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Elsevier

  • New Strategies Targeting Cancer Metabolism

    Anticancer Drugs, Synthetic Analogues and Antitumor Agents
    • 1st Edition
    • Galal H. Elgemeie + 1 more
    • English
    New Strategies Targeting Cancer Metabolism: Anticancer Drugs, Synthetic Analogues and Antitumor Agents presents up-to-date synthetic strategies for three categories of antimetabolites: antifolates, purines and pyrimidines, the main classes of antimetabolites which are integrated into various pharmaceutical agents. Many of these antimetabolites are considered potent chemotherapeutic agents which have great potential impact on medical research. These main classes of antimetabolites are used in the treatment of critical diseases including cancer, malignancies, autoimmune diseases, and many other non-malignant diseases. Antineoplastic drugs such as alkylating agents which have significant effects are described. Novel synthetic strategies for many anticancer alkylating agents including nitrogen mustards, chlorambucil, melphalan, ifosamide, oxaliplatin and temozolomide are explored. Natural products have offered some of the most significant drugs for treating cancer, as many drugs currently in clinical use are derived from natural products as camptothecins, vinca alkaloids, and derivatives of podophyllotoxin. They provide a contribution that is essential for modern drug discovery and development. In this book, insights into a broad array of novel compounds are reviewed, well-recognized synthetic approaches are emphasized for further anticancer drug development and discovery, and the biological evaluation of novel synthesized compounds are included. This comprehensive reference is a valuable resource for medical chemists working in drug discovery and development, as well as pharmacologists and biochemists working in related fields.

  • Taylor and Hoyt's Pediatric Ophthalmology and Strabismus

    • 6th Edition
    • Christopher J. Lyons + 1 more
    • English
    Providing foundational knowledge and expert guidance on the complete spectrum of childhood eye disorders and strabismus, Taylor and Hoyt's Pediatric Ophthalmology and Strabismus, 6th Edition, remains the #1 reference of choice for practicing and trainee pediatric ophthalmologists. Edited by global leaders in the field, Drs. Christopher J. Lyons and Scott R. Lambert, this newly revised volume offers authoritative coverage of all the pediatric ophthalmic conditions you’re likely to encounter in practice, including the latest clinical advances in etiology, diagnosis, and medical and surgical management. Comprehensive updates, as well as new chapters, images, and video clips, make this well-regarded title the most current and complete reference available in this evolving field.

  • Comparative Management of Spine Pathology

    • 1st Edition
    • Kaisorn Chaichana + 1 more
    • English
    Unique in the field, Comparative Management of Spine Pathology presents commonly encountered spinal cases with side-by-side, case-by-case comparisons that clearly show how various experts would handle the same case. This second volume in the Neurosurgery: Case Management Comparison Series offers multiple opinions from international experts in both neurosurgery and orthopaedics, each of whom explains their preferred approach and management style for the same case. This format allows for quick and helpful comparisons of different ways to approach a lesion, advantages and disadvantages of each approach, and what each expert is looking for in how they would manage a particular case.

  • Water - Energy - Food Nexus Narratives and Resource Securities

    A Global South Perspective
    • 1st Edition
    • Tafadzwa Mabhaudhi + 4 more
    • English
    Water–Energy–Food Nexus Narratives and Resource Securities: A Global South Perspective provides a knowledge synthesis on the water–energy–food (WEF) nexus, focusing primarily on the global south. By presenting concepts, analytical tools, and case studies, the book serves as a practical resource for researchers, policymakers, and practitioners in sustainability and functional roles across all three sectors. It addresses key issues related to data availability, tools, indices, metrics, and application across multiple scales, beginning with a summary of existing knowledge. Finally, it examines the WEF nexus, presents global insights, and discusses future considerations and implications. This book presents an overview of existing knowledge on the WEF nexus and examines how such research aligns with emerging global WEF nexus perspectives, making it ideal for professionals, government entities, private industry, and the general public.

  • Chemistry at the Frontier with Physics and Computer Science

    Theory and Computation
    • 1st Edition
    • Sergio Rampino
    • English
    Chemistry at the Frontier with Physics and Computer Science: Theory and Computation shows how chemical concepts relate to their physical counterparts and can be effectively explored via computational tools. It provides a holistic overview of the intersection of these fields and offers practical examples on how to solve a chemical problem from a theoretical and computational perspective, going from theory to models, methods and implementation. Sections cover both sides of the Born-Oppenheimer approximation (nuclear dynamics and electronic structure), chemical reactions, chemical bonding, and cover theory to practice on three related physical problems (wavepacket dynamics, Hartree-Fock equations and electron-cloud redistribution). Drawing on the interdisciplinary knowledge of its expert author, this book provides a contemporary guide to theoretical and computational chemistry for all those working in chemical physics, physical chemistry and related fields.

  • Financing Investment in Water Security

    Recent Developments and Perspectives
    • 1st Edition
    • Xavier Leflaive + 2 more
    • English
    Investing in Water and Growth: Recent Developments and Perspectives addresses this conundrum in a cohesive and practical way. It is a one-stop shop for understanding why the financing of water-related expenditures matters, what is at stake, and the options available to ensure water-related investment needs are properly financed in ways that generate benefits for communities and contribute to sustainable growth. The book combines the perspectives of policymakers, economists and financiers in a unique, multidimensional and multidisciplinary approach. The book is structured into four distinct parts that target a specific set of questions and content development. Each section of the book has a multidisciplinary approach that provides a robust overview of key issues. The book combines different types of knowledge – from theory to practice, providing a full view of the topics discussed.

  • Rehabilitación multimodal en cirugía

    • 1st Edition
    • Jaime Ruiz-Tovar + 1 more
    • Spanish
    La recuperación intensificada es un abordaje multidisciplinar del cuidado del paciente sometido a cirugía mayor, e implica cambios significativos en el manejo pre-, intra- y postoperatorio para facilitar su óptima recuperación. Rehabilitación multimodal en cirugía recoge la evidencia científica más actual sobre los componentes de la recuperación intensificada y sobre su aplicabilidad en los diferentes procedimientos quirúrgicos. Además, describe los distintos aspectos de la recupera­ción intensificada desde la perspectiva de los especialistas implicados, y expone los protocolos desarrollados para cada especialidad en España. Por todo ello, constitu­ye una útil herramienta tanto para el amplio grupo de profesionales sanitarios que intervienen en los cuidados perioperatorios —cirujanos, anestesiólogos, enfermeras, endocrinólogos, rehabilitadores, geriatras, internistas, médicos de atención primaria o especialistas en Ciencias de la Actividad Física y del Deporte, entre otros— como para los gestores clínicos y los coordinadores de calidad de los centros hospitalarios.

  • GNSS Seismogeodesy

    • 1st Edition
    • Jianghui Geng
    • English
    GNSS Seismogeodesy: Theory and Applications combines GNSS and seismology theory and applications to offer both disciplines the background information needed to combine forces. It explores the opportunities for integrating GNSS and seismometers, as well as applications for earthquake and tsunami early warning applications. The book allows seismologists to better understand how GNSS positions are computed and how they can be combined with seismic data and allows geodesists to better understand how to apply GNSS to monitoring of crustal motion.This book is a valuable reference for researchers and students studying the interdisciplinary connection between GNSS geodesy and strong-motion seismology. It will also be ideal for anyone working on new approaches for monitoring and predicting geologic hazards.

  • Artificial Intelligence in Urban Planning and Design

    Technologies, Implementation, and Impacts
    • 1st Edition
    • Imdat As + 2 more
    • English
    Artificial Intelligence in Urban Planning and Design: Technologies, Implementation, and Impacts is the most comprehensive resource available on the state of Artificial Intelligence (AI) as it relates to smart city planning and urban design. The book explains nascent applications of AI technologies in urban design and city planning, providing a thorough overview of AI-based solutions. It offers a framework for discussion of theoretical foundations of AI, AI applications in the urban design, AI-based research and information systems, and AI-based generative design systems. The concept of AI generates unprecedented city planning solutions without defined rules in advance, a development raising important questions issues for urban design and city planning. This book articulates current theoretical and practical methods, offering critical views on tools and techniques and suggests future directions for the meaningful use of AI technology.

  • Arritmias en pediatría

    • 1st Edition
    • Vincent C. Thomas + 1 more
    • Spanish
    El manejo de un paciente pediátrico con arritmia puede ser intimidante. Los latidos cardiacos rápidos, la afectación cardiaca o el resultado potencialmente grave crea una sensación de inquietud en el profesional sanitario. Arritmias en pediatría aborda el reto que suponen estas preocupaciones y proporciona un método simple y lógico para el manejo del paciente pediátrico con arritmias. El objetivo principal de este texto es proporcionar una visión de la mente del electrofisiólogo pediátrico cuando se encuentra con escenarios clínicos habituales. Cada capítulo comienza con un caso clínico que representa las experiencias clínicas más comunes en las que un profesional sanitario consulta a un electrofisiólogo pediátrico. El lector encontrará inmediatamente después una discusión del diagnóstico, el proceso de pensamiento clínico involucrado, las opciones de tratamiento, los resultados esperados y cómo manejar los resultados anticipados e imprevistos.

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