Skip to main content
Elsevier
View Cart

Supercritical Fluid Chromatography and Extraction

  • 2nd Edition - November 19, 2025
  • Latest edition
  • Editors: Caroline West, Colin F. Poole
  • Language: English

Supercritical fluid chromatography (SFC) is a rapidly developing laboratory technique for the separation and identification of compounds in mixtures. Recent, significant… Read more

World Book Day celebration

Where learning shapes lives

Up to 25% off trusted resources that support research, study, and discovery.

Explore resources

Description

Supercritical fluid chromatography (SFC) is a rapidly developing laboratory technique for the separation and identification of compounds in mixtures. Recent, significant improvements in instrumentation have rekindled interest in SFC and have enhanced its standing in the scientific community. Many scientists are familiar with column liquid chromatography and its potential beyond traditional liquid chromatography, yet many of its capabilities remain underappreciated. Supercritical Fluid Chromatography and Extraction explores contemporary supercritical fluid chromatography and extraction and how it should be implemented in laboratory science for analysis, isolation, and production.

New to This Edition
This new edition details recent advances and applications of supercritical fluids in sample prep, instrumental analysis, and process-scale, including SFE, making it a comprehensive resource for both techniques. Further enhancements to this edition include:
  • Expanded section on SFC theory to include gradient elution
  • A new chapter on general detectors for SFC
  • Enhanced method development coverage, with focus on gradient elution practices
  • Includes multidimensional SFC, SFC × SFC, and LC-SFC
  • Features comprehensive information on accelerated solvents, comparing solvent and extraction techniques.
  • Highlights environmental monitoring and analysis applications of SFE.
Widely used in the food industry for decades, SFE is now expanding into new fields. Supercritical Fluid Chromatography and Extraction, Second Edition serves as a valuable resource for chemical engineers, chemists, researchers, students, and academics working with supercritical fluids at preparative and process scales. It’s also an ideal introduction for newcomers to SFC and SFE.

Key features

  • Covers method development for SFC and SFE across instrument platforms and process scale for both techniques
  • Combines comprehensive coverage of both techniques in one volume
  • Edited and authored by leading chromatography and extraction experts
  • Contains over 200 figures and tables for clarity and key concept retention
  • Showcases applications in environmental monitoring, food, natural products, forensic science, petrochemicals, pharmaceuticals, and bioanalysis

Readership

Chemical engineers and chemists working with supercritical fluid at both preparative- and process-scale applications, researchers, academics and students working in various fields, anyone interesting in beginning their work within the field of supercritical fluid chromatography and extraction

Table of contents

1. Core concepts and milestones in the exploitation of supercritical fluids in separation science

2. Theory of supercritical fluid chromatography

3. Stationary phases for supercritical fluid chromatography

4. Stationary phases for the separation of stereoisomers by supercritical fluid chromatography

5. Co-solvents and mobile phase additives in supercritical fluid chromatography

6. Method development in supercritical fluid chromatography

7. Instrument platforms for supercritical fluid chromatography

8. General detectors for supercritical fluid chromatography

9. Mass spectrometric detection in supercritical fluid chromatography

10. Multidimensional supercritical fluid chromatography

11. Method validation in supercritical fluid chromatography

12. Sample preparation for supercritical fluid chromatography

13. Supercritical fluid chromatography of amino acids and peptides

14. Supercritical fluid chromatography of lipids

15. Supercritical fluid chromatography of stereoisomers

16. Applications of supercritical fluid chromatography in environmental analysis

17. Applications of supercritical fluid chromatography in food analysis

18. Applications of supercritical fluid chromatography in forensic analysis

19. Applications of supercritical fluid chromatography in natural product analysis

20. Applications of supercritical fluid chromatography in the analysis of petrochemicals

21. Applications of supercritical fluid chromatography in the pharmaceutical industry

22. Applications of supercritical fluid chromatography in bioanalysis

23. Theory for preparative supercritical fluid chromatography

24. Instrument platforms for preparative and process scale supercritical fluid chromatography

25. Applications of preparative and process scale supercritical fluid chromatography in the pharmaceutical industry

26. Applications of preparative and process scale supercritical fluid chromatography of natural products

27. Core concepts and fundamentals of supercritical fluid extraction

28. Instrument platforms for supercritical fluid extraction

29. Pressurized hot-water and accelerated solvent extraction

30. Supercritical fluid extraction of essential oils

31. Supercritical fluid extraction of lipids and bio-oils

32. Supercritical fluid extraction of agricultural products

33. Supercritical fluid extraction of petroleum products

34. Applications of Supercritical fluid extraction for environmental analysis

Product details

  • Edition: 2
  • Latest edition
  • Published: November 21, 2025
  • Language: English

About the editors

CW

Caroline West

Caroline West received a PhD in Chemistry from the University of Paris-Saclay, France (2005) then was appointed as an Assistant Professor in analytical chemistry at the University of Orleans, France. She was later promoted to Full Professor (2020) in the same university. Her main scientific interests lie in fundamentals of chromatographic separation in liquids and supercritical fluids, both in achiral and chiral modes. She also applies these methods to different samples, such as pharmaceuticals and natural products. She is the author of over 100 papers, 7 book chapters, and has presented above 100 talks in national and international conferences and seminars. In 2015, she received the “LC‐GC Emerging Leader in Chromatography” award from LC‐GC North America and was ranked several times among the most influential people in analytical chemistry by “The Analytical Scientist” magazine (“Top 40 under 40” 2014 & 2018, “The Power List” 2019, 2020 & 2021). More recently, she was the recipient of the Jubilee medal from the Chromatographic Society (2021).
Affiliations and expertise
Assistant Professor in Analytical Chemistry, University of Orléans, France

CP

Colin F. Poole

Colin F. Poole was born and educated in the United Kingdom receiving a B.Sc. in Chemistry from the University of Leeds (1971) followed by graduate studies at the University of Bristol, MSc. in analytical chemistry (1972), and Ph.D. with Prof. E. D. Morgan at the University of Keele (1975) on the analysis of insect moulting hormones. Since 1980 he has been at the Department of Chemistry, Wayne State University, Detroit, Michigan, USA , except for 1995-1996, spent as the Governors’ Lecturer and Professor of Analytical Chemistry at Imperial College of Science, Technology & Medicine, London, in the United Kingdom. He is a former Science Advisor to the US Food and Drug Administration, a position he occupied for 25 years. Professor Poole has broad interests in the separation and detection of small molecules in biological, environmental, and food samples using a range of sample preparation, chromatographic and data analysis tools. He is the co-author of over 400 papers, 20 books, an editor of Journal of Chromatography A and a member of the editorial boards of 5 other analytical chemistry journals. .
Affiliations and expertise
Department of Chemistry, Wayne State University, Detroit, MI, USA

View book on ScienceDirect

Read Supercritical Fluid Chromatography and Extraction on ScienceDirect