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Elsevier

Elsevier Science

  • Advances in Developmental Biology

    • 1st Edition
    • Volume 4a
    • Paul Wassarman
    • English
    Volume 4 of Advances in Developmental Biology and Biochemistry consists of five chapters that review specific aspects of fly and mammalian development. In Chapter 1, Y. Mishina and R. Behringer discuss various aspects of Müllerian-inhibiting substance (MIS) in mammals, from a brief history of its discovery to recent studies of the MIS gene in transgenic and knock-out animals. In Chapter 2, C. Rushlow and S. Roth discuss the role of the dpp-group genes in dorsoventral patterning of the Drosophila embryo. In Chapter 3, M. Yip and H. Lipshitz discuss the terminal (asegmental termini) gene hierarchy of Drosophila and the genetic control of tissue specification and morphogenesis. In Chapter 4, R. Bachvarova discusses induction of mesoderm and the origin of anterior-posterior polarity in the mouse embryo, using the frog embryo as a paradigm. In Chapter 5, P. Vogt discusses human Y chromosome function in male germ cell development.

  • Growth Factors, Part A

    • 1st Edition
    • C. Bondy + 1 more
    • English
    This series provides a variety of different discussions on topics within the field of growth factors and cytokines in health and disease.

  • Receptors of Cell Adhesion and Cellular Recognition

    • 1st Edition
    • Volume 3
    • A.G. Lee
    • English
    Volume 3 of Biomembranes covers receptors of cell adhesion and cellular recognition. Proteins in the plasma membrane of cells are heavily involved in processes of cell adhesion, but such proteins were not actually isolated and characterized until the mid-1970s. Since then, application of the methods of molecular biology has led to the recognition of four major classes of cell adhesion molecule (CAMs), the immunoglobulin super family, the cadherins, the integrins, and the selecting. A convenient system in which to study the importance of cell adhesion is in blood platelets where aggregation eventually leads to thrombus formation in a process involving a range of surface glycoproteins. Interaction with the extracellular matrix is exemplified by CD44, the receptor for hyaluronan, and a complex carbohydrate that is a major component of the extracellular matrix surrounding migrating and proliferating cells. Membrane-associated mucins have a variety of effects on cell adhesion. The super family of immunoglobulin related proteins also include the T cell receptors and the major histocompatibility complex (MHC), which, together with the receptors for immunoglobulins (the Fc receptors), are of fundamental importance in the processes of immunity. Volume 3 of Biomembranes explores the structures and functions of the molecules involved in these important functions of the cell.

  • Membrane Protein Transport

    • 1st Edition
    • Volume 3
    • S.S. Rothman
    • English
    This is the third volume in a series on membrane protein transfer. Membrane protein transport underlies the topological disposition of many proteins within cells and it is this disposition that allows for the co-ordination of the central cellular processes, such as metabolism.

  • Advances in Developmental Biochemistry

    • 1st Edition
    • Volume 4b
    • Paul Wassarman
    • English
    Volume 4 of Advances in Developmental Biology and Biochemistry consists of five chapters that review specific aspects of sea urchin, fly, and mammalian development. In Chapter 1, A. Bejsovec and M. Peifer discuss the nature and role of the wingless/Wnt-1 signaling pathway in Drosophila, as well as in amphibia and mammals. In Chapter 2, C. Ettensohn and colleagues discuss cell interactions, cell fate specification, and morphogenesis in sea urchin embryos. In Chapter 3, E. Kubli discusses the nature and role of a Drosophila sex-peptide that serves as a pheromone involved in reproduction. In Chapter 4, T. Gridley discusses the expression and functions of several vertebrate homologs of the neurogenic genes of Drosophila. In Chapter 5, J. Pollard and R. Stanley discuss the pleiotropic roles for colony stimulating factor-1 in development as defined by the mouse mutation osteopetrotic.

  • Cell Chemistry and Physiology: Part IV

    • 1st Edition
    • Volume 4D
    • Edward Bittar
    • English
    This volume is intended to complete the Cell Chemistry and physiology module. It is about how the traditional boundaries of cell chemistry and physiology are being erased by molecular biology. We do not think it necessary to elaborate on this theme, particularly since the body of core knowledge found in this volume brings us a stage closer to answering the question, "what makes cell biology into a new discipline?"The first part of the volume deals with the chemistry of actin and myosin and is followed by chapters on cell motility, ATP synthesis in muscle, and contraction in smooth and skeletal muscle. Here the reader is immediately made aware of the contributions molecular biology is making to our understanding of the molecular mechanisms underlying muscle contraction. It is perhaps enough to point out that Huxley's concept of the cross-bridge cycle and generation of force can now be explained in molecular terms. Topics such as muscle fatigue and muscle disorders, as well as malignant hyperthermia are bound to arouse active learning in the student and set the stage for problem-based learning.Most medical students look askance at thermobiology. We think this is a mistake; hence, we have included a section dealing with this subject. This brings us to the chapter on the heat shock response, which at the very outset makes clear that many stressors besides heat are known to result in heat shock gene expression. Many of the heat shock proteins occur in unstressed cells and some of them behave as chaperones. These proteins also reach high levels in a wide range of diseases including neurodegenerative disorders. Whether certain diseases are the result of mutations in the heat shock genes is not yet known. As will be appreciated, much of the work done in this field involved the use of cultured cells. Animal cells in culture are the subject of the last chapter.

  • Advances in Structural Biology

    • 1st Edition
    • Volume 4
    • S.K. Malhotra
    • English
    The present volume continues the trend established in previous volumes in this series on Advances in Structural Biology. As in the past, diverse topics of current importance relevant to the theme of the series are included in the fourth volume.

  • Cell Chemistry and Physiology: Part III

    • 1st Edition
    • Volume 4C
    • Edward Bittar
    • English
    The first section of this volume consists of five chapters to the nature of membrane transport systems. A chapter on secondary active glucose transport has been omitted because this topic is slated to appear in the Nephrobiology module. Chapter 6 deals with oxidase control of plasma membrane proton transport, while chapter 7 addresses the question of how cell volume is regulated. Although we chose not to have a separate chapter covering additional co-transport systems namely, Na+ -K+ -2CI-, KCI, -HCO-3, as well as CI- -HCO-3 exchange and K+ and CI- movements through channels, the role of each in cell volume regulation is emphasized in Chapter 7. Instead of devoting an entire section to the thermodynamics of metabolism, we thought it desirable to have the subjects of medical imaging and NMR of cell metabolism discussed in some detail in two chapters. These are followed by a chapter on the thermodynamic instrument - the calorimeter. Calrimetry allows the measurement of net changes of heat in cells, tissues, organs and whole body. As will be recognized, heat dissipation does not arise only from chemical reactions but also from interactions between macromolecules and conformational changes in protein complexes and mass Ca2+ movement such as that occurring in contracting skeletal muscle. The last chapter provides an account of equilibrium and non-equilibrium thermodynamics and the enthalpy balance method. It reveals that calometric measurements are useful in studies of clinical and toxicological problems.

  • Biotechnology Annual Review

    • 1st Edition
    • Volume 2
    • M.R. El-Gewely
    • English
    The Biotechnology Annual Review series aims at covering developments in the field of biotechnology in the form of comprehensive, illustrated and well-referenced reviews. Recent expansion in this field, both industrial and educational, along with the increase in the number of new journals reporting new results, has greatly increased the need for exactly this type of series, continuously providing reviews.Every volume, published yearly, will cover a different aspect of biotechnology.The "Editorial Board" of Biotechnology Annual Review encourages suggestions and contributions of articles from industry or from academic institutions that would constitute a comprehensive covering of a relevant topic in biotechnology.Propos... for contributions and/or suggestions for topics for future volumes in this series should be sent to the Editor:Professor M.R. El-GewelyDepartment of biotechnologyUnivers... of TromsøIMB, MH-ByggetN-9037 TromsøNorwayTel: (+47) 77 644654Fax: (+47) 77 645350

  • 11th International Congress on Catalysis - 40th Anniversary

    Part A & B + CD-ROM
    • 1st Edition
    • Volume 101
    • J.W. Hightower + 3 more
    • English
    These proceedings contain 145 papers - 7 plenary lectures and 138 submitted papers selected for oral presentation. The plenary lectures include five overviews of vital research areas by highly respected researchers and two overviews of advances in the science and technology of catalysis made during the last 40 years. The first group explores the forces that drive innovation in catalysis, constrained geometry in metallocene olefin polymerization, characterization and design of oxide surfaces, photocatalysis, and factors required in the molecular design of catalysts. Two others are presented by researchers who attended the first ICC meeting 40 years ago and who have been substantive contributors to science and engineering developments that have occurred since then.The proceedings differ from those published previously in two important ways. Firstly, the papers were published prior to the meeting for distribution to all delegates who attended the meeting in Baltimore. Secondly, none of the discussions at the meeting are included, which has the advantage of smaller size (only 2 volumes, less than 1,600 pages) which should make the books more attractive to libraries and other repositories of research literature. A CD-ROM, comprising all the material covered in the 2 volumes, is also included.

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