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Elsevier

Academic Press

  • Trace Amines and Neurological Disorders

    Potential Mechanisms and Risk Factors
    • 1st Edition
    • Tahira Farooqui + 1 more
    • English
    Trace Amines and Neurological Disorders: Potential Mechanisms and Risk Factors explores trace amines which, under normal conditions, are present in the mammalian brain and peripheral nervous tissues at very low (nanomolar) concentrations. However, in a diverse array of human pathologies ranging from substance abuse, depression, attention deficit hyperactivity disorder, eating disorders, schizophrenia, and other neurological and neuropsychiatric diseases, the levels of trace amines are unusually high with an imbalance in their functions. Furthermore, the rapid turnover of trace amines is evidenced by their dramatic increases following treatment with monoamine oxidase inhibitors (MAOI) or deletion of the MAO genes. This suggests that the concentration of trace amines may be considerably higher at neuronal synapses than predicted by steady-state measures, implicating some pathophysiological role. Therefore, understanding molecular mechanisms and developing selective agonists and antagonists for trace amine-associated receptors (TAARs) has become a good approach for treating these diseases. Although the effects of trace amines at low physiological concentrations in mammalian species have been difficult to demonstrate, they may serve to maintain the neuronal activity of other monoamine neurotransmitters by possessing postsynaptic modulatory effects, particularly dopamine and serotonin, within defined physiological limits. Such an effect of trace amines makes them ideal candidates for the development of novel therapeutics for a wide range of human disorders. This book presents up-to-date, cutting-edge, and comprehensive information on the link between trace amines and neurological disorders.

  • The Boundary Element Method for Engineers and Scientists

    Theory and Applications
    • 2nd Edition
    • John T. Katsikadelis
    • English
    The Boundary Element Method for Engineers and Scientists: Theory and Applications is a detailed introduction to the principles and use of boundary element method (BEM), enabling this versatile and powerful computational tool to be employed for engineering analysis and design. In this book, Dr. Katsikadelis presents the underlying principles and explains how the BEM equations are formed and numerically solved using only the mathematics and mechanics to which readers will have been exposed during undergraduate studies. All concepts are illustrated with worked examples and problems, helping to put theory into practice and to familiarize the reader with BEM programming through the use of code and programs listed in the book and also available in electronic form on the book’s companion website.

  • Aquaculture Virology

    • 1st Edition
    • Frederick S.B. Kibenge + 1 more
    • English
    To date textbooks on viruses infecting fish, crustaceans and molluscs, the three main aquatic animal farmed groups, have been on the whole “diseases-centric” and individual viral diseases selected based on “epizoo-centric” approaches with little to no coverage of the basic biology of the viruses, in contrast to textbooks on viruses infecting terrestrial – farmed, pet, and free-range (wild) – animals and humans. Despite considerable advances in animal virology in recent years coupled with an economically important global aquaculture industry, knowledge of viruses of animal aquaculture is still sparse and in some cases outdated although these viruses are closely related to well-known virus families. The last book in fish virology (Fish viruses and fish viral diseases 1988, Wolf, K.) was published in the 1980s. A lot of work has been done on fish viruses and many new aquatic animal viruses continue to be discovered. Aquaculture Virology provides the current state of knowledge of aquatic animal viruses within the current virus classification and taxonomic context thereby allowing the reader to draw on the principles of general virology. This book is a systematic and concise resource useful to anyone involved with or looking to move into aquaculture and fisheries. Clinical veterinarians, aquaculture disease practitioners, biologists, farmers, and all those in industry, government or academia who are interested in aquatic animal virology will find this book extremely useful.

  • Ion Channels in Health and Disease

    • 1st Edition
    • Geoffrey S. Pitt
    • English
    Ion Channels in Health and Disease provides key insight to allow researchers to generate discoveries across disease states. A single resource that integrates disparate areas of biology and disease ion channel biology, this publication includes cross-referencing for disease, channels, and tissues. Offers a broad view of research of interest to early and experienced researchers across biological and biomedical research.

  • Synthetic Biology and Metabolic Engineering in Plants and Microbes Part A: Metabolism in Microbes

    • 1st Edition
    • Volume 575
    • English
    Synthetic Biology and Metabolic Engineering in Plants and Microbes: Part A, the new volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods, synthetic biology, and metabolic engineering in plants and microbes, and includes sections on such topics as the uses of integrases in microbial engineering, biosynthesis, and engineering of tryptophan derived metabolites, regulation and discovery of fungal natural products, and elucidation and localization of plant pathways.

  • Fund Custody and Administration

    • 1st Edition
    • David Loader
    • English
    Fund Custody and Administration provides an overall perspective of investment funds without limiting its analysis to specific fund structures, as other books do. Since governance and oversight of investment funds are now major regulatory requirements, administrators and custodians must place greater emphasis on the custody and safekeeping of fund assets, on the independent and robust valuation of the assets, and on collateral management. By focusing on both the asset transactions made by the investment manager for the portfolio and on the transactions in the shares or units of the fund itself, it gives readers insights about the essential elements of investment fund management and administration, regardless of their geographical backgrounds.

  • Digital Terrain Analysis in Soil Science and Geology

    • 2nd Edition
    • Igor Florinsky
    • English
    Digital Terrain Analysis in Soil Science and Geology, Second Edition, synthesizes the knowledge on methods and applications of digital terrain analysis and geomorphometry in the context of multi-scale problems in soil science and geology. Divided into three parts, the book first examines main concepts, principles, and methods of digital terrain modeling. It then looks at methods for analysis, modeling, and mapping of spatial distribution of soil properties using digital terrain analysis, before finally considering techniques for recognition, analysis, and interpretation of topographically manifested geological features. Digital Terrain Analysis in Soil Science and Geology, Second Edition, is an updated and revised edition, providing both a theoretical and methodological basis for understanding and applying geographical modeling techniques.

  • The Neurobiology of Schizophrenia

    • 1st Edition
    • Ted Abel + 1 more
    • English
    The Neurobiology of Schizophrenia begins with an overview of the various facets and levels of schizophrenia pathophysiology, ranging systematically from its genetic basis over changes in neurochemistry and electrophysiology to a systemic neural circuits level. When possible, the editors point out connections between the various systems. The editors also depict methods and research strategies used in the respective field. The individual backgrounds of the two editors promote a synthesis between basic neuroscience and clinical relevance.

  • Biological Distance Analysis

    Forensic and Bioarchaeological Perspectives
    • 1st Edition
    • Marin A. Pilloud + 1 more
    • English
    Biological Distance Analysis: Forensic and Bioarchaeological Perspectives synthesizes research within the realm of biological distance analysis, highlighting current work within the field and discussing future directions. The book is divided into three main sections. The first section clearly outlines datasets and methods within biological distance analysis, beginning with a brief history of the field and how it has progressed to its current state. The second section focuses on approaches using the individual within a forensic context, including ancestry estimation and case studies. The final section concentrates on population-based bioarchaeological approaches, providing key techniques and examples from archaeological samples. The volume also includes an appendix with additional resources available to those interested in biological distance analyses.

  • Stream Ecosystems in a Changing Environment

    • 1st Edition
    • Jeremy B. Jones + 1 more
    • English
    Stream Ecosystems in a Changing Environment synthesizes the current understanding of stream ecosystem ecology, emphasizing nutrient cycling and carbon dynamics, and providing a forward-looking perspective regarding the response of stream ecosystems to environmental change. Each chapter includes a section focusing on anticipated and ongoing dynamics in stream ecosystems in a changing environment, along with hypotheses regarding controls on stream ecosystem functioning. The book, with its innovative sections, provides a bridge between papers published in peer-reviewed scientific journals and the findings of researchers in new areas of study.

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