Hyaluronan Signaling and Turnover

1st Edition - July 23, 2014

Authors: Melanie Simpson, Paraskevi Heldin

Hardback ISBN:

9 7 8 - 0 - 1 2 - 8 0 0 0 9 2 - 2

eBook ISBN:

9 7 8 - 0 - 1 2 - 8 0 0 3 9 3 - 0

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are… Read more

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Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics. This volume covers hyaluronan signaling and turnover.

Preface
Chapter One: Emerging Roles for Hyaluronidase in Cancer Metastasis and Therapy
- Abstract
- 1 Introduction
- 2 Of Mole Rats and Men: Insights About HA and Cancer
- 3 Hyaluronidase Expression in Cancer
- 4 Hyaluronidase Function and the Metastatic Process
- 5 Hyaluronidase Targeting in Cancer Therapy and Imaging
- 6 Conclusions and Future Perspective
- Acknowledgments
Chapter Two: Targeting Hyaluronic Acid Family for Cancer Chemoprevention and Therapy
- Abstract
- 1 Introduction
- 2 Targeting HA Production
- 3 Targeting HA Signaling
- 4 HA as a Carrier for Drug Delivery
- 5 Targeting HA Receptors
- 6 Targeting HAase
- 7 Conclusion
- Acknowledgments
Chapter Three: Aberrant Posttranscriptional Processing of Hyaluronan Synthase 1 in Malignant Transformation and Tumor Progression
- Abstract
- 1 Splicing and Cancer
- 2 Control of Pre-mRNA Splicing
- 3 Impact on Cancer of Alterations in Splicing Machinery
- 4 Aberrant Splicing of Hyaluronan Synthase 1
- 5 Clinical Impact of Aberrant HAS1 Splicing
- 6 Genetic Variations in HAS1
- 7 Functional Impact of HAS1Vs
- 8 Functional Outcomes of HAS1Vs in Transfectants
- 9 HAS1Vs and Mitotic Catastrophe
- 10 Conclusion
- Acknowledgments
Chapter Four: Hyaluronan Synthases Posttranslational Regulation in Cancer
- Abstract
- 1 Introduction
- 2 HA Synthesis
- 3 HA Catabolism
- 4 HAS2 Phosphorylation, AMPK, and Its Dual Effects on Tumors
- 5 O-GlcNAcylation and Cancer
- 6 Conclusions
- Acknowledgment
Chapter Five: Hyaluronan-Coated Extracellular Vesicles—A Novel Link Between Hyaluronan and Cancer
- Abstract
- 1 Introduction
- 2 Extracellular Vesicles as Novel Communicators Between Cells
- 3 EVs Promote Tumor Progression
- 4 HA Synthesis Enhances Shedding of Extracellular Vesicles
- 5 HA–EVs as Predictors, Targets, and Carriers of Therapy
- 6 Conclusions
- Acknowledgments
Chapter Six: Hyaluronan in the Healthy and Malignant Hematopoietic Microenvironment
- Abstract
- 1 Introduction
- 2 BM MSC, Their Derivatives, and HA
- 3 Macrophages and HA in the BM
- 4 Endothelial Cells and HA in BM
- 5 Nerve Cells and HA in BM
- 6 Role of HA in the BM Microenvironment in Hematological Malignancies
- 7 Conclusion
Chapter Seven: Hyaluronan Regulation of Endothelial Barrier Function in Cancer
- Abstract
- 1 Introduction
- 2 HA Regulation of Vascular Integrity
- 3 HA Regulation of Endothelial Barrier Function During Tumor Angiogenesis
- 4 HA Regulation of Endothelial Barrier Function During Cancer Metastasis
- 5 Potential Therapeutic Effects of HMW-HA in Inhibiting Endothelial Barrier Disruption During Cancer Progression
- 6 Conclusions
- Acknowledgments
Chapter Eight: HAS2 and CD44 in Breast Tumorigenesis
- Abstract
- 1 Introduction
- 2 Molecular Classification of Breast Cancer
- 3 Role of Stromal HA in Tumor Progression
- 4 Expression of HAS Genes and Breast Cancer Malignancy
- 5 HA–CD44 Interactions: A Regulatory Network During TGFβ-Mediated EMT
- 6 Conclusions
- Acknowledgments
Chapter Nine: CD44 is a Multidomain Signaling Platform that Integrates Extracellular Matrix Cues with Growth Factor and Cytokine Signals
- Abstract
- 1 Introduction
- 2 Ligation of ECM Components by CD44
- 3 CD44: Coreceptor for Cell-Surface Receptors
- 4 CD44 as a Multidomain Signal Integration Platform
- 5 Concluding Remarks
Chapter Ten: Hyaluronan–CD44 Interaction Promotes Oncogenic Signaling, microRNA Functions, Chemoresistance, and Radiation Resistance in Cancer Stem Cells Leading to Tumor Progression
- Abstract
- 1 Introduction
- 2 Regulation of Tumor Progression by HA/CD44
- 3 Activation of CSCs by HA/CD44
- 4 Conclusion
- Acknowledgments
Chapter Eleven: Advances and Advantages of Nanomedicine in the Pharmacological Targeting of Hyaluronan-CD44 Interactions and Signaling in Cancer
- Abstract
- 1 Introduction
- 2 Importance of Targeting Hyaluronan–CD44 in Tumors
- 3 Therapeutic Interventions/Strategies That Target Hyaluronan and/or CD44 to Perturb Hyaluronan-CD44 Interactions in Tumors
- 4 Advances in Nanomedicine Related with Hyaluronan-CD44 Targeting
- 5 Concluding Remarks/Conclusions
- Acknowledgments
Chapter Twelve: Hyaluronan/RHAMM Interactions in Mesenchymal Tumor Pathogenesis: Role of Growth Factors
- Abstract
- 1 Introduction
- 2 The Role of Hyaluronan and Its Receptors in Fibrosarcoma
- 3 GF Signaling and ECM Organization in Fibrosarcoma Pathogenesis
- 4 Concluding Remarks
Chapter Thirteen: CD147: Regulator of Hyaluronan Signaling in Invasiveness and Chemoresistance
- Abstract
- 1 Introduction
- 2 Structure and Pleiotropic Functions of CD147
- 3 CD147-Induced HA Synthesis and Signaling
- 4 CD147–HA Axis in Cellular Invasion
- 5 CD147–HA Axis in Chemoresistance
- 6 Induction of the CD147–HA Axis by Kaposi's Sarcoma-Associated Herpesvirus
- 7 Conclusions
Index