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  • Advances in Medicinal Chemistry

    • 1st Edition
    • Volume 5
    • A.B. Reitz + 1 more
    • English
    Volume 5 of Advances in Medicinal Chemistry contains four intriguing and detailed accounts of the close interface between synthetic chemistry, structure-activity relationships, biochemistry, and pharmacology. In Chapter 1, there is a comprehensive survey of the immunophilin area specifically focussing on neuroregenerative applications in the central nervous system. In Chapter 2, there is an overview of the development of a potent analgesic compound that works via modulation of neuronal nicotinic acetylcholine receptors. In Chapter 3, there is a description of dopamine D-2 autoreceptor partial agonists as potential therapy for the treatment of schizophrenia. In Chapter 4, there is a summary of the successful program in which potent non-peptide inhibitors of HIV protease from the AIDS virus were developed.

  • Gap Junctions

    • 1st Edition
    • Volume 30
    • E.L. Hertzberg
    • English
    The objective in editing this volume was twofold: to provide a reasoned overview of the field as well as to furnish one that provided this overview within the context of the intellectual boundaries of those who initially attempted to define the purview of gap junction research. The latter objective has been realized by selecting the topics for review in this volume. The former objective was achieved by securing the cooperation of leaders in their fields as chapter co-authors.

  • Biological Psychiatry

    • 1st Edition
    • Volume 14
    • Edward Bittar
    • English
    It is now widely recognised that biological psychiatry is rapidly coming into its own. For over the last three decades dramatic advances in this young discipline have been made, all of which attest to the staying power of the experimental method. Those who made this revolution in knowledge happen are a breed of investigators availing themselves of the tools of molecular biology, pharmacology, genetics, and perhaps, above all, the technology of neuroimaging. The introduction of the interdisciplinary method of approach to the study of psychopathology had made it very clear that neuroimaging, as a set of techniques, is unique in that it is gradually providing us with evidence supporting Kraepelin's original view that mental illness is closely associated with abnormal changes in the brain.Broadly speaking, there are presently two structural techniques in neuroimaging - computed tomography and magnetic resonance imaging (MRI) - and three functional techniques - single photon emission tomography (SPECT), positron emission tomography and magnetic resonance imaging (fMRI). Through PET technology, for example, we have learned that, in early brain development, the primitive areas, mostly the brain stem and thalamus, are the first to show high activity in an infant. This is followed by the development of cortical areas by year one. Between the ages of four to 10, the cortex is almost twice as active in the child as in the adult. This information alerts us to what might happen in the way of trauma in abused children, especially those under the age of three. Child abuse increases the risk of physical changes, not only in the stress systems, but also in brain development (Glaser and Weissman). In addition to the difficult problem of post-traumatic stress disorder (PTSD), we have to take into account the possibility of other types of mental illness as the consequences of child abuse. These include depression, eating disorders, and drug and alcohol problems.The combination of PET and fMRI represents a more remarkable example of the power of neuroimaging since the two have made it feasible to map accurately in vitro identifiable cortical fields, or networks. In a landmark NIH investigation of human cortical reorganization (plasticity), persuasive evidence was brought forward showing that the process of learning as a motor task involves a specific network of neurons. These neurons occur in the cortical field that is responsible for that particular task. Such findings are important partly because they provide evidence supporting the current notion that labor in the cortex is divided among ensembles of specialized neurons that cooperate in the performance of complex tasks. Cooperation, then, in this, sense implies crosstalk among ensembles and that signals are both processed and retransmitted to neighbouring ensembles. To understand the workings of these ensembles, much better spatial and temporal resolution in functional brain mapping is required. This can be achieved with an NMR instrument whose magnet is 4.1 Tesla or more.

  • Advances in Space Biology and Medicine

    • 1st Edition
    • Volume 7
    • S.L. Bonting
    • English
    During the past several years there has been a shortage of flight opportunities for biological and medical projects. And those that were available usually had severe restrictions on instrumentation, number of subjects, duration, time allotted for performing the experiments, a possibility for repetition of experiments. It is our hope and expectation that this will change once the international Space Station is in full operation. The advantages of a permanent space station, already demonstrated by the Russian Mir station, are continuous availability of expert crew and a wide range of equipment, possibility of long-term experiments where this is waranted, increased numbers of subjects through larger laboratory space, proper controls in the large 1-G centrifuge, easier repeatability of experiments when needed.The limited number of flight opportunities during recent years probably explains why it has taken so long to acquire a sufficient number of high quality contributions for this seventh volume of Advances in Space Biology and Medicine. While initially the series wassailed at annually appearing volumes, we are now down to a biannual appearance. Hopefully, it will be possible to return to annual volumes in the future when results from space station experimentation at beginning to pour in.The first three chapters of this volume deal with muscle. Fejtek and Wassersug provide a survey of all studies on muscle of rodents flown in space, and include an interesting demography of this aspect of space research. Riley reviews our current knowledge of the effects of long-term spaceflight and re-entry on skeletal muscle, and considers the questions still to be answered before we can be satisfied that long-term space missions, such as on the space station, can be safely undertaken. Stein reviews our understanding of the nutritional and hormonal aspects of muscle loss in spaceflight, and concludes that the protein loss in space could be deleterious to health during flight and after return. Strollo summarizes our understanding of the major endocrine systems on the ground, then considers what we know about their functioning in space, concluding that there is much to be learned about the changes taking place during spaceflight. The many problems of providing life support (oxygen regeneration and food supply) during extended stay on the Moon, on Mars, or in space by means of plant cultivation are discussed by Salisbury. The challenges of utilizing electrophoresis in microgravity for the separation of cells and proteins are illustrated and explained by Bauer and colleagues. Finally, the chapter on teaching of space life sciences by Schmitt shows that this field of science has come of age, but also that its multidisciplinary character poses interesting challenges to teaching it.

  • Ecosystems of Disturbed Ground

    • 1st Edition
    • Volume 16
    • L.R. Walker
    • English
    As the human population inexorably grows, its cumulative impact on the Earth's resources is hard to ignore. The ability of the Earth to support more humans is dependent on the ability of humans to manage natural resources wisely. Because disturbance alters resource levels, effective management requires understanding of the ecology of disturbance. This book is the first to take a global approach to the description of both natural and anthropogenic disturbance regimes that physically impact the ground. Natural disturbances such as erosion, volcanoes, wind, herbivory, flooding and drought plus anthropogenic disturbances such as foresty, grazing, mining, urbanization and military actions are considered. Both disturbance impacts and the biotic recovery are addressed as well as the interactions of different types of disturbance. Other chapters cover processes that are important to the understanding of disturbance of all types including soil processes, nutrient cycles, primary productivity, succession, animal behaviour and competition. Humans react to disturbances by avoiding, exacerbating, or restoring them or by passing environmental legislation. All of these issues are covered in this book.Managers need better predictive models and robust data-collections that help determine both site-specfic and generalized responses to disturbance. Multiple disturbances have a complex effect on both physical and biotic processes as they interact. This book provides a wealth of detail about the process of disturbance and recovery as well as a synthesis of the current state of knowledge about disturbance theory, with extensive documentation.

  • Peripheral and Spinal Mechanisms in the Neural Control of Movement

    • 1st Edition
    • Volume 123
    • M.D. Binder
    • English
    In the last decade, we have witnessed a striking maturation of our understanding of how neurons in the spinal cord control muscular activity and movement. Paradoxically, a host of new findings have revealed an unexpected versatility in the behavior of these well-studied neural elements and circuits. In this volume, the world's leading experts review the current state of our knowledge of motor control, outline their latest results and developments, and delineate the seminal unresolved questions in this vibrant field of research. The volume begins with a commentary and overview of our current understanding of the peripheral and spinal basis of motor control. The remainder of the volume is divided into seven sections, each focused on a different problem. The first chapter in each section provides some historical review and presages the experimental findings and hypotheses that are discussed in subsequent chapters.Topics include the biomechanics of neuromuscular systems, the properties of motoneurons and the muscle units they control, spinal interneurons, pattern generating circuits, locomotion, descending control of spinal circuits, comparative physiology of motor systems, and motor systems neurophysiology studied in man. The book serves as a unique reference volume and should be essential reading for anyone interested in motor systems. Moreover, the volume's comprehensive coverage of a wide range of topics make it an effective textbook for graduate level courses in motor control neurobiology, kinesiology, physical therapy, and rehabilitation medicine.

  • Interlaboratory Studies and Certified Reference Materials for Environmental Analysis

    The BCR Approach
    • 1st Edition
    • Volume 22
    • E.A. Maier + 1 more
    • English
    The participation in interlaboratory studies and the use of Certified Reference Materials (CRMs) are widely recognised tools for the verification of the accuracy of analytical measurements and they form an integral part of quality control systems used by many laboratories, e.g. in accreditation schemes. As a response to the need to improve the quality of environmental analysis, the European Commission has been active in the past fifteen years, through BCR activity (now renamed Standards, Measurements and Testing Programme) in the organisation of series of interlaboratory studies involving expert laboratories in various analytical fields (inorganic, trace organic and speciation analysis applied to a wide variety of environmental matrices). The BCR and its successor have the task of helping European laboratories to improve the quality of measurements in analytical sectors which are vital for the European Union (biomedical, agriculture, food, environment and industry); these are most often carried out in support of EC regulations, industrial needs, trade, monitoring activities (including environment, agriculture, health and safety) and, more generally, when technical difficulties hamper a good comparability of data among EC laboratories. The collaborative projects carried out so far have placed the BCR in the position of second world CRM producer (after NIST in the USA).Interlaboratory Studies and Certification of Reference Materials for Environmental Analysis gives an account of the importance of reference materials for the quality control of environmental analysis and describes in detail the procedures followed by BCR to prepare environmental reference materials, including aspects related to sampling, stabilization, homogenisation, homogeneity and stability testing, establishment of reference (or certified) values, and use of reference materials. Examples of environmental CRMs produced by BCR within the last 15 years are given, which represent more than 70 CRMs covering different types of materials (plants, biological materials, waters, sediments, soils and sludges, coals, ash and dust materials) certified for a range of chemical parameters (major and trace elements, chemical species, PAHs, PCBs, pesticides and dioxins).The final section of the book describes how to organise improvement schemes for the evaluation method and/or laboratory performance. Examples of interlaboratory studies (learning scheme, proficiency testing and intercomparison in support to prenormative research) are also given.

  • Invertebrate Biodiversity as Bioindicators of Sustainable Landscapes

    Practical Use of Invertebrates to Assess Sustainable Land Use
    • 1st Edition
    • Maurizio G. Paoletti
    • English
    Reducing environmental hazard and human impact on different ecosystems, with special emphasis on rural landscapes is the main topic of different environmental policies designed in developed countries and needed in most developing countries. This book covers the bioindication approach of rural landscapes and man managed ecosystems including both urbanised and industrialised ones. The main techniques and taxa used for bioindication are considered in detail. Remediation and contamination is faced with diversity, abundance and dominance of biota, mostly invertebrates. Invertebrate Biodiversity as Bioindicators of Sustainable Landscapes provides a basic tool for students and scientists involved in landscape ecology and planning, environmental sciences, landscape remediation and pollution.

  • Caribbean Basins

    • 1st Edition
    • Volume 4
    • P. Mann
    • English
    This 21-chapter volume provides a regionally-comprehen... collection of original studies of Caribbean basins conducted by academic and petroleum geologists and geophysicists in the early and mid-1990s. The common tectonic events discussed in the volume including the rifting and passive margin history of North and South America that led to the formation of the Caribbean region; the entry of an exotic, Pacific-derived Great Arc of the Caribbean at the leading edge of the Caribbean oceanic plateau; the terminal collision of the arc and plateau with the passive margins fringing North and South America; and subsequent strike-slip and accretionary tectonics that affected the arc-continent collision zone.Two introductory chapters (Part A) utilize recent advances in quantitative plate tectonic modeling and satellite-based gravity measurements to place the main phases of Caribbean basin formation into a global plate tectonic framework. Nineteen subsequent chapters are organized geographically and focus on individual or groups of genetically-linked basins. Part B consists of five chapters which mainly focus on basins overlying the North America plate in the Gulf of Mexico, Cuba and the Bahamas that record its rifting from South America in late Jurassic to Cretaceous time. Part C has six chapters that focus on smaller, usually heavily faulted and onshore Cenozoic basins of the northern Caribbean that formed in response to arc collisional and strike-slip activity along the evolving North America-Caribbean plate boundary. The two chapters in Part D focus on Cenozoic basins related to the Lesser Antilles arc system of the eastern Caribbean. Part E is comprised of three chapters on the Jurassic-Recent sedimentary basins of the eastern Venezuela and Trinidad area of the southeastern Caribbean. These basins reflect both the Jurassic-Cretaceous rifting and passive margin history of separation between the North and South America plates as well as a much younger phase of Oligocene to recent transpression between the eastward migrating Lesser Antilles arc and accretionary wedge and the South America continent. The three chapters of Part F contain deep penetration seismic reflection and other geophysical data on the largely submarine Cretaceous Caribbean oceanic plateau that forms the nucleus of the present-day Caribbean plate.

  • Ceramics and Ceramic Composites

    Materialographic Preparation
    • 1st Edition
    • G. Elssner + 3 more
    • English
    Ceramics and ceramic composites are now used in almost all areas of technology and have potential for even greater and more widespread applications. To make this a reality, it is increasingly necessary to understand the microstructure of the material and its relationship with properties and performance. Central to this is the characterization of the material, in particular using optical and scanning electron microscopy techniques.This book acts as an expert guide to the various steps necessary for successful and accurate characterization of these materials including the crucially important preparation stage, the techniques used to reveal the microstructure and the analysis of the results.In particular, the book presents fundamental information on preparing polished sections of ceramics and ceramic composites including the main steps of sampling, sectioning, mounting and impregnation, and mechanical grinding, lapping and polishing. It discusses microstructural imaging in the optical microscope (OM) and the use of the scanning electron microscope (SEM). Etching or contrast enhancement following final polishing in order to reveal the material's microstructure is also covered.An entire chapter is devoted to material-specific preparation procedures for polished sections. These procedures take into account the properties of the ceramic or composite being examined and the purpose of the examination. They have proven to be very suitable for the respective materials and are effective for revealing the pores. The examples presented here for ceramics and ceramic composites provide polished sections of good to excellent quality for routine examination under the optical microscope. They include tips for etching and contrast enhancement, as well as microstructural images. Chapter 5 discusses the preparation of polished sections for purposes of examination and contains information on producing oblique sections and controlled removal of material. It also addresses the production of thin sections. As a complement to the examination of the microstructure, chapter 6 provides insight into the evaluation of hardness testing indentations. Chapter 7 concludes this work with an overview of the technical literature.

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