Biotechnology in Healthcare presents up-to-date knowledge on the emerging field of biotechnology as applied to the healthcare industry. Biotechnology has revolutionized healthcare in the last two decades by developing and introducing novel diagnostics, therapeutics, and preventive measures; whether it is noncommunicable or communicable disease, primary or secondary care, or public health, it has shown its immense potential to provide a solution to the healthcare providers, physicians, and allied health care professionals.The second volume, Applications and Initiatives, contains 19 chapters focused on the applications of biotechnology related to public healthcare, hospital management, oncology, neurodegenerative and infectious diseases, regenerative medicine, IVF, clinical trials, precision food, FMGCs, PPCPs, pharmaceuticals, and smart technologies to monitor pandemic. Further, this volume also presents government initiatives and entrepreneurship challenges in healthcare biotechnology sector.This is a valuable resource for students, biotechnologists, bioinformaticians, clinicians, and members of biomedical and healthcare fields who need to understand more about the promising developments of the emerging field of biotechnology in healthcare.
Although scientists recognize the role of epigenetic mechanisms in DNA damage response, the complex, mechanistic interplay between chromatin regulation and DNA repair is still poorly understood. Comprehending how these processes are connected in time and space and play out in developmental processes may reveal novel directions for new research and disease treatment. Epigenetics and DNA Damage, a new volume in the Translational Epigenetics series, offers a thorough grounding in the relationship between DNA Damage, epigenetic modifications, and chromatin regulation. Early chapters address the basic science of DNA damage and its association with various epigenetic mechanisms, including DNA methylation, post-translational histone modifications, histone variants, chromatin remodeling, miRNAs, and lncRNAs. This is followed by a close discussion of DNA damage and epigenetics in metabolism, aging, cellular differentiation, immune function, stem cell biology, and cancer, tying recent research to translational application in disease understanding. Later chapters examine possible epigenetic therapies combining DNA damage induction and epigenetic alteration, as well as instructive chapters on how to analyze DNA damage and epigenetic alterations in new research.
A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, Sixth Edition features the latest research surrounding the application of pharmacology in drug discovery in an effort to equip readers with a deeper understanding of complex and rapid changes in this field. Written by well-respected pharmacologist, Terry P. Kenakin, this primer is an indispensable resource for anyone involved in drug discovery. This edition has been reorganized for better flow and clarity and includes material on new technologies for screening (virtual, DNA encoded libraires, fragment-based) and a major section on phenotypic (target agnostic) screening for new leads and determination of drug targets. With full color illustrations as well as new examples throughout, this book remains a top reference for all industry and academic scientists and students directly involved in drug discovery or pharmacologic research. New material includes a discussion of the determination of target engagement, including numerous new ways to demonstrate the physical interaction of molecules with drug targets and new drug candidates such a mRNA, gene therapy, antibodies and information on CRISPR and genomics.
Technologies to Recover Polyphenols from AgroFood By-products and Wastes: Applications in Different Fields covers the most used technologies to extract and recover polyphenols from all kinds of by-products and wastes generated by the food industry, restaurant and agricultural sectors. Polyphenols are characterized by different AgroFood by-products and waste sources, hence this book explores the practical applications of these polyphenols in the development of functional foods and pharmaceutical and cosmetic products. Containing definitions, case studies, applications, literature reviews, and coverage of recent developments, this book will be a welcomed resource for food scientists, including those working in sustainability, agriculture and engineering.
Nonlinear Control for Blood Glucose Regulation of Diabetic Patients: An LMI-Based Approach exposes readers to the various existing mathematical models that define the dynamics of glucose-insulin for Type 1 diabetes patients. After providing insights into the mathematical model of patients, the authors discuss the need and emergence of new control techniques that can lead to further development of an artificial pancreas. The book presents various nonlinear control techniques to address the challenges that Type 1 diabetic patients face in maintaining their blood glucose level in the safe range (70-180 mg/dl). The closed-loop solution provided by the artificial pancreas depends mainly on the effectiveness of the control algorithm, which acts as the brain of the system. APS control algorithms require a mathematical model of the gluco-regulatory system of the T1D patients for their design. Since the gluco-regulatory system is inherently nonlinear and largely affected by external disturbances and parametric uncertainty, developing an accurate model is very difficult.
Hazardous and Trace Materials in Soil and Plants: Sources, Effects and Management explores the latest advancements in reducing, avoiding and eliminating soil contaminants that challenge the health and safety of agricultural plants. With a focus on minimizing the production of those hazardous substances, controlling their distribution and ensuring safe utilization, the book explores each contributing area and provides insights toward improved, sustainable and secure production. This is an excellent reference resource on both current research and future directions from laboratory research to field applications. The combined impacts of climate change and industrialization have led to increased and diversified threats to the health of the soil in which our food crops are grown, as well as in the plants themselves. This dual-hazard scenario is increasingly recognized as a threat to not just the environment, but to global food security as agricultural soils contaminated with pollutants alter plant metabolism, thus resulting in reduced crop quality and production quantity.
Metals and Metalloids in Soil-Plant-Water Systems: Phytophysiology and Remediation Techniques examines the impact of metal/metalloid contamination on the plant lifecycle, along with microbes present in soil. Highlighting uptake and translocation, the book also examines antioxidant, photosynthesis and growth characteristics of plants grown in metal contaminated soil. Beginning with an introduction to different sources of soil and water pollution, chapters assess the environmental cytotoxicity pollution impact on plants, as well as how the generation of reactive oxygen and nitrogen species in plant tissues is affected. The book also discusses various soil remediation methodologies, including the potential applications of metal oxidizing microbes and nanomaterials. This is an essential resource for researchers and students interested in plant physiology, soil science, environmental science and agriculture.
The Temporal Lobe, Volume 187 covers the exponential growth of studies on the relationships between brain and language/cognition, many of which involved the temporal lobe. This volume summarizes research on the anatomy and function of the temporal lobe under both normal and pathological conditions. In addition, it discusses the interactions of the temporal lobe with other brain structures. The book highlights the role of the temporal lobe in language processing as well as vision, object, face recognition and processing. The book also discusses the temporal lobe's role in reading, speech and the processing of color, music, action and memory. Temporal lobe disorders, assessments and treatments are also covered, including encephalitis, Alzheimer’s, epilepsy, Korsakov’s syndrome, and more.