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Elsevier

Books in Life sciences

  • Transporters in Drug Discovery and Development

    Detailed Concepts and Best Practice
    • 1st Edition
    • Yurong Lai
    • English
    Written by a leading researcher in the field, Transporters in Drug Discovery and Development provides a comprehensive and practical guide to drug transporter families that are the most important for drug discovery and development. It covers: an overview of transporter families and organ distribution; clinical relevant drug-drug interaction; clinical relevant polymorphism; drug transporter related pharmacokinetic, pharmacodynamics and toxicity; in vitro/in vivo probes of drug transport studies; the practical methodologies of industrial transporter screening and translational aspect in drug discovery and developments.

  • Laboratory Methods in Enzymology: Cell, Lipid and Carbohydrate

    • 1st Edition
    • Volume 533
    • English
    Methods in Enzymology volumes provide an indispensable tool for the researcher. Each volume is carefully written and edited by experts to contain state-of-the-art reviews and step-by-step protocols. In this volume, we have brought together a number of core protocols concentrating on Cell, Lipid and Carbohydrate, complementing the traditional content that is found in past, present and future Methods in Enzymology volumes.

  • Biological DNA Sensor

    The Impact of Nucleic Acids on Diseases and Vaccinology
    • 1st Edition
    • Ken Ishii + 1 more
    • English
    Biological DNA Sensor defines the meaning of DNA sensing pathways and demonstrates the importance of the innate immune responses induced by double stranded DNA (dsDNA) through its influencing functions in disease pathology and immune activity of adjuvants for vaccines. Though discussed in specific subsections of existing books, dsDNA and its immunogenic properties has never received the complete treatment given in this book. Biological DNA Sensor approaches the impact of dsDNA's immunogenicity on disease and vaccinology holistically. It paints a complete and concise picture on the topic so you can understand this area of study and make more informed choices for your respective research needs. Chapters are authored by researchers who are renowned for their research focus, ensuring that this book provides the most complete views on the topics.

  • Diabetes

    Oxidative Stress and Dietary Antioxidants
    • 1st Edition
    • Victor R. Preedy
    • English
    Diabetes: Oxidative Stress and Dietary Antioxidants bridges the trans-disciplinary divide among diabetologists, endocrinologists, and nutritionists in understanding and treating diabetes. The book covers, in a single volume, the science of oxidative stress in diabetes and the potentially therapeutic use of natural antioxidants in the diet or food matrix. The processes within the science of oxidative stress are described in concert with other processes such as apoptosis, cell signaling, receptor-mediated responses and more. This approach recognizes that diseases are usually multifactorial and that oxidative stress is a single component of this.Pharmacological treatments for diabetes are commonly marked by unwanted side effects, leading to treatment efforts using naturally occurring substances. But a plant-based approach alone is not sufficient; understanding the processes inherent in the oxidative stress of diabetes is vital for clinical workers, dietitians, and nutritionists.This translational work provides that understanding. The book begins by covering the basic biology of oxidative stress from molecular biology to imaging in relation to diabetes. There are chapters on neuropathy, nephropathy, atherosclerosis, cardiomyopathy, and retinopathy. The book then moves on to antioxidants in foods, including plants, components of the diet, and their relevance to diabetes.

  • Advances in Marine Biology

    • 1st Edition
    • Volume 66
    • English
    Advances in Marine Biology has been providing in-depth and up-to-date reviews on all aspects of marine biology since 1963--over 40 years of outstanding coverage! The series is well known for its excellent reviews and editing. Now edited by Michael Lesser (University of New Hampshire, USA) with an internationally renowned Editorial Board, the serial publishes in-depth and up-to-date content on many topics that will appeal to postgraduates and researchers in marine biology, fisheries science, ecology, zoology, and biological oceanography.

  • Neuroanatomy of Language Regions of the Human Brain

    • 1st Edition
    • Michael Petrides
    • English
    Many studies of the neural bases of language processes are now conducted with functional and structural neuroimaging. Research is often compromised because of difficulties in identifying the core structures in the face of the complex morphology of these regions of the brain. Although there are many books on the cognitive aspects of language and also on neurolinguistics and aphasiology, Neuroanatomy of Language Regions of the Human Brain is the first anatomical atlas that focuses on the core regions of the cerebral cortex involved in language processing. This atlas is a richly illustrated guide for scientists interested in the gross morphology of the sulci and gyri of the core language regions, in the cytoarchitecture of the relevant cortical areas, and in the connectivity of these areas. Data from diffusion MRI and resting-state connectivity are integrated iwth critical experimental anatomical data about homologous areas in the macaque monkey to provide the latest information on the connectivity of the language-relevant cortical areas of the brain. Although the anatomical connectivity data from studies on the macaque monkey provide the most detailed information, they are often neglected because of difficulties in interpreting the terminology used and in making the monkey-to-human comparison. This atlas helps investigators interpret this important source of information. Neuroanatomy of Language Regions of the Human Brain will assist investigators of the neural bases of language in increasing the anatomical sophistication of their research adn in evaluating studies of language and the brain.

  • Polyphenols in Human Health and Disease

    • 1st Edition
    • Ronald Ross Watson + 2 more
    • English
    Polyphenols in Human Health and Disease documents antioxidant actions of polyphenols in protection of cells and cell organelles, critical for understanding their health-promoting actions to help the dietary supplement industry. The book begins by describing the fundamentals of absorption, metabolism and bioavailability of polyphenols, as well as the effect of microbes on polyphenol structure and function and toxicity. It then examines the role of polyphenols in the treatment of chronic disease, including vascular and cardiac health, obesity and diabetes therapy, cancer treatment and prevention, and more.

  • Platelets and Aspirin-Induced Asthma

    Pathogenesis and Melatonin
    • 1st Edition
    • Helen Evsyukova
    • English
    Platelets and Aspirin-Induced Asthma is the first book to be published that reflects research conducted on aspirin-induced asthma pathogenesis. It is examined through positions of neuroimmunoendocrine interactions in organism. The Melatonin hormone plays a key role, being the regulator and coordinator of complicated and interrelated biological processes. This new concept of aspirin-induced asthma pathogenesis suggests new methods for treatment of this disease by means of correcting the melatonin content in the patient’s organism. Investigations into the mechanisms of aspirin-induced asthma as a pathology of melatonin producing cells of platelets helps to determine high-risk groups and develop preventive measures and adequate therapy.

  • The Rat Brain in Stereotaxic Coordinates

    • 7th Edition
    • George Paxinos + 1 more
    • English
    Since its first edition in 1982, the Paxinos and Watson rat brain atlas has become the most trusted source of accurate coordinates and anatomical information in laboratories throughout the world. It has been cited over 60,000 times, making it the most cited publication in neuroscience. The seventh edition incorporates new findings on developmental gene expression and presents the boundaries of neuromeres in sagittal sections.

  • Techniques in Protein Chemistry

    • 1st Edition
    • Choh Hao Li
    • English
    Hormonal Proteins and Peptides: Techniques in Protein Chemistry, Volume IX presents the various methods in protein chemistry and discusses their use for hormonal protein investigations. This book examines the approach to investigating biologically active peptides, which is based on a combination of chromatographic and fluorometric procedures. Organized into five chapters, this volume starts with an overview of the fluorometric methods for analysis of peptides and proteins with focus on their use in high performance liquid chromatography. This text then presents a thorough discussion on partition chromatography of proteins and peptides. Other chapters consider a comprehensive account of absorption and fluorescence techniques for the structural analysis of proteins. This book presents as well a comprehensive discussion on optical rotatory dispersion and circular dichroism methods and their application for the study of protein conformation. The final chapter deals with the historical aspects of fetuin and ultracentrifuge. This book is a valuable resource for chemists, biologists, endocrinologists, and physicians.

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