Preface to Fourth (1983) EditionPreface to First (1979) EditionPreface to Second (1980) EditionPreface to Third (1982) EditionIschemic Heart Disease I. Natural History Angina Myocardial Infarction Aneurysm The Changing Mortality of Coronary Heart Disease Progression of Coronary Atherosclerosis Regression II. Epidemiology and Risk Factors Age, Sex, and Genetics Alcohol Blood Pressure Coffee Contraceptives and Endogenous Endocrine Influences Diabetes Mellitus Hematocrit Lipids Obesity Physical Fitness Psychosocial Risks Radiation Retiring Risk Intervention Smoking Trace Metals and Minerals (including Water Hardness) Uric Acid III. Clinical Aspects of Ischemic Heart Disease Angina Arrhythmias and Conduction Defects Asymptomatic or Unrecognized Ischemia and Myocardial Infarction Bezold-Jarisch Reflex Diabetes Extension vs Expansion of Myocardial Infarction Fever Heart Size Hypertension Hyperventilation Hypoxemia Humoral Control Ischemic Cardiomyopathy Left Main Coronary (LMC) Disease and "Left Main Equivalent" (LME) Pericarditis Peripheral Vascular Disease Prehospital Course Premonitory Symptoms (Prodrome) of an Acute Coronary Event Prognosis and Survival Pulmonary Edema Pulmonary Function Pulse Renal Disease Retinal Changes as an Indicator of Coronary Heart Disease Rupture Sex Shock Site of Infarction and Its Significance Sudden Death and Prehospital Cardiac Arrest Thromboembolism Valsalva Maneuver Ventricular Aneurysm and Thrombosis Young People with Coronary Heart Disease IV. Pathogenesis, Pathophysiology, and Pathology Alcohol Anomalies of Coronary Arteries Aortic Regurgitation Arteriovenous Fistula Atherogenesis Atrial Involvement Collaterals Complement Coxsackie Virus Drugs and Coronary Heart Disease Metabolism of Ischemia Myocardial Bridging Myocardial Oxygen Supply and Demand Nephrotic Syndrome Pathologic Anatomy and Its Significance Physiology of Coronary Heart Disease (Hemodynamics) Radiation Thromboembolism, Platelets, Prostaglandins, and Vasospastics Mechanisms Ventricular Function V. Diagnosis History Physical Examination Bayes' Theorem. The Effect of Pretest Likelihood of Disease on the Utility of Diagnostic Tests The Electrocardiogram at Rest Ambulatory Monitoring (Dynamic Electrocardiogram; DCG) Transtelephonic Monitoring Exercise (Stress) Electrocardiography The Chemistry of Ischemia Scintigraphy (Radioisotopic Imaging) Echocardiography Fluoroscopy Systolic Time Intervals Sizing of Infarction Cardiac Catheterization (Hemodynamic, Cardiodynamic, and Coronary Arteriographic Studies) VI. Therapy Changing Patterns of Therapy Medical Management Special Therapeutic Situations SurgeryValvular Heart Disease I. Etiology and Incidence II. Clinical Aortic Stenosis (AS) Aortic Regurgitation (AR) Mitral Stenosis (MS) Mitral Regurgitation (MR) Mitral Annular Calcification Mitral Valve Prolapse (MVP; Click Syndrome) Tricuspid Valve Prolapse (Multiple Floppy Valves) Tricuspid Stenosis (TS) and Regurgitation (TR) Embolic Complications The Myocardial Impairment and Hypertrophy of Valvular Disease Diagnosis Prognosis III. Therapy of Valvular Heart Disease Medical Pacing SurgeryArrhythmias and Conduction Defects I. Cardiac Rhythm in Healthy Populations II. Supraventricular Arrhythmias Paroxysmal Supraventricular Tachycardia (PSVT) Atrial Flutter Atrial Fibrillation (AF) Atrial Dissociation Atrial Asystole Chaotic Atrial Mechanisms Junctional Mechanisms Hemodynamics of Atrioventricular Dissociation III. Ventricular Arrhythmias Etiology and Mechanisms Risk and Natural History Site, Significance, and Prognosis Associate Conduction Defects Ventricular Tachycardia (VT) Ventricular Fibrillation (VF) IV. Diagnosis Electrocardiogram Ambulatory Recordings Exercise Testing Electrophysiology Studies Echocardiogram V. Long Q-T Syndromes (LQTS) and Torsade de Pointes Criteria Etiology and Pathophysiology Clinical Pathology Treatment Results and Prognosis VI. Conduction Classification Atrial Atrioventricular Block (AVB) His-Purkinje Conduction, Bundle Branch, and Fascicular Block Accelerated Conduction [Wolff-Parkinson-White (WPW), Lown-Ganong-Levine (LGL), and Concealed Accessory Pathways] Conduction as Affected by Electrolytes VII. Sick Sinus Syndrome (including Carotid Sinus Syncope) Etiology and Pathology Clinical Characteristics Associated Arrhythmias and Conduction Defects Drug Effects Diagnosis Risk and Prognosis VIII. Treatment of Arrhythmias and Conduction Defects Indications for Treatment General Principles Results of Treatment Antiarrhythmic Agents Pacemaker Therapy Neuromechanical Maneuvers Atrial Ventricular Ablation by Catheter Techniques SurgeryAcromegalyAgingAlcoholAmyloidosisAnemia (including Sickle Cell Anemia)Aneurysms and Dissections of Great VesselsAnorexia NervosaArteritisAthletic HeartBartter's SyndromeBehcet's SyndromeCarcinoidCardiomyopathy I. Hypertrophic Cardiomyopathy (HCM) Etiology Pathology Ventricular Function and Hemodynamics Mechanism of Obstruction Cavity Obliteration Mechanism of Systolic Anterior Mitral Motion (SAM) and Mitral Prolapse Apical Hypertrophy Symptoms and Clinical Course Arrhythmias and Conduction Defects Hypertrophic Cardiomyopathy in Childhood Natural History, Prognosis, and Sudden Death Coronary Artery Disease and Hypertrophic Cardiomyopathy Other Associated Cardiac Diseases Endocarditis Diagnosis Treatment II. Congestive (Dilated) Cardiomyopathy Etiology Prevalence and Prognosis Clinical Aspects Electrophysiology Treatment III. Restrictive CardiomyopathyCardiopulmonary Resuscitation (CPR)ChemotherapyCirrhosisCongenital Heart Disease in the AdultCongestive Heart Failure and Pulmonary Edema I. Pathogenesis and Pathophysiology II. Positive Inotropic Agents Digitalis Other Positive Inotropic Agents II. Diuretics and Cathartics Potassium-Wasting Diuretics Potassium-Sparing Diuretics Mode and Duration of Action General Clinical Considerations Side Effects IV. Unloading Programs Physiology of Unloading Clinical Response Precautions Specific Agents Comparative Effects of Vasodilators V. Miscellaneous Agents VI. Beta Blockers VII. Calcium InhibitorsCollagen and Connective Tissue Disease I. Systemic Lupus Erythematosus (SLE) II. Scleroderma III. Periarteritis Nodosa IV. Polymyositis V. Ehlers - Danlos Syndrome VI. Rheumatoid Arthritis VII. Marfan Syndrome VIII. MucopolycaccharidosesElectrocardiography I. P Wave II. The QRS Interval R Wave Progression Hemodialysis Hypertrophy Axis Shifts and Conduction Defects Hemodynamic Correlates III. The QT Interval IV. The ST Segment Injury Patterns Early Repolarization Syndrome The Juvenile Pattern V. T Wave VI. Voltage VII. Osborne Wave VIII. Vectorcardiogram IX. Effects of AgingEndocarditis I. Bacterial Clinical Specific Risks Bacteriology Diagnosis Prognosis Special Therapeutic Considerations Prophylaxis II. Nonbacterial Fungal Endocarditis Parasitic Endocarditis Rickettsial Endocarditis Marantic (Nonbacterial) EndocarditisFabry's Disease (Angiokeratomea Corporis Diffusum Universale)Heat StrokeHemochromatosisHypereosinophilic SyndromesHypertension I. Prevalence and Significance II. Etiologic Correlates III. Hemodynamics and the Evolution of Hypertension Earliest Derangements Borderline and Labile Hypertension Hyperkinetic Essential Hypertension Hypertension in the Elderly IV. The Humoral Aspects of Hypertension Pathophysiology Etiologic Endocrine Mechanisms V. Neurovascular Sspects of Hypertension Autonomic Manipulation Baroreceptors Vascular Reactivity VI. Renal and Renovascular Mechanisms VII. Volume Overload Hypertension VIII. Miscellaneous Hypertensive Relationships Alcohol Contraceptives Other Chemicals and Drugs Diabetes Diet, Salt, and Obesity Gaisbock's Syndrome Pediatrics Pregnancy Quadriplegia Race IX. Malignant (Accelerated) Hypertension X. Anatomic and Clinical Consequences Left Ventricle Right Ventricle XI. Measurement XII. Prediction, Detection, and Diagnosis XIII. Treatment Indications and Special Therapeutic Considerations Pharmacologic Therapy Nonpharmacologic TherapyHypotensionMagnesiumMarfan's SyndromeMarijuanaMucocutaneous Lymph Node Syndrome (MCLS; Kawasaki's Disease)Muscular DystrophyMyocarditisMyxedemaObesityPericardium I. Function II. Acute Pericarditis Etiology Diagnosis III. Constrictive-Effusive Pericarditis Etiology Clinical Aspects and Diagnosis IV. Pericardial Effusion and Tamponade Clinical Aspects Diagnosis TreatmentPeripheral Vascular Disease I. Arterial Disease Etiology and Pathogenesis Physical Diagnosis Pharmacotheraphy II. Venous DiseasePregnancyPulmonary Disease I. Alveolar Hypoventilation Pathophysiology Clinical Aspects Treatment II. Chronic Obstructive Lung Disease (COPD) Natural History Clinical Ventricular Function Hemodynamics Heart Size Adenoids Arrhythmias Electrocardiogram Echocardiogram Pulmonary Embolism Therapeutic Considerations III. Iatrogenic Lung Disease IV. Noncardiac Pulmonary Edema V. Pulmonary Hemorrhage VI. Adult Respiratory Distress Syndrome (ARDS) Pathophysiology Adaptation to Oxygen Diagnosis Gastrointestinal Complications Therapy VII. Pleural EffusionPulmonary Vascular Disease I. Pulmonary Embolism (PE) and Peripheral Venous Disease Clinical Aspects Diagnosis Prognosis Treatment II. Pulmonary Hypertension Classification Etiology Pathophysiology Symptoms Diagnosis Prognosis TherapyRadiationRheumatic FeverRheumatoid ArthritisSarcoidosisSounds and MurmursStrokeThrombocytopenic PurpuraThyroidTime Intervals, Systolic and Diastolic I. Systolic Hemodynamic Correlation Electrocardiographic Correlation Clinical Correlation II. Diastolic Time IntervalsTraumaTumors of the HeartSupplements I-VIIIAbbreviationsGuide to Journal AbbreviationsIndex