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Elsevier

Elsevier Science

  • Medical Applications of Mass Spectrometry

    • 1st Edition
    • Karoly Vekey + 2 more
    • English
    Mass spectrometry is fast becoming an indispensable field for medical professionals. The mass spectrometric analysis of metabolites and proteins promises to revolutionize medical research and clinical diagnostics. As this technology rapidly enters the medical field, practicing professionals and students need to prepare to take full advantage of its capabilities. Medical Applications of Mass Spectrometry addresses the key issues in the medical applications of mass spectrometry at the level appropriate for the intended readership. It will go a long way to help the utilization of mass spectrometry in medicine.The book comprises five parts. A general overview is followed by a description of the basic sampling and separation methods in analytical chemistry. In the second part a solid foundation in mass spectrometry and modern techniques of data analysis is presented. The third part explains how mass spectrometry is used in exploring various classes of biomolecules, including proteins and lipids. In the fourth section mass spectrometry is introduced as a diagnostic tool in clinical treatment, infectious pathogen research, neonatal diagnostics, cancer, brain and allergy research, as well as in various fields of medicine: cardiology, pulmonology, neurology, psychiatric diseases, hemato-oncology, urologic diseases, gastrointestinal diseases, gynecology and pediatrics. The fifth part covers emerging applications in biomarker discovery and in mass spectrometric imaging.

  • Environmental Design Guidelines for Low Crested Coastal Structures

    • 1st Edition
    • Stephen J. Hawkins + 3 more
    • English
    The effect of manmade activities is primarily local but can extend far away from the location of intervention. This underlines the importance of establishing coastal zone management plans covering large stretches of coastlines. In recent years, interest in Low Crested Structures (coastal defense structures with a low-crest) has been growing together with awareness of the sensitivity to environmental impacts produced by coastal defenses. The relation between wave climate, beach erosion, beach defence means, habitat changes and beach value, which clearly exists based on EC research results, suggests the necessity of an integrated approach when designing coastal protection schemes. In accordance with this need, the present design guidelines cover structure stability and construction problems, hydro and morphodynamic effects, environmental effects (colonisation of the structure and water quality), societal and economic impacts (recreational benefits, swimming safety, beach quality). Environmental Design Guidelines for Low Crested Coastal Structures is specifically dedicated to Low Crested Structures, and provides methodological tools both for the engineering design of structures and for the prediction of performance and environmental impacts of such structures. A briefing of current best practice for local and national planning authorities, statutory agencies and other stakeholders in the coastal zone is also covered. Presented in a generic way, this book is appropriate throughout the European Union, taking into account current European Commission policy and directives for the promotion of sustainable development and integrated coastal zone management.

  • Stories of Success

    Personal Recollections. X
    • 1st Edition
    • Volume 45
    • English
    This book is the latest volume in the highly successful series Comprehensive Biochemistry. It provides a historical and autobiographical perspective of the developments in the field through the contributions of leading individuals who reflect on their careers and their impact on biochemistry. Volume 45 is essential reading for everyone from graduate student to professor, placing in context major advances not only in biochemical terms but in relation to historical and social developments. Readers will be delighted by the lively style and the insight into the lives and careers of leading scientists of their time.

  • Solid-Liquid Two Phase Flow

    • 1st Edition
    • Sümer M. Peker + 1 more
    • English
    This book is an undertaking of a pioneering work of uniting three vast fields of interfacial phenomena, rheology and fluid mechanics within the framework of solid-liquid two phase flow. No wonder, much finer books will be written in the future as the visionary aims of many nations in combining molecular chemistry, biology, transport and interfacial phenomena for the fundamental understanding of processes and capabilities of new materials will be achieved. Solid-liquid systems where solid particles with a wide range of physical properties, sizes ranging from nano- to macro- scale and concentrations varying from very dilute to highly concentrated, are suspended in liquids of different rheological behavior flowing in various regimes are taken up in this book. Interactions among solid particles in molecular scale are extended to aggregations in the macro scale and related to settling, flow and rheological behavior of the suspensions in a coherent, sequential manner. The classical concept of solid particles is extended to include nanoparticles, colloids, microorganisms and cellular materials. The flow of these systems is investigated under pressure, electrical, magnetic and chemical driving forces in channels ranging from macro-scale pipes to micro channels. Complementary separation and mixing processes are also taken under consideration with micro- and macro-scale counterparts.

  • The Art of Cryogenics

    Low-Temperature Experimental Techniques
    • 1st Edition
    • Guglielmo Ventura + 1 more
    • English
    Cryogenics is the study of low temperature interactions - temperatures well below those existing in the natural universe. The book covers a large spectrum of experimental cases, including basic vacuum techniques, indispensable in cryogenics. Guidance in solving experimental problems and numerous numerical examples are given, as are examples of the applications of cryogenics in such areas as underground detectors and space applications. Updated tables of low-temperature data on materials are also presented, and the book is supplemented with a rich bibliography. Researchers (graduate and above) in the fields of physics, engineering and chemistry with an interest in the technology and applications of low-temperature measurements, will find this book invaluable.

  • Cardiovascular Development

    • 1st Edition
    • Volume 18
    • English
    In 1993, Rolf Bodmer described a gene he named tinman that was required for the formation of the dorsal aorta of the fly. Flies without a functional tinman gene had no heart. Quickly, mammalian counterparts of the tinman gene were identified and found to be expressed by early cardiomyogenic precursors and by cardiomyocytes throughout heart development. Since then, significant progress has been made in the understanding of molecular and genetic determinants of heart formation. An ever growing number of genes have been identified that are required for cardiogenesis, as evidenced by severe abnormalities in cardiac development produced by inactivation in the mouse or inhibition of gene function in other model organisms. Cardiovascular Development covers some of the latest research in the study of heart formation. Volume Editor Rolf Bodmer has assembled a world-class list of contributors whose research uses a variety of animal models and whose findings are certain to enhance our understanding of this exciting field.

  • Casting Aluminum Alloys

    • 1st Edition
    • Michael V Glazoff + 2 more
    • English
    Casting Aluminum Alloys summarizes research conducted at Moscow Institute of Steel and Alloy during many decades in part together with Alcoa Inc. The research covered areas of the structure, properties, thermal resistance, corrosion and fatigue of aluminum alloys in industrial manufacturing.

  • Symmetry, Structure, and Spacetime

    • 1st Edition
    • Volume 3
    • Dean Rickles
    • English
    In this book Rickles considers several interpretative difficulties raised by gauge-type symmetries (those that correspond to no change in physical state). The ubiquity of such symmetries in modern physics renders them an urgent topic in philosophy of physics. Rickles focuses on spacetime physics, and in particular classical and quantum general relativity. Here the problems posed are at their most pathological, involving the apparent disappearance of spacetime! Rickles argues that both traditional ontological positions should be replaced by a structuralist account according to which relational structure is what the physics is about.

  • Solution Thermodynamics and its Application to Aqueous Solutions

    A Differential Approach
    • 1st Edition
    • Yoshikata Koga
    • English
    As the title suggests, we introduce a novel differential approach to solution thermodynamics and use it for the study of aqueous solutions. We evaluate the quantities of higher order derivative than the normal thermodynamic functions. We allow these higher derivative data speak for themselves without resorting to any model system. We thus elucidate the molecular processes in solution, (referred to in this book “mixing scheme”), to the depth equal to, if not deeper, than that gained by spectroscopic and other methods. We show that there are three composition regions in aqueous solutions of non-electrolytes, each of which has a qualitatively distinct mixing scheme. The boundary between the adjacent regions is associated with an anomaly in the third derivatives of G. The loci of the anomalies in the temperature-composit... field form the line sometimes referred as “Koga line”. We then take advantage of the anomaly of a third derivative quantity of 1-propanol in the ternary aqueous solution, 1-propanol – sample species – H2O. We use its induced change as a probe of the effect of a sample species on H2O. In this way, we clarified what a hydrophobe, or a hydrophile, and in turn, an amphiphile, does to H2O. We also apply the same methodology to ions that have been ranked by the Hofmeister series. We show that the kosmotropes (salting out, or stabilizing agents) are either hydrophobes or hydration centres, and that chaotropes (salting in, or destablizing agents) are hydrophiles.

  • Pesticide Risk Assessment in Rice Paddies: Theory and Practice

    • 1st Edition
    • Ettore Capri + 1 more
    • English
    Rice is cultivated throughout the world under submerged conditions. The high water requirements and the heavy pesticide load used in rice paddies worldwide have resulted in contamination of associated surface water, such as streams, ditches, rivers and lakes. The uniform risk assessment approach which has been developed for other crops is not applicable to rice paddies, because of the specific conditions applied to rice cultivation. Pesticide Risk Assessment in Rice Paddies: Theory and Practice fills the gap in information on this subject. Written by experts, this book summarizes the methods used for pesticide risk assessment in rice paddies, the limitations and problems encountered and future developments. It also examines the various agronomic, pesticide application and risk assessment approaches used in different rice cultivated zones in Asia, America and Europe and is an essential reference for those working in this area.

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