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Books in Life sciences

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    • Knobil and Neill's Physiology of Reproduction

      • 4th Edition
      • November 15, 2014
      • Tony M. Plant + 1 more
      • English
      • Hardback
        9 7 8 0 1 2 3 9 7 1 7 5 3
      • eBook
        9 7 8 0 1 2 3 9 7 7 6 9 4
      The Fourth Edition of Knobil & Neill continues to serve as a reference aid for research, to provide the historical context to current research, and most importantly as an aid for graduate teaching on a broad range of topics in human and comparative reproduction. In the decade since the publication of the last edition, the study of reproductive physiology has undergone monumental changes. Chief among these advances are in the areas of stem cell development, signaling pathways, the role of inflammation in the regulatory processes in the various tissues, and the integration of new animal models which have led to a greater understanding of human disease. The new edition synthesizes all of this new information at the molecular, cellular, and organismal levels of organization and present modern physiology a more understandable and comparative context.

    • Conformation in Biology and Drug Design

      • 1st Edition
      • May 10, 2014
      • Sidney Udenfriend + 2 more
      • English
      • Paperback
        9 7 8 1 4 8 3 2 0 4 5 7 4
      • eBook
        9 7 8 1 4 8 3 2 1 8 0 0 7
      The Peptides: Analysis, Synthesis, Biology, Volume 7: Conformation in Biology and Drug Design focuses on the analysis of peptides, emphasizing the use of physical methods in peptide conformational analysis and the relationship of conformational properties of peptides to biological properties. This book consists of nine chapters. Chapter 1 provides a brief overview of the perspective on the application of physical methods to peptide conformational analysis. The use of circular dichroism (CD) spectroscopy to examine the conformational properties of peptides in solution is elaborated in Chapter 2, while the use of fluorescence spectroscopy to examine the special relationships of aromatic side-chain groups to one another is discussed in Chapter 3. In Chapter 4, the use of various theoretical methods to calculate the conformations of peptides is described. The methods used to stimulate peptide conformations and dynamics are outlined in Chapter 5. The last four chapters examine various aspects of the use of nuclear magnetic resonance (NMR) in peptide conformational analysis. This volume is suitable for biologists, specialists, and researchers interested in peptides and proteins.

    • Agglutination, Complement, Neutralization, and Inhibition

      • 1st Edition
      • May 10, 2014
      • Curtis A. Williams + 1 more
      • English
      • Paperback
        9 7 8 1 4 8 3 2 0 7 1 6 2
      • eBook
        9 7 8 1 4 8 3 2 2 0 5 9 8
      Methods in Immunology and Immunochemistry, Volume IV: Agglutination, Complement, Neutralization, and Inhibition provides information pertinent to direct and indirect agglutination reactions. This book covers a variety of topics, including complement-fixation procedures, isolation of complement components, hemolytic intermediates, complement-related proteins, and neutralization reactions. Organized into three chapters, this volume begins with an overview of test-tube agglutinations that are preferred for blood grouping with saline agglutinins that require more than a few minutes for agglutination. This text then describes blood group antibodies that agglutinate red blood cells suspended in saline. Other chapters consider the classical pathway of complement utilization. This book discusses as well the complexity of events leading to hemolysis of erythrocytes by complement. The final chapter deals with the ability of antitoxin to neutralize diphtheria toxin and explains the quantitative relationships between antigen and antibody. This book is a valuable resource for immunologists, scientists, and research workers.

    • Electroporation-Based Therapies for Cancer

      • 1st Edition
      • July 25, 2014
      • Raji Sundararajan
      • English
      • Paperback
        9 7 8 0 0 8 1 0 1 5 2 7 8
      • Hardback
        9 7 8 1 9 0 7 5 6 8 1 5 2
      • eBook
        9 7 8 1 9 0 8 8 1 8 2 9 4
      Electroporation-Base... Therapies for Cancer reviews electroporation-base... clinical studies in hospitals for various cancer treatments, including melanomas, head and neck cancers, chest wall breast carcinomas, and colorectal cancers, as well as research studies in the lab using cell lines, primary cells, and animals. Cancer kills about one American per minute, amounting to over 500,000 deaths in the United States and millions, worldwide, each year. There is a critical need for safe, effective, and affordable alternative treatment modalities, especially for inoperable, recurring, and chemo-resistant cancers, that do not respond well to current treatment regimen. An electrical-pulse-med... enhanced drug delivery technique known as electroporation is one way to effectively treat these patients. This technique is especially suitable for low- and middle-income countries, where lack of infrastructure and resources leads to cancer diagnoses at late stages. This quick, safe, effective, economical, out-patient-based technique is a boon to these patients for palliative and other care with enhanced quality of life. This book features discussions by interdisciplinary authors—including practicing oncological surgeons, medical professionals, and academic and other researchers—of the basics and clinical medical applications of electroporation.

    • Neuropharmacology

      • 1st Edition
      • April 24, 2014
      • P. B. Bradley + 1 more
      • English
      • Paperback
        9 7 8 0 0 8 0 2 0 5 6 5 6
      • eBook
        9 7 8 1 4 8 3 1 4 0 0 0 1
      Neuropharmacology is a collection of papers presented at a symposium of the XXVI International Congress of Physiological Sciences, held in New Delhi, India in 1974. Contributors focus on the neurochemical action of central analgesics and their biochemistry, particularly Viminol R2 and azidomorphine, based on evidence derived using neurohistochemical techniques. This text is comprised of six chapters; the first of which deals with cholinergic mechanisms in narcotic analgesics. This topic is followed by a discussion on the research on the effects of drugs such as morphine on the central nervous system using amine fluorescence histochemistry; the effect of dextromoramide and methadone on dopamine metabolism in comparison with haloperidol and amphetamine; and the use of pharmacological models to predict opiate dependence. A chapter is devoted to a pharmacological study of the in vivo increase in the cyclic AMP content of rat striatum and nucleus accumbens due to the action of amphetamine, apomorphine, opiates, and antipsychotic drugs, along with the effect of this change on dopamine receptors. This book will appeal to scientists representing all the major areas of pharmacology, including clinical pharmacology and toxicology, as well as to internists, psychiatrists, neurologists, and anesthesiologists.

    • Stem Cell Biology and Tissue Engineering in Dental Sciences

      • 1st Edition
      • November 5, 2014
      • Ajaykumar Vishwakarma + 3 more
      • English
      • Paperback
        9 7 8 0 1 2 8 1 0 1 2 0 9
      • Hardback
        9 7 8 0 1 2 3 9 7 1 5 7 9
      • eBook
        9 7 8 0 1 2 3 9 7 7 7 8 6
      Stem Cell Biology and Tissue Engineering in Dental Sciences bridges the gap left by many tissue engineering and stem cell biology titles to highlight the significance of translational research in this field in the medical sciences. It compiles basic developmental biology with keen focus on cell and matrix biology, stem cells with relevance to tissue engineering biomaterials including nanotechnology and current applications in various disciplines of dental sciences; viz., periodontology, endodontics, oral & craniofacial surgery, dental implantology, orthodontics & dentofacial orthopedics, organ engineering and transplant medicine. In addition, it covers research ethics, laws and industrial pitfalls that are of particular importance for the future production of tissue constructs. Tissue Engineering is an interdisciplinary field of biomedical research, which combines life, engineering and materials sciences, to progress the maintenance, repair and replacement of diseased and damaged tissues. This ever-emerging area of research applies an understanding of normal tissue physiology to develop novel biomaterial, acellular and cell-based technologies for clinical and non-clinical applications. As evident in numerous medical disciplines, tissue engineering strategies are now being increasingly developed and evaluated as potential routine therapies for oral and craniofacial tissue repair and regeneration.

    • Mammalian Protein Metabolism

      • 1st Edition
      • May 12, 2014
      • H. N. Munro + 1 more
      • English
      • eBook
        9 7 8 1 4 8 3 2 7 2 9 1 7
      Mammalian Protein Metabolism, Volume II focuses on the processes, methodologies, and reactions involved in mammalian protein metabolism, including toxicities, amino acid imbalance, and digestion and absorption. The selection first offers information on the nutritive value of dietary proteins, amino acid toxicities and imbalances, and protein requirements. Discussions focus on the protein requirements of adults, infants, and children, amino acid requirements, protein requirements in pregnancy, amino acid imbalance, mixed diets, and nutritive value and maintenance. The text then ponders on protein metabolism and requirements in pregnancy and lactation and protein metabolism and requirements in the newborn. The publication examines protein metabolism and requirements in the elderly; anomalies of amino acid metabolism; and physical injury and its effects on protein metabolism. Topics include general disturbance of protein metabolism following physical injury, nature of inflammatory reaction, acquired disturbances of amino acid metabolism, plasma proteins, nitrogen balance, digestion and absorption, and protein withdrawal. The text then elaborates on protein metabolism and tumor growth, experimental protein-calorie deficiency, and the clinical aspects of protein malnutrition. The selection is a dependable source of data for researchers interested in mammalian protein metabolism.

    • Nasals, Nasalization, and the Velum

      • 1st Edition
      • Volume 5
      • May 19, 2014
      • English
      • eBook
        9 7 8 1 4 8 3 2 9 5 6 2 6
      Although nasalization has been discussed in the context of more general aspects of linguistics in other books, this text is the first and primary resource focusing solely on nasalization. This volume features articles discussing all aspects of nasalization, including physiology, perception, aerodynamics, acoustics, phonetic and phonological representations, research methodology, and instrumentation. Each chapter examines important research advances achieved within the last ten years and closes with a detailed discussion of the current research.

    • A Pharmacology Primer

      • 4th Edition
      • March 26, 2014
      • Terry P. Kenakin
      • English
      • Hardback
        9 7 8 0 1 2 4 0 7 6 6 3 1
      • eBook
        9 7 8 0 1 2 4 0 7 6 8 9 1
      A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, 4th Edition features the latest ideas and research about the application of pharmacology to the process of drug discovery to equip readers with a deeper understanding of the complex and rapid changes in this field. Written by well-respected pharmacologist, Terry P. Kenakin, this primer is an indispensable resource for all those involved in drug discovery. This edition has been thoroughly revised to include material on data-driven drug discovery, biased signaling, structure-based drug design, drug activity screening, drug development (including pharmacokinetics and safety Pharmacology), and much more. With more color illustrations, examples, and exercises throughout, this book remains a top reference for all industry and academic scientists and students directly involved in drug discovery, or pharmacologic research.

    • Immunointervention in Autoimmune Diseases

      • 1st Edition
      • June 28, 2014
      • J. F. Bach
      • English
      • Paperback
        9 7 8 0 1 2 0 6 9 8 6 0 8
      • eBook
        9 7 8 1 4 8 3 2 8 2 2 6 8
      Immunointervention in Autoimmune Diseases is a collection of papers presented at the 1988 International Meeting by the same title, held in Paris, France. This text contains 21 chapters and begins with surveys of the role of antigen in autoimmune responses and the moving boundaries between physiology and pathology of immunity. The succeeding chapters deal with the regulation, immunosuppressive therapy, infections, and immunointervention of autoimmune disorders. These topics are followed by discussions of specific immunosuppressive therapy for a particular disease, including type I diabetes, T-cell leukemia, and systemic lupus erythomatosus. This work also explores the principles of allograft, the use of monoclonal antibody, and OKT3. The remaining chapters consider the maintenance of autoimmunity and the risk/benefit in immunointervention for autoimmune diseases. This book will prove useful to immunologists, pathologists, physiologists, and researchers.

Related subjects

Agricultural and biological sciences

Drug discovery

Immunology

Microbiology and virology

Neuroscience

Pharmaceutical sciences

Pharmacology

Toxicology