Skip to main content
Elsevier
View Cart

Books in Life sciences

BooksJournals

    • Current Topics in Bioenergetics

      • 1st Edition
      • June 28, 2014
      • C. P. Lee
      • English
      • Paperback
        9 7 8 1 4 8 3 2 0 3 5 5 3
      • eBook
        9 7 8 1 4 8 3 2 1 6 9 8 0
      Current Topics in Bioenergetics, Volume 14 provides information pertinent to the structure and function relationship of energy-transducing membranes. This book presents a number of biochemical and biophysical approaches that are valuable in some systems. Organized into five chapters, this volume begins with an overview of cytochrome oxidase, a noncrystallizable membrane protein. This text then determines the interaction of small organic molecules with biological membranes on a molecular level. Other chapters consider the various physical techniques that are used to investigate the structural and dynamic properties of proteins, lipids, and membranes, including neutron diffraction, X-ray diffraction, electron microscopy, optical rotatory dispersion, nuclear magnetic resonance, fluorescence spectroscopy, and Raman spectroscopy. This book discusses as well the biological importance of metal ions. The final chapter deals with optical activity spectroscopy as a recognized tool for the examination of the conformation of biological macromolecules. This book is a valuable resource for biochemists, biophysicists, and biologists.

    • The Cell Surface: Mediator of Developmental Processes

      • 1st Edition
      • May 10, 2014
      • Stephen Subtelny + 1 more
      • English
      • Paperback
        9 7 8 1 4 8 3 2 4 6 0 2 4
      • eBook
        9 7 8 1 4 8 3 2 7 1 9 1 0
      The Cell Surface: Mediator of Developmental Processes contains the papers presented at the 38th Symposium of the Society for Developmental Biology, held at the University of British Columbia in Vancouver, Canada in June 1979. The compendium is divided into three parts. The first part provides a summary of the status of the knowledge about the cell surface, which includes the plasma membrane, its associated cytoskeleton and the variety of surface-associated macromolecules. The second portion focuses on the early development of the cell surface. A wide spectrum of techniques, systems, and results in the study of the cell surface are presented. The last part shows a variety of experimental systems in which the cell surface figures prominently in important developmental events. The results from experiments on plant symbiosis, mammalian teratocarcinomas, adhesion and cell shape, and various extracellular macromolecules are detailed extensively. Cytologists, microbiologists, biologists, and other scientists in allied fields will find the publication very insightful.

    • The Antigens

      • 1st Edition
      • May 10, 2014
      • Michael Sela
      • English
      • Paperback
        9 7 8 1 4 8 3 2 4 6 4 6 8
      • eBook
        9 7 8 1 4 8 3 2 6 9 5 7 3
      The Antigens, Volume V is a comprehensive treatise covering all aspects of antigens, including their chemistry and biology as well as their immunologic role and expression. Four complex problems of direct relevance to human health are explored, namely, tumor antigens, antigens of helminths, cytotoxic lymphocytes, and complement. Comprised of four chapters, this volume begins with a review of classic studies of tumor-specific transplantation antigens, followed by a discussion on the detection and purification of tumor antigens; the immune response to tumor antigens; and the role of tumor antigens in the escape of tumors from immunological control. The reader is then introduced to some aspects of the different functions of antigens of helminths, along with the immune response in helminthiasis. The book also examines the generation, properties, and mode of action of antibody-independent cytolytic T lymphocytes before concluding with an analysis of the complement system and its reaction pathways as well as its role as an autoantigen. This monograph will be of interest to practitioners and researchers in immunology, experimental and clinical medicine, biochemistry, and other disciplines.

    • Evolutionary Origins and Early Development of Number Processing

      • 1st Edition
      • Volume 1
      • October 31, 2014
      • David C. Geary + 2 more
      • English
      • Hardback
        9 7 8 0 1 2 4 2 0 1 3 3 0
      • eBook
        9 7 8 0 1 2 8 0 0 8 8 8 1
      The first volume in this ground-breaking series focuses on the origins and early development of numerical cognition in non-human primates, lower vertebrates, human infants, and preschool children. The text will help readers understand the nature and complexity of these foundational quantitative concepts and skills along with evolutionary precursors and early developmental trajectories.

    • Cholinergic Ligand Interactions

      • 1st Edition
      • June 28, 2014
      • D. J. Triggle + 2 more
      • English
      • Paperback
        9 7 8 1 4 8 3 2 4 7 6 9 4
      • eBook
        9 7 8 1 4 8 3 2 7 6 5 6 4
      Cholinergic Ligand Interactions presents the papers read at a symposium held at the State University of New York at Buffalo, 25-26 May 1970. The recent purification and crystallization of acetylcholinesterase together with real progress in the purification of receptor components indicated the desirability of organizing a symposium to discuss not only these aspects but also the structural bases for cholinergic ligand interaction with these macromolecules, the conformational changes involved with ligand binding, the quantitation of cholinergic ligand binding sites, and the roles of acetylcholinesterase and its isozymes in muscle disease. The volume contains nine chapters and begins with a study on possible conformational changes in acetylcholinesterase... This is followed by separate chapters on the subunits of acetylcholinesterase... in vitro studies with the cholinergic receptor of the eel electroplax; identification and isolation of acetylcholine receptors; assay and properties of essential (junctional) cholinesterases of the rat diaphragm; and structural variations in cholinergic ligands. Subsequent chapters deal with ligand interactions at the muscarinic receptors and changes in cholinesterases isozymes during normal and dystrophic muscle development.

    • Enzymology in the Practice of Laboratory Medicine

      • 1st Edition
      • May 10, 2014
      • Philip Blume + 1 more
      • English
      • Paperback
        9 7 8 1 4 8 3 2 3 6 3 7 7
      • eBook
        9 7 8 1 4 8 3 2 7 7 7 0 7
      Enzymology in the Practice of Laboratory Medicine focuses on disease processes, enzymatic reactions and activities, and diagnosis and management of diseases. The selection first offers information on developments in the search for mechanisms of enzymic catalysis; application of the spin labeling technique to biological membranes; and the properties of membrane bound enzymes involved in energy transduction processes. Discussions focus on possible clinical interrelationships of membrane function, mitochondrial membrane transactions, mechanical details of chymotryptic catalysis, and physical nature of globular proteins. The text then elaborates on metalloenzymes, enzyme measurement, and enzymology, clinical chemistry, and development of fast analyzers. The publication examines the analytical uses of immobilized enzymes; origin of serum enzymes and the basis for their variation; and the screening methods for glycolytic enzyme deficiencies in red blood cells. Topics include factors contributing to normal variation of enzyme activity, catabolism of enzymes, mechanism of release from cells to plasma, and determination of urea in blood and urine. The selection is a dependable reference for researchers interested in the application of enzymology in laboratory medicine.

    • Personalized Cancer Chemotherapy

      • 1st Edition
      • December 5, 2014
      • Da Yong Lu
      • English
      • Hardback
        9 7 8 0 0 8 1 0 0 3 4 6 6
      • Paperback
        9 7 8 0 0 8 1 0 1 6 2 2 0
      • eBook
        9 7 8 0 0 8 1 0 0 3 4 7 3
      Personalized Cancer Chemotherapy separately describes and addresses "individualized cancer chemotherapy" (ICC) strategies new and old, to provide readers with new insights into their characteristics and techniques, as well as key debates and future trends in this area. The book devotes chapters to drug sensitivity testing, cancer biomarkers and bioinformatics detection, pharmacogenetics, individualized antimetastatic therapy, drug combinations, assistant chemotherapy, and cost-effectiveness considerations. A major obstacle to controlling cancer growth and metastases in patients is the inappropriate use of anticancer and antimetastatic drugs. Researchers and clinicians are now beginning to focus on ICC also called "personalized cancer chemotherapy" (PCC), to improve therapeutic quality and outcomes by selecting and prescribing the most appropriate and effective drugs. Using genetic, molecular, and bioinformatics data and modern experimental techniques, known tumor genes can be detected more easily than ever before; the average speed of genetic sequencing has increased 15,000 to 50,000 times since the Human Geonme Project was completed. This book will help readers understand the pros and cons of each individualized cancer chemotherapy strategy from different angles so as to make good judgments and predictions of drug responses and clinical outcomes.

    • Pyruvate and Fatty Acid Metabolism

      • 1st Edition
      • Volume 18
      • June 28, 2014
      • Marcel Florkin + 1 more
      • English
      • eBook
        9 7 8 1 4 8 3 1 9 3 1 6 8
      Comprehensive Biochemistry, Volume 18S: Pyruvate and Fatty Acid Metabolism focuses on the processes, methodologies, principles, and reactions involved in pyruvate and fatty acid metabolism, including broad outlines of the metabolism of amino acids, proteins, carbohydrates, lipids, and their derived products. The selection first ponders on pyruvate dehydrogenase complex and citric acid cycle. Numerical analyses of the various reaction sequences are presented. The text also takes a look at fatty acid metabolism. Discussions focus on fatty acid oxidation and biosynthesis, elongation and desaturation of fatty acids, and control of fatty acid oxidation and biosynthesis. The book is a valuable reference for researchers interested in pyruvate and fatty acid metabolism.

    • Brain-Computer Interfacing for Assistive Robotics

      • 1st Edition
      • September 24, 2014
      • Vaibhav Gandhi
      • English
      • Paperback
        9 7 8 0 1 2 8 0 1 5 4 3 8
      • eBook
        9 7 8 0 1 2 8 0 1 5 8 7 2
      Brain-computer interface (BCI) technology provides a means of communication that allows individuals with severely impaired movement to communicate with assistive devices using the electroencephalogram (EEG) or other brain signals. The practicality of a BCI has been possible due to advances in multi-disciplinary areas of research related to cognitive neuroscience, brain-imaging techniques and human-computer interfaces. However, two major challenges remain in making BCI for assistive robotics practical for day-to-day use: the inherent lower bandwidth of BCI, and how to best handle the unknown embedded noise within the raw EEG. Brain-Computer Interfacing for Assistive Robotics is a result of research focusing on these important aspects of BCI for real-time assistive robotic application. It details the fundamental issues related to non-stationary EEG signal processing (filtering) and the need of an alternative approach for the same. Additionally, the book also discusses techniques for overcoming lower bandwidth of BCIs by designing novel use-centric graphical user interfaces. A detailed investigation into both these approaches is discussed.

    • Recombinant DNA Laboratory Manual

      • 1st Edition
      • May 12, 2014
      • Judith W. Zyskind + 1 more
      • English
      • Paperback
        9 7 8 1 4 8 3 2 0 7 5 4 4
      • eBook
        9 7 8 1 4 8 3 2 2 0 9 7 0
      Recombinant DNA Laboratory Manual is a laboratory manual on the fundamentals of recombinant DNA techniques such as gel electrophoresis, in vivo mutagenesis, restriction mapping, and DNA sequencing. Procedures that are useful for studying either prokaryotes or eukaryotes are discussed, and experiments are included to teach the fundamentals of recombinant DNA technology. Hands-on computer sessions are also included to teach students how to enter and manipulate sequence information. Comprised of nine chapters, this book begins with an introduction to bacterial growth parameters, how to measure bacterial cell growth, and how to plot cell growth data. The discussion then turns to the isolation and analysis of chromosomal DNA in bacteria and Drosophila; plasmid DNA isolation and agarose gel analysis; and introduction of DNA into cells. Subsequent chapters deal with Tn5 mutagenesis of pBR329; DNA cloning in M13; DNA sequencing; and DNA gel blotting, probe preparation, hybridization, and hybrid detection. The book concludes with an analysis of lambda phage manipulations. This manual is intended for advanced undergraduate or beginning graduate students and should also be helpful to established investigators who are changing their research focus.

Related subjects

Agricultural and biological sciences

Drug discovery

Immunology

Microbiology and virology

Neuroscience

Pharmaceutical sciences

Pharmacology

Toxicology