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Elsevier Science

  • Metal Fatigue: Effects of Small Defects and Nonmetallic Inclusions

    • 1st Edition
    • Yukitaka Murakami
    • English
    Metal fatigue is an essential consideration for engineers and researchers who are looking at factors that cause metals to fail through stress, corrosion, etc. This is an English translation of a book originally published in Japan in 1993, with an additional two chapters on the fatigue failure of steels and the effect of surface roughness on fatigue strength. The methodology is based on important and reliable results and may be usefully applied to other fatigue problems not directly treated in this book.

  • European Symposium on Computer Aided Process Engineering - 12

    • 1st Edition
    • Volume 10
    • J. Grievink + 1 more
    • English
    This book contains 182 papers presented at the 12th Symposium of Computer Aided Process Engineering (ESCAPE-12), held in The Hague, The Netherlands, May 26-29, 2002. The objective of ESCAPE-12 is to highlight advances made in the development and use of computing methodologies and information technology in the area of Computer Aided Process Engineering and Process Systems Engineering. The Symposium addressed six themes: (1) Integrated Product&Process Design; (2) Process Synthesis & Plant Design; (3) Process Dynamics & Control; (4) Manufacturing & Process Operations; (5) Computational Technologies; (6) Sustainable CAPE Education and Careers for Chemical Engineers. These themes cover the traditional core activities of CAPE, and also some wider conceptual perspectives, such as the increasing interplay between product and process design arising from the often complex internal structures of modern products; the integration of production chains creating the network structure of the process industry and optimization over life span dimensions, taking sustainability as the ultimate driver.

  • Progress in Medicinal Chemistry

    • 1st Edition
    • Volume 39
    • English
    This volume covers contemporary advances in five important areas of pharmacology and medicinal chemistry including: a comprehensive account of inhibitors of the caspase family of proteolytic enzymes that represent a new class of anti-inflammatory and antiapoptotic agents of potential value in rheumatoid arthritis, and other peripheral and central indications; adoc umented survey of semi-synthetic and totally synthetic antibiotics and anti HIV agents and their sites of interaction; inhibitors of the intracellular enzyme acyl-CoA: cholesterol O-acyltransferase (ACAT) developed for the treatment of hypercholesterolemia... and recent progress in growth hormone secretagogues, with the focus on strategies to improve oral bioavailability and duration of action. Inhibition of the proteolytic enzyme, hepatitis C protease N-3(NS3), required for viral replication, is one of the most attractive targets for HCV infections. Progress and prospects in the design of peptide and non-peptide inhibitors are described here. design and clinical potential of new drug molecules; valuable summaries of structure-activity relationships in topical areas of medicinal chemistry; and extensive references to the biology, medicinal chemistry and clinical aspects of each topic.

  • Geophysical Inverse Theory and Regularization Problems

    • 1st Edition
    • Michael S. Zhdanov
    • English
    This book presents state-of-the-art geophysical inverse theory developed in modern mathematical terminology. The book brings together fundamental results developed by the Russian mathematical school in regularization theory and combines them with the related research in geophysical inversion carried out in the West. It presents a detailed exposition of the methods of regularized solution of inverse problems based on the ideas of Tikhonov regularization, and shows the different forms of their applications in both linear and nonlinear methods of geophysical inversion. This text is the first to treat many kinds of inversion and imaging techniques in a unified mathematical manner.The book is divided in five parts covering the foundations of the inversion theory and its applications to the solution of different geophysical inverse problems, including potential field, electromagnetic, and seismic methods. The first part is an introduction to inversion theory. The second part contains a description of the basic methods of solution of the linear and nonlinear inverse problems using regularization. The following parts treat the application of regularization methods in gravity and magnetic, electromagnetic, and seismic inverse problems. The key connecting idea of these applied parts of the book is the analogy between the solutions of the forward and inverse problems in different geophysical methods. The book also includes chapters related to the modern technology of geophysical imaging, based on seismic and electromagnetic migration.This volume is unique in its focus on providing a link between the methods used in gravity, electromagnetic, and seismic imaging and inversion, and represents an exhaustive treatise on inversion theory.

  • Risk Assessment and Management of Repetitive Movements and Exertions of Upper Limbs

    Job Analysis, Ocra Risk Indicies, Prevention Strategies and Design Principles
    • 1st Edition
    • Volume 2
    • Daniela Colombini
    • English
    In industrialised countries, musculo-skeletrical disorders of the upper limbs represent one of the commonest work-related diseases. All working activities habitually requiring repetitive upper limb movements and exertions represent a potential risk for these disorders under certain conditions. This practical manual provides a clear and detailed solution to the problem of assessing and consequently managing these risks in conformity with European Union legislation covering the safety and protection of workers' health. The book contains many tables, diagrams and schedules, enhancing its practical value. The methods it proposes for analyzing and designing or redesigning jobs and tasks do not require sophisticated equipment and are largely based on situations encountered in large manufacturing factories. Since risk analysis also concerns how jobs and tasks are organized, many concepts and terms are defined that prevention experts can share with those responsible for planning and organizing manufacturing activities on the shop floor.

  • Interactions of Microorganisms with Radionuclides

    • 1st Edition
    • Volume 2
    • M.J. Keith-Roach + 1 more
    • English
    Many environmental processes are influenced, if not controlled, by microbial action and it is becoming increasingly important to develop an understanding of microbial roles in geochemistry. This book brings together state of the art research into microbiological processes and the extent to which they affect or can be used to control radioactive elements. The basic principles and fundamental mechanisms by which microbes and radionuclides interact are outlined, the methodology described, potential microbial influences on waste repositories examined, direct and indirect effects on transport both on local and global scales considered and potential technological applications identified.The book is directed towards advanced undergraduate students, postgraduates and researchers in the areas of environmental radioactivity, environmental microbiology, biotechnology and radioactive waste management. It will also be of interest to regulators, policy makers and non-governmental organisations.This novel and timely book offers a fully integrated approach to a topical international issue.

  • Exploratory Analysis of Metallurgical Process Data with Neural Networks and Related Methods

    • 1st Edition
    • Volume 12
    • C. Aldrich
    • English
    This volume is concerned with the analysis and interpretation of multivariate measurements commonly found in the mineral and metallurgical industries, with the emphasis on the use of neural networks.The book is primarily aimed at the practicing metallurgist or process engineer, and a considerable part of it is of necessity devoted to the basic theory which is introduced as briefly as possible within the large scope of the field. Also, although the book focuses on neural networks, they cannot be divorced from their statistical framework and this is discussed in length. The book is therefore a blend of basic theory and some of the most recent advances in the practical application of neural networks.

  • Growth and Lactogenic Hormones

    • 1st Edition
    • Volume 2
    • L. Matera + 1 more
    • English
    For more than seventy years evidence has accumulated documenting the existence of a bi-directional communication network between growth hormone and the immune system. In the past twenty years there has been a tremendous proliferation of information detailing the workings of the growth hormone and insulin-like growth factor axis. A multitude of growth factors and binding proteins have been identified. More and more evidence supporting the important role of the growth hormone IGF network in the well functioning of the normal immune system has been documented. Clearly the challenge today is not to prove, but to understand, the neuroimmune regulatory role of GLH in its entire complexity.The ultimate goal of this volume and of all the other volumes of this series is to promote the understanding of the science and to ease human suffering.

  • International Perspectives on Child and Adolescent Mental Health

    • 1st Edition
    • Volume 2
    • Nirbhay N Singh + 2 more
    • English
    The papers included in this volume highlight research and practice in child and adolescent mental health from around the world. As systems of care are different across countries and cultures, it is imperative that knowledge is shared and lessons learned. The biennial Elsevier conference on Child and Adolescent Mental Health is designed to provide a forum for mental health and educational experts from various disciplines and countries.

  • Optical Biosensors: Present & Future

    • 1st Edition
    • Frances S. Ligler + 1 more
    • English

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