Marihuana Biological Effects

Contents

List of Participants

Foreword

Introduction

Marihuana and The Cell—Gabriel Nahas

I. Quantification of Cannabinoids and their Metabolites in Body Fluids and Tissues: Pharmacokinetics

Introduction to Quantification of Cannabinoids and their Metabolites in Biological Fluids

Applications of Mass Spectrometry in Cannabinoid Research

Identification and Measurement of Cannabinoids and their in Vivo Metabolites in Liver by Gas Chromatography—Mass Spectrometry

Relation Between Effects of Cannabinoid Derivatives On The Twitch Response of the Isolated Guinea Pig Ileum and their Psychotropic Properties

Delta-7-Tetrahydrocannabinol, A Non-Psychotropic Cannabinoid: Structureactivity Considerations in the Cannabinoid Series

The Radioimmunoassay of Cannabinoids; Its Clinical, Pharmacological and Forensic Applications

Determination of Cannabinoids in Urine by Emit Homogenous Enzyme Immunoassay

In Vitro Metabolism of Tetrahydrocannabinol by Rhesus Monkey Liver and Human Liver

Pharmacokinetics and Disposition of Delta-9-Tetrahydrocannabinol and Its Metabolites

Summary of Session

II. Cannabinoids and Cellular Metabolism

A. Isolated Cell Preparations

Inhibitory Effects of Delta-9-Tetrahydrocannabinol and Other Psychotropic Drugs On Cultured Lymphocytes

Inhibition by Thc of Thymidine Transport: A Plasma Membrane Effect

Effect of Delta-9-Tetrahydrocannabinol in Nucleoside and Amino Acid Uptake in Reuber H35 Hepatoma Cells

Cannabinoids: The Influence On Cell Proliferation and Macromolecular Biosynthesis

Difference in Response to Vitamin C Between Marihuana and Tobacco Smoke Exposed Human Cell Cultures

Marihuana and Cell Function—R. A. Carchman

Effect of (—) Delta-9-THC On ATPase Systems From Various Sources

(—)Trans-Delta-9-Tetrahydrocannabinol: Synaptosomal Phospholipids, Synaptosomal Plasma Membrane (Na+-K+)-ATPase, and Thiopentone Anaesthesia in Mice

Biochemical Alterations Induced by Cannabinoids in the Leydig Cells of the Rat Test Is in Vitro: Effects On Testosterone and Protein Synthesis

Influence of Delta-9-Tetrahydrocannabinol On Contraction Rate and Enzymatic Activity of Embryonic Heart Cells

B. In Vivo Preparations

Effects of Cannabis On Lungs

An Experimental Animal Model For Quantifying the Biologic Effects of Marijuana on the Defense System of the Lung

Cannabinoids and Membrane-Bound Enzymes

The Effects of Cannabinoids On Rat Brain Synaptosomes

The Effect of in Vivo Treatment With ( — ) Delta-1-Tetrahydrocannabinol, and other Psychoactive Drugs On the in Vitro Uptake of Biogenic Amines

Long Term Effects of Delta-9-Tetrahydrocannabinol in Mice

Hypoploid Metaphases in Cultured Lymphocytes of Marihuana Smokers

Observations in Chronic Hashish Users: Nuclear Aberrations in Blood and Sperm and Abnormal Acrosomes in Spermatozoa

Summary of Session II

III. Cannabis and Reproduction

Effects of Cannabis On Sex Hormones and Testicular Enzymes of The Rodent

Effects of Cannabinoids On Spermatogenesis in Mice

Effects of Marihuana Inhalation On Spermatogenesis of The Rat

Changes in Human Spermatozoa Associated With High Dose Marihuana Smoking

Effects of Cannabinoids On Reproductive Organs in the Female Fischer Rat

Effect of Delta-9-Tetrahydrocannabinol (Thc) On Female Reproductive Function

The Effect of A Crude Marihuana Extract On Embryonic and Foetal Development of the Rabbit

Effects of Cannabis On Fetal Development of Rodents

Reproduction in Rhesus Monkeys Chronically Exposed to Delta-9-THC

Summary of Session III

IV. Cannabis and The Brain

Ultrastructural and Biochemical Changes in Cns Induced by Marihuana

Brain Biochemical Alterations in Neonates of Dams Treated Orally Withdelta

Cannabis and The Brain With Special Reference to The Limbic System

Cannabis and Brain-Stimulation Reward

Cannabis and The Development of Tolerance

Pharmacological Similarities and Interactions Between Cannabis and Opioids

Delta-9-Tetrahydrocannabinol and the Quasi-Morphine Withdrawal Syndrome

Cannabis and Epilepsy

Marihuana and Epilepsy: Paradoxical Anticonvulsant and Convulsant Effects

Effects of Cannabis On Human EEGn

Effects of Marihuana On Pain and Verbal Memory: A Sensory Decision Theory Analysis

Residual Effects of High-Dose Cannabis Treatment On Learning, Muricidal Behavior ad Neurophysiological Correlates in Rats

Social Behavior of Rhesus Monkeys Chronically Exposed to Moderate Amounts of Delta-9-Tetrahydrocannabinol

Chronic Marihuana Smoking: Its Effect On Function and Structure of the Primate Brain

Summary of Session IV

Concluding Summary

Appendix—Cannabis and Alcohol: The Green and The Red

Author Index

Subject Index