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Stem Cell Biology and Tissue Engineering in Dental Sciences bridges the gap left by many tissue engineering and stem cell biology titles to highlight the significance of translati… Read more
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Stem Cell Biology and Tissue Engineering in Dental Sciences bridges the gap left by many tissue engineering and stem cell biology titles to highlight the significance of translational research in this field in the medical sciences. It compiles basic developmental biology with keen focus on cell and matrix biology, stem cells with relevance to tissue engineering biomaterials including nanotechnology and current applications in various disciplines of dental sciences; viz., periodontology, endodontics, oral & craniofacial surgery, dental implantology, orthodontics & dentofacial orthopedics, organ engineering and transplant medicine. In addition, it covers research ethics, laws and industrial pitfalls that are of particular importance for the future production of tissue constructs.
Tissue Engineering is an interdisciplinary field of biomedical research, which combines life, engineering and materials sciences, to progress the maintenance, repair and replacement of diseased and damaged tissues. This ever-emerging area of research applies an understanding of normal tissue physiology to develop novel biomaterial, acellular and cell-based technologies for clinical and non-clinical applications. As evident in numerous medical disciplines, tissue engineering strategies are now being increasingly developed and evaluated as potential routine therapies for oral and craniofacial tissue repair and regeneration.
Basic and clinical researchers in the fields of biomedical science, cell biology, nanoscience, nanotechnology, biomaterial science and engineering, bioengineering, and cell biology working within dental sciences research
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His main research interests are the molecular control of tooth development, dental stem cell biology and tooth bioengineering. He has published over 270 research papers including articles in Nature, Science, PNAS and Cell press. He has supervised over 40 PhD students and receives funding from the MRC. He is a member of the MRC Centre for Transplantation and Biomedical Research Centre.
In 2004 he was awarded the Craniofacial Biology Research Award by the International Association for Dental Research in recognition of his contribution to the understanding of how teeth develop and in 2006 his paper “Stem cell-based tissue engineering of teeth” received the William J Gies award for best publication is Biomaterials and Bioengineering from the same organisation. He is on the editorial boards of several journals including J. Dent. Res. and J. Clin. Perio.
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Songtao Shi, D.D.S., Ph.D., is Professor at the University of Southern California Ostrow School of Dentistry. Dr. Shi received his D.D.S. degree and certificate in Pediatric Dentistry from the Peking University School of Stomatology and Ph.D. in Craniofacial Biology from the University of Southern California. Prior to joining the faculty at the University of Southern California, he served as a Principal Investigator and Clinical Fellow for nine years at the National Institute of Dental and Craniofacial Research. His research program focuses on understanding mechanism of mesenchymal stem cell (MSC)-associated diseases, developing new experimental disease models, and exploring feasibility of translating these bench discoveries to clinical therapies.
His group and his collaborators were the first to identify dental pulp stem cells, baby tooth stem cells, periodontal ligament stem cells, root apical papilla stem cells, tendon stem cells, gingiva stem cells, sclera MSCs, and benign tumor MSCs from keloid and ossifying fibroma. In translational study, Dr. Shi’s team has used these stem cells to regenerate a variety of tissues, including dentin, pulp, periodontal ligament, tendon, bone, bio-root. Dr. Shi and his collaborators were the first to use MSCs to treat systemic lupus erythematosus (SLE), periodontitis, bisphosphonate-related osteonecrosis of the jaw-like disease (BRONJ) in animal models and patients. Additionally, Dr. Shi and his collaborators were the first to generate BRONJ, osteoradionecrosis, keloid, and ossifying fibroma diseases in mouse and swine models. To understand mechanisms of MSC-based therapies, Dr. Shi’s team revealed that MSC mediated bone regeneration was regulated by recipient T cell, which is the pioneer study showing association between cell-based tissue engineering and immune response. Additionally, Dr. Shi and his collaborators discovered that MSC-mediated immunotherapy in human and mouse model is associated the interplay between the donor cells and recipient T cells via Fas/FasL pathway. Recently, Dr. Shi’s team first time showed that MSCs contribute to orofacial benign tumor development via an epigenetic regulation network.
Dr. Shi has published more than 150 peer-reviewed articles in a variety of high-impact scientific journals, of which he served as the corresponding author in Nat Medicine, Cell Stem Cell, Lancet, J Clin Invest, Nat Biotechnol, Proc Natl Acad Sci U S A, Cell Research, Blood, J Bone Miner Res, Stem Cells, PLoS ONE, and J Dent Res. Dr. Shi’s research is supported by NIH grants and funding from California Institute of Regenerative Medicine.
Dr. Shi has served on several local and national committees and boards including Scientific Editor for the PLoS ONE and Associate Editor for Oral Diseases. He is recipient of the 2013 IADR Distinguished Scientist Award for Pulp Biology & Regeneration. He is on the editorial board of Stem Cell Research & Therapy, the editorial board of World Journal of Stem Cells, and the editorial board of Chinese Journal of Dental Research. Dr. Shi is Changjing Scholar in the Fourth Military Medical University, Distinguished Visiting Professor in Tongji University, Visiting Professor in XiangYa School of Medicine & Stomatology, Central South University (CSU), and distinguished visiting professor in Dankook University, Korea.
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