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Elsevier

Books in Pharmacology

Elsevier's Pharmacology collection studies how drugs interact with biological systems to improve health and treat disease. It covers pharmacodynamics, exploring drug effects on biology, and pharmacokinetics, studying how the body affects drugs. Branches like Pharmacogenetics. Essential for pharmacologists, this collection offers invaluable insights into drug interactions, efficacy, and safety, crucial for advancing drug development and improving patient outcomes.

  • Progress in Medicinal Chemistry

    • 1st Edition
    • Volume 31
    • English
    This book contains six chapters, each of which is a self-contained, thorough review by an expert in the field of a particular topic in medicinal chemistry, bacteriology or pharmacology. Each topic is a currently active subject of research in either the quest for new drugs or a better understanding of the role of known biochemical phenomena. In addition, all of the chapters contain an extensive list of relevant reference books, papers and other publications. The book will be of great interest to medicinal and pharmaceutical chemists, and will serve as a valuable source of reference.

  • Sigma Receptors

    • 1st Edition
    • Volume 12
    • English
    This is the 12th in the Neuroscience Perspectives Series. The existence of sigma receptors in the central nervous system has only relatively recently been established. In line with the aims of Neuroscience Perspectives, this volume will cover the historical background of the subject, together with the physiological, molecular biological and pharmacological aspects, with a discussion on the concept of sigma receptors subtypes and their postulated relevance for CNS disorders.

  • Immunopharmacology of Neutrophils

    • 1st Edition
    • English
    About the Series:The consequences for diseases involving the immune system such as AIDS, and chronic inflammatory diseases such as bronchial asthma, rheumatoid arthritis, and atherosclerosis, now account for a considerable economic burden to governments worldwide. In response there has been an enormous research effort investigating the basic mechanisms underlying such diseases, and a tremendous drive to identify novel therapeutic applications for their prevention and treatment. Though a plethora of immunological studies have been published in recent years, little has been written about the implications of such research for drug development. As a consequence, this area has not gained the prominence of other new fields such as molecular pharmacology or neuropharmacology, and a focal information source for the many pharmacologists interested in diseases of the immune system remains unpublished. The Handbook of Immunopharmacology series provides such a source through the commissioning of a comprehensive collection of volumes on all aspects of immunopharmacology. Editors have been sought after for each volume who are not only active in their respective areas of expertise, but who also have a distinctly pharmacological bias to their research. The series follows three main themes, each represented by volumes on individual component topics. The first covers each of the major cell types and classes of inflammatory mediators ("cells and mediators"). The second covers each of the major organ systems and the diseases involving the immune and inflammatory responses that can affect them ("systems"). The third covers different classes of drugs currently used to treat these diseases as well as those under development ("drugs"). About the Book:This book addresses the key issues that face neutrophils during their very short but extremely important lives. The discovery that neutrophils have the capacity to phagocytose and kill foreign organisms set the stage for a fascinating research field that continues to stimulate exciting new findings throughout the world. Neutrophils target the sites of infection or injury, and are thus equipped with sensors for soluble signals ("chemoattractants") generated in the tissue in response to tissue infection or injury, and sensors for molecules on surfaces. These receptors are important so that the cell can distinguish, for example, activated endothelium to stimulate adherence and emigration, or alternatively the bacterial surface to stimulate phagocytosis and killing. A deficiency in any of these mechanisms can result in life-threatening infection. An over-reaction can result in damage to the tissues that the neutrophil should be programmed to protect.

  • The G-Protein Linked Receptor Facts Book

    • 1st Edition
    • Steve Arkinstall
    • English
    How do you keep track of basic information on the proteins you work with? Where do you find details of their physicochemical properties, amino acid sequences, gene organization? Are you tired of scanning review articles, primary papers and databases to locate that elusive fact?The Academic Press FactsBook series will satisfy scientists and clinical researchers suffering from information overload. Each volume provides a catalogue of the essential properties of families of molecules. Gene organization, amino acid sequences, physicochemical properties, and biological activity are presented using a common , easy–to-follow format. Taken together they compile everything you wanted to know about proteins but were too busy to look for.

  • Immunopharmacology of Joints and Connective Tissues

    • 1st Edition
    • English
    The consequences for diseases involving the immune system such as AIDS, and chronic inflammatory diseases such as bronchial asthma, rheumatoid athritis, and atherosclerosis, now account for a considerable economic burden to governments worldwide. In response there has been an enormous research effort investigating the basic mechanisms underlying such diseases, and a tremendous drive to identify novel therapeutic applications for their preventions and treatment. Though a plethora of immunological studies have been published in recent years, little has been written about the implications of such research for drug development. As a consequence, this area has not gained the prominence of other new fields such as molecular pharmacology or neuropharmacology, and a focal information source for many pharmacologists interested in diseases of the immune system remains unpublished. The Handbook of Immunopharmacology series provides such a source through the commissioning of a comprehensive collection of volumes on all aspects immunopharmacology. Editors have been sought after for each volume who are not only active in their respective areas of expertise, but who also have distinctly pharmacological bias to their research. The series follows three main themes, each represented by volumes on individual component topics. The first covers each of the major cell types and classes of inflammatory responses that can affect them ("Systems"). The third covers different classes of diseases as well as those under development ("Drugs").

  • Analytical Profiles of Drug Substances and Excipients

    • 1st Edition
    • Volume 22
    • English
    Although the official compendia define a drug substance as to identity, purity, strength, and quality, they normally do not provide other physical or chemical data, nor do they list methods of synthesis or pathways of physical or biological degradation and metabolism. Such information is scattered throughout the scientific literature and the files of pharmaceutical laboratories. Analytical Profiles of Drug Substances and Excipients brings this information together into one source. The series has recently been expanded to include profiles of excipient materials.

  • Immunopharmacology of Mast Cells and Basophils

    • 1st Edition
    • English
    There has been a steady and continued research effort directed to understanding both the function and the role of mast cells and basophils ever since these cells were first described at the end of the nineteenth century. One of the most significant advances has perhaps been the appreciation of the fact that mast cells do not represent a single homogenous population of cells: they display heterogeneity at the morphological, biochemical and functional levels. The one characteristic that unites all types of mast cells and basophils appears to be the possession of the high affinity membrane receptor for immunoglobulin E, through which the cells may be stimulated. This volume begins with a review of the origin and development of mast cells and basophils. It continues by reviewing our knowledge of the stimuli to mast cells and basophils and the biochemical mechanisms which link the signal generated by stimulus to the response machinery of the cell. Further chapters deal with the drug control of mast cell and basophil responses, the heterogeneity of the cells' functions and the mediators' release by the cells, along with the morphological aspects of the cells' function. This book is completed by a selection of examples which examine the role of the mast cells or basophils in lung, skin and gastrointestinal tract. However, the role of the mast cell with regard to normal physiology, remains an open question. This book aims to provide an up-to-date account of mast cell and basophil biology, together with an insight into the functional relevance of these cells in some tissue types.

  • Immunopharmacology of the Heart

    • 1st Edition
    • English
    This volume sets out to consider a range of cardiac diseases for which drugs may play a therapeutic role by virtue of their effects on aspects of the immune system. The book reviews diseases of the heart which may involve an immunopharmacologica... component, and methods and techniques for the study of physiological and biochemical functions in the heart. An important focus is the immunopharmacology of the coronary vascular endothelium and the role of cellular and biochemical components of the immune system in the pathogenesis of atherosclerosis. The content also includes a review of the use of immunologically relevant agents in the setting of cardiac transplantation from aclinical perspective. Immunotherapy has a definite role to play in cardiology to a greater or lesser extent than other forms of intervention, depending on the type of cardiac disease. Immunopharmacology of the Heart aims to identify and clarify this role and points to potential developments of the future. Immunopharmacology of the Heart is a volume for the SYSTEMS theme of The Handbook of Pharmacology. In common with all other volumes it contains standardized illustrations and terms/abbreviations (glossaries of illustrations and terms published at the back of the volume). Other topics covered include: Leukocytes and their role in ischaemic heart disease. Complement activation. Sudden cardiac death. The stunned myocardium and reperfusion injury.

  • Progress in Nucleic Acid Research and Molecular Biology

    • 1st Edition
    • Volume 46
    • English

  • Annual Reports in Medicinal Chemistry

    • 1st Edition
    • Volume 28
    • English

  • Progress in Medicinal Chemistry

    • 1st Edition
    • Volume 30
    • English
    In this volume, the medicinal chemistry of the rapidly expanding family of retinoids, of promising semi-synthetic erythromycins and of the multifaceted amidines is reviewed. Another chapter continues the coverage of inorganic elements which have a medical role; recent studies on the various biological roles of manganese are also examined. Inhibition of enkephalin-degrading enzymes is reviewed, as are studies of the digitalis recognition site which are expected to lead to the development of more highly selective inotropic drugs. This work should be of value to medicinal chemists, pharmacists and pharmacologists. It should also be appreciated by all newcomers, as well as those who wish to be kept up to date with recent work on these topics.

  • Progress in Nucleic Acid Research and Molecular Biology

    • 1st Edition
    • Volume 45
    • English

  • Advances in Pharmacology

    • 1st Edition
    • Volume 24
    • English

  • Carotenoids, Part B: Metabolism, Genetics, and Biosynthesis

    • 1st Edition
    • Volume 214
    • John N. Abelson + 1 more
    • English
    The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

  • Progress in Nucleic Acid Research and Molecular Biology

    • 1st Edition
    • Volume 44
    • English

  • Platelets: Receptors, Adhesion, Secretion, Part B

    • 1st Edition
    • Volume 215
    • John N. Abelson + 1 more
    • English
    This volume contains a comprehensive collection of methods for the isolation of platelet membranes, subcellular organelles, the cytoskeleton, and for the assay and purification of platelet receptors.

  • Progress in Nucleic Acid Research and Molecular Biology

    • 1st Edition
    • Volume 43
    • English

  • Carotenoids, Part A, Chemistry, Separation, Quantitation, and Antioxidation

    • 1st Edition
    • Volume 213
    • John N. Abelson + 1 more
    • English
    This volume and its companion, volume 214 of Methods in Enzymology, present a comprehensive, state-of-the-art compilation of the molecular and cellular methodology needed for pursuing research with carotenoids.

  • Annual Reports in Medicinal Chemistry

    • 1st Edition
    • Volume 27
    • English

  • Advances in DNA Sequence-specific Agents

    • 1st Edition
    • Volume 1
    • L.H. Hurley
    • English
    This volume is aimed in general at scientists who have an interest in deciphering the molecular mechanisms for sequence recognition of DNA. The methods have general applicability to small molecules as well as oligomers and proteins, while the examples provide general principles involved in sequence recognition.

  • Progress in Nucleic Acid Research and Molecular Biology

    • 1st Edition
    • Volume 42
    • English

  • International Review of Neurobiology

    • 1st Edition
    • Volume 33
    • English
    Published since 1959, this serial presents in-depth reviews of key topics in neuroscience, from molecules to behavior. The serial stays keenly atuned to recent developments through the contributions of first-class experts in the many fields of neuroscience. Neuroscientists as well as clinicians, psychologists, physiologists and pharmacoloists will find this serial an indispensable addition to their library.

  • Progress in Medicinal Chemistry

    • 1st Edition
    • Volume 29
    • English
    The 29th volume of the series presents yet again, an exemplary survey of a wide range of current topics in medicinal chemistry and pharmacology. Eight expert reviews emphasize the relationships between chemical structure and pharmacological activity. These detailed discussions of some of the most exciting developments in the field today, will prove of great value to future research. The book begins with a study of anti-inflammatory activities of 5-lipoxygenase inhibitors, followed by an overview of the antiarrhythmic therapeutic possibilities offered by Class III electrophysiological agents. Structures and activities of some opioid ligands are surveyed, and the investigation into pharmacologically active pyridazine derivatives is continued. Dopamine D2 receptor agonists offer exciting therapeutic potential, as do ondansetron and related 5-HT 3 antagonists. The herbal origin of many modern drugs is yet again reflected in a survey of the herb feverfew. The volume concludes, as it began, with enzyme inhibition - in this case concerning synthetic inhibitors of interstitial collagenases.

  • Advances in Pharmacology

    • 1st Edition
    • Volume 23
    • English

  • Analytical Profiles of Drug Substances and Excipients

    • 1st Edition
    • Volume 20
    • English
    Although the official compendia define a drug substance as to identity, purity, strength, and quality, they normally do not provide other physical or chemical data, nor do they list methods of synthesis or pathways of physical or biological degradation and metabolism. Such information is scattered throughout the scientific literature and the files of pharmaceutical laboratories. Analytical Profiles of Drug Substances brings this information together into one source.

  • Advances in Pharmacology

    • 1st Edition
    • Volume 22
    • English

  • Cytochrome P450

    Protein-Dna Interactions
    • 1st Edition
    • Volume 206
    • John N. Abelson + 1 more
    • English
    This volume represents the first collection of methodological approaches to P450 investigation which includes the use of molecular biological techniques. It is designed for use by those who study the P450 super family. Methods are presented for the identification and characterization of unique forms of P450 mRNA and protein, for expression of P450s in heterologous systems, for the study of human P450s, and for the characterization of P450s in different tissues.

  • Drug Resistance As a Biochemical Target in Cancer Chemotherapy

    • 1st Edition
    • Makoto Ogawa
    • English
    Drug Resistance as a Biochemical Target in Cancer Chemotherapy covers the proceedings of the 13th Bristol-Myers Squibb Symposium on Cancer Research, entitled ""Drug Resistance as a Biochemical Target in Cancer Chemotherapy"", hosted by the Japanese Foundation for Cancer Research in Tokyo. This book is divided into four parts encompassing 18 chapters that summarize the results of both preclinical and clinical research on circumvention of drug resistance. The first two parts discuss the genetic aspects of multidrug resistance and the proteins involved in drug resistance. These parts also examine the structure, function, and expression of P-glycoproteins, with an emphasis on the role of these proteins as targets for cancer chemotherapy. The third part describes the methods for detection of P-glycoprotein and its antagonists to counter clinical drug resistance. This topic is followed by a discussion on the interactions among steroid hormones, steroid hormone receptors, antiandrogens, biological-response modifiers, and cytotoxic drugs in human breast cancer. The concluding part explores the clinical applications of chemosensitizers in cancer therapy. This part also considers the alternative clinical approaches against drug failure, including non-crosss-resistant therapies, autologous bone marrow transplantation, dose-intensive therapy, and high-dose chemotherapy. Biomedical scientists and researchers and clinicians will find this book invaluable.

  • Annual Reports in Medicinal Chemistry

    • 1st Edition
    • Volume 26
    • English

  • Progress in Nucleic Acid Research and Molecular Biology

    • 1st Edition
    • Volume 41
    • English

  • Progress in Nucleic Acid Research and Molecular Biology

    • 1st Edition
    • Volume 40
    • English

  • Progress in Medicinal Chemistry

    • 1st Edition
    • Volume 28
    • English
    The six reviews in this volume cover once again a most comprehensive range of topics. The anti-malarial activity of the 8-aminoquinolines is examined, with an eye to the development of a single, broad-spectrum drug. Chelation, important in removal of toxic metals from the body, is reviewed for tripositive elements. A new and promising approach to total parenteral nutrition is described. Our indebtedness to the plant origins of many modern drugs is noted in the context of new chemicals. Heterosteroids and receptor-specific opioid peptides constitute two further topics, each case highlighting the wide range of relevant biologically active compounds. Yet another volume challenging the staggering diversity of the field of medicinal chemistry.

  • Progress in Nucleic Acid Research and Molecular Biology

    • 1st Edition
    • Volume 39
    • English

  • Annual Reports in Medicinal Chemistry

    • 1st Edition
    • Volume 25
    • English

  • Advances in Pharmacology

    • 1st Edition
    • Volume 21
    • English

  • Progress in Nucleic Acid Research and Molecular Biology

    • 1st Edition
    • Volume 38
    • English

  • Progress in Medicinal Chemistry

    • 1st Edition
    • Volume 27
    • English
    There are five main subject areas in this volume in the series on medicinal chemistry. The first is a review of the understanding of Alzheimer's disease and the development of drugs for its treatment; the second, looking at recent efforts in modifying a naturally occuring anticancer (campothecin) for chemotherapy; the third covers the problem of getting a drug to a specific site within the context of phosphates and phosphonates; a survey of sterilization using aldehydes for the destruction of microbes both inside and outside the human body is reviewed in the fourth; and the last chapter is an account of the progress made in the biologically active enantiomer for complex synthetic asymmetric drug molecules.

  • Progress in Nucleic Acid Research and Molecular Biology

    • 1st Edition
    • Volume 37
    • English

  • Annual Reports in Medicinal Chemistry

    • 1st Edition
    • Volume 24
    • English

  • Progress in Nucleic Acid Research and Molecular Biology

    • 1st Edition
    • Volume 36
    • English

  • Annual Reports in Medicinal Chemistry

    • 1st Edition
    • Volume 23
    • English

  • Progress in Nucleic Acid Research and Molecular Biology

    • 1st Edition
    • Volume 35
    • English

  • Progress in Medicinal Chemistry

    • 1st Edition
    • Volume 25
    • English
    There are five main subject areas in this volume in the series on medicinal chemistry. The first is a review of the understanding of Alzheimer's disease and the development of drugs for its treatment; the second, looking at recent efforts in modifying a naturally occuring anticancer (campothecin) for chemotherapy; the third covers the problem of getting a drug to a specific site within the context of phosphates and phosphonates; a survey of sterilization using aldehydes for the destruction of microbes both inside and outside the human body is reviewed in the fourth; and the last chapter is an account of the progress made in the biologically active enantiomer for complex synthetic asymmetric drug molecules.

  • Progress in Nucleic Acid Research and Molecular Biology

    • 1st Edition
    • Volume 34
    • English

  • Vitamins and Coenzymes, Part G

    • 1st Edition
    • Volume 122
    • Nathan P. Colowick + 1 more
    • English
    The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all fields of life sciences.

  • Peptide Growth Factors, Part A

    • 1st Edition
    • Volume 146
    • Nathan P. Colowick + 1 more
    • English
    The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all fields of life sciences.

  • Peptide Growth Factors, Part B

    • 1st Edition
    • Volume 147
    • Nathan P. Colowick + 1 more
    • English
    The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all fields of life sciences.

  • Annual Reports in Medicinal Chemistry

    • 1st Edition
    • Volume 22
    • English

  • Progress in Nucleic Acid Research and Molecular Biology

    • 1st Edition
    • Volume 33
    • English

  • Annual Reports in Medicinal Chemistry

    • 1st Edition
    • Volume 21
    • English

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