Green Approaches in Medicinal Chemistry for Sustainable Drug Design: Methods, Second Edition reveals how medicinal chemistry can play a direct role in addressing this issue. After providing essential context on the growth of green chemistry in relation to drug discovery, the book identifies a range of practical techniques and useful insights, revealing how medicinal chemistry techniques can be used to improve efficiency, mitigate failure, and increase the environmental benignity of the entire drug discovery process. Drawing on the knowledge of a global experts, the book encourages the growth of green medicinal chemistry, and supports medicinal chemists, drug discovery researchers, pharmacologists, and more.This volume covers synthesis methods following green chemistry principles, contributing to sustainability by saving energy, using lesser toxic reagents/solvents/catalysts and environmentally benign sources, including plants and agricultural materials.
Applications of Green Nanomaterials in Analytical Chemistry, Volume 105 in the Comprehensive Analytical Chemistry series, highlights new advances in the field, with this new volume presenting interesting chapters, including Introduction (Modern Perspective of analysis with Green NMs), Green Nanomaterials based Sample Preparation techniques, Molecularly imprinting polymer nanomaterials-based sensing/detection and separation/removal of estrogenic compounds from environmental samples, Green Nanomaterials in Extraction Techniques, Green Nanomaterials in Sample Pre-treatment Processes, Lab on Chip with Green Nanomaterials, and much more.Other chapters cover Emerging green carbon dots: Opto-electronic and Morpho-structural properties for sensing applications, Green Nanomaterials based Nanosensors, Green Nanomaterials in Electroanalytical Chemistry, BioSensors with Green Nanomaterials, Green synthesis of metal based nanomaterials and their sensing application, Analytical Sensing with Green Nanomaterials, Lateral flow assay with green nanomaterials, Green nanomaterials for sorbent-based extraction techniques in food analysis, Green Nanomaterials for Chromatographic Techniques, Membranes with Green Nanomaterials, Conclusion: Future of Analytical Chemistry
The Alkaloids: Chemistry and Biology, Volume 91, the newest release in a series that has covered the topic for more than 60 years, discusses key aspects of alkaloid chemistry, biology and pharmacology. Sections in this release include chapters on Recent Progress in the Chemistry of Naphthylisoquinoline Alkaloids.
Chemical Theory and Multiscale Simulation in Biomolecules: From Principles to Case Studies helps readers understand what simulation is, what information modeling of biomolecules can provide, and how to compare this information with experiments. Beginning with an introduction to computational theory for modeling, the book goes on to describe how to control the conditions of modeling systems and possible strategies for time-cost savings in computation. Part Two further outlines key methods, with step-by-step guidance supporting readers in studying and practicing simulation processes. Part Three then shows how these theories are controlled and applied in practice, through examples and case studies on varied applications. This book is a practical guide for new learners, supporting them in learning and applying molecular modeling in practice, whilst also providing more experienced readers with the knowledge needed to gain a deep understanding of the theoretical background behind key methods.
Recent Advances in Organometallic Chemistry: Synthetic, Mechanistic and Medicinal Perspective highlights recent advancements in the field of organometallic chemistry. Containing essential information for researchers and advanced-level students, especially those working in chemical synthesis, the book describes the role of organometallic compounds in different combinations in organic synthesis and pharmaceuticals as well as discussing spectral, magnetic and sensing features of the compounds. Including the role of computational investigations towards the mechanistic study of biomimic complexes in catalytic transformation reactions, the book provides a large number of examples along with their leading applications in other fields.Each chapter covers basic strategies, which are illustrated along with examples of the latest advancements in the field and in-depth explanations.
Sustainable Quality Improvements for Isotope Dilution in Molecular Ultratrace Analyses: Fitness for Purpose, Performance-Based Criteria, and Measurement Uncertainty uses a novel Sustainable Quality Improvement (SQI) framework with the aim of helping to re-introduce much needed flexibility and restore accountability and integrity necessary for developing confidence in products obtained with these specialty assays. The book can also be used as a comprehensive reference text for data and information on matrix-specific target analytes detection/quantitation limits, and measurement of uncertainties for planning purposes, congeners profiles, multi-phasic, multi-component and multi-analyte samples processing flow charts, and useful definitions of the underlying technology-relevant terminologies.The SQI framework around which the book is constructed paves the way for the innovative technological solutions described in the book and is powered by three key elements: Fitness for Purpose, Performance-Based Measurement System, and Measurement Uncertainty. Together, they facilitate the development and validation of advanced methodologies to resolve many of the contemporary issues associated with continuously evolving and demanding regulatory requirements. A stronger focus on effective performance feedback is demonstrated to help laboratories rethink their own approach to quality improvements.
Chuanyi Wang, Abdellkader Labidi and Eric Lichtfouse
March 15, 2024
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Organic Radicals summarizes the applications of these materials in several fields, in addition to analyzing challenges, limitations and impacts of materials containing organic radicals on human, plants, water, soil, and animals. Sections cover uses of organic radicals as effective precursors for block molecules building and discuss their effectiveness as precursors of organic radical- containing materials synthesis and their applications in medicine, biology, electronics, environmental sciences, plastics synthesis, polymers building and the several impacts after organic radicals uses. In recent years, the rapid development of organic radical-containing materials has afforded an interesting research area in various applications.
Computational Phytochemistry, Second Edition, explores how recent advances in computational techniques and methods have been embraced by phytochemical researchers to enhance many of their operations, refocusing and expanding the possibilities of phytochemical studies. By applying computational aids and mathematical models to extraction, isolation, structure determination, and bioactivity testing, researchers can obtain highly detailed information about phytochemicals and optimize working approaches.This book aims to support and encourage researchers currently working with or looking to incorporate computational methods into their phytochemical work. Topics in this book include computational methods for predicting medicinal properties, optimizing extraction, isolating plant secondary metabolites, and building dereplicated phytochemical libraries. The roles of high-throughput screening, spectral data for structural prediction, plant metabolomics, and biosynthesis are all reviewed before the application of computational aids for assessing bioactivities and virtual screening is discussed. Illustrated with detailed figures and supported by practical examples, this book is an indispensable guide for all those involved with the identification, extraction, and application of active agents from natural products.This new edition captures remarkable advancements in mathematical modeling and computational methods that have been incorporated in phytochemical research, addressing, e.g., extraction, isolation, structure determination, and bioactivity testing of phytochemicals.
Glycosphingolipids in the Central Nervous System: Diversity in Structure, Metabolism, Distribution, and Function comprehensively covers progress made in the discovery, profiling and understanding of the metabolism, function and functional mechanism of GSLs in the CNS –as well as their synthesis, relationships with and therapeutic applications to neurodegenerative disorders, and related CNS diseases. Due to the important roles of GSLs in the CNS and various CNS-related diseases, the interest in these biomolecules is growing. GSLs are the principal glycolipids on the cell surface and an essential constituent of the cell membrane. They are widespread, but especially enriched in the central nervous system (CNS) in vertebrates. The diversity of GSL structures forges the molecular foundation for their broad spectrum of activity.
Jai Singh, Ajaya Kumar Singh, Bhawana Jain + 1 more
March 1, 2024
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Metal Organic Frameworks: Fundamentals to Advanced offers a substantial and complete treatment of published results. The book includes a summary of current research, along with an in- depth explanation of Metal organic frameworks (MOFs) and applications in this versatile area. Metal organic frameworks (MOFs) are structured frameworks made up of metal ions and organic molecules. These materials are similar to sponges and can absorb, retain and remove molecules from their pores. As a result, metal-organic frameworks (MOFs) are the most rapidly evolving substances in chemistry with the highest surface areas due to their well-ordered pore structure.The exciting and vast surface area allows for more chemical reactions and molecule adsorption, hence this new resource provides the newest updates on the topics covered.