Life sciences print books and ebooks | Elsevier

The Path from Biomarker Discovery to Regulatory Qualification

1st Edition
July 16, 2013
Federico Goodsaid + 1 more
English
Paperback
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eBook
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The Path from Biomarker Discovery to Regulatory Qualification is a unique guide that focuses on biomarker qualification, its history and current regulatory settings in both the US and abroad. This multi-contributed book provides a detailed look at the next step to developing biomarkers for clinical use and covers overall concepts, challenges, strategies and solutions based on the experiences of regulatory authorities and scientists. Members of the regulatory, pharmaceutical and biomarker development communities will benefit the most from using this book—it is a complete and practical guide to biomarker qualification, providing valuable insight to an ever-evolving and important area of regulatory science. For complimentary access to chapter 13, 'Classic' Biomarkers of Liver Injury, by John R. Senior, Associate Director for Science, Food and Drug Administration, Silver Spring, Maryland, USA, please visit the following site: http://tinyurl.com/C...

Nonclinical Development of Novel Biologics, Biosimilars, Vaccines and Specialty Biologics

1st Edition
June 27, 2013
Lisa M. Plitnick + 1 more
English
Hardback
9 7 8 0 1 2 3 9 4 8 1 0 6
eBook
9 7 8 0 1 2 3 9 4 8 2 3 6

Nonclinical Development of Novel Biologics, Biosimilars, Vaccines and Specialty Biologics is a complete reference devoted to the nonclinical safety assessment of novel biopharmaceuticals, biosimilars, vaccines, cell and gene therapies and blood products. This book compares and contrasts these types of biologics with one another and with small molecule drugs, while incorporating the most current and essential international regulatory documents. Each section discusses a different type of biologic, as well as early characterization strategies, principles of study design, preclinical pharmacokinetics and pharmacodynamics and preclinical assays. An edited book that is authored by leading experts in the field, this comprehensive reference provides critical insights to all researchers involved in early through late stage biologics.

Advances in Drug Research

1st Edition
Volume 20
October 22, 2013
Bernard Testa
English
Hardback
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Paperback
9 7 8 1 4 8 3 2 3 4 9 2 2
eBook
9 7 8 1 4 8 3 2 6 5 4 3 8

Advances in Drug Research, Volume 20 focuses on the general themes of drug research and description of specific drug classes. This book is divided into four chapters. Chapter 1 discusses the extrapolation of toxicological and pharmacological data from animals to humans. The second chapter deals with the tissue binding of drugs, considering the relative ponderal importance of tissue versus blood macromolecules. The therapeutic use of plants and consumption of medicinal plants are elaborated in Chapter 3. The last chapter covers the field of histaminergic agonists and antagonists, describing breakthroughs such as H2-receptor antagonists, non-sedating H1-receptor antagonists, and H3-receptors. This publication is valuable to drug researchers and students interested in advances in drugs.

Thalamic Networks for Relay and Modulation

1st Edition
September 3, 2013
Diego Minciacchi + 2 more
English
Paperback
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Hardback
9 7 8 0 0 8 0 4 2 2 7 4 9
eBook
9 7 8 1 4 8 3 1 6 3 5 0 5

Thalamic Networks for Relay and Modulation is the third in a series that springs from an idea of Giorgio Macchi who wished to establish periodical updates on thalamic research by bringing to Italy investigators who would engage in an international sharing of ideas and experiences. It reflects the renewed interest in the modulation of thalamic relay activity by intrinsic and extrinsic sources, while continuing to underscore the essential role of the thalamus as the gatekeeper of the cerebral cortex and of the pathways to perception. The papers that form the substance of this book were presented at a Symposium held at the Catholic University, Rome, Italy, in September 1992, as a Satellite to the 15th Annual Meeting of the European Neuroscience Association. The volume is organized into four parts. Part I is basically concerned with developmental and evolutionary approaches. Part II highlights relay functions of visual, motor, and somatosensory relay nuclei and relay functions of the intralaminar nuclei. Part III deals primarily with the pharmacology of thalamic neurons. Part IV emphasizes the mechanisms that underlie the functional assembly of thalamic cells into collectively acting ensembles, largely revealed in rhythmic oscillations, and on the behavioral manifestations that accompany them.

The Principles of Forest Yield Study

1st Edition
October 22, 2013
Ernst Assmann
P. W. Davis
English
Paperback
9 7 8 1 4 8 3 1 1 8 5 1 2
eBook
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The Principles of Forest Yield Study: Studies in the Organic Production, Structure, Increment and Yield of Forest Stands reviews the progress that has been made in the field of forest yield studies, especially those concerning the organic production, structure, increment, and yield of forest stands. Topics covered include woody growth as part of the total produce of plant societies; growth and form of forest trees; constitution and development of stands; and forest stand structure, increment, and yield in relation to silvicultural treatment. This book is divided into five sections and begins with an overview of the history of forest yield studies, as well as the place of forest yield theory in forest science. Research objectives and methods employed in forest yield studies are outlined. The discussion then turns to the interactions between soil, climate and plant production; the social structure of tree crops; growth performance of tree crops in relation to site; and disturbances in the normal trend of increment. The use of fertilizers for amelioration and treatment of forest soils are discussed from the standpoint of yield studies. This monograph will be a useful resource for practitioners in forestry, the natural sciences, plant physiology, soil science, and meteorology.

Cardiovascular Review 1983

1st Edition
October 22, 2013
Gerald C. Timmis + 2 more
English
Paperback
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Hardback
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eBook
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Cardiovascular Review 1983 is an attempt to assimilate most of the clinically germane English-speaking cardiologie literature in as concise and timely a format as possible. Thus, this textual compendium of individual reports represents as current a summary of cardiologic thinking as the publishing process will allow. With 1625 references having been added to the 1982 edition, bringing the total to almost 7000, the Review constitutes not only as ready and comprehensive an updated reference as is probably available, but also a bibliographic resource. The table of contents has been constructed to reflect the order in which the preponderance of cardiologic literature appears. Thus, ischemic heart disease, valvular heart disease, arrhythmias, and conduction defects have been assigned a high priority reflected by their location in the first few sections of this book. Thereafter, topics ranging from acromegaly to tumors of the heart have been addressed in alphabetical order.

Beyond Drugs

1st Edition
October 22, 2013
Stanley Einstein
English
Paperback
9 7 8 1 4 8 3 1 2 5 0 3 9
Hardback
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eBook
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Beyond Drugs is a 12-chapter book that first presents the critical issues and definitions involved in the study of drug abuse. Subsequent chapters describe the effects of drugs, the drug users, and the contemporary drug culture. Other chapters talk about education, prevention, treatment, and legal control efforts of drug abuse. This book will be useful to those who are generally concerned about drug abuse.

Nervous System Theory

1st Edition
October 22, 2013
K. N. Leibovic
English
Paperback
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Hardback
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eBook
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Nervous System Theory: An Introductory Study focuses on the nervous system theory, stressing the means for understanding the nature of the biological system rather than the elaboration of mathematical theories. This book begins with a discussion on single-cell responses, followed by a discussion of sensory information processing that leads into models of perceptual processes and their possible neural bases. This text concludes with some general principles and theoretical investigations relating to units that make up a nervous system, through a sensory pathway and central structures. The peripheral stimuli that explain the operations of the brain are also described. This publication is a good reference for neurologists, medical practitioners, and researchers conducting work on the nervous system theory.

Marine Mycology

1st Edition
October 22, 2013
Jan Kohlmeyer + 1 more
English
Paperback
9 7 8 1 4 8 3 2 4 1 8 8 3
Hardback
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eBook
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Marine Mycology: The Higher Fungi deals with the higher marine fungi, i.e., Ascomycotina, Basidiomycotina, and Deuteromycotina. This book combines features of a monograph with those of a text. It includes sections on ecological groups of fungi and other topics, such as phylogeny, ontogeny, physiology, and vertical and geographical distribution, providing information on known facts and open questions. The taxonomic-descriptiv... part contains complete descriptions of each genus and species, together with substrates, range, etymology of generic and specific names, and literature. There are keys for all species within a given genus, and a general illustrated key leads to the individual species. The taxonomic section is based on examinations of almost all of the filamentous marine fungi, and unpublished data on new hosts and geographical distributions are included for many species. The filamentous higher marine fungi are represented by 149 Ascomycetes, 4 Basidiomycetes, and 56 Deuteromycetes. The majority, namely 191 (91%) of the filamentous fungi, are obligately marine species, whereas the remainder are facultatively marine. One new species and seven new combinations are proposed. The yeasts are treated in a separate chapter and comprise 177 species or varieties.

Agricultural Insurance

1st Edition
October 22, 2013
P. K. Ray
English
eBook
9 7 8 1 4 8 3 1 9 0 5 7 0

Agricultural Insurance: Principles and Organization and Application to Developing Countries states that agriculture is subject to special elements of uncertainty. The risk inherent in agriculture has been exhaustively discussed in the text. Risks in agriculture can be characterized as property risk and personal risk. Natural risk such as storms, plant diseases, and insect pests is another topic covered in the book. A type of risk that is identified as drought, inundation, frost and freeze, hail, and tornado is called meteorological risk. The book also discusses another form of risk, which is named social risk. Occurrence such as fire, theft or burglary, embezzlement, and technological change belongs to this type of risk. A chapter of the book is devoted to the ways on how to remedy the risks enumerated. Another section of the book defines the term insurance. This section introduces such topic as probability, uncertainty, and the law of large numbers. The book notes that in order for agricultural risk to be insurable, it must satisfy some parameters. The text will provide valuable insight for farmers, financial planners, statisticians, students, and researchers in the field of risk management.

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