1st Edition
    • Noor Kalsheker + 1 more
    • English
    Alpha-1-antitrypsin Deficiency: Biology, Diagnosis, Clinical Significance, and Emerging Therapies is the authoritative reference on AATD, providing standards for diagnosis, monitoring, treatment and appropriate avenues of research. The book covers the disease from basic biology and epidemiology, to clinical impact, and includes the understanding of the natural history of the disease and the significant advances that have been made in the last 20 years, including the three-dimensional structure of the molecule, its broad biological activity and improved therapeutic options, including replacement therapy and gene therapy. The editors have recruited international experts in the field to contribute evidence-based chapters and insights on future developments in the understanding of this disease.

  • Atlas of the Human Body

    Central Nervous System and Vascularization
    • 1st Edition
    • Branislav Vidic + 1 more
    • English
    Atlas of Human Body: Central Nervous System and Vascularization is a multidisciplinary approach to the technical coverage of anatomical structures and relationships. It contains surface and 3D dissection images, native and colored cross sectional views made in different planes, MRI comparisons, demonstrations of cranial nerve origins, distribution of blood vessels by dissection, and systematic presentation of arterial distribution from the precapillary level, using the methyl metacrylate injection and subsequent tissue digestion method.　 Included throughout are late prenatal (fetal) and early postnatal images to contribute to a better understanding of structure/relationsh... specificity of differentiation at various developmental intervals (conduits, organs, somatic, or branchial derivatives). Each chapter features clinical correlations providing a unique perspective of side-by side comparisons of dissection images, magnetic resonance imaging and computed tomography. Created after many years of professional and scientific cooperation between the authors and their parent institutions, this important resource will serve researchers, students, and doctors in their professional work.

  • Metabolism and Pathophysiology of Bariatric Surgery

    Nutrition, Procedures, Outcomes and Adverse Effects
    • 1st Edition
    • Victor R. Preedy + 2 more
    • English
    Pathophysiology of Bariatric Surgery: Metabolism, Nutrition, Procedures, Outcomes and Adverse Effects uses a metabolic and nutritional theme to explain the complex interrelationships between obesity and metabolic profiles before and after bariatric surgery. The book is sectioned into seven distinct areas, Features of Obesity, Surgical Procedures, Nutritional Aspects, Metabolic Aspects, Diabetes, Insulin Resistance and Glucose Control, Cardiovascular and Physiological Effects, and Psychological and Behavioral Effects. Included is coverage on the various types of bariatric surgery, including Roux-en-Y gastric bypass, gastric banding, sleeve gastrectomy, biliopancreatic diversion, and jejunoileal bypass, as well as the variations upon these procedures.

  • Hyperpolarized and Inert Gas MRI

    From Technology to Application in Research and Medicine
    • 1st Edition
    • Mitchell S. Albert + 1 more
    • English
    Hyperpolarized and Inert Gas MRI: Theory and Applications in Research and Medicine is the first comprehensive volume published on HP gas MRI. Since the 1990’s, when HP gas MRI was invented by Dr. Albert and his colleagues, the HP gas MRI field has grown dramatically. The technique has proven to be a useful tool for diagnosis, disease staging, and therapy evaluation for obstructive lung diseases, including asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis. HP gas MRI has also been developed for functional imaging of the brain and is presently being developed for molecular imaging, including molecules associated with lung cancer, breast cancer, and Alzheimer’s disease. Taking into account the ongoing growth of this field and the potential for future clinical applications, the book pulls together the most relevant and cutting-edge research available in HP gas MRI into one resource.

  • The Microbiota in Gastrointestinal Pathophysiology

    Implications for Human Health, Prebiotics, Probiotics, and Dysbiosis
    • 1st Edition
    • Martin H. Floch + 2 more
    • English
    The Microbiota in Gastrointestinal Pathophysiology: Implications for Human Health, Prebiotics, Probiotics and Dysbiosis is a one-stop reference on the state-of-the-art research on gut microbial ecology in relation to human disease. This important resource starts with an overview of the normal microbiota of the gastrointestinal tract, including the esophagus, stomach, Ileum, and colon. The book then identifies what a healthy vs. unhealthy microbial community looks like, including methods of identification. Also included is insight into which features and contributions the microbiota make that are essential and useful to host physiology, as is information on how to promote appropriate mutualisms and prevent undesirable dysbioses. Through the power of synthesizing what is known by experienced researchers in the field, current gaps are closed, raising understanding of the role of the microbiome and allowing for further research.

  • Biomarkers of Kidney Disease

    • 2nd Edition
    • Charles L. Edelstein
    • English
    Biomarkers of Kidney Disease, Second Edition, focuses on the basic and clinical research of biomarkers in common kidney diseases, detailing the characteristics of an ideal biomarker. The latest techniques for biomarker detection, including metabolomics and proteomics are covered in the book. This comprehensive book details the latest advances made in the field of biomarker research and development in kidney diseases. The book is an ideal companion for those interested in biomarker research and development, proteomics and metabolomics, kidney diseases, statistical analysis, transplantation, and preeclampsia. New chapters include biomarkers of cardiovascular disease in patients with CKD, biomarkers of Polycystic Kidney Disease, and biomarkers and the role of nanomedicine.

  • Diagnostic Molecular Pathology

    A Guide to Applied Molecular Testing
    • 1st Edition
    • William B. Coleman + 1 more
    • English
    Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing is organized around disease types (genetic disease, infectious disease, neoplastic disease, among others). In each section, the authors provide background on disease mechanisms and describe how laboratory testing is built on knowledge of these mechanisms. Sections are dedicated to general methodologies employed in testing (to convey the concepts reflected in the methods), and specific description of how these methods can be applied and are applied to specific diseases are described. The book does not present molecular methods in isolation, but considers how other evidence (symptoms, radiology or other imaging, or other clinical tests) is used to guide the selection of molecular tests or how these other data are used in conjunction with molecular tests to make diagnoses (or otherwise contribute to clinical workup). In addition, final chapters look to the future (new technologies, new approaches) of applied molecular pathology and how discovery-based research will yield new and useful biomarkers and tests. Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing contains exercises to test readers on their understanding of how molecular diagnostic tests are utilized and the value of the information that can be obtained in the context of the patient workup. Readers are directed to an ancillary website that contains supplementary materials in the form of exercises where decision trees can be employed to simulate actual clinical decisions.

  • Percutaneous Surgery of the Upper Urinary Tract

    Handbook of Endourology
    • 1st Edition
    • Petrisor Aurelian Geavlete
    • English
    Percutaneous Surgery of the Upper Urinary Tract: Handbook of Endourology contains five focused, review-oriented volumes that are ideal for students and clinicians looking for a comprehensive review rather than a whole course. Each volume is easily accessible through eBook format. Topics covered review both the endourological diagnosis and treatment of prostate, urethral, urinary bladder, upper urinary tract, and renal pathology. All chapters describe the most recent techniques, review the latest results, and analyze the most modern technologies. In the past ten years, the field of endourology has expanded beyond the urinary tract to include all urologic minimally invasive surgical procedures. Recent advancements in robotic and laparoscopic bladder surgery make this one of the fastest moving fields in medicine. As current textbooks are too time-consuming for busy urologists or trainees who also need to learn other areas of urology, this collection provides quick references and over 4000 images that are appropriate for fellows as well as those teaching in the field.

  • Ideal Marriage Its Physiology and Technique

    • 2nd Edition
    • Th. H. Van De Velde
    • English
    Ideal Marriage: Its Physiology and Technique, Second Edition concentrates on the cultivation of the technique of eroticism as an art in marriage. This book consists of historical facts and practical details that set the sexual relationship in the nostalgic prose of a more leisured age. The topics discussed include the four corner-stones of marriage; glimpses into general human sexual physiology; olfactory sexua1 impressions; and notes on the sexual physiology of the adult woman. The protection of ovum after expulsion from follicle; internal or endocrine testicular secretion; and normal stages of sexual intercourse are also elaborated. This publication likewise covers the stronger inclination of women to love-bite; alleged dangers of urethritis for man; and intercourse during illness and morbid conditions. This edition is useful to individuals interested in the erotic arts.

  • Sex Differences in Physiology

    • 1st Edition
    • Gretchen Neigh + 1 more
    • English
    Sex Differences in Physiology is an all-encompassing reference that details basic science research into sex differences in all physiological fields. It includes scientific discoveries concerning sex differences in cardiovascular, respiratory, renal, gastrointestinal, and musculoskeletal physiology. In addition, coverage of the development, endocrinology, neurophysiology, immunity, and metabolism is included, making this important reference a resource that will meet the needs of investigators interested in incorporating sex differences into their research programs, while also providing clinicians with the basis for providing the best sex-based medical treatment options available.

  • Retrograde Ureteroscopy

    Handbook of Endourology
    • 1st Edition
    • Petrisor Aurelian Geavlete
    • English
    Retrograde Ureteroscopy: Handbook of Endourology contains five focused, review-oriented volumes that are ideal for students and clinicians looking for a comprehensive review rather than a whole course. Topics covered review both the endourological diagnosis and treatment of prostate, urethral, urinary bladder, upper urinary tract, and renal pathology, with all chapters describing the most recent techniques, reviewing the latest results, and analyzing the most modern technologies. In the past ten years, the field of endourology has expanded beyond the urinary tract to include all urologic, minimally-invasive surgical procedures. Recent advancements in robotic and laparoscopic bladder surgery make this one of the fastest moving fields in medicine. As current textbooks are too time-consuming for busy urologists or trainees who also need to learn other areas of urology, this collection provides a quick references with over 4000 images that are appropriate for fellows and those teaching in the field.

  • Biomechanics of the Female Pelvic Floor

    • 1st Edition
    • Lennox Hoyte + 1 more
    • English
    Biomechanics of the Female Pelvic Floor, Second Edition, is the first book to specifically focus on this key part of women’s health, combining engineering and clinical expertise. This edited collection will help readers understand the risk factors for pelvic floor dysfunction, the mechanisms of childbirth related injury, and how to design intrapartum preventative strategies, optimal repair techniques, and prostheses. The authors have combined their expertise to create a thorough, comprehensive view of female pelvic floor biomechanics in order to help different disciplines discuss, research, and drive solutions to pressing problems. The book includes a common language for the design, conduct, and reporting of research studies in female PFD, and will be of interest to biomechanical and prosthetic tissue engineers and clinicians interested in female pelvic floor dysfunction, including urologists, urogynecologists, maternal fetal medicine specialists, and physical therapists.

  • Endoscopic Diagnosis and Treatment in Prostate Pathology

    Handbook of Endourology
    • 1st Edition
    • Petrisor Aurelian Geavlete
    • English
    Handbook of Endourology contains five focused, review-oriented volumes that are ideal for students and clinicians looking for a comprehensive review rather than a whole course. Each volume is easily accessible through eBook format. Topics covered review both the endourological diagnosis and treatment of prostate, urethral, urinary bladder, upper urinary tract, and renal pathology. All chapters describe the most recent techniques, review the latest results, and analyze the most modern technologies. In the past ten years, the field of endourology has expanded beyond the urinary tract to include all urologic minimally invasive surgical procedures. Recent advancements in robotic and laparoscopic bladder surgery make this one of the fastest moving fields in medicine. As current textbooks are too time-consuming for busy urologists or trainees who also need to learn other areas of urology, this collection provides quick references and over 4000 images that are appropriate for fellows as well as those teaching in the field.

  • Endoscopic Diagnosis and Treatment in Urethral Pathology

    Handbook of Endourology
    • 1st Edition
    • Petrisor Aurelian Geavlete
    • English
    Handbook of Endourology contains five focused, review-oriented volumes that are ideal for students and clinicians looking for a comprehensive review rather than a whole course. Each volume is easily accessible through eBook format.Topics covered review both the endourological diagnosis and treatment of prostate, urethral, urinary bladder, upper urinary tract, and renal pathology. All chapters describe the most recent techniques, review the latest results, and analyze the most modern technologies. In the past ten years, the field of endourology has expanded beyond the urinary tract to include all urologic minimally invasive surgical procedures. Recent advancements in robotic and laparoscopic bladder surgery make this one of the fastest moving fields in medicine. As current textbooks are too time-consuming for busy urologists or trainees who also need to learn other areas of urology, this collection provides quick references and over 4000 images that are appropriate for fellows as well as those teaching in the field.

  • Early Vascular Aging (EVA)

    New Directions in Cardiovascular Protection
    • 1st Edition
    • Michael Hecht Olsen + 2 more
    • English
    Early Vascular Aging (EVA): New Directions in Cardiovascular Protection brings together the last decade of research related to the characterization of EVA, as well as the predictive power of pulse wave velocity (PWV). The book presents a novel approach to the problem of cardiovascular disease, showing it in relation to great vessels disease and revealing a comprehensive approach to the problem of increased rigidity of the great vessels, its causes, and further consequences. Information provided is accompanied by online access to a supplemental website with video clips of anatomic specimens, cardiac imaging, and surgical procedures.

  • Anti-Angiogenesis Drug Discovery and Development

    Volume 2
    • 1st Edition
    • Atta-ur Rahman + 1 more
    • English
    The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pro-angiogenesis is highly desirable for the treatment of cardiovascular diseases, wound healing disorders, and more. Efforts to understand the molecular basis, both for inhibition and induction, have yielded fascinating results. Originally published by Bentham and now distributed by Elsevier, Anti-Angiogenesis Drug Discovery and Development, Volume 2 is an compilation of well-written reviews on various aspects of the anti-angiogenesis process. These reviews have been contributed by leading practitioners in drug discovery science and highlight the major developments in this exciting field in the last two decades. These reader-friendly chapters cover topics of great scientific importance, many of which are considered significant medical breakthroughs, making this book excellent reading both for the novice as well as for expert medicinal chemists and clinicians.

  • Textiles for Sportswear

    • 1st Edition
    • Roshan Shishoo
    • English
    Textiles for Sportswear is an important book that systematically covers key trends in design and materials, the use of novel and smart fabrics, and a range of specific applications. The book begins by surveying the principles of textile applications in sport, including design, materials, and production technology. The uses of smart textiles in sportswear are then examined, from intelligent materials to wearable technology. Final sections of the text explore comfort in sportswear, sportswear for protection, and recent advances in sportswear technology that are currently being applied to particular sports.

  • Handbook of Fertility

    Nutrition, Diet, Lifestyle and Reproductive Health
    • 1st Edition
    • Ronald Ross Watson
    • English
    Handbook of Fertility: Nutrition, Diet, Lifestyle and Reproductive Health focuses on the ways in which food, dietary supplements, and toxic agents, including alcohol and nicotine affect the reproductive health of both women and men. Researchers in nutrition, diet, epidemiology, and endocrinology will find this comprehensive resource invaluable in their long-term goal of understanding and improving reproductive health. This book brings together a broad range of experts researching the different aspects of foods and dietary supplements that promote or detract from reproductive health. Section One contains several overview chapters on fertility, how it is assessed, and how it can be affected by different metabolic states, nutritional habits, dietary supplements, the action of antioxidants, and lifestyle choices. Sections Two and Three consider how male and female fertility are affected by obesity, metabolic syndrome, hormonal imbalance, and even bariatric surgery. Section Four explores the ways diet, nutrition, and lifestyle support or retard the success of in vitro fertilization, while Section Five explores how alcohol and other drugs of abuse lower fertility in both women and men.

  • The Protective Arm of the Renin Angiotensin System (RAS)

    Functional Aspects and Therapeutic Implications
    • 1st Edition
    • Thomas Unger + 2 more
    • English
    The Protective Arm of the Renin Angiotensin System: Functional Aspects and Therapeutic Implications is the first comprehensive publication to signal the protective role of a distinct part of the renin–angiotensin system (RAS), providing readers with early insight into a complex system which will become of major medical importance in the near future. Focusing on recent research, The Protective Arm of the Renin Angiotensin System presents a host of new experimental studies on specific components of the RAS, namely angiotensin AT2 receptors (AT2R), the angiotensin (1–7) peptide with its receptor Mas, and the enzyme ACE 2, which exert significant beneficial, health-promoting actions by counterbalancing the well-known harmful arm of the RAS with its classical angiotensin AT1 receptor. This innovative concept of the protective arm of the RAS, examined in this reference, represents an indispensable background and will be a strong support for biomedical students, researchers, cardiologists, surgeons, nephrologists, diabetologists, and endocrinologists, as well as any other physician or researcher concerned with RAS physiology, pathophysiology and clinical implications.

  • Integrative Approaches for Health

    Biomedical Research, Ayurveda and Yoga
    • 1st Edition
    • Bhushan Patwardhan + 2 more
    • English
    Despite spectacular advances, modern medicine faces formidable global challenges in several key areas—notably the persistence of major killer diseases such as malaria, tuberculosis, leprosy, and newer threats including HIV/AIDS, resistant infections, and Ebola. As such, modern medicine has not led to a significant decrease in chronic diseases like diabetes, obesity, and other degenerative and autoimmune diseases. The authors believe that modern medicine needs to experience a paradigm shift, an integration of traditions—in particular from the ancient systems like Ayurveda and Yoga. Integrative Approaches for Health: Biomedical Research, Ayurveda and Yoga brings together the basic principles of interdisciplinary systems approach for an evolving construct of future medicine. Such an approach is already emerging at the cutting edge of current research in omics, bioinformatics, computational and systems biology. Several leading institutions of medicine have adopted Yoga and complementary medicine to widen their reach, and deepen effectiveness in therapeutic practices. The amalgam of modern medicine, with its strengths in scientific rigor, blended with the basic principles of life drawn from Ayurveda and Yoga might evolve into a medicine of tomorrow. Integrative approaches are no longer alternative, perhaps taking these approaches is the only possible way to heal our sick planet. This book introduces important trends and tools for biomedical researchers and physicians alike, to innovate the practice of medicine for the better.

  • Alcohol and Its Biomarkers

    Clinical Aspects and Laboratory Determination
    • 1st Edition
    • Amitava Dasgupta
    • English
    Alcohol and Its Biomarkers: Clinical Aspects and Laboratory Determination is a concise guide to all currently known alcohol biomarkers, their clinical application, and the laboratory methods used to detect them. Pathologists can use this resource to understand the limitations and cost factors associated with each method for determining certain alcohol biomarkers. In addition, interferences in these determinations are discussed, so that clinicians can understand the causes of falsely elevated biomarkers and pathologists and laboratory scientists can potentially eliminate them. The book focuses on the analytical methods used to detect alcohol in blood and urine, the limitations of alcohol determination using enzymatic methods, and the differences between clinical and forensic alcohol measurement. Chapters also cover cutting-edge alcohol biomarkers for potential use.

  • Human Chorionic Gonadotropin (hCG)

    • 2nd Edition
    • Laurence A. Cole
    • English
    Human chorionic gonadotropin (hCG) is produced during pregnancy by the embryo. It promotes progesterone production by corpus luteal cells. It also functions in pregnancy to promote angiogenesis in uterine vasculature, it immuno-blands the invading placental tissue so it is not rejected by the maternal uterine tissues, promotes the growth of the uterus in line with the growth of the fetus, promotes the differentiation of growing cytotrophoblast cells, promotes the quiescence of contractions in the uterine myometrium during the course of pregnancy, and also has function in growth and development of fetal organs. The first edition described the detailed biology, clinical chemistry, and clinical perspectives of hCG and associated molecules, and examines hCG, hyperglycosylated hCG and hCG free ß-subunit, 3 separate and independent molecules with totally sovereign physiological functions. The second edition will include coverage of the many new discoveries that have been made in the last five years: hCG analogues may be the actual driving signal of all human cancers. The editor estimates that 40% of the out of date material will be excluded and replaced with 40% of the exciting new findings. The book will also have a much clearer pregnancy and cancer focus.