Life sciences print books and ebooks | Elsevier

The Funding of Biopharmaceutical Research and Development

1st Edition
October 31, 2013
David R Williams
English
Hardback
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eBook
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The funding of biopharmaceutical research and development provides a comprehensive critical review of the funding of research and development (R&D) in the human biopharmaceutical market sector. It addresses both private and public funding sources available in the US and internationally. The biopharmaceutical market is among the most research-intensive market sectors globally. Clinical researchers face a multitude of public and private funding options with respect to bringing their idea or innovation to market. These funding options are continually changing and complex, and are expected to decrease in the near future. A lack of understanding of the scale, scope, and inner workings of the funding aspects of R&D can, at times, act as a barrier for all involved, and can slow down or even eliminate the R&D process. The book lessens these barriers by describing the theoretical underpinnings, present practice, and trends in R&D funding in this market sector, both in the US and internationally. This includes a review and discussion of public-private partnership activity and their inner-workings, noting the complementary relationship between public and private funding. The book also contains an overview of the inner-workings of strategic alliance activity, including the advantages and disadvantages for each party. It goes on to provide an outline of venture capital activity, detailing the methods by which venture capital firms raise capital and are organized, a description of the venture capital-entrepreneur arrangement, and the effects of this arrangement. The book also presents an overview of the IPO process and the various fates of firms going public.

Bacterial Cellular Metabolic Systems

1st Edition
March 26, 2013
K. Shimizu
English
Hardback
9 7 8 1 9 0 7 5 6 8 0 1 5
eBook
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The metabolic regulation of a cell system is of critical importance in systems biology, and a robust model of these mechanisms is essential in predicting the effects on the metabolism of both the culture environment and the knockout of specific genes. Bacterial cellular metabolic systems focuses on this highly topical subject in relation to culture environment and provides a detailed analysis from gene level to metabolic level regulation, as well as offering a discussion of the most recent modelling approaches. The book begins with an introduction to metabolic mechanisms and to the metabolic regulation of a cell, before moving on to discussing the action of global regulators in response to a specific culture environment. The second half of the book examines conventional flux balance analysis and its applications, 13C-metabolic flux analysis, and the effect of a specific gene knockout on the metabolism.

Food Legislative System of the UK

1st Edition
October 22, 2013
Stephen J. Fallows
English
Paperback
9 7 8 0 4 0 7 0 1 5 4 0 1
eBook
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Food Legislative System of the UK discusses the principles underlying the country's food laws, the historical context of today's food legislation, and the process for amendments in legislation. The book also reviews the influences on the system such as those arising from interest groups, the changing diet, and health environment. In addressing the Food Legislative System of the United Kingdom, the book tackles various examples of food legislation and numerous food- related advisory bodies. Industry, consumer, or enforcement pressures can initiate changes and modifications of laws. Once ministers are convinced that a prima-facie case exists for amending food legislation, they will seek advice from various authorities; make a draft, and present it for full parliamentary procedure. For example, the "Food and Environment Bill" has passed through Parliament by ministers representing the Ministry of Agriculture, Fisheries and Food, while the "Food Bill" has gone through another route with the chief legal officers and company. The book emphasizes the mechanisms through which change is achieved, as well as the points when opportunities exist for interest groups to make their views known to the decision makers. The book can be helpful for food lobbyists, consumer food groups, nutritionists, political scientists, and heads of food and welfare organizations.

Infant Nutrition

1st Edition
October 22, 2013
F. W. Clements
English
Paperback
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eBook
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Infant Nutrition: Its Physiological Basis covers the physiological aspects of the nutrition of the fetus and young infant. This book is composed of 12 chapters that evaluate the data on the physical and chemical properties of the human and cow’s milk. It effectively addresses the aspects of tissue metabolism and the composition of a new born infant. The first chapters deal with the factors affecting placenta permeability; features of placenta; maternal supply and placental transmission of individual nutrients; secretion and components of human milk; and the constitution, chemical, and biological properties of milk. A comparison of the amino acid content of human and cow’s milk is also covered. Other chapters consider the analysis of the sucking and swallowing motion of the infant, as well as the physiological weight loss of the neo-natal period. The calorie and nutritional requirement of infants and children are presented. The last chapter is devoted to the protein requirements of young infants. The book can provide useful information to doctors, pediatricians, students, and researchers.

Evaluation of Drug Activities

1st Edition
October 22, 2013
D R Laurence + 1 more
English
eBook
9 7 8 1 4 8 3 2 6 2 8 4 0

Evaluation of Drug Activities: Pharmacometrics, Volume 2 provides information pertinent to the fundamental aspects of pharmacometrics. This book covers a variety of topics, including anticholinesterases, antitussives, cardioactive agents, diuretics, dermatological agents, and estrogens. Organized into 21 chapters, this volume begins with an overview of anticholinesterases and its pharmacological and physiological actions. This text then examines the diversity of methods for evaluating antitussive drugs, which is related to the complexity of cough reflexes. Other chapters consider tests for cardioactive substances of three general classes, namely, the cardiac glycosides, the coronary vasodilators, and the anti-arrhythmics. This book discusses as well the introduction of many diuretics into therapeutic practice during the past years bears witness to the convenience and success of the tests available for assessing drugs of this class. The final chapter deals with drugs affecting lipid levels in plasma. This book is a valuable resource for chemists, physiologists, pharmacologists, and clinicians.

Biology of Insect Eggs

1st Edition
October 2, 2013
H. E. Hinton
English
eBook
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Biology of Insect Eggs is a three-volume account of the biology of insect eggs and covers topics ranging from oviposition and respiratory systems to the respiratory efficiency of egg plastrons. Hydropyles and water relations are also discussed, along with colleterial glands, enemies of insect eggs, and devices used by insects to defend their eggs against enemies. The first volume of this book begins with an overview of a number of controversial points related to insect eggs, such as size of eggs, the kinds of metamorphosis, apolysis and ecdysis, and arrangement of orders of insects. The second volume contains chapters that deal with the structure of the female reproductive system; vitellogenesis; and the development of the micropylar complex. It also provides an account of the eggs of each order of insects, including Ephemeroptera, Orthoptera, and Cheleutoptera as well as Phthiraptera, Hemiptera, and Coleoptera. The third volume is the index to subjects, species, and the bibliography which contains more than 4,000 entries. This monograph will be of interest to biologists and entomologists.

Aspects of Neural Ontogeny

1st Edition
October 22, 2013
A. F. W. Hughes
English
Paperback
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Hardback
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eBook
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Aspects of Neural Ontogeny focuses on the interaction between the nervous system and peripheral organs during development, including history and development of neurons and the functions of nerves and muscles. The book first offers information on the development of neurons, including formation and growth of nerve fibers; growth cone and the extension of nerve fibers; history of the neuron theory; and path of nerve fibers. The manuscript then elaborates on the innervation of the tetrapod limb and the center and periphery. Discussions focus on the relationships between the ventral horn and muscles of the limb; experimental studies on limb plexus and limb nerves; and relationships between spinal nerves and limb muscles. The publication takes a look at the ontogeny of behavior, as well as pattern of motility, spontaneous movements, tetrapod limb, and experimental studies. The book is a dependable reference for readers interested in neural ontogeny.

Comparative Neuropathology

1st Edition
October 22, 2013
J. R. M. Innes + 1 more
English
eBook
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Comparative Neuropathology focuses on documented accounts of neurologic diseases and congenital defects in animals. The book first offers information on neuropathology, neuroanatomy, and cerebrospinal fluid (CSF). The domesticated animals that have CSF include horses, dogs, pigs, cats, rabbits, and cattle. The text then elaborates on neurologic diseases of apes and monkeys. Discussions focus on confluent leucoencephalosis and perivascular myelosis, encephalopathies and dysenteric syndromes, meningitis, epilepsies, tuberculosis, cerebellar atrophy and experimental manganese poisoning, and choreic syndrome in baboons with corticostriate encephalitis. The publication examines the diseases of the skeletal muscle and hypophysis, including general reactions of muscles to injuries, congenital defects, muscular dystrophies, changes in muscle associated with specific diseases, and tumor. The manuscript also takes a look at inherited diseases and congenital anomalies, protozoan and bacterial infections, and demyelinating or myelinoclastic diseases. The text is a dependable reference for readers interested in comparative neuropathology.

Plant Proteins

1st Edition
October 22, 2013
G. Norton
English
Paperback
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Hardback
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eBook
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Plant Proteins is a compendium of papers discussing, in general, plant proteins as materials for human foods, and in particular, the properties, biosynthesis, deposition of reserves in seeds, undesirable factors, production, and nutritional aspects of plant proteins in the food industry. Some papers review the properties and biosynthesis of plant proteins, the synthesis of chloroplast proteins, and legume seed proteins. Other papers discuss the development of protein reserves in seeds, as well as the toxicity and antagonistic actions in relation to amino acid and protein synthesis. One paper examines the world supply and demand for sources of protein from three plant sources, namely cereals, oilseeds, and legumes. Another paper discusses the capabilities of certain species of micro-organisms to synthesize from a few simple raw materials all the main components needed in the diet of a human or a farm animal. One paper notes that the acceptance of plant protein foods in society depends on their presentation, flavor, texture, appearance, identity, and product name. This compendium will benefit agronomists, agriculturists, biochemists, microbiologists, nutritionists, botanists, chemists, economists, food scientists, physicists and plant breeders.

Biotechnology and Food Quality

1st Edition
October 22, 2013
Shain-dow Kung + 2 more
English
Hardback
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Paperback
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eBook
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Biotechnology and Food Quality focuses on the potential of biotechnology in quantitatively and qualitatively modifying agriculture. The selection first offers information on the benefits of agricultural biotechnology on developed and developing countries, food quality education, and food quality, biotechnology, and the food company. Discussions focus on consumer concerns, demographic and social changes, scope and future role of food quality, and improvement of agricultural raw materials and processed foods. The manuscript then underscores how to make technology transfer work and the regulatory considerations of biotechnology. The text examines the characterization and modification of maize storage proteins; genetic modification of traits of interest to consumers and processors; and omega-3 fatty acid improvements in plants. Topics include genetic engineering of fatty acid biosynthesis, cellular genetics, molecular biology, application of technology to food products, and genetic engineering of lysine-containing alpha zeins. Cell wall dynamics, prospects for the use of genetic engineering in the manipulation of ethylene biosynthesis and action in higher plants, and molecular interactions of contractile proteins are also elaborated. The selection is a highly recommended source of data for biotechnologists, agriculturists, and food experts.

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