Life sciences print books and ebooks | Elsevier

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

1st Edition
December 31, 2014
M. A. Hayat
English
Hardback
9 7 8 0 1 2 8 0 1 0 3 2 7
eBook
9 7 8 0 1 2 8 0 1 0 5 3 2

Volume 6 provides coverage of the mechanisms of regulation of autophagy; intracellular pathogen use of the autophagy mechanism; the role of autophagy in host immunity; and selective autophagy. Attention is given to a number of mechanistic advances in the understanding of regulation, particularly the importance of nutrient availability; microRNAs; and cross-talk with other protein degradation pathways. Intracellular pathogen repurposing of autophagy for pathogenic benefit is also provided, with coverage of Herpesvirus protein modulation of autophagy; the varicella-zoster virus and the maintenance of homeostasis; and the relationship between autophagy and the hepatitis b virus. The significance of autophagy in host defense is elucidated, providing a specific focus on facilitation of antigen presentation; participation in thymic development; and the sharing of regulatory nodes with innate immunity. Selective autophagy for the degradation of mitochondria and endocytosed gap junctions are also explored. This book is an asset to newcomers as a concise overview of the regulation of autophagy, its role in host defense and immunity, and selective autophagy, while serving as an excellent reference for more experienced scientists and clinicians looking to update their knowledge. Volumes in the Series Volume 1: Molecular Mechanisms. Elucidates autophagy’s association with numerous biological processes, including cellular development and differentiation, cancer, immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer’s, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases. Volume 2: Role in General Diseases. Describes the various aspects of the complex process of autophagy in a myriad of devastating human diseases, expanding from a discussion of essential autophagic functions into the role of autophagy in proteins, pathogens, immunity, and general diseases. Volume 3: Role in Specific Diseases. Explores the role of autophagy in specific diseases and developments, including: Crohn’s Disease, Gaucher Disease, Huntington’s Disease, HCV infection, osteoarthritis, and liver injury, with a full section devoted to in-depth exploration of autophagy in tumor development and cancer, as well as the relationship between autophagy and apoptosis.Volume 4: Mitophagy. Presents detailed information on the role of mitophagy, the selective autophagy of mitochondria, in health and disease, by delivering an in-depth treatment of the molecular mechanisms involved in mitophagy initiation and execution, as well as the role of mitophagy in Parkinson Disease, cardiac aging, and skeletal muscle atrophy. Volume 5: Role in Human Diseases. Comprehensively describes the role of autophagy in human diseases, delivering coverage of the antitumor and protumor roles of autophagy; the therapeutic inhibition of autophagy in cancer; and the duality of autophagy’s effects in various cardiovascular, metabolic, and neurodegenerative disorders.Volume 6: Regulation of Autophagy and Selective Autophagy. Provides coverage of the mechanisms of regulation of autophagy; intracellular pathogen use of the autophagy mechanism; the role of autophagy in host immunity; and selective autophagy. Volume 7: Role of Autophagy in Therapeutic Applications. Provides coverage of the latest developments in autophagosome biogenesis and regulation; the role of autophagy in protein quality control; the role of autophagy in apoptosis; autophagy in the cardiovascular system; and the relationships between autophagy and lifestyle. Volume 8: Autophagy and Human Diseases. Reviews recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, and introduces new, more effective therapeutic strategies, in the development of targeted drugs and programmed cell death, providing information that will aid on preventing detrimental inflammation.Volume 9: Necrosis and Inflammation in Human Diseases. Emphasizes the role of Autophagy in necrosis and inflammation, explaining in detail the molecular mechanism(s) underlying the formation of autophagosomes, including the progression of Omegasomes to autophagosomes.

Biomolecular Electronics

1st Edition
April 3, 2014
Paolo Facci
English
Hardback
9 7 8 1 4 5 5 7 3 1 4 2 8
Paperback
9 7 8 0 1 2 8 1 0 3 0 3 6
eBook
9 7 8 1 4 5 5 7 3 1 5 2 7

Biomolecular Electronics – the electrical control of biological phenomena – is a scientific challenge that, once fully realized, will find a wide range of applications from electronics and computing to medicine and therapeutic techniques.This new arena of biomolecular electronics is approached using familiar concepts from many areas such as electrochemistry, device electronics and some mechanisms of gene expression level control. Practical techniques are explored by which electrical and electronic means can be used to control biological reactions and processes. Also, the current and future applications for this new and expanding field are discussed.This book is aimed at scientists and engineers involved in both research and commercial applications across fields including bioelectronics, bionanotechnology, electrochemistry and nanomedicine – providing a state-of-the-art survey of what's going on at the boundary between biology and electronic technology at the micro- and nano- scales, along with a suggestive insight into future possible developments.

Advances in Lipid Research

1st Edition
Volume 4
November 25, 2014
Rodolfo Paoletti + 1 more
English
Paperback
9 7 8 1 4 8 3 2 1 1 0 0 8
eBook
9 7 8 1 4 8 3 2 2 4 4 3 5

Advances in Lipid Research, Volume 4 provides information pertinent to the actions of catecholamines to lipid metabolism. This book discusses lipid metabolism in microorganisms wherein one relates specifically to the fatty acids of microorganisms and the other to general aspects of lipid metabolism in microorganisms. Organized into seven chapters, this volume begins with an overview of some of the contributions of lipid research to the understanding of the clotting mechanism. This text then examines the extent to which dietary carbohydrate interferes in lipid metabolism. Other chapters consider the lipid-mobilizing effects of adrenomimetic agents, which are highly specific for the depot type of adipose tissue. This book discusses as well a number of areas of bacterial lipid biochemistry that are under investigation. The final chapter deals with the procedures for assessing the purity of labeled lipids by organic synthesis, biosynthesis, and isotope exchange techniques. This book is a valuable resource for biochemists, scientists, and research workers.

Structure and Function of Biological Membranes

1st Edition
June 28, 2014
Lawrence I. Rothfield
English
Paperback
9 7 8 1 4 8 3 2 4 5 8 0 5
eBook
9 7 8 1 4 8 3 2 8 1 9 6 4

Structure and Function of Biological Membranes explains the membrane phenomena at the molecular level through the use of biochemical and biophysical approaches. The book is an in-depth study of the structure and function of membranes. It is divided into three main parts. The first part provides an overview of the study of the biological membrane at the molecular level. Part II focuses on the detailed description of the overall molecular organization of membranes. The third part covers the relationship of the molecular organization of membranes to specific membrane functions; discusses catalytic membrane proteins; presents the role of membranes in important cellular functions; and looks at the membrane systems in eukaryotic cells. Biochemists, cell physiologists, biologists, researchers, and graduate and postdoctoral students in the field of biology will find the text a good reference material.

Disorders of Mineral Metabolism

1st Edition
May 10, 2014
Jack W. Coburn + 1 more
English
Paperback
9 7 8 1 4 8 3 2 3 6 6 7 4
eBook
9 7 8 1 4 8 3 2 6 5 3 5 3

Disorders of Mineral Metabolism, Volume II: Calcium Physiology is a nine-chapter text that deals with the normal function of calcium, with much emphasis on a host of intracellular functions. This volume discusses the calcium absorption, excretion, and homeostasis, as well as the hormonal modifiers of its metabolism. The role of connective tissue and bone, the major storehouse of body calcium, is reviewed in terms of collagen metabolism. This book will prove useful to biochemists, pathophysiologists, and workers in the medical field.

Cytogenetics of Cells in Culture

1st Edition
July 18, 2014
R. J. C. Harris
English
Paperback
9 7 8 1 4 8 3 2 5 4 0 1 2
eBook
9 7 8 1 4 8 3 2 8 1 9 9 5

Cytogenetics of Cells in Culture is a compendium of papers that deals with techniques to detect patterns of DNA replication, cellular control mechanisms, and chromosome analyses with automated instrumentation. Some papers discuss the effects of cell hybridization and of noxious substances such as radiation, chemical agents, and viruses on chromosomal patterns. Other papers focus on the influence of altered chromosomal complement on the survival of cells to long-term tissue culture or to ionizing radiation treatment. A couple of papers points out that naturally occurring chromosomal abnormalities in mammalian populations are relatively rare and are not necessarily associated with physical defects or disease. One paper notes that chromosomes in cells with different functions have different patterns of replication in which the changes are small and hidden. The chromosomes will usually be neutralized showing little of the characteristic pattern of replication or condensation during the early cleavage stages, that will later change into differentiated characteristic ways for each tissue type. Another paper describes chromosome breakage associated with viruses and DNA inhibitors. The compendium can prove beneficial for biochemists, micro-biologists, cellular researchers, and academicians involved in the study of cellular biology or physiology.

Practical Guide to Clinical Computing Systems

2nd Edition
November 7, 2014
Thomas Payne
English
Paperback
9 7 8 0 1 2 8 1 0 3 2 0 3
Hardback
9 7 8 0 1 2 4 2 0 2 1 7 7
eBook
9 7 8 0 1 2 7 9 9 9 1 9 7

Although informatics trainees and practitioners who assume operational computing roles in their organization may have reasonably advanced understanding of theoretical informatics, many are unfamiliar with the practical topics - such as downtime procedures, interface engines, user support, JCAHO compliance, and budgets - which will become the mainstay of their working lives. Practical Guide to Clinical Computing Systems 2nd edition helps prepare these individuals for the electronic age of health care delivery. It is also designed for those who migrate into clinical computing operations roles from within their health care organization. A new group of people interested in this book are those preparing for Clinical Informatics board certification in the US. The work provides particular differentiation from the popular first edition in four areas: 40% more content detailing the many practical aspects of clinical informatics. Addresses the specific needs of the Clinical Informatics board certification course – for which it is presently recommended by the ABPM Focus on new tech paradigms including cloud computing and concurrency – for this rapidly changing field.

Progress in Immunology

1st Edition
May 10, 2014
Bernard Amos
English
eBook
9 7 8 1 4 8 3 2 5 8 1 2 6

Progress in Immunology: First International Congress of Immunology is a collection of papers and summaries of the workshops conducted at the First International Congress of Immunology. The proceedings review significant advances that have been made in the field of immunology and covers topics ranging from the structure and genetics of antibodies to lymphocyte membranes and the role of antibodies and complexes in immune tissue damage. Cell cooperation in the immune response is also examined. This volume is organized into 15 sections and begins with a discussion on the structure of immunoglobulins and results of experiments which support the domain hypothesis and the evolution of immunoglobulins by gene duplication, along with the presence of genetic markers in V regions. The reader is then introduced to expansion and contraction in the evolution of immunoglobulin gene pools; receptors for C3 on B lymphocytes and their possible role in the immune response; and subpopulations of thymus cells and thymus-derived lymphocytes. Tne remaining sections focus on effector mechahisms of cell-mediated immunity; genetic control of immune responsiveness; immune disorders in humans such as glomerulonephritis and rheumatoid arthritis; and viruses involved in immunopathology. This book is dedicated to immunologists.

Mollusca

1st Edition
May 10, 2014
Peter W. Hochachka
English
Paperback
9 7 8 1 4 8 3 2 4 8 4 7 9
eBook
9 7 8 1 4 8 3 2 7 6 0 3 8

The Mollusca, Volume 1: Metabolic Biochemistry and Molecular Biomechanics provides information pertinent to the advances in the traditional areas of biochemistry and in other developed areas that have become a part of molluskan biochemistry. This book discusses the developments in the various aspects of molecular biomechanics and environmental biochemistry. Organized into 11 chapters, this volume begins with an overview of the phylum Mollusca. This text then provides information about the general features of the main classes and their evolution, the anatomical organization of mollusks, and a classification of the primary taxonomic groups of mollusks. Other chapters consider the functional mechanical properties of two protein rubbers found in molluskan connective tissues. This book discusses as well the mechanical properties of molluskan mucins. The final chapter deals with the significance of quinone tanning in mollusks. This book is a valuable resource for researchers of the Mollusca and other phyla, as well as to teachers and qualified graduate students. Biochemists and physiologists will also find this book useful.

The Biochemistry of Parasites

1st Edition
May 20, 2014
Gerald M. Slutzky
English
Paperback
9 7 8 1 4 8 3 1 2 5 6 6 4
Hardback
9 7 8 0 0 8 0 2 6 3 8 1 6
eBook
9 7 8 1 4 8 3 1 5 8 0 8 2

The Biochemistry of Parasites documents the proceedings of the Satellite Conference of the 13th Meeting of the Federation of European Biochemical Societies (FEBS) held in Jerusalem, August 1980. The conference presented the opportunity to summarize work done by parasite biochemists and introduce this field to workers in classical biochemistry. The 45 papers in this volume are divided into two sections covering parasite biomembranes and parasite metabolism. The papers in the biomembranes section are further divided in two parts: the parasite membrane (Part I) and adherence of the parasite to host tissues (Part II). Part I is concerned with both classical and novel aspects of membrane structure and function. It includes studies on the membrane of the leishmania; the surface coat of trypanosomes; membrane function; and transport across the cell membrane. Part II covers topics such as the adherence of pathenogenic microorganisms and the importance of of carbohydrates in parasite-host adherence. The papers in the parasite metabolism section focus primarily on three groups of parasites: leishmania, malaria, and helminthes. Topics covered include the isolation and characterization of a proteolytic enzyme from Plasmodium lophurae (duck malaria); the selection and culture of malaria parasites resistant to aminopterin; and regulation of cyclic AMP metabolism in Leishmania promastigotes and amastigotes.

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health

Books in Life sciences