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Books in Life sciences

Cisplatin
Current Status and New Developments
1st Edition
October 22, 2013
Archie W. Prestayko
English
Cisplatin: Current Status and New Developments is a collection of papers presented at a symposium sponsored by the University of Alabama in Birmingham Comprehensive Cancer Center and the Bristol Laboratories in Syracuse, ?ew York, and held on September 27-28, 1979, in Atlanta, Georgia. The symposium provided a forum for assessing developments with regards to cisplatin as an anticancer drug, with emphasis on its clinical application in a wide variety of adult and pediatric malignancies as well as the mechanism by which the drug appears to cause tumor cell death. Comprised of 39 chapters, this book begins with a preclinical overview of cisplatin, focusing on its mechanism of action, pharmacology, antitumor activity, analogs, and toxicity. The discussion then turns to the effects of cisplatin on DNA and the possible relationships to cytotoxicity and mutagenicity in mammalian cells; lethal activity of platinum compounds in combination with pyrimidine derivatives; and ultrastructural effects of cisplatin. Subsequent chapters focus on the rationale of combination chemotherapy; toxic side effects of platinum analogs; radiopharmacokinetic... of cisplatin; and the use of cisplatin for the treatment of malignancies such as ovarian cancer and advanced adenocarcinoma of the prostate. This monograph will be useful to oncologists and pharmacologists.
The Living Barrier
A Primer on Transfer across Biological Membranes
1st Edition
October 22, 2013
Roy J. Levin
English
The Living Barrier: A Primer on Transfer across Biological Membranes provides information pertinent to the movement of molecules across cell membranes. This book covers a variety of topics, including cell membrane, membrane transfer, water transfer, and movement of charged solutes. Organized into nine chapters, this book begins with an overview of the basic ideas of the cell membrane and reviews the experimental evidence about the structure of the cell membrane. This text then reviews the classical electron microscope pictures of membranes. Other chapters consider the interactions between electrical potentials and the movements of charged substances, which make the membrane transfer of these substances much more complicated than those of neutral molecules. This book discusses as well the aspects of water structure and its influence on membrane permeability. The final chapter deals with the methods by which membranes are synthesized. This book is a valuable resource for biochemists, physiologists, pharmacologists, and botanists.
Theory and Practice of Blood Flow Measurement
1st Edition
October 22, 2013
John P. Woodcock
English
Theory and Practice of Blood Flow Measurement presents the methods for determining the metrics of blood flow in the major vessels. This book is organized into two sections encompassing 16 chapters that discuss the theories behind the different techniques of flow measurement and the performance of flowmeters and their practical application to determining blood flow volume in the tissues and organs. Considerable chapters are devoted to various methods of blood measurement, including dilution, transport, and thermal techniques, as well as the effect of catheter sampling on the shape of indicator dilution curves. Other chapters are concerned with the possible errors in the application of indicator dilution techniques and the types of dilution indicator, and measurement of indicator concentration. A chapter is devoted to the advantages and disadvantages of thermistor flowmeter. The last chapter focuses on the design of a thermal dilution catheter. The book can provide useful information to physicists, bioengineers, surgeons, students, and researchers.
Models of Human Memory
1st Edition
October 22, 2013
Donald A. Norman
English
Models of Human Memory provides an overview of the state of knowledge on human memory models. The book begins with an introductory chapter on the basic stages of the memory system and the historical roots of memory models. The remaining chapters are organized into five parts. Part I on memory systems covers topics such as a system for perception and memory; multi-trace strength theory of memory; and a model for postperceptual verbal memory that postulates a single memory store, with multiple copies, called replicas, created in memory by rehearsal processes. Part II presents studies phoneme storage and word recognition. Part III on memory for associations examines the storage-retrieval theory for the memorizing processes and presents simple model of short-term memory (STM) for paired associates. Part IV on storage and retrieval mechanisms deals with mechanisms of repetition and rehearsal in short-term memory; models of recall and recognition; and memory search models. Part V presents a theory of human long-term associative memory; and examines conceptual and methodological interactions between information-processi... investigations of cognitive activity and attempts to build models of memory.
Cell Culture
1st Edition
October 22, 2013
P. Michael Conn
English
Methods in Neurosciences, Volume 3: Quantitative and Qualitative Microscopy is a collection of papers that deals with microscopic techniques in statistical measures. This volume describes microscopy using sophisticated stains and dyes to advance observation of tests and experiments. Section I describes autoradiography including micro chemical methods, high-resolution autoradiography, and single- or double-label quantitative autoradiography for use in imaging of brain activity patterns or determining cerebral physiology. Section II discusses the quantification of structures through statistical and computational methods including dynamic video imaging technology. Section III explains the use of tracers, toxins, or dyes in tracing neuronal connections. One paper addresses the use of small injections of axonally transported fluorescent tracers. Section IV explains staining technology such as using the silver impregnation method for frozen sections of human nervous tissue that are gathered from tissues preserved in formalin. Section V addresses freezing techniques and those using freeze-fracture methods in neurobiology. The text also discusses cryoprotection and other freezing methods to control ice crystals found in fixed or unfixed brain tissues. Section VI presents the combined and high-resolution methods in polarization microscopy and microscopic investigations. Cellular biologists, micro-chemists, and scientific researchers in the field of micro- and cellular biology will appreciate this book.
Field and Laboratory Guide to Tree Pathology
2nd Edition
October 22, 2013
Robert O. Blanchard + 1 more
English
The Second Edition of this classic text is completely up-to-date with new chapters, new information on diseases, updated citations, and revised taxonomy and terminology of the fungi, bacteria, and other organisms that affect trees. Field and Laboratory Guide to Tree Pathology presents field and laboratory techniques as well as basic information for students, foresters, plant scientists, and arboriculturalists on tree disease pathology. The revised edition includes expanded historical documentation, updated taxonomy and terminology for both pests and diseases, an entirely new introduction, new chapters on tree biology, general control strategies, and diagnostic techniques. A new section of color plates will help readers in the identification of tree pathogens. All the references have been comprehensively updated, and the exercises included for students have been revised, making this guide a useful tool for students, teachers, and practitioners interested in tree disease.
Principles and Practices for the Safe Processing of Foods
1st Edition
October 22, 2013
H J Heinz
David A. Shapton + 1 more
English
Principles and Practices for the Safe Processing of Foods presents information on the design, construction, and sanitary maintenance of food processing plants. This book also provides guidelines for establishing and implementing the Hazard Analysis Critical Control Points (HACCP) System and for training personnel in hygienic practices. This text is divided into 13 chapters and begins with the assessment of corporate policies concerning the controlled production of clean, wholesome foods in a sanitary manner. The next chapters deal with some of the requirements for safe food processing, including the establishment and implementation of HACCP rules, building status, sanitation, and personnel. A chapter briefly covers the structure of some microorganisms that affect safe food, such as viruses, bacteria, and fungi. This topic is followed by discussions of the biological factors underlying food safety, preservation, and stability; the principles and application of microbiological control methods; pathogenicity and pathogen profiles; and enzymes and their importance in food spoilage. The last chapters examine the aspects of microbiological safety in food preservation technologies and the criteria for ingredients and finished products. This book will prove useful to food manufacturers, policy makers, and public health workers.
Molecular Endocrinology
2nd Edition
October 22, 2013
Franklyn F. Bolander
English
Aimed at graduate level courses, this textbook provides students with a solid background in the basics of molecular endocrinology. Molecular Endocrinology, Second Edition, summarizes the area and provides an in-depth discussion of the molecular aspects of hormone action, including hormone-receptor interactions, second messenger generation, gene induction, and post-transcriptional control. Thoroughly revised and updated, the Second Edition includes new information on growth factors, hematopoietic-immune factors, nonclassical hormones, receptors, transduction, transcriptional regulation, as well as other relevant topics.Incorporating an abundance of new information, this text retains the self-contained, focused, and easily readable style of the First Edition. Professionals in related fields will also find this book to be a helpful summary and general reference source.
Brain Imaging
An Introduction
1st Edition
October 22, 2013
John R. Bradshaw
English
Brain Imaging: An Introduction presents diverse manifestations of brain disease as shown by neuroradiology. It discusses the full potential of new diagnostic techniques. It addresses the technique most appropriate for a given injury. Some of the topics covered in the book are the plain skull radiographs; plain-film tomography; radionucleic brain scanning; cerebral angiography; pituitary and parasellar lesions; sensory disorders; malignant glioma; the posterior fossa and cranial nerves; dementia and psychotic states; imaging tecniques in brain diagnosis; and metastatic disease. The definition of craniotomy is covered. The hyperostosis of sphenoid wing is discussed. The text describes the skull fracture, intracranial air, and leptomeningeal cyst. A study of the cerebral ultrasound and cerebral angiography are presented. A chapter is devoted to the angiographic pathology and computerized axial tomography. Another section focuses on the use of magnetic resonance imaging. The book can provide useful information to radiologists, doctors, physical therapists, students, and researchers.
Symposium on Clinical Pharmacology
Biochemical Pharmacology
1st Edition
October 22, 2013
William A. Creasey + 2 more
English
Symposium on Clinical Pharmacology reviews advances in clinical pharmacology, with emphasis on how to materially improve the efficacy of cancer chemotherapy. Topics range from absorption, protein binding, distribution, and excretion of antineoplastic drugs to factors affecting the biotransformation and activity of antitumor drugs. The transport of tumor-inhibitory agents across cell membranes is also examined, together with factors influencing drug selectivity and the mechanisms of clinical drug resistance. This volume is comprised of 23 chapters and begins with a brief summary of the different kinds of pharmacokinetic models and how detailed kinetic investigations of a drug in animals may provide further insight into modes of its clinical use. The next chapter considers the chief factors in determining the effective concentration of a drug at a receptor site as well as the duration and intensity of drug effect, citing antineoplastic agents as examples. The role of enzymatic activation and inactivation in drug selectivity is also discussed, along with the general mechanisms of clinical resistance to cancer chemotherapy; biochemical and pharmacological principles of combination chemotherapy; and the reaction and effects of nitrosoureas. This book will be of interest to clinicians, pharmacologists, and biochemists.

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