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Books in Chemistry

Chemistry topic areas include: physical and theoretical, computational, organic, organometallic and inorganic, pharmaceutical and medicinal, analytical and bioanalytical, nuclear, general, nanochemistry, geochemistry, materials and polymer, as well as environmental, green and sustainable chemistry.

BooksJournals

    • Pharmaceutical and Biomedical Applications of Capillary Electrophoresis

      • 1st Edition
      • Volume 2
      • August 13, 1996
      • S.M. Lunte + 1 more
      • English
      • Paperback
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      The book describes the theory and applications of Capillary Electrophoresis (CE) in the field of pharmaceutical and biomedical analysis. It is targeted towards users who are intimately involved in analytical problems, especially those which involve small samples. This book presents the technique of capillary electrophoresis from the point of view of the serious hands-on use in the field of pharmaceutical and biomedical analysis. An overview of general theory is presented to acquaint the novice with the fundamental principles. A more theoretical approach is taken in the presentation of electrokinetic chromatography. The next chapter discusses advances in column technologies, the preceding chapters having provided a foundation as to how separations occur. In the next three chapters, recognized experts in their fields present fundamentals and state-of-the-art techniques in the areas of optical, electrochemical and mass spectrometric detection. The major focus of the remaining chapters is on applications. This includes the analysis of pharmaceuticals, amino acids and peptides, macromolecules, nucleosides, nucleotides and oligonucleotides. The use of CE for analysis of small ions and separation of biological particles is also discussed. The issue of sample preparation for analysis by CE is addressed, especially as it relates to clinical analysis.

    • Indoles

      • 1st Edition
      • May 28, 1996
      • Richard J. Sundberg
      • English
      • Hardback
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      • Paperback
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      Indoles continue to be of great interest to the pharmaceutical industry and at the current time several thousand specific new derivatives are reported annually. Research has been driven by the wide range of indole derivatives which occur in nature and through the biological activity of many indole derivatives, of both natural and synthetic origin.This book provides a systematic guide to the most useful and important reactions in the field for both synthesis and synthetic modification of the indole ring. While including the most recently developed and promising methods, it also updates informationavailable on classical methods to give the reader an up-to-date and comprehensive view of the subject. The methods are illustrated by procedures drawn from the literature and by tables including examples chosen to indicate both the scope of applicabilityand variations in methodology. The organization of the book is based on the retrosynthetic concept of identifying the bond(s) formed in the reaction, which in turn identifies potential starting materials.

    • Principles of Asymmetric Synthesis

      • 1st Edition
      • Volume 14
      • November 21, 1996
      • R.E. Gawley + 1 more
      • English
      • Paperback
        9 7 8 0 0 8 0 4 1 8 7 5 9
      • Hardback
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      The world is chiral. Most of the molecules in it are chiral, and asymmetric synthesis is an important means by which enantiopure chiral molecules may be obtained for study and sale. Using examples from the literature of asymmetric synthesis (more than 1300 references), the aim of this book is to present a detailed analysis of the factors that govern stereoselectivity in organic reactions. It is important to note that the references were each individually checked by the authors to verify relevance to the topics under discussion. The study of stereoselectivity has evolved from issues of diastereoselectivity... through auxiliary-based methods for the synthesis of enantiomerically pure compounds (diastereoselectivit... followed by separation and auxiliary cleavage), to asymmetric catalysis. In the latter instance, enantiomers (not diastereomers) are the products, and highly selective reactions and modern purification techniques allow preparation - in a single step - of chiral substances in 99% ee for many reaction types. After an explanation of the basic physical-organic principles of stereoselectivity, the authors provide a detailed, annotated glossary of stereochemical terms. A chapter on "Analytical Methods" provides a critical overview of the most common methods for analysis of stereoisomers. The authors then follow the 'tried-and-true' format of grouping the material by reaction type. Thus, there are four chapters on carbon-carbon bond forming reactions (enolate alkylations, organometal additions to carbonyls, aldol and Michael reactions, and cycloadditions and rearrangements), one chapter on reductions and hydroborations (carbon-hydrogen bond forming reactions), and one on oxidations (carbon-oxygen and carbon-nitrogen bond forming reactions). Leading references are provided to natural product synthesis that have been accomplished using a given reaction as a key step. In addition to tables of examples that show high selectivity, a transition state analysis is presented to explain - to the current level of understanding - the stereoselectivity of each reaction. In one case (Cram's rule) the evolution of the current theory is detailed from its first tentative (1952) postulate to the current Felkin-Anh-Heathcock formalism. For other reactions, only the currently accepted rationale is presented. Examination of these rationales also exposes the weaknesses of current theories, in that they cannot always explain the experimental observations. These shortcomings provide a challenge for future mechanistic investigations.

    • Mass Spectrometry for Biotechnology

      • 1st Edition
      • February 1, 1996
      • Gary Siuzdak
      • English
      • Paperback
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      If you investigate biological systems and might use mass spectrometry in your research but need to know more about it, this book is for you. It introduces the fundamental concepts of mass spectrometry and how mass spectrometers work. It also presents recent advancements particularly interesting to bio-researchers in an easy-to-understand manner that does not require extensive background in chemistry, math, or physics.

    • Fundamentals of Inorganic Membrane Science and Technology

      • 1st Edition
      • Volume 4
      • November 19, 1996
      • A.J. Burggraaf + 1 more
      • English
      • Hardback
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      Inorganic membrane science and technology is a new field of membrane separation technology which until recently was dominated by the earlier field of polymer membranes. Currently the subject is undergoing rapid development and innovation.The present book describes the fundamental principles of both synthesis of inorganic membranes and membrane supports and also the associated phenomena of transport and separation in a semi-quantitative form.Features of this book:- Examples are given which illustrate the state-of-the-art in the synthesis of membranes with controlled properties- Future possibilities and limitations are discussed- The reader is provided with references to more extended treatments in the literature- Potential areas for future innovation are indicated.By combining aspects of both the science and technology of inorganic membranes this book serves as a useful source of information for scientists and engineers working in this field. It also provides some observations of important investigators who have contributed to the development of this subject.

    • Organic Chemistry in Action

      • 2nd Edition
      • Volume 51
      • May 9, 1996
      • F. Serratosa + 1 more
      • English
      • eBook
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      The first edition of this book was welcomed with great enthusiasm by teachers and students. It therefore seemed opportune to publish a second, revised, updated and extended edition. Unfortunately, Professor Fèlix Serratosa died before he could complete this task. Some new material has been added, the more significant changes being:. The book has been restructured into two well-differentiated sections: Part A, dealing with conventional organic synthesis, and Part B, devoted exclusively to computer-assisted organic synthesis and based on the former Chapter 11 and Appendices 2, 3 and 4 of the first edition. As decided in advance, Part B was to be the sole responsibility of Dr. Josep Xicart, who prepared the first versions of the CHAOS (Computerisation and Heuristics Applied to Organic Synthesis) program under the direction of Professor Serratosa.

    • Molecular Electrostatic Potentials

      • 1st Edition
      • Volume 3
      • November 22, 1996
      • J.S. Murray + 1 more
      • English
      • Paperback
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      • Hardback
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      Over the past 25 years, the molecular electrostatic potential has become firmly established as an effective guide to molecular interactions. With the recent advances in computational technology, it is currently being applied to a variety of important chemical and biological systems. Its range of applicability has expanded from primarily a focus on sites for electrophilic and nucleophilic attack to now include solvent effects, studies of zeolite, molecular cluster and crystal behavior, and the correlation and prediction of a wide range of macroscopic properties. Moreover, the increasing prominence of density functional theory has raised the molecular electrostatic potential to a new stature on a more fundamental conceptual level. It is rigorously defined in terms of the electron density, and has very interesting topological characteristics since it explicitly reflects opposing contributions from the nuclei and the electrons.This volume opens with a survey chapter by one of the original pioneers of the use of the electrostatic potential in studies of chemical reactivity, Jacopo Tomasi. Though the flow of the succeeding chapters is not stringently defined, the overall trend is that the emphasis changes gradually from methodology to applications. Chapters discussing more theoretical topics are placed near the end. Readers will find the wide variety of topics provided by an international group of authors both convincing and useful.

    • Progress in Heterocyclic Chemistry

      • 1st Edition
      • Volume 8
      • August 23, 1996
      • H. Suschitzky
      • English
      • Paperback
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      Progress in Heterocyclic Chemistry (PHC) is an annual review series commissioned by the International Society of Heterocyclic Chemistry (ISHC). The volumes in the series contain both highlights of the previous year's literature on heterocyclic chemistry and articles on new developing topics of interest to heterocyclic chemists. The highlight chapters in Volume 8 are all written by leading researchers in their field and these chapters constitute a systematic survey of the important original material reported in the literature on heterocyclic chemistry in 1995. The volume also contains an article on Geminal Diazides of Heterocycles and an article on Radical Methodologies for the synthesis of heterocyclic compounds.As with previous volumes in the series, Volume 8 will enable academic and industrial chemists, and advanced students to keep abreast of developments in heterocyclic chemistry in an effortless way.

    • Hypervalent Iodine in Organic Synthesis

      • 1st Edition
      • November 14, 1996
      • A. Varvoglis
      • English
      • Hardback
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      • Paperback
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      This book describes the fascinating chemistry of the many kinds of organic compounds of hypervalent iodine. Each chapter deals with a particular iodine compound or families of compounds which have been used as reagents in a plethora of useful transformations. These include assorted oxidation, such as with the precious Dess-Martin reagent as well as with a wide range of further reactions. Prominent features of hypervalent iodine reagents derived from iodobenzene are: ready availability, operational simplicity, mild reaction conditions, and high efficiency. They are environmentally safe and can be recycled. New species may be easily prepared by introducing substituents in the benzene ring or changing the ligand attached to iodine. Their combination with other reagents broadens considerably their synthetic potential. Today, no synthetic chemist can afford to ignore the valuable hypervalentiodine reagents.

    • Data Analysis for Hyphenated Techniques

      • 1st Edition
      • Volume 17
      • March 14, 1996
      • E.J. Karjalainen + 1 more
      • English
      • Paperback
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      Based on a concrete set of working MATLAB programs, the book begins with a short program of snippets describing basic principles and proceeds to a complete application program filling a central analytical need: obtaining pure spectra from the observed overlapping spectra, with standard deviations for thesolutions obtained.The strength of the book is the open nature of the programs. All programs can be read, tested and modified by the user. The mathematical principles needed for the proper treatment of experimental data are thoroughly described. The first part of the book describes how data iscollected, converted and prepared for the actual deconvolution. Practical working algorithms such as the Savitzky-Golay smoothing method are emphasized. The reader can see how searches in spectral libraries can be greatly speeded up by proper formulation of the calculation. Basic signal processing is described by illustrative examples.The main part of the book describes the deconvolution of overlapping chromatographic peaks. Principle component analysis is described and used as a useful tool. The main emphasis is a discussion of a deconvolution method, OSCAR (Optimization by Stepwise Constraining of Alternating Regression), developed by the authors. The results can be validated as OSCAR calculates confidence intervals for the spectra and elution curves.For users who do not want to enter the programs by hand a separate CD-ROM is available. It contains the programs and extensive sample data files. The CD-ROM has instructional multimedia showing step by step how the programs are used for the problems in the book. The MATLAB programs and datafiles can be directly run on Windows® and Macintosh® computers having a MATLAB interpreter.

Related subjects

Analytical chemistry

Chemistry general

Inorganic chemistry

Organic chemistry

Physical and theoretical chemistry

Spectroscopy