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Elsevier

Academic Press

  • Current Topics in Cellular Regulation

    • 1st Edition
    • Volume 16
    • Bernard L. Horecker + 1 more
    • English
    Current Topics in Cellular Regulation, Volume 16 considers the advances in the general area of cellular regulation. This book discusses the subcellular distribution of hexokinase in brain homogenates and experimental evidence for bound hexokinase as a compartmental control point. The enzymology and biologic significance of cytochrome c methylation, polyaromatic-biosynt... multienzyme system, and proteolytic modulation of gene expression in sporulation are also elaborated. This text likewise covers the occurrence of cyclic nucleotide-synthesiz... and -degrading enzymes in the mammalian brain and calcium ion as a positive effector of oocyte maturation. This volume is beneficial to biologists and researchers conducting work on the basic mechanisms involved in the regulation of diverse cellular activities.

  • Advances in Lipid Research

    • 1st Edition
    • Volume 15
    • Rodolfo Paoletti + 1 more
    • English
    Advances in Lipid Research, Volume 15 is a four-chapter text that covers important aspects of lipid chemistry, including biomembranes and fungal lipids. The first chapter is devoted to the long-range order in biomembranes. This chapter presents evidence that the proteins and lipids of biological membranes are partitioned into functional and structural aggregates in the plane of the membrane. The second chapter surveys the pharmacology and toxicology of steroids and related compounds. This chapter also provides the methodology, physiologic and transport mechanisms, and effects on the central nervous system. The third chapter explores all aspects of lipid composition of all classes of fungi. This chapter also discusses the intracellular distribution and biosynthesis of the lipid components of fungi. The fourth chapter considers the biochemistry of plant sterols, including structure, stereochemistry, biosynthesis, metabolism, and function. This book will be of value to lipid chemists, biochemists, and researchers.

  • Molecular Mechanisms of Immunological Self-Recognition

    • 1st Edition
    • Frederick Alt + 1 more
    • English
    Molecular Mechanisms of Immunological Self-Recognition covers the understanding of immunological self-recognition. The introductory chapter of the book summarizes the dawn of the insight into immunological tolerance, and provides an overview of research on the underlying mechanisms. The book addresses the developments in the molecular mechanisms of B and T cell tolerance and describes the failure of tolerance in autoimmunity. The text concludes by furnishing orienting perspectives and highlighting new information presented. The novel findings characterized as impressive advances pertain to the areas of B cell development and the generation of molecular diversity; V gene usage, especially from transgenes, in positive and negative thymic selection; the handling of positive and negative signals by T and B cells; anergy in postthymic T cells; the design of peptide-based therapy for autoimmune diseases; and the design of therapy with the aid of monoclonal antibodies. Immunologists will find the text useful.

  • Laminar Flow Forced Convection in Ducts

    A Source Book for Compact Heat Exchanger Analytical Data
    • 1st Edition
    • R. K. Shah + 1 more
    • Thomas F. Irvine + 1 more
    • English
    Laminar Flow Forced Convection in Ducts is a sourcebook for compact heat exchanger analytical data. This book describes the analytical solutions for laminar fluid flow and forced convection heat transfer in circular and noncircular pipes, including applicable differential equations and boundary conditions involving velocity and temperature problems of fluid flow. The book also discusses fluid flow—how much power is required to pump fluids through the heat exchanger, as well as the heat transfer—the determination of q" distribution, and the temperature of fluid and walls. The text also analyzes the coolant or heat transfer fluid flows in a nuclear power reactor composed of a bundle of circular section fuel rods located inside a round tube. R.A. Axford addresses fluid flow and heat transfers results for the rod bundle geometry in "Heat Transfer in Rod Bundles." The book also provides an overview and guidelines that can be used for the designer and the applied mathematician. This book is suitable for engineers working in electronics, aerospace, instrumentation, and biomechanics that use cooling or heating exchanges or solar collection systems.

  • Speech and Language

    Advances in Basic Research and Practice
    • 1st Edition
    • Volume 1
    • Norman J. Lass
    • English
    Speech and Language: Volume 1, Advances in Basic Research and Practice is a compendium of papers that discusses the processes and pathologies of, as well as applies theories and clinical issues to, speech and language. Some papers discuss perception of speech in early infancy, the problems faced by speech clinicians, and the anatomy of the perioral motor system. Based on data compiled on the infant's perception of speech sounds, one paper notes that human infants discriminate depending on fine temporal and frequency changes in a complex auditory array. Infants also show perceptual constraints while listening to speech characterized as adult- like; they are also predisposed to perceive certain speech-sound categories such as vowel and fricative categories. One paper examines the suggestion of Kent (1976) that "acoustic characteristics of children's speech...hold the promise of sensitive methods for the study of speech maturation and developmental disorders." This investigation involves the following: the recent attempts at multidimensional analyses of speech and perception; a measure of perceptual contrast; and results of feature comparison efforts. The compendium is well suited for linguists, ethnologists, psychologists, and researchers whose works involve linguistics, language learning, communications, and syntax.

  • Speech and Language

    Advances in Basic Research and Practice
    • 1st Edition
    • Volume 9
    • Norman J. Lass
    • English
    Speech and Language: Advances in Basic Research and Practice, Volume 9 is a collection of contributions that discuss a broad range of topics on speech and language processes and pathologies. This volume contains seven contributions covering a wide array of topics on speech and language. It covers topics on speech development and production in normal and hearing-impaired speakers; integrated speech and language instruction for the hearing-impaired adolescent; and laryngectomee rehabilitation. Also discussed are subjects on sensory and motor changes during development and aging; the phonetic structure of errors in the perception of fluent speech; and the multiple meanings of phoneme and their confusions. Linguists, speech pathologists, and researchers on language development will find the book very insightful and informative.

  • Current Topics in Cellular Regulation

    • 1st Edition
    • Volume 19
    • Bernard L. Horecker + 1 more
    • English
    Current Topics in Cellular Regulation, Volume 19 analyzes the advances in the general area of cellular regulation. This book discusses the evidence indicating that synthesis of the histidine enzymes is regulated and drugs affecting ribonucleotide reductase. The analogy principle in comparative biochemistry of allosteric regulation of metabolism, steady-state model of glucose metabolism in adipose tissue, and sensitivity of enzyme activity to changing ion concentrations are also elaborated. This publication likewise covers the cAMP-dependent protein kinases of nervous tissue and amino acid sequences of IGF I and II. This volume is a good reference for biologists and researchers conducting work on the basic mechanisms involved in the regulation of diverse cellular activities.

  • Experimental Manipulation of Gene Expression

    • 1st Edition
    • Masayori Inouye
    • English
    Experimental Manipulation of Gene Expression discusses a wide range of host systems in which to clone and express a gene of interest. The aims are for readers to quickly learn the versatility of the systems and obtain an overview of the technology involved in the manipulation of gene expression. Furthermore, it is hoped that the reader will learn enough from the various approaches to be able to develop systems and to arrange for a gene of particular interest to express in a particular system. The book opens with a chapter on the design and construction of a plasmid vector system used to achieve high-level expression of a particular phage regulatory protein normally found in minute amounts in a phage-infected bacterial cell. This is followed by separate chapters on topics such as high-level expression vectors that utilize efficient Escherichia coli lipoprotein promoter as well as various other portions of the lipoprotein gene Ipp; DNA cloning systems for streptomycetes; and the design and application of vectors for high-level, inducible synthesis of the product of a cloned gene in yeast.

  • Mechanisms of Eukaryotic DNA Recombination

    • 1st Edition
    • Max E Gottesman + 1 more
    • English
    Mechanisms of Eukaryotic DNA Recombination is a collection of papers that discusses advances in eukaryotic genetic recombination. Papers address issues in eukaryotic genetic recombination, particularly DNA integration in mammalian genomes, genetic recombination in Drosophila or Caenorhabditis; the manipulation of the mouse genome; genome organization; and genetic recombination in protozoa. One paper discusses chromatid interactions during intrachromosomal recombination in mammalian cells, namely, intrachromatid and sister chromatid. Another paper analyzes the implication for chromosomal recombination and gene targeting; results on extrachromosomal recombination show that circles are inefficient substrates for recombination even if only one of two substrates in an intermolecular reaction is circular. One author discusses the genetics and molecular biology of recombination, citing the work of Watson and Crick, stating that crossing-over occurs between genes (not within them). He also explains that the formation and resolution of recombination intermediaries depend on enzyme or other proteins. This book will prove invaluable to cellular biologists, microbiologists, and researchers engaged in genetics and general biology.

  • Current Topics in Cellular Regulation

    • 1st Edition
    • Volume 25
    • Bernard L. Horecker + 1 more
    • English
    Current Topics in Cellular Regulation: Volume 25 is a collection of papers that deals with GTP, the central regulator of cellular anabolism, and the quantitative approach to metabolic control. , Other papers describe the inactivation and aldolases by limited proteolysis by lysosomal cathepsin M, the regulatory functions of proline, pyrroline-5-carboxyl... acid, as well as the characteristics of a hormonal regulation of amino acid transport. One paper suggests that GTP, possibly acting through high guanine nucleotide energy charge, acts to stimulate a wide variety of anabolic processes involved in cell growth or proliferation. Another paper proposes that lysosomes are responsible for the degradation of proteins and other macromolecules, and in regulating cytosolic enzymes. This action is due to the presence of selected proteinases (located on the outer lysosomal surface) that are active at neutral pH, and also which catalyze only limited proteolysis of cytosolic proteins. One paper describes the characteristics and hormonal regulation of a specific transport system for neutral amino acids, namely, the System A-mediated transport. The collection can prove beneficial for biochemists, micro-biologists, bio-physicists, cellular researchers, and academicians involved in the study of cellular biology.

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