Books in Medicinal chemistry

Progress in Medicinal Chemistry

1st Edition
Volume 43
April 16, 2005
F.D. King + 1 more
English
Hardback
9 7 8 0 4 4 4 5 1 5 7 2 8

The Progress in Medicinal Chemistry series spans a wide range of topics of interest to the drug discovery community. This particular volume touches upon the following:* The Herg ion channel * Fluorescence-based high throughput assay * Aprepitant and neurokinin receptors * Muscarinic receptor targets * Gene activation pathways * Malaria and antimalarial drugs * HIV virus mutation and new therapeuticsProgress in Medicinal Chemistry is available online on ScienceDirect — full-text online of volumes 41 onwards. Elsevier book series on ScienceDirect gives multiple users throughout an institution simultaneous online access to an important compliment to primary research. Digital delivery ensures users reliable, 24-hour access to the latest peer-reviewed content. The Elsevier book series are compiled and written by the most highly regarded authors in their fields and are selected from across the globe using Elsevier’s extensive researcher network. For more information about the Elsevier Book Series on ScienceDirect Program, please visit:http://www.inf...

Annual Reports in Medicinal Chemistry

1st Edition
Volume 39
December 15, 2004
Annette M. Doherty
English
eBook
9 7 8 0 0 8 0 4 7 1 9 7 6

Annual Reports in Medicinal Chemistry continues to focus on providing timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies. Sections I-IV are disease orientated and generally report on specific medicinal agents. Sections V and VI continue to emphasize important topics in medicinal chemistry, biology, and drug design.

The Role of Chemistry in the Evolution of Molecular Medicine

1st Edition
April 16, 2004
Imre Csizmadia + 2 more
English
Hardback
9 7 8 0 4 4 4 5 1 5 8 8 9

This volume entitled 'The Role of Chemistry in the Evolution of Molecular Medicine' contains a collection of papers that form the proceedings of the Symposium held at the University of Szeged (27-29 June 2003). As well as covering developments in the field over the last 60 years, the proceedings of this Symposium has laid the foundations for the future of the field of molecular medicine. Contributors span a wide range of molecular science disciplines including mathematics, physics, computer science, chemistry, biochemistry, biology and medicine, and cover the whole territory in agreement with the legacy of Professor Albert Szent-Györgyi. This volume was particularly inspired by the booklet published in 1960 by Albert Szent-Györgyi under the title 'Introduction to submolecular biology', and the contents of this booklet have been included here in its entirety as an Appendix.

The Practice of Medicinal Chemistry

2nd Edition
June 11, 2003
Camille Georges Wermuth
English
eBook
9 7 8 0 0 8 0 4 9 7 7 7 8

The Practice of Medicinal Chemistry, 2E, is a single-volume source on the practical aspects of medicinal chemistry. The successful first edition was nicknamed "The Bible" by medicinal chemists, and the second edition has been updated, expanded and refocused to reflect developments over the last decade. Emphasis is put on how medicinal chemists conduct their search for and design of new drug entities. In contrast to competing books, it focuses on the chemistry rather than pharmacological concepts or descriptions of the various therapeutic classes of drugs. Most medicinal chemists working in the pharmaceutical industry are organic synthetic chemists who must acquire a strong knowledge of medicinal chemistry as they enter the industry. This book aims to be their practical handbook - a complete guide to the drug discovery process.

Advances in Clinical Chemistry

1st Edition
Volume 37
February 12, 2003
Herbert E. Spiegel
English
eBook
9 7 8 0 0 8 0 4 9 0 2 6 7

This volume, edited for the last time by H.E. Spiegel, continues the objective of expanding the intellectual horizon of clinical chemistry. The fields of analytical, anatomical, sub-cellular and molecular sciences are all represented in this volume.

Macrolide Antibiotics

2nd Edition
June 10, 2002
Satoshi Omura
English
Hardback
9 7 8 0 1 2 5 2 6 4 5 1 8
eBook
9 7 8 0 0 8 0 5 3 5 6 8 5

Macrolide Antibiotics: Chemistry, Biochemistry, and Practice, Second Edition explores the discovery of new macrolide antibiotics, their function, and their clinical use in diseases such as cancer, AIDS, cystic fibrosis and pneumonia. This book discusses the creation of synthetic macrolides and the mechanisms of antibiotic activity. The uses for antimicrobial macrolides in clinical practice are also covered. This book is designed to appeal to both the basic and applied research communities interested in microbiology, bacteriology, and antibiotic/antifunga... research and treament.

Advances in Clinical Chemistry

1st Edition
Volume 36
October 9, 2001
Herbert E. Spiegel + 2 more
English
eBook
9 7 8 0 0 8 0 4 9 0 2 5 0

For more than thirty years, this serial has broadened the technical scope and expanded the scientific base of clinical chemistry. These volumes clarify the areas of molecular biology and informatics and the monitoring of physiological parameters in critical situations as they pertain to clinical chemistry. Each volume of Advances in Clinical Chemistry contains an index, and each chapter includes references.

Sun Protection in Man

1st Edition
Volume 3
July 31, 2001
P.U. Giacomoni
English
Hardback
9 7 8 0 4 4 4 5 0 8 3 9 3
eBook
9 7 8 0 0 8 0 5 1 8 1 6 9

"Sun Protection in Man" looks at the beneficial and harmful effects of solar radiation. The physiological consequences of sun exposure have been systematically studied starting at the end of the nineteenth century and we now have accumulated knowledge about how Caucasian and Asian skins reacts to solar radiation. The chemical effects of solar ultraviolet radiation have been analyzed with particular emphasis during the second half of the twentieth century. Research on micro-organisms has allowed us to understand the mechanisms of UV-induced mutagenesis and photosensitization. Studies with laboratory rodents have opened the path to the understanding of UV-induced immune-depression, carcinogenesis, photo-damage and photo-aging. The results of these studies have enabled other scientists to investigate the same phenomena in human organs such as the skin and the eye. UV radiation damages hair, as well. The present knowledge in these fields is summarized in some of the chapters of this monograph.Mass phenomenon in Europe with the generalization of summer vacations which were a consequence of social reforms introducing the concept of "paid vacations". This created a need for protection and opened a market for sunscreens. This monograph is concerned with sun protection as a whole and is not just "another book on sunscreens". Nonetheless, in these days of general concern, it is important to learn about the efficiency of sunscreens. Several authors discuss how to reduce the number of impinging photons and explain why sunscreens seem to offer less protection than expected. Guidelines are given on how to use sunscreens in everyday life, which are expressed rigorously though clearly, for access to the common reader.Our knowledge on the relationship between sun and humans is at the early stages of development. Industrial and commercial activities are concerned by the development of this knowledge, and rules have been and will be promulgated to guarantee efficacy and safety of sun-products. It is hoped that this monograph will be of interest to the scholar, the layman and the legislator.

Aluminium and Alzheimer's Disease

1st Edition
July 3, 2001
C. Exley
English
eBook
9 7 8 0 0 8 0 5 2 5 5 0 1

The subject of aluminium and Alzheimer's disease has been plagued with controversy. This controversy has served to obscure much of the scientific research in this field, and subsequently has obscured the possibility that aluminium is a contributory factor in the aetiology of Alzheimer's disease. This book brings together many of the world's leading scientists researching aluminium and life and contains their critical summaries on the known facts about aluminium toxicity in man and to offer an opinion on the implications of this knowledge on a link between aluminium and Alzheimer's disease. The subject areas of the chapters were chosen to reflect the myriad of ways that aluminium is known to impact upon mammalian physiology and function and range from clinical studies, through animal models of disease to the detailed biochemistry of aluminium toxicity. Chapters are also included on epidemiology and other factors involved in the aetiology of Alzheimer's.This is the first time that this subject has been treated in such a comprehensive manner. The research detailed in each chapter, includes the latest research in the field, it has been critically appraised and this appraisal has been used by each author to present an informed opinion of its relevance to aluminium and Alzheimer's disease. The chapters are much more than reviews; they are a statement of the state of the art and of what the future may hold for research in this field. As a whole they show the high quality of research that has been carried out in our efforts to understand the toxicity of aluminium in man and that we are far away from discounting the possibility that aluminium is a contributory factor in the aetiology of Alzheimer's disease.

Advances in Medicinal Chemistry

1st Edition
Volume 5
December 27, 1999
A.B. Reitz + 1 more
English
Hardback
9 7 8 0 7 6 2 3 0 5 9 3 3
eBook
9 7 8 0 0 8 0 5 2 6 7 7 5

Volume 5 of Advances in Medicinal Chemistry contains four intriguing and detailed accounts of the close interface between synthetic chemistry, structure-activity relationships, biochemistry, and pharmacology. In Chapter 1, there is a comprehensive survey of the immunophilin area specifically focussing on neuroregenerative applications in the central nervous system. In Chapter 2, there is an overview of the development of a potent analgesic compound that works via modulation of neuronal nicotinic acetylcholine receptors. In Chapter 3, there is a description of dopamine D-2 autoreceptor partial agonists as potential therapy for the treatment of schizophrenia. In Chapter 4, there is a summary of the successful program in which potent non-peptide inhibitors of HIV protease from the AIDS virus were developed.

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Physical Sciences & Engineering

Social Sciences & Humanities

Health

Books in Medicinal chemistry

Progress in Medicinal Chemistry

Annual Reports in Medicinal Chemistry

The Role of Chemistry in the Evolution of Molecular Medicine

The Practice of Medicinal Chemistry

Advances in Clinical Chemistry

Macrolide Antibiotics

Advances in Clinical Chemistry

Sun Protection in Man

Aluminium and Alzheimer's Disease

Advances in Medicinal Chemistry