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Breast Pathology
- 3rd Edition - May 19, 2023
- Author: David J Dabbs
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 7 9 5 2 2 - 7
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 7 9 5 2 3 - 4
Written with useful practicality in mind, Breast Pathology, 3rd Edition, provides surgical pathologists with authoritative guidance on the selection and best use of proper… Read more
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Request a sales quoteWritten with useful practicality in mind, Breast Pathology, 3rd Edition, provides surgical pathologists with authoritative guidance on the selection and best use of proper diagnostic techniques when reporting on breast specimens. Dr. David J. Dabbs and a team of internationally acclaimed pathologists incorporate genomic and molecular information, gross and microscopic findings, radiologic and laboratory diagnosis, theranostics, and immunohistochemistry to cover every aspect of benign and malignant lesions of the breast, helping you minimize diagnostic variation and error in the sign-out room.
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Brings you fully up to date with recent advances, including new molecular information for breast entities, new surgical techniques, more widely used multigene prognostic tests, and assays used to determine treatment, such as PD-L1 as a new immunotherapy biomarker for triple-negative breast cancer.
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Incorporates the latest classifications of breast pathology and molecular diagnosis.
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Organizes each topical chapter around relevant genomic and molecular information, clinical presentation, gross and microscopic pathologic findings and diagnostic and molecular immunohistochemistry.
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Maps immunohistochemistry for each entity according to diagnostic, theranostic, and genomic applications, with specific regard to disease entities in each chapter.
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Discusses breast specimen handling in detail to assure proper sampling and processing for optimal molecular and immunohistochemistry resulting.
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Supplies a convenient quick reference at the beginning of each chapter that includes all relevant diagnostic, theranostic, and genomic data for fast retrieval.
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Features approximately 2,000 full-color pathological images that clearly depict clinical, radiological, molecular, immunohistochemical, and theranostic aspects of disease.
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Includes biomarker guideline updates throughout.
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Reflects updates to new tumor staging data in the American Joint Committee on Cancer (AJCC) 8th Edition and updated ASCO/CAP guidelines for interpreting HER2 assays.
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Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
- Cover image
- Title page
- Table of Contents
- Any screen, Any time, Anywhere
- Copyright
- Contributors
- 1. Breast Development, Physiology, and Histology
- Abstract
- Normal Breast
- Developmental Disorders
- Breast Changes in Transgender Individuals
- Summary
- References
- 2. Reactive and Inflammatory Conditions of the Breast
- Abstract
- Mammary Duct Ectasia
- Fat Necrosis
- Granulomatous Lobular Mastitis
- Sclerosing Lymphocytic Lobulitis
- IgG4-related Sclerosing Mastitis
- Breast Infarction
- Reactive Changes Related to Needle Biopsy
- Nodular Fasciitis of the Breast
- Systemic Disease in Breast Parenchyma
- Summary
- References
- 3. Infections of the Breast
- Abstract
- Lactational Breast Infection
- Nonlactational Breast Infection
- Cystic Neutrophilic Granulomatous Mastitis (CNGM)
- Zuska (SMOLDering) Breast Disease
- Miscellaneous Breast Infections
- Summary
- References
- 4. Epidemiology of Breast Cancer
- Abstract
- Introduction
- Risk Factors for Breast Cancer (Tables 4.1, 4.2)
- Summary
- References
- 5. Patient Safety in Breast Pathology
- Changing Role of Pathologists in Breast Cancer Diagnosis and Management
- Current Challenges in the Practice of Breast Pathology
- Mechanisms to Minimize Errors in Breast Pathology
- Implementation of Patient Safety–Centered Breast Pathology in Practice
- Summary
- References
- 6. Gross Examination of Breast Specimens
- Abstract
- General Principles for Gross Examination of Breast Specimens
- Percutaneous Core Needle Biopsies
- Recommendations for Handling and Processing of Breast Core Needle Biopsies
- Surgical Excisions/Lumpectomies
- Separately Submitted Margins and Re-Excision Specimens
- Mastectomies
- Pitfalls in Evaluation of Excisions and Mastectomies
- Axillary Lymph Nodes
- Examination of Breast Prostheses (Implants)
- Fresh Tissue Collection for Research and Clinical Purposes
- Summary
- References
- 7. Sentinel Lymph Node Biopsy
- Abstract
- Clinical Parameters and Feasibility Issues
- Predictors of Sentinel Node Metastasis
- Pathological Evaluation
- American Joint Committee on Cancer Staging of Sentinel Nodes
- Controversial Issues with Regard to Histological Assessment
- Histological Pitfalls
- Predictors of Nonsentinel Involvement
- Critical Issues
- Summary
- References
- 8. Breast Imaging Modalities for Pathologists
- Mammography
- Ultrasound
- Magnetic Resonance Imaging
- Molecular Breast Imaging
- Computed Tomography/Positron Emission Tomography
- Sentinel Lymph Node Imaging
- Methods for Obtaining, Marking, and Localizing a Tissue Sample
- New Methods on the Horizon
- Summary
- References
- 9. Predictive and Prognostic Marker Testing in Breast Pathology: Immunophenotypic Subclasses of Disease
- Abstract
- Introduction
- Hormone Receptors in Breast Carcinoma
- HER2 (ERBB2) Oncogene in Breast Cancer
- Other relevant prognostic/predictive markers
- Summary
- Acknowledgments
- References
- 10. Molecular-Based Testing in Breast Disease for Therapeutic Decisions
- Abstract
- Gene Expression Profiling Using Microarray Technology and Real-Time Reverse Transcription Polymerase Chain Reaction
- Prognostic and Predictive Gene Expression Signatures
- Other Gene Expression Signatures
- MicroRNAs in Breast Cancer
- Circulating Tumor Cells
- Summary
- References
- 11. Diagnostic Immunohistology of the Breast
- Abstract
- Introduction
- Assessment of Stromal Invasion
- Immunohistochemistry of papillary lesions
- Proliferative Ductal Epithelial Lesions and in Situ Carcinomas
- Tumor Type Identification by Immunohistochemistry
- Lobular Carcinoma Variants and Former Lobular Variants
- Immunohistochemistry for Identifying Special Types of Breast Carcinomas
- Paget’s Disease of the Breast
- Detection of Lymphatic Space Invasion
- Sentinel Lymph Node Examination
- Systemic Metastasis of Breast Carcinoma
- Fibroepithelial Tumors
- References
- 12. Fibroepithelial Lesions
- Abstract
- Fibroadenoma
- Phyllodes Tumor
- Summary
- References
- 13. Papilloma and Papillary Lesions
- Abstract
- Papilloma
- Differential Diagnosis
- Summary
- References
- 14. Adenosis and Microglandular Adenosis
- Abstract
- Introduction
- Adenosis
- Microglandular Adenosis
- Summary
- References
- 15. Nipple Adenoma (Florid Papillomatosis of the Nipple)
- Abstract
- Normal Nipple Anatomy
- Nipple Adenoma
- Summary
- References
- 16. Radial Scar
- Abstract
- Radial Scar
- Clinical Imaging
- Summary
- References
- 17. Myoepithelial Lesions of the Breast
- Abstract
- Adenomyoepithelioma and Malignant Adenomyoepithelioma
- Adenoid Cystic Carcinoma
- Pleomorphic Adenoma
- Mammary Myofibroblastoma
- Summary
- References
- 18. Fibrocystic Change and Usual Epithelial Hyperplasia of Ductal Type Fibrocystic Change
- Abstract
- Clinical Presentation
- Clinical Imaging
- Gross Pathology
- Microscopic Pathology
- Ductal Neoplasia (ADH/DCIS) in Preexisting Usual Ductal Hyperplasia
- Summary
- References
- 19. Columnar Cell Change, Flat Epithelial Atypia, and Atypical Ductal Epithelial Hyperplasia
- Abstract
- Introduction: Screening and Detection
- Columnar Cell Lesions: Benign and Atypical
- Atypical Ductal Hyperplasia (ADH)
- Low-Grade Breast Neoplasia Pathway
- Summary
- References
- 20. Molecular Classification of Breast Carcinoma
- Abstract
- Introduction
- Intrinsic Gene Set–based Molecular Classification
- Molecular Classification of Triple-negative Breast Carcinomas
- Other Molecular Subtypes (Claudin-low Tumors)
- Other Molecular Subtypes (Molecular Apocrine Class)
- Molecular Classifications of HER2+ Breast Carcinomas
- Molecular Analyses of Special Subtype Carcinomas
- Molecular Profiling of Metastatic Disease
- Other Multigene Prediction Assays
- Immunohistochemical Surrogates to Molecular Classes
- Future of Molecular Testing
- References
- 21. Lobular Neoplasia and Invasive Lobular Carcinoma
- Abstract
- Lobular Carcinoma In Situ and Atypical Lobular Hyperplasia
- Invasive Lobular Carcinoma
- Molecular Pathology of Lobular Carcinoma
- Summary
- References
- 22. Ductal Carcinoma In Situ
- Abstract
- Ductal Carcinoma In Situ
- Summary
- References
- 23. Invasive Ductal Carcinoma of No Special Type and Histological Grade
- Abstract
- Invasive Carcinoma of No Special Type (Ductal NST)
- Differential Diagnosis
- Summary
- Acknowledgement
- References
- 24. Triple-Negative and Basal-like Carcinoma
- Abstract
- Introduction
- Triple-Negative Breast Carcinoma Molecular Classification
- Basal-like Breast Carcinoma
- Summary
- References
- 25. Metaplastic Breast Carcinoma
- Abstract
- Metaplastic Carcinoma
- Differential Diagnoses
- Summary
- References
- 26. Apocrine Carcinoma of the Breast
- Abstract
- Introduction
- Clinical Presentation
- Clinical Imaging
- Gross Pathology
- Histology
- Immunohistochemistry
- Molecular Pathology
- Ultrastructure
- Treatment
- Prognosis
- Differential Diagnosis
- References
- 27. Paget’s Disease of the Breast
- Abstract
- Epidemiology
- Pathogenesis
- Clinical Presentation
- Clinical Imaging and Diagnosis
- Macroscopic Pathology
- Microscopic Pathology
- Histological Variants
- Cytology
- Immunohistochemistry
- Differential Diagnosis
- Molecular Pathology
- Treatment and Prognosis
- Summary
- References
- 28. Pathology of Neoadjuvant Therapeutic Response of Breast Carcinoma
- Abstract
- Introduction
- Predictors of Therapeutic Response
- Evaluation of Therapeutic Response
- Posttreatment Prognostic and Predictive Factors
- Systems for Evaluating Degree of Response
- Reporting of Posttreatment Specimens
- Summary
- References
- 29. Special Types of Invasive Breast Carcinoma: Tubular Carcinoma, Cribriform Carcinoma, Mucinous Carcinoma, Micropapillary Carcinoma
- Abstract
- Introduction
- Tubular Carcinoma
- Invasive Cribriform Carcinoma
- Mucinous Carcinoma
- Invasive Micropapillary Carcinoma
- Summary
- References
- 30. Rare Breast Carcinomas: Adenoid Cystic Carcinoma, Neuroendocrine Carcinoma, Secretory Carcinoma, Carcinoma With Osteoclast-like Giant Cells, Lipid-Rich Carcinoma, and Glycogen-Rich Clear Cell Carcinoma
- Introduction
- Adenoid Cystic Carcinoma
- Neuroendocrine Carcinoma
- Secretory Carcinoma
- Carcinoma With Osteoclast-like Giant Cells
- Lipid-Rich Carcinoma
- Glycogen-Rich Clear Cell Carcinoma
- Summary
- References
- 31. Mesenchymal Tumors of the Breast
- NON-PRINT ITEMAbstract
- Hamartoma
- Benign Vascular Lesions
- Malignant Vascular Tumors
- Myofibroblastic and Fibroblastic Tumors and Tumor-like Proliferations
- Smooth Muscle Tumors
- Adipocytic Tumors
- Other Sarcomas
- Peripheral Nerve Sheath Tumors
- References
- 32. Neoplasia of the Male Breast
- Abstract
- Introduction
- Embryogenesis and Puberty
- Benign Proliferative Lesions
- Benign Papillary Lesions
- Fibroepithelial Lesions
- Gynecomastia
- Other Benign Disorders of the Male Breast
- Carcinoma of the Male Breast
- Screening and Diagnosis
- Precursor Lesions
- Invasive Carcinoma
- Summary
- References
- 33. Breast Tumors in Children and Adolescents
- Abstract
- Introduction
- Juvenile Papillomatosis
- Papillary Ductal Hyperplasia (Papilloma, Papillomatosis)
- Fibroepithelial Tumors
- Atypical Ductal Hyperplasia
- Carcinoma
- OTHER MALIGNANT TUMORS
- Summary
- References
- 34. Hematolymphoid Tumors of the Breast
- NON-PRINT ITEMAbstract
- Introduction
- Major Non-Hodgkin’s Lymphomas Involving the Breast
- Other Non-Hodgkin’s Lymphomas
- Plasmacytic Neoplasms
- Classic Hodgkin’s Lymphoma
- Myeloid Neoplasms and Extramedullary Hematopoiesis
- Histiocytic/Dendritic Cell Proliferations
- Summary
- References
- 35. Metastatic Tumors in the Breast
- NON-PRINT ITEMAbstract
- Introduction
- Summary
- References
- 36. Next-Generation Sequencing and the Management of Patients With Clinically Advanced Breast Cancer
- Abstract
- Introduction
- History of DNA Sequencing and the Human Genome
- DNA Sequencing Technologies
- Comparison of Traditional and NGS Strategies for Cancer Cell Genomic Sequencing
- Challenges for Delivering NGS Results for Cancer Patients
- Next-Generation Sequencing in the Management of Clinically Advanced Breast Cancer
- Genomic Alterations in Uncommon Breast Cancer Subtypes
- Next-Generation Sequencing and Immune Checkpoint Inhibitors
- New Techniques Impacting the Molecular Management of Patients With Relapsed Breast Cancer
- Summary
- References
- Index
- Confidence is ClinicalKey
- No. of pages: 1019
- Language: English
- Edition: 3
- Published: May 19, 2023
- Imprint: Elsevier
- Hardback ISBN: 9780323795227
- eBook ISBN: 9780323795234
DD
David J Dabbs
Dr Dabbs has twenty years of experience in the surgical pathology of solid tumors, with additional subspecialty-focused interest in the study of tumors of unknown origin, breast carcinoma, gynecologic pathology and tumor cytopathology. He served as Member of Medical & Scientific Advisory Board of US LABS, Inc. He offers national workshops in breast pathology and immunohistochemistry and has presented more than 100 papers in peer-reviewed journals and at national meetings
Affiliations and expertise
Professor of Pathology, University of Hawaii, John A Burns School of Medicine, Honolulu, Hawaii