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Elsevier

Elsevier Science

  • Morbid Anatomy of the Genome

    • 1st Edition
    • Volume 2
    • R.S. Verma
    • English
    The technical advances in molecular biology have endowed us with a wealth of knowledge, which has allowed us to identify the cause of diseases not only at a single gene level but at a greater magnitude, where a substitution or deletion of a single base pair can be identified. Our present task is to establish a clear link between phenotype and nucleotide sequence. Obviously, a gene is no longer an imaginary entity. Recent discoveries in a number of bewildering traits, whose inheritance do not follow simple mendelian rules, have caused much amazement. For example, fragile X-syndrome, spine and bulbar muscular atrophy and myotic dystrophy arise from "triples repeat mutation" and amplification in future generations. Genetic diseases which are inherited, can now be diagnosed prenatally; an idea that was once inconceivable.The aim of the second volume, entitled Morbid Anatomy of the Genome, is to reflect on the importance of molecular genetics in modern medicine. The field has expanded so as to warrant a volume dedicated exclusively toward understanding those who wish to know the cause, detection and in turn treatment of such diseases. In this volume, I have commissioned several scientists to contribute 12 chapters. A chapter describing a special role of molecular genetics in combating genetic diseases through gene therapy has also been included, while chapter 13 is a commentary.A complete account of all diseases whose genetic basis is well established would be a herculean task and is not within the scope of a single volume format. Therefore a few specific topics have been chosen which may be of the greatest interest to scientists and clinicians. The purpose of this issue is to keep abreast of the latest developments in a select group of genetic diseases.

  • Biological Function of Gangliosides

    • 1st Edition
    • Volume 101
    • L. Svennerholm + 6 more
    • English
    This book focuses on the role of gangliosides in three areas of medicine in which rapid progress has been made in the last decade: cancer, peripheral neuropathies and Alzheimer's disease. The volume further reflects progress in the pathogenesis of peripheral neuropathies, and the controversial role of gangliosides, also in therapeutic administration. There is a section on the role of gangliosides in neuronal differentiation and development and their receptor functions and cell surface activities. This excellent addition to the renowned Progress in Brain Research series also contains an invaluable plenary lecture on molecular basis of cell adhesion by Nobel prizewinner Gerald Edelman.

  • Spices, Herbs and Edible Fungi

    • 1st Edition
    • Volume 34
    • G. Charalambous
    • English
    This volume is a collection of papers covering various aspects of an important group of botanicals which have long been used to improve the flavor of food. It contains fresh material prepared especially for it by researchers and other technically trained workers from universities, government and industrial research groups and industry worldwide.It will be of great value to food scientists, medical researchers, analytical and synthetic organic chemists, chefs, and all those involved with, and interested in, food and food flavours in general.

  • Foundation Engineering

    • 1st Edition
    • Volume 75
    • S. Hansbo
    • English
    The object of this book is to shed light on the most important design aspects encountered in foundation engineering and to present basic design principles representative of the developed part of the world. Modern geotechnical investigation methods and their interpretation are exemplified. The philosophy of the new European code for geotechnical design is presented. The most important and practical aspects of ground modification techniques are included. This book can be used as a textbook for senior undergraduate and graduate students. It can also serve as a combined text- and handbook for professional engineers working in the field of geotechnical engineering. Line drawings and photographs accompany the text.

  • Volcanic Ash Soils

    Genesis, Properties and Utilization
    • 1st Edition
    • Volume 21
    • S. Shoji + 2 more
    • English
    Volcanic eruptions are generally viewed as agents of destruction, yet they provide the parent materials from which some of the most productive soils in the world are formed. The high productivity results from a combination of unique physical, chemical and mineralogical properties. The importance and uniqueness of volcanic ash soils are exemplified by the recent establishment of the Andisol soil order in Soil Taxonomy. This book provides the first comprehensive synthesis of all aspects of volcanic ash soils in a single volume. It contains in-depth coverage of important topics including terminology, morphology, genesis, classification, mineralogy, chemistry, physical properties, productivity and utilization. A wealth of data (37 tables, 81 figures, and Appendix) mainly from the Tohoku University Andisol Data Base is used to illustrate major concepts. Twelve color plates provide a valuable visual-aid and complement the text description of the world-wide distribution for volcanic ash soils.This volume will serve as a valuable reference for soil scientists, plant scientists, ecologists and geochemists interested in biogeochemical processes occurring in soils derived form volcanic ejecta.

  • Fundamentals of Adsorption

    • 1st Edition
    • Volume 80
    • M Suzuki
    • English
    Fundamentals of Adsorption contains 2 plenary lectures and 96 selected papers from the IVth International Conference, Kyoto, May, 1992. The topics cover a wide range of studies from fundamentals to applications: characterization of porous adsorbents, molecular simulation, adsorption isotherms, diffusion in adsorbents, breakthrough detection, chromatography, pressure swing operation, etc. Model studies on adsorption, surface characterization, microporosimetry, molecular simulations of equilibrium and diffusion, computer simulation of adsorption beds, and many theoretical studies are also included. Special attention is given to: bulk gas separation and purification, solvent recovery, bioproduct separation, environmental pollution control, methane storage, adsorption cooling and resources recovery.

  • The Biochemistry of Archaea (Archaebacteria)

    • 1st Edition
    • Volume 26
    • M. Kates + 2 more
    • English
    In the last 10 years, considerable information has accumulated on the biochemistry of archaea. In this volume, the subject as a whole is treated in a comprehensive manner. The book brings together recent knowledge concerning general metabolism, bioenergetics, molecular biology and genetics, membrane lipid and cell-wall structural chemistry and evolutionary relations, of the three major groups of archaea: the extreme halophiles, the extreme thermophiles, and the methanogens.Subjects included are: the evolutionary relationship of these microorganisms to all other living cells; special metabolic features of archeaea; protein structural chemistry; cell envelopes; molecular biology in archaea including DNA structure and replication, transcription apparatus, translation apparatus, and ribosomal structure; and a final chapter on the molecular genetics of archaea. This comprehensive scope ensures its usefulness to researchers, and stimulates further study in this rapidly developing field.

  • Extracellular Matrix

    • 1st Edition
    • Volume 6
    • H.K. Kleinman
    • English
    Studies on the components of the extracellular matrix have expanded recently and greatly increased our understanding of their biological functions and roles in development and in disease. Because so many new areas have been defined, selection of chapter topics was difficult to limit. Areas with recent developments in both basic knowledge and diseased states have been emphasized. Some of the chapters detail evolving frontiers which are of intense interest, but complete information is not known. For example, several bone morphogenetic factors have been described and others likely exist. The structures of these multifunctional proteins are determined and they appear related. The description of extracellular matrix component receptors is far from complete, but worthy of a progress report since much is already known. Of particular interest is the "promiscuity" of some of these receptors in their interaction with more than one matrix protein and even different ligand specificities on different cell types. Such variability these interactions challenges conventional ideas on the specificity of ligand-receptor interactions. The collagens were traditionally thought of as structural molecules but now have been found to be biologically active. The number of genetically distinct collagen genes is greater than 27 (still increasing!) and their gene regulation is unique. The demonstration of a bi-directional promoter for the æ1 and æ2 collagen IV chains has stimulated research on gene regulation and the DNA binding proteins. A number of diseases have also been shown recently to involve collagens. The proteoglycans have been thought of as largely carbohydrate-contain... molecules with the research emphasis placed on the sugars. With the recent DNA sequencing of several protein cores, these molecules have been found to be of tremendous interest. The basement membrane heparan sulfate proteoglycan contains domains with homologies to laminin, immunoglobulin, and LDL. Proteoglycans have multiple activities and function as adhesion factors, cellular receptors, growth factor binding sites, etc.Several chapters are devoted to whole basement membrane and to other matrix components such as fibronectin, thrombospondin, laminin, collagen IV, entactin/nidogen, and elastin which have been shown to have remarkable effect on normal and malignant cell behavior. The structures of these matrix components have been described, and now active sites as well as alternate forms are being defined. The role in tumor growth and acquired and genetic diseases is also reviewed. The potential clinical use of the molecules or active sites is only briefly mentioned but likely to be important in the future.

  • Molecular Biology Frontiers

    • 1st Edition
    • Volume 2
    • T.P. Mommsen + 1 more
    • English
    This second volume in the series covers such topics as DNA fingerprinting of fishes, the cytochromes P450 in fish, the molecular biology of bacterial fish diseases, and new insights into the origins of the diversity and distribution of fish antifreeze proteins. The book will be of great value to fisheries scientists, animal biochemists, physiologists and endocrinologists, and aquaculturists. It will provide researchers and students alike with a pertinent information source from theoretical and experimental angles.

  • Analytical Applications of Circular Dichroism

    • 1st Edition
    • Volume 14
    • N. Purdie + 1 more
    • English
    Circular dichroism is a special technique which provides unique information on dissymmetric molecules. Such compounds are becoming increasingly important in a wide variety of fields, such as natural products chemistry, pharmaceutics, molecular biology, etc. The content of this book has been selected in order to feature the unique aspects of circular dichroism, and how these strengths can be of assistance to workers in the field.Substantial discussions have been provided regarding the particular phenomena associated with dissymmetric compounds which give rise to the circular dichroism effect. Reviews are also given of the type of instrumentation available for the measurement of these effects. A number of chapters cover the wide range of applications illustrating the power of the method. Owing to its broad appeal, the book will be of interest to workers in all areas of chemistry and pharmaceutical science.

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