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Elsevier

Books in Analytical separations

  • Fluorescence Spectroscopy in Analytical Chemistry

    A Practical Approach
    • 1st Edition
    • Suresh Kumar Kailasa + 2 more
    • English
    Fluorescence Spectroscopy in Analytical Chemistry: A Practical Approach provides a comprehensive overview of the fundamental, theoretical aspects and advanced applications of fluorescence spectroscopy in analytical chemistry. The book provides basic knowledge and recent advances, enabling new users to effectively apply techniques. Readers will gain significant insights into recent developments of organic and inorganic fluorophores and their potential applications in fluorescence spectroscopy for quantitative analysis of various molecules. Sections explore the challenges and potential applications, with an emphasis on understanding the theory, detection mechanisms, and new fluorophores for molecular recognition.The book is a valuable resource, practical guide, and roadmap to fluorescence spectroscopy for all chemists, analytical scientists, academics, and researchers investigating organic and inorganic fluorophore-based sensor technology for molecular and ionic species sensing. It is also an important reference for researchers, bioanalytical chemists, and technologists working on fluorescence spectroscopy.

  • Supercritical Fluid Chromatography and Extraction

    • 2nd Edition
    • Caroline West + 1 more
    • English
    Supercritical fluid chromatography (SFC) is a rapidly developing laboratory technique for the separation and identification of compounds in mixtures. Recent, significant improvements in instrumentation have rekindled interest in SFC and have enhanced its standing in the scientific community. Many scientists are familiar with column liquid chromatography and its potential beyond traditional liquid chromatography, yet many of its capabilities remain underappreciated. Supercritical Fluid Chromatography and Extraction explores contemporary supercritical fluid chromatography and extraction and how it should be implemented in laboratory science for analysis, isolation, and production.New to This EditionThis new edition details recent advances and applications of supercritical fluids in sample prep, instrumental analysis, and process-scale, including SFE, making it a comprehensive resource for both techniques. Further enhancements to this edition include:Expanded section on SFC theory to include gradient elutionA new chapter on general detectors for SFCEnhanced method development coverage, with focus on gradient elution practicesIncludes multidimensional SFC, SFC × SFC, and LC-SFCFeatures comprehensive information on accelerated solvents, comparing solvent and extraction techniques.Highlight... environmental monitoring and analysis applications of SFE.Widely used in the food industry for decades, SFE is now expanding into new fields. Supercritical Fluid Chromatography and Extraction, Second Edition serves as a valuable resource for chemical engineers, chemists, researchers, students, and academics working with supercritical fluids at preparative and process scales. It’s also an ideal introduction for newcomers to SFC and SFE.

  • Comprehensive Sampling and Sample Preparation

    • 2nd Edition
    • Mustafa Soylak
    • English
    Comprehensive Sampling and Sample Preparation, Second Edition, Four Volume Set is a complete treatment of the theory and methodology of sampling in all physical phases and the theory of sample preparation for all major extraction techniques. In its four volumes, fundamentals of sampling and sample preparation are reinforced through broad and detailed sections dealing with Biological and Medical, Environmental and Forensic, and Food and Beverage applications. Emerging areas in the field are discussed in-depth and contributions are organized to reflect the way in which analytical chemists approach a problem.The latest edition includes updated chapters along with new chapters on exciting topics including micro- and nano extractions, green solvents, nanomaterials, nanocomposites in extraction studies, and solid-phase extractions. This work will appeal to a broad audience of analytical chemists. It will also assist educators and practitioners in the preparation of courses and to spark students’ interest in sampling and sample preparation.

  • Essentials in Modern HPLC Separations

    • 2nd Edition
    • Serban C. Moldoveanu + 1 more
    • English
    Essentials in Modern HPLC Separations, Second Edition discusses the role of separation in high performance liquid chromatography (HPLC). This new and updated edition systematically presents basic concepts as well as new developments in HPLC. Starting with a description of basic concepts, it provides important guidance for the practical utilization of various HPLC procedures, such as the selection of the HPLC type, proper choice of the chromatographic column, selection of mobile phase and selection of the method of detection, all of which are in correlation with the physico-chemical characteristics of the compounds separated. Every chapter has been carefully reviewed, with several new sections added to bring the book completely up-to-date. Hence, it is a valuable reference for students and professors in chemistry.

  • Principles and Practice of Modern Chromatographic Methods

    • 2nd Edition
    • Kevin Robards + 1 more
    • English
    Principles and Practice of Modern Chromatographic Methods, Second Edition takes a comprehensive, unified approach in its presentation of chromatographic techniques. Like the first edition, the book provides a scientifically rigid, but easy-to-follow presentation of chromatography concepts that begins with the purpose and intent of chromatographic theory - the “what and why” that are left out of other books attempting to cover these principles. This fully revised second edition brings the content up-to-date, covering recent developments in several new sections and an additional chapter on composite methods. New topics include sample profiling, sample preparation, sustainable green chemistry, 2D chromatography, miniaturization/nano... HILIC, and more.

  • Carbohydrate Analysis by Modern Liquid Phase Separation Techniques

    • 2nd Edition
    • Ziad El Rassi
    • English
    Carbohydrate Analysis by Modern Liquid Phase Separation Techniques, Second Edition, presents readers with the various principles of modern liquid phase separation techniques and their contributions to the analysis of complex carbohydrates and glycoconjugates. In a selection of all-new chapters, this fully updated volume covers each technique in detail. The book aims to help analysts solve any of the many practical problems they may face in tackling the analysis of carbohydrates. In addition, it addresses current difficulties that must be resolved in carbohydrate research, thus inspiring further important technological developments to meet these challenges. This is an essential resource for anyone seeking a broad view of the science of carbohydrates and separation techniques.

  • Gas Chromatography

    • 2nd Edition
    • Colin Poole
    • English
    Gas Chromatography, Second Edition, offers a single source of authoritative information on all aspects relating to the practice of gas chromatography. A focus on short, topic-focused chapters facilitates the identification of information that will be of immediate interest for familiar or emerging uses of gas chromatography. The book gives those working in both academia and industry the opportunity to learn, refresh and deepen their understanding of fundamental and instrumental aspects of gas chromatography and tools for the interpretation and management of chromatographic data. Users will find a consolidated guide to the selection of separation conditions and the use of auxiliary techniques. This new edition restores the contemporary character of the book with respect to those involved in advancing the technology, analyzing the data produced, or applying the technique to new application areas. New topics covered include hyphenated spectroscopic detectors, micromachined instrument platforms, derivatization and related microchemical techniques, petrochemical applications, volatile compounds in the atmosphere, and more.

  • Separation Methods in Drug Synthesis and Purification

    • 2nd Edition
    • Volume 8
    • Klara Valko
    • English
    Separation Methods in Drug Synthesis and Purification, Second Edition, Volume Eight, provides an updated on the analytical techniques used in drug synthesis and purification. Unlike other books on either separation science or drug synthesis, this volume combines the two to explain the basic principles and comparisons of each separation technique. New sections to this volume include enantiomer separation using capillary electrophoresis (CE) and capillary electro- chromatography, the computer simulation of chromatographic separation for accelerating method development, the application of chromatography and capillary electrophoresis used as surrogates for biological processes, and new developments in the established techniques of chromatography and preparative methods.

  • Basic Multidimensional Gas Chromatography

    • 1st Edition
    • Volume 12
    • English
    Basic Multidimensional Gas Chromatography is aimed at the next generation of multidimensional gas chromatography users who will require basic training in the fundamentals of both GC and GCxGC. This book fills the current need for an inexpensive, straightforward guidebook to get new users started. It will help new users determine when to add or purchase a multidimensional system and teach them to optimize and maximize the capability of each system. Readers will also learn to select specific modes for each portion of a multidimensional analysis. This ideal resource is a concise, hard-hitting text that provides the facts needed to get users up and running.

  • Evaluating Water Quality to Prevent Future Disasters

    • 1st Edition
    • Volume 11
    • English
    Evaluating Water Quality to Prevent Future Disasters, volume 11 in the Separation Science and Technology series, covers various separation methods that can be used to avoid water catastrophes arising from climate change, arsenic, lead, algal bloom, fracking, microplastics, flooding, glyphosphates, triazines, GenX, and oil contamination. This book provides a valuable resource that will help the reader solve their potential water contamination problems and help them develop their own new approaches to monitor water contamination.

  • Membrane Separation Principles and Applications

    From Material Selection to Mechanisms and Industrial Uses
    • 1st Edition
    • Ahmad Fauzi Ismail + 3 more
    • English
    Membrane Separation Principles and Applications: From Material Selection to Mechanisms and Industrial Uses, the latest volume in the Handbooks in Separation Science series, is the first single resource to explore all aspects of this rapidly growing area of study. Membrane technology is now accepted as one of the most effective tools for separation and purification, primarily due to its simple operation. The result has been a proliferation of studies on this topic; however, the relationships between fundamental knowledge and applications are rarely discussed. This book acts as a guideline for those who are interested in exploring membranes at a more progressive level. Covering methods of pressure driving force, partial pressure driving force, concentration driving force, electrical potential driving force, hybrid processes, and more, this volume is more complete than any other known resource on membrane separations.

  • Supercritical Fluid Chromatography

    • 1st Edition
    • Colin F. Poole
    • English
    Supercritical fluid chromatography (SFC) is a rapidly developing laboratory technique for the separation and identification of compounds in mixtures. Significant improvements in instrumentation have rekindled interest in SFC in recent years and enhanced its standing in the scientific community. Many scientists are familiar with column liquid chromatography and its strengths and weaknesses, but the possibilities brought to the table by SFC are less well-known and are underappreciated. Supercritical Fluid Chromatography is a thorough and encompassing reference that defines the concept of contemporary practice in SFC and how it should be implemented in laboratory science. Given the changes that have taken place in SFC, this book presents contemporary aspects and applications of the technique and introduces SFC as a natural solution in the larger field of separation science. The focus on state-of-the-art instrumental SFC distinguishes this work as the go-to reference work for those interested in implementing the technique at an advanced level.

  • Selection of the HPLC Method in Chemical Analysis

    • 1st Edition
    • Serban C. Moldoveanu + 1 more
    • English
    Selection of the HPLC Method in Chemical Analysis serves as a practical guide to users of high-performance liquid chromatography and provides criteria for method selection, development, and validation. High-performance liquid chromatography (HPLC) is the most common analytical technique currently practiced in chemistry. However, the process of finding the appropriate information for a particular analytical project requires significant effort and pre-existent knowledge in the field. Further, sorting through the wealth of published data and literature takes both time and effort away from the critical aspects of HPLC method selection. For the first time, a systematic approach for sorting through the available information and reviewing critically the up-to-date progress in HPLC for selecting a specific analysis is available in a single book. Selection of the HPLC Method in Chemical Analysis is an inclusive go-to reference for HPLC method selection, development, and validation.

  • Modern Sample Preparation for Chromatography

    • 1st Edition
    • English
    Sample preparation is applied to make real world samples amenable for chromatographic analysis, or to improve the results of this type of analysis. A wide variety of procedures are applied for this purpose, and their description is the main goal of the present book. The principles of these procedures are explained, discussing their advantages and disadvantages, and their applicability to different types of samples as well as their fit for different types of chromatographic analysis. This provides a guide for choosing the appropriate sample preparation for a given analysis. The book also contains numerous literature references and examples of sample preparation for different matrices. The material is presented in three parts, one discussing physical methods used in sample preparation such as filtration, distillation, solvent extraction, solid phase extraction, electro-separations.

  • Distillation

    Fundamentals and Principles
    • 1st Edition
    • Andrzej Gorak + 1 more
    • English
    Distillation: Fundamentals and Principles — winner of the 2015 PROSE Award in Chemistry & Physics — is a single source of authoritative information on all aspects of the theory and practice of modern distillation, suitable for advanced students and professionals working in a laboratory, industrial plants, or a managerial capacity. It addresses the most important and current research on industrial distillation, including all steps in process design (feasibility study, modeling, and experimental validation), together with operation and control aspects. This volume features an extra focus on the conceptual design of distillation.

  • Distillation

    Operation and Applications
    • 1st Edition
    • Andrzej Gorak + 1 more
    • English
    Distillation: Operation and Applications—winner of the 2015 PROSE Award in Chemistry & Physics from the Association of American Publishers—is a single source of authoritative information on all aspects of the theory and practice of modern distillation, suitable for advanced students and professionals working in a laboratory, industrial plants, or a managerial capacity. It addresses the most important and current research on industrial distillation, including all steps in process design (feasibility study, modeling, and experimental validation), together with operation and control aspects. This volume features an extra focus on distillation applications.

  • Distillation: Equipment and Processes

    • 1st Edition
    • Andrzej Gorak + 1 more
    • English
    Distillation: Equipment and Processes—winner of the 2015 PROSE Award in Chemistry & Physics from the Association of American Publishers—is a single source of authoritative information on all aspects of the theory and practice of modern distillation, suitable for advanced students and professionals working in a laboratory, industrial plants, or a managerial capacity. It addresses the most important and current research on industrial distillation, including all steps in process design (feasibility study, modeling, and experimental validation), together with operation and control aspects. This volume features an extra focus on distillation equipment and processes.

  • Pharmaceutical and Biomedical Applications of Liquid Chromatography

    • 1st Edition
    • Volume 1
    • W.J. Lough + 2 more
    • English
    This volume reflects the changes that have taken place in the pharmaceutical industry over the last ten years, most notably the increased importance attached to the question of chirality, the growing influence of biotechnology and the need for more rigorous documentation and validation of analytical methods and procedures.The first part of this book deals with the application of new technology to pharmaceutical and biomedical analysis, reflecting the present needs for increased speed, sensitivity and selectivity in the analysis of drugs. The second chapter provides an overview of capillary electophoresis, which represents one of the most inportant analytical developments to impact directly on pharmaceutical development in recent years. Although not a chromatographic technique, capillary electrophoresis was considered too important to be ignored.Over the last 25 years, liquid chromatography has grown into a mature analytical technique and many of the fundamental issues concerned with retention and separation are well defined. The practitioners of modern liquid chromatography spend as much time in the development of techniques for sampling handling and automation as they do in the development of the separation. Therefore, Part Two of this book describes some of the recent advances in the areas of sample handling and the isolation of compounds from biological samples, including solid phase extraction, restricted access media for direct injection, coupled column technology and microdialysis. Similarily, Part Three contains two chapters concerned with liquid chromatographic methods for the isolation of drug substances, peptides and proteins from other complex media.The pharmaceutical industry and the process of drug development are highly regulated and the increasing importance that the regulatory authorities attach to validation has had a significant impact on the analytical techniques used for the analysis of drugs. Although this has increased the workload of analysts in the pharmaceutical industry, it has also improved the quality of analytical methods used in the support of investigational and new drug applications as well as the quality of methods published more recently in the literature. Consequently, Part Four of this volume describes approaches to the optimization and validation of liquid chromatography methods for the analysis of drugs in the bulk form, in pharmaceutical formulations and biological fluids.

  • Liquid Chromatography

    Fundamentals and Instrumentation
    • 1st Edition
    • Salvatore Fanali + 3 more
    • English
    A single source of authoritative information on all aspects of the practice of modern liquid chromatography suitable for advanced students and professionals working in a laboratory or managerial capacity

  • Liquid Chromatography

    Applications
    • 1st Edition
    • Salvatore Fanali + 3 more
    • English
    A single source of authoritative information on all aspects of the practice of modern liquid chromatography suitable for advanced students and professionals working in a laboratory or managerial capacity

  • Chromatography Today

    • 5th Edition
    • C.F. Poole + 1 more
    • English
    Chromatography Today provides a comprehensive coverage of various separation methods: gas, liquid, thin-layer, and supercritical fluid-chromatography... and capillary electrophoresis. Particular attention is paid to the optimization of these techniques in terms of kinetic parameters and retention mechanisms. When these facts are understood, method selection and optimization becomes a more logical process. Sample preparation methods are treated fully as they frequently represent an integral part of the total analytical method. Also described are preparative-scale separations used for isolating significant amounts of product which are generally achieved under conditions that are not identical to those used for analytical separations. The most common hyphenated methods used for sample identification are discussed from the perspective of the information they yield and the requirements of common interfaces. The scope and level of discussion are designed to be appropriate for various user groups. This book should be suitable for use as a graduate-level student textbook in separation science, a text for professional institutes offering short courses in chromatography, and as a self-study guide for chromatographers to refresh their knowledge of the latest developments in the field. The book is extensively illustrated with over 200 figures, 110 tables and 3,300 references, largely to the contemporary literature.

  • Practical Capillary Electrophoresis

    • 1st Edition
    • Bozzano G Luisa
    • English
    High performance capillary electrophoresis (HPCE) is the newest and perhaps most powerful separation technique available today. This single-authored text provides an integrated, comprehensive, and clearly illustrated look at the field. Users of HPCE will gain a basic understanding of principles underlying electrophoresis and go on to learn about mode selection, methods development, detection, and quantative analysis. Ideally suited for analytical chemists and analytical biochemists with applications involving small molecules, proteins, peptides, DNA, and ion separations, this book provides a comparative assessment of related techniques. The author is an internationally recognised scientist and serves as the instructor for short courses on HPCE as offered by the American Chemical Society.

  • Contemporary Practice of Chromatography

    • 1st Edition
    • C.F. Poole + 1 more
    • English
    Written for all those who use chromatography as an analytical tool, this book covers all areas of gas, liquid, and thin-layer chromatography; no other book offers the same scope. The authors have had considerable experience in teaching graduate-level courses and the material presented here has been tried and tested, having formed the basis for short courses taught to groups of industrial chemists. Emphasis is on the practice of chromatographic methods, including ``how to'' sections and numerous examples of calculation methods. Extensively illustrated, the book contains numerous tables of all useful constants, materials and formulas frequently used by chromatographers. Valuable features are the chapters on sample preparation for chromatographic analysis, on instrumental methods for sample identification, and the comprehensive literature review.

  • Liquid Chromatographic Analysis of Food and Beverages V2

    • 1st Edition
    • George Charalambous
    • English
    Liquid Chromatographic Analysis of Food and Beverages, Volume 2 focuses on the role and utilization of reversed-phase separation techniques in the food, agricultural, biochemical, biomedical, and clinical area. This book discusses the high pressure liquid chromatography; estimation of dextrose equivalent value of starch hydrolysates from liquid chromatographic profiles; and analysis of gluconic acid in botrytized wines. The HPLC of carbohydrate products; reducing sugar derivatization for ultraviolet absorption detection in HPLC analyses; and quantitative determination of dextromethorphan hydrobromide in cough remedies by high precision liquid chromatography are also elaborated. This text likewise discusses the separation of hop compounds by reverse-phase HPLC and analysis of polymethoxylated flavones in orange juice and fruit parts. This book is a good reference for food technologists and researchers conducting work on liquid chromatographic analysis of food and beverages.

  • Essentials in Modern HPLC Separations

    • 1st Edition
    • Serban C. Moldoveanu + 1 more
    • English
    Essentials in Modern HPLC Separations discusses the role of separation in high performance liquid chromatography (HPLC). This up-to-date reference systematically covers new developments in types and characteristics of stationary phases, mobile phases, and other factors of this technique that influence separation of compounds being analyzed. The volume also considers the selection process for stationary and mobile phases in relation to the molecules being separated and examined, as well as their matrices. The book includes a section on the contemporary applications of HPLC, particularly the analysis of pharmaceutical and biological samples, food and beverages, environmental samples, and more.

  • Gas Chromatography

    • 1st Edition
    • Colin Poole
    • English
    This title provides comprehensive coverage of modern gas chromatography including theory, instrumentation, columns, and applications addressing the needs of advanced students and professional scientists in industry and government laboratories. Chapters are written by recognized experts on each topic. Each chapter offers a complete picture with respect to its topic so researchers can move straight to the information they need without reading through a lot of background information.

  • Detectors in Gas Chromatography

    • 1st Edition
    • Volume 4
    • English

  • Gas Chromatography of Polymers

    • 1st Edition
    • Volume 10
    • English

  • Instrumental Liquid Chromatography

    A Practical Manual on High Performance Liquid Chromatographic Methods
    • 1st Edition
    • Volume 5
    • English

  • Liquid Chromatography Detectors

    • 1st Edition
    • Volume 11
    • English

  • Chromatography of Steroids

    • 1st Edition
    • Volume 8
    • English

  • Radiochromatography

    The Chromatography and Electrophoresis Radiolabelled Compounds
    • 1st Edition
    • Volume 14
    • English

  • Chromatography of Alkaloids, Part A

    Thin-Layer Chromatography
    • 1st Edition
    • Volume 23A
    • English

  • Chromatography

    Fundamentals and Applications of Chromatographic and Electrophoretic Methods. Part A: Fundamentals and Techniques
    • 1st Edition
    • Volume 22A
    • English

  • Chromatography of Antibiotics

    • 1st Edition
    • Volume 1
    • English

  • 75 Years of Chromatography

    A Historical Dialogue
    • 1st Edition
    • Volume 17
    • English

  • Antibiotics

    Isolation, Separation and Purification
    • 1st Edition
    • Volume 15
    • English

  • Chromatography of Alkoloids, Part B

    Gas-Liquid Chromatography and High-Performance Liquid Chromatography
    • 1st Edition
    • Volume 23B
    • English
    The first of two books which provide an unparalleled reference source and handbook for everyone involved with alkaloid analyses. The first volume gives a comprehensive summary of the literature on thin layer chromatography of alkaloids. It presents the most effective methods for the separation and detection of alkaloids occurring in plant material, biological material, pharmaceutical preparations and drugs of abuse.

  • HPTLC - High Performance Thin-Layer Chromatography

    • 1st Edition
    • Volume 9
    • English

  • Techniques

    • 1st Edition
    • Volume 18A
    • Z. Deyl
    • English

  • Handbook of Methods and Instrumentation in Separation Science

    Volume 1
    • 1st Edition
    • Colin Poole
    • English
    Handbook of Methods and Instrumentation in Separation Science, Volume 1 provides concise overviews and summaries of the main methods used for separation. It is based on the Encyclopedia of Separation Science. The handbook focuses on the principles of methods and instrumentation. It provides general concepts concerning the subject matter; it does not present specific procedures. This volume discusses the separation processes including affinity methods, analytical ultracentrifugation, centrifugation, chromatography, and use of decanter centrifuge and dye. Each methodology is defined and compared with other separation processes. It also provides specific techniques, principles, and theories concerning each process. Furthermore, the handbook presents the applications, benefits, and validation of the processes described in this book. This handbook is an excellent reference for biomedical researchers, environmental and production chemists, flavor and fragrance technologists, food and beverage technologists, academic and industrial librarians, and nuclear researchers. Students and novices will also find this handbook useful for practice and learning.

  • Handbook of Methods and Instrumentation in Separation Science

    Volume 2
    • 1st Edition
    • English
    Handbook of Methods and Instrumentation in Separation Science, Volume 2 provides concise overviews and summaries of the main methods used for separation. The contents are based on the Encyclopedia of Separation Science. The handbook focuses on the principles of methods and instrumentation. It provides general concepts concerning the subject matter; it does not present specific procedures. The volume discusses the separation processes including crystallization, distillation, electrophoresis, extraction, flotation, ion exchange, membrane separations, and particle size separations. Each separation process is defined and compared with other methodologies. It also provides specific techniques under each method of separation. Moreover, the handbook presents the applications and advantages of the processes described in this book. The handbook is an excellent reference for environmental and production chemists, biomedical researchers, food and beverage technologists, flavor and fragrance technologists, nuclear researchers, and academic and industrial librarians. Students and novice will also find this handbook useful.

  • Comprehensive Two Dimensional Gas Chromatography

    • 1st Edition
    • Volume 55
    • Lourdes Ramos
    • English
    The book reviews the basic concepts and highlights the most relevant advances and developments that have taken place in the field of comprehensive two dimensional gas chromatography (GC x GC) since its introduction in 1991. The several instrumental and technical approaches assayed and developed during these seventeen years and that have contributed to the development of this powerful separation technique and to its increasing application in many areas is explained and comprehensively illustrated through a number of chapters devoted these specific topics. More specialized aspects of the technique, including theoretical aspects, modelization of the chromatographic process, software developments, and alternative couplings is also covered. Finally, special attention is paid to data treatment, for both qualitative and quantitative analysis. This book will be a practical resource that will explain from basic to specialized concepts of GC x GC and will show the current state-of-the-art and discuss future trends of this technique.

  • Capillary Electrophoresis Methods for Pharmaceutical Analysis

    • 1st Edition
    • Volume 9
    • Satinder Ahuja + 1 more
    • English
    Capillary electrophoresis (CE) is a powerful analytical technique that is widely used in research and development and in quality control of pharmaceuticals. Many reports of highly efficient separations and methods have been published over the past 15 years. CE offers several advantages over high-pressure or high-performance liquid chromatography (HPLC). These include simplicity, rapid analysis, automation, ruggedness, different mechanisms for selectivity, and low cost. Moreover, EC requires smaller sample size and yet offers higher efficiency and thus greater resolution power over HPLC. These characteristics are very attractive in research and development, even more so in pharmaceutical quality control (QC) and stability monitoring (SM) studies. This book will provide busy pharmaceutical scientists a complete yet concise reference guide for utilizing the versatility of CE in new drug development and quality control.

  • Fluorine and Health

    Molecular Imaging, Biomedical Materials and Pharmaceuticals
    • 1st Edition
    • Alain Tressaud + 1 more
    • English
    Fluorine and Health presents a critical multidisciplinary overview on the contribution of fluorinated compounds to resolve the important global issue of medicinal monitoring and health care. The involved subjects are organized in three thematic parts devoted to Molecular Imaging, Biomedical Materials and Pharmaceuticals. Initially the key-position of partially fluorinated low molecular weight compounds labelled either with the natural 19F-isotope for Magnetic Resonance Imaging (MRI) or labelled with the radioactive [18F]-isotope for Positron Emission Tomography (PET) is highlighted. Both non-invasive methods belong to the most challenging in vivo imaging techniques in oncology, neurology and in cardiology for the diagnosis of diseases having the highest mortality in the industrialized countries. The manifold facets of fluorinated biomaterials range from inorganic ceramics to perfluorinated organic molecules. Liquid perfluorocarbons are suitable for oxygen transport and as potential respiratory gas carriers, while fluorinated polymers are connected to the pathology of blood vessels. Another important issue concerns the application of highly fluorinated liquids in ophthalmology. Moreover, fluorine is an essential trace element in bone mineral, dentine and tooth enamel and is applied for the prophylaxis and treatment of dental caries. The various origins of human exposure to fluoride species is detailed to promote a better understanding of the effect of fluoride species on living organisms.Medicinall... relevant fluorinated molecules and their interactions with native proteins are the main focus of the third part. New molecules fluorinated in strategic position are crucial for the development of pharmaceuticals with desired action and optimal pharmacological profile. Among the hundreds of marketed active drug components there are more than 150 fluorinated compounds. The chapters will illustrate how the presence of fluorine atoms alters properties of bioactive compounds at various biochemical steps, and possibly facilitate its emergence as pharmaceuticals. Finally the synthetic potential of a fluorinase, the first C-F bond forming enzyme, is summarized.

  • Magnetic Cell Separation

    • 1st Edition
    • Volume 32
    • English
    Cell separation is at the core of current methods in experimental biology and medicine. Its importance is illustrated by the large number of physical and biochemical principles that have been evaluated for application to cell separation. The development of cell separation methods is driven by the needs of biological and medical research, and the ever-increasing demands for sensitivity, selectivity, yield, timeliness and economy of the process. The interdisciplinary nature of research in this area and the volume of information available in research publications and conferences necessitates a basic description of the fundamental processes involved in magnetic cell separation that may help the user in navigating this wealth of information available online and in scientific publications. This book will appeal to researchers in many areas utilizing this technique, including those working in cell biology, clinical research, inorganic chemistry, biochemistry, chemical engineering, materials science, physics and electrical engineering.

  • HPLC Method Development for Pharmaceuticals

    • 1st Edition
    • Volume 8
    • Satinder Ahuja + 1 more
    • English
    High pressure, or high performance, liquid chromatography (HPLC) is the method of choice for checking purity of new drug candidates, monitoring changes during scale up or revision of synthetic procedures, evaluating new formulations, and running control/assurance of the final drug product. HPLC Method Development for Pharmaceuticals provides an extensive overview of modern HPLC method development that addresses these unique concerns. Includes a review and update of the current state of the art and science of HPLC, including theory, modes of HPLC, column chemistry, retention mechanisms, chiral separations, modern instrumentation (including ultrahigh-pressure systems), and sample preparation. Emphasis has been placed on implementation in a pharmaceutical setting and on providing a practical perspective. HPLC Method Development for Pharmaceuticals is intended to be particularly useful for both novice and experienced HPLC method development chemists in the pharmaceutical industry and for managers who are seeking to update their knowledge.

  • Liquid Chromatography of Natural Pigments and Synthetic Dyes

    • 1st Edition
    • Volume 71
    • Tibor Cserháti
    • English
    This latest volume in the series entitled Liquid Chromatography of Natural Pigments and Synthetic Dyes presents an overview of the latest developments in the field while critically evaluating this method of analysis and providing comparisons of the various liquid chromatographic separation techniques that are currently available. Natural pigments and synthetic dyes are extensively used in various fields of everyday life including food production, textile industry, paper production, agricultural practice and research and water science and technology. Besides their capacity for increasing the marketability of products, natural pigments have shown advantageous biological activity as antioxidants and anticancer agents. On the negative side, synthetic pigments have a significant impact on the environment and can cause adverse toxicological side effects. Both pigment classes exhibit considerable structural diversity. As the stability of the pigments against hydrolysis, oxidation and other environmental and technological conditions is markedly different, the exact determination of the pigment composition may help for the prediction of the shelf-life of products and the assessment of the influence of technological steps on the pigment fractions resulting in more consumer friend processing methods. Furthermore, the qualitative determination and identification of the pigments may contribute to the establishment of the provenance of the product. The unique separation capacity of liquid chromatographic (LC) techniques makes it a method of preference for the analysis of pigments in any complicated accompanying matrices.

  • Modern Instrumental Analysis

    • 1st Edition
    • Volume 47
    • Satinder Ahuja + 1 more
    • English
    Modern Instrumental Analysis covers the fundamentals of instrumentation and provides a thorough review of the applications of this technique in the laboratory. It will serve as an educational tool as well as a first reference book for the practicing instrumental analyst. The text covers five major sections:1. Overview, Sampling, Evaluation of Physical Properties, and Thermal Analysis2. Spectroscopic Methods 3. Chromatographic Methods 4. Electrophoretic and Electrochemical Methods 5. Combination Methods, Unique Detectors, and Problem Solving Each section has a group of chapters covering important aspects of the titled subject, and each chapter includes applications that illustrate the use of the methods. The chapters also include an appropriate set of review questions.

  • Fundamentals of Preparative and Nonlinear Chromatography

    • 2nd Edition
    • Georges Guiochon + 2 more
    • English
    Fundamentals of Preparative and Nonlinear Chromatography, Second Edition is devoted to the fundamentals of a new process of purification or extraction of chemicals or proteins widely used in the pharmaceutical industry and in preparative chromatography. This process permits the preparation of extremely pure compounds satisfying the requests of the US Food and Drug Administration. The book describes the fundamentals of thermodynamics, mass transfer kinetics, and flow through porous media that are relevant to chromatography. It presents the models used in chromatography and their solutions, discusses the applications made, describes the different processes used, their numerous applications, and the methods of optimization of the experimental conditions of this process.