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Elsevier

Books in Life sciences

  • The Peptides

    Volume II Synthesis, Occurrence, and Action of Biologically Active Polypeptides
    • 1st Edition
    • Eberhard Schröder + 1 more
    • English
    The Peptides, Volume II: Synthesis, Occurrence, and Action of Biologically Active Polypeptides focuses on the synthesis of biologically active polypeptides and analogues. The publication first offers information on linear peptides and heterodetic cyclic peptides. Discussions focus on depsipeptides, polycyclic and monocyclic disulfides, naturally occurring biologically active peptides, glandular hormones, and tissue hormones. The text then ponders on homodetic cyclic peptides, including homodetic cyclic homomeric peptide antibiotics, polycyclic biologically active polypeptides, and homodetic cyclic heteromeric peptide antibiotics. The manuscript takes a look at the problems related with the synthesis of biologically active polypeptides, giving emphasis to a number of movements which elaborated on the matter and the advancements of preparative techniques and approaches leading to the purification of intermediates and end products. The publication is a valuable reference for researchers interested in the occurrence, synthesis, and action of biologically active polypeptides.

  • Oxygenases

    • 1st Edition
    • Osamu Hayaishi
    • English
    Oxygenases focuses on the processes, methodologies, technologies, and approaches involved in oxygenases, including its distribution in animals, plants, and microorganisms and its role in the metabolism of aromatic, cyclic, and aliphatic compounds. The selection first offers information on the history and scope of oxygenases, methodology of oxygen isotopes, and phenolytic oxygenases. Discussions focus on the separation and purification of compounds for isotopic analysis; general properties and mechanisms of action of oxygenases; physiological significance of oxygenases; dehydrogenases, oxidases, and oxygenases; and problems and restrictions in the use of oxygen-18. The text then examines aromatic hydroxylations, oxygenases in lipid and steroid metabolism, and bacterial oxidation of hydrocarbons. Topics include anaerobic oxidation of alkanes, involvement of molecular oxygen in hydrocarbon utilization, steroid hydroxylation mechanisms, oxygenases in the biosynthesis of steroid hormones, conversion of dopamine to norepinephrine, and general discussion of mechanism of aerobic hydroxylation reactions. The selection is a valuable reference for researchers interested in the process of oxygenases.

  • Immunocytochemistry

    Practical Applications in Pathology and Biology
    • 1st Edition
    • Julia M. Polak + 1 more
    • English
    Immunocytochemistry: Practical Applications in Pathology and Biology focuses on the processes, principles, methodologies, and approaches involved in the applications of immunocytochemistry in pathology and biology. The selection first takes a look at the development and scope of immunocytochemistry; techniques and practice used in immunocytochemistry; and raising and testing antibodies for immunocytochemistry. The book then ponders on raising antibodies to small peptides, use of semithin frozen sections in immunocytochemistry, and colloidal gold probes in immunocytochemistry. Discussions focus on the production of gold probes, localization of mouse serum albumin in the mammary gland, immunogens and the immune response, production of antisera, and antibody specificity in immunocytochemistry. The publication takes a look at double immunoenzymatic labelling, lectin histochemistry, immunocytochemical localization of noradrenaline, adrenaline, and serotonin, and immunocytochemistry of cell and tissue cultures. Immunocytochemistry in endocrine pathology and indirect immunofluorescence in the study and diagnosis of organ-specific autoimmune diseases are also discussed. The selection is a dependable source of information for researchers interested the practical applications of immunocytochemistry in pathology and biology.

  • Normal and Malignant Cell Growth

    Recent Results in Cancer Research: Fortschritte der Krebsforschung, Progrès dans les Recherches sur le Cancer
    • 1st Edition
    • R. J. M. Fry + 2 more
    • English
    Normal and Malignant Cell Growth is a compendium of papers from the "Proceedings of the Third Cancer Training Grant" of the University of Chicago that deals with the processes associated with malignant neoplasia, as well as the cell proliferation kinetics of normal tissues. One paper presents the techniques used in the study on the proliferation kinetics of hemopoietic stem cells, suggesting that the hemopoietic stem cell population is not homogenous but consists of a "primitive pluripotential stem cell." A series of experiments at the Brookhaven National Laboratory investigates the relationship of cell survival, specifically that of stem cells, to the survival of the irradiated test animal. One result of the experiment shows a rapid migration of a number of stem cells from shielded marrow into unshielded marrow at the pressure of a rapid circulating pool. The numbers of stem cells are somewhat dependent on the dose given to the unshielded marrow, and are greater with the greater dose. Another paper also investigates the four methods that are used in the study of cellular kinetics in human tumors. This compendium can prove helpful for biochemists, micro-biologists, cellular researchers, and academicians involved in the study of cellular biology, physiology or oncology.

  • Differential Oral Diagnosis in Systemic Disease

    • 1st Edition
    • Alvin F. Gardner
    • English
    Differential Oral Diagnosis in Systemic Disease focuses on oral manifestations of systemic disease, including glomerulonephritis, hepatitis, cirrhosis, and lung infection. The publication first takes a look at the diseases of the heart and blood-vessels, respiratory tract, and genito-urinary system correlated to the oral tissues. Topics include metastatic neoplasms from the kidney to the oral region, malignant neoplasms of the kidney, glomerulonephritis, metastases of neoplasms of the lungs to the oral cavity, dental sepsis and lung infection, thrombophlebitis, and congenital anomalies of the heart. The manuscript ponders on the diseases of the liver and biliary tract and gastro-intestinal tract correlated to the oral tissues and diseases of the hematopoietic system. Discussions focus on oral manifestations of alterations in white blood-cells and red blood-cells, oral manifestations of diseases of the gastro-intestinal tract, diseases of the stomach and the intestine, cirrhosis of the liver, correlation of fatty change of the liver to dentistry, and transmission of viral hepatitis correlated to dentistry. The book is a dependable reference for dentists and physicians wanting to study the oral manifestations of systemic disease.

  • The Chemistry and Metabolism of Drugs and Toxins

    An Introduction to Xenobiochemistry
    • 1st Edition
    • Michael Briggs + 1 more
    • English
    The Chemistry and Metabolism of Drugs and Toxins: An Introduction to Xenobiochemistry covers all chemical aspects of the interaction between an organism and foreign compounds. This book provides information pertinent to the fundamental aspects of human xenobiochemistry. Organized into four chapters, this book begins with an overview of the commonly used substances and mentions their actions and side-effects. This text then explains the various classes of pharmaceutical products and discusses the interactions between foreign compounds that may be of clinical significance. Other chapters consider the metabolism of selected pharmaceuticals and examine the addition of foreign compounds to foods as flavors, colors, etc. This book discusses as well the metabolism of food carcinogens as well as the metabolism of food toxins. The final chapter deals with the different enzymic activities in snake venoms. This book is a valuable resource for biologists, biochemists, microbiologists, pharmacologists, organic chemists, research scientists, and research workers.

  • Gel Electrophoresis of Proteins

    • 1st Edition
    • Michael J Dunn
    • English
    Gel Electrophoresis of Proteins focuses on the techniques, methodologies, reactions, and approaches involved in gel electrophoresis of proteins. The selection first covers steady-state gel electrophoresis systems and one-dimensional PAA-gel electrophoretic techniques to separate functional and denatured proteins. Discussions focus on affinity electrophoresis, structure and physico-chemical properties of polyacrylamide gels, moving boundary electrophoresis, isotachophoresis, fundamental steady-state electrophoresis systems, and fundamental properties of steady-state electrophoresis systems. The text then reviews conventional isoelectric focusing and immobilized pH gradients and high resolution two-dimensional polyacrylamide-gel electrophoresis. Topics include production of narrow pH gradients, extended pH gradients, polymerization kinetics, IEF in agarose matrices, titration curves, two-dimensional electrophoresis under non-denaturing conditions, and IEF in polyacrylamide matrices. The book tackles quantifying patterns from two-dimensional PAGE, protein staining and detection methods, and immunoelectrophoreti... methods. Concerns include post-electrophoretic organic protein stains, silver and enzyme stains, detection of radioactive proteins, and programming languages. The selection is highly recommended for researchers wanting to conduct studies on gel electrophoresis of proteins.

  • Control of Energy Metabolism

    • 1st Edition
    • Britton Chance + 2 more
    • English
    Control of Energy Metabolism: A Colloquium of the Johnson Research Foundation focuses on the processes, reactions, and approaches involved in the control of energy metabolism. The selection first offers information on the respiratory chain as a model for metabolic control in multi-enzyme systems, dynamics and control in cellular reactions, and computer-based analysis of biochemical data. The text then explores purification and properties of rabbit skeletal muscle phosphofructokinase; multiple forms of heart phosphofructokinase; and mechanisms of inhibition and activation of phosphofructokinase in Novikoff ascites tumor cells. Discussions focus on the properties of purified phosphofructokinase; effect of heart extracts on reactivation of phosphofructokinase; active and inactive forms of phosphofructokinase; and effect of hexose phosphate and adenylic nucleotides on reactivation of phosphofructokinase. The manuscript takes a look at enzyme and metabolite profiles; coordinated stimulation of hexokinase and phosphofructokinase by phosphate in a reconstituted system of glycolysis; control of hexokinase in ascites tumor glycolysis; and cation flux across the mitochondrial membrane as a possible pacemaker of tissue metabolism. The selection is a vital reference for biochemists and researchers interested in the control of energy metabolism.

  • The Status of Enzymes and Hormones in Therapy

    • 1st Edition
    • G. F. Walker
    • English
    The Status of Enzymes and Hormones in Therapy reviews the status of therapy with enzymes and hormones, with emphasis on endocrine preparations of thyroid and parathyroid, ovarian hormones, pituitary hormones, thymus, and suprarenal glands as well as testis, spleen, brain and muscle tissue, and other organs such as the bile and placenta. The landmarks used are the British Pharmacopoeia, the British Pharmaceutical Codex published in September 1934, and clinical records selected from the literature. Comprised of two chapters, this book begins with an introduction to endocrine therapy, focusing on the need for clinicians to properly assess the clinical potency of the remedies they use based on considerations such as whether they clearly recognize in their patient a hormonic lack, or whether the preparation is smoothly active when administered by the route they propose. The second chapter deals with various endocrine preparations, including commercial preparations of thyroid; ovarian and pituitary hormones; stomach; pancreas; bone marrow; hemoglobin; and pineal, mammary, lymphatic, and prostate glands. This monograph is intended for clinicians interested in the therapeutic uses of enzymes and hormones.

  • The Plasma Proteins

    Isolation, Characterization, and Function
    • 1st Edition
    • Frank W Putnam
    • English
    The Plasma Proteins, Volume I: Isolation, Characterization, and Function focuses on the reactions, properties, characteristics, and transformations of plasma proteins. The selection first offers information on the fractionation and isolation of purified components by precipitation methods and electrophoretic and ultracentrifugal analysis of normal human serum. Discussions focus on correlation of electrophoretic and ultracentrifugal results, electrophoretic analytical methodology and results, parameters influencing protein solubility, and techniques for the separation of proteins by precipitation methods. The text then ponders on the chromatography of plasma proteins and chemical composition and molecular parameters of purified plasma proteins. The manuscript elaborates on plasma albumin and macroglobulins and high molecular weight antibodies. Topics include immunological properties, physical and chemical properties of normal and pathological macroglobulins, purity, homogeneity, and variability, denaturation behavior, and sulfhydryl groups, mercaptalbumin, and the mercury dimer. The book then examines glycoproteins and metal-binding plasma proteins and cation transport. The selection is a highly recommended reference for biochemists and clinicians interested in plasma proteins.

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