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  • Monoclonal Antibodies Against Bacteria

    Volume III
    • 1st Edition
    • Alberto J. L. Macario + 1 more
    • English
    Monoclonal Antibodies Against Bacteria, Volume III covers the basis for understanding developments of practical importance in the health sciences within the area of microbiology and infectious diseases, focusing on advances made possible by monoclonal antibodies. This 12-chapter volume specifically considers the basic principles of hybridoma technology. The introductory chapters deal with treponemal antigens of significance for understanding syphilis, yaws, pinta, salmonellosis, and other gastroenteropathies. The subsequent chapters highlight pediatric infections and the strategies for molecular analyses of bacterial antigens, focusing on cell walls, S layers, and sheaths. The remaining chapters examine the bacterial toxins involved in gaseous gangrene and other forms of cell damage, such as diphtheria, caries and periodontal diseases, and bacteria relevant to animal sciences. This book will prove useful to internists, pediatricians, surgeons, dentists, veterinarians, clinical pathologists, and laboratory technologists.

  • Disorders of Mineral Metabolism

    Trace Minerals
    • 1st Edition
    • Felix Bronner + 1 more
    • English
    Disorders of Mineral Metabolism, Volume I: Trace Minerals covers the pathophysiology of clinically relevant minerals and elements. This volume focuses on minerals whose average daily intake is under 50 mg. This text is composed of 12 chapters that tackle the clinical relevance and essentiality of various trace minerals in the human body, with particular emphasis on the disorders due to their abnormal metabolism. The trace mineral and elements considered in this volume include iron, coppers, zinc, lead, nickel, manganese, chromium, molybdenum, cadmium, aluminum, tin, lithium, and fluoride. Each chapter discusses the properties, body requirements, analysis, nutritional interactions, and toxicity of the mineral. This book will prove useful to biochemists, pathophysiologists, and workers in the medical field.

  • Cell Biology

    A Laboratory Handbook
    • 1st Edition
    • Julio E Celis
    • English
    Cell Biology: A Laboratory Handbook, Volume 3 is a handbook on cell biology and covers topics ranging from transfer of macromolecules and small molecules to cloning of embryos, transgenics, and gene targeting. Cell-free extracts, permeabilized cell systems, and expression systems are also discussed, along with proteins. Comprised of 58 chapters, this volume begins with a detailed account of microinjection of RNA, DNA, and proteins into somatic cells, followed by an analysis of computer-automated capillary microinjection of macromolecules into living cells. The reader is then introduced to syringe loading as a method for inserting macromolecules into cells in suspension; electroporation of cells; and the use of liposomes in drug targeting. Subsequent chapters focus on the cloning of rabbit embryos by nuclear transplantation; gene targeting by homologous recombination in embryonic stem cells; production and isolation of recombinant viruses; and gel electrophoresis. This book will be of interest to geneticists and molecular biologists.

  • Metabolic Pathways

    Energetics, Tricarboxylic Acid Cycle, and Carbohydrates
    • 3rd Edition
    • David M. Greenberg
    • English
    Metabolic Pathways, Third Edition, Volume I: Energetics, Tricarboxyl Acid Cycle, and Carbohydrates provides information pertinent to the determination of the sequential steps of the different metabolic pathways and the isolation and characterization of the enzymes catalyzing the several steps. This book discusses the chemical steps in the metabolism of the constituents of major significance in living organisms. Organized into seven chapters, this edition begins with an overview of the concept of free energy and the various methods of obtaining free energy data. This text then examines the relations between free energy and other quantities of direct interest, such as equilibrium constants, electromotive forces, and heats of reactions. Other chapters consider the transformation of energy from one form to another that is accomplished in living systems by specialized structures. The final chapter deals with the importance of L-ascorbic acid in the prevention of scurvy and its mode of action at the molecular level. This book is a valuable resource for biochemists.

  • Photosynthesis

    The Biochemistry of Plants
    • 1st Edition
    • M. D. Hatch + 1 more
    • English
    The Biochemistry of Plants: A Comprehensive Treatise, Volume 8: Photosynthesis provides information pertinent to the biochemistry of photosynthesis. This book focuses on the photosynthesis of higher plants but some consideration is given to algal and bacterial photosynthesis. Organized into 11 chapters, this volume begins with an overview of the excitation of a light-harvesting pigment by an absorbed light quantum. This text then discusses the evidence to support the hypothesis that chlorophyll–protein complexes are represented at the supramolecular level by some of the intramembranous particles seen on chloroplast freeze-fracture faces. Other chapters consider the absorption of light energy by accessory pigments and transferred to chlorophyll in the blue-green, red, and brown algae. This book discusses as well that certain cyanobacteria respond to the color of the incident light by altering their biliprotein composition. The final chapter deals with dark reaction of photosynthesis. This book is a valuable resource for plant biochemists, neurobiochemists, molecular biologists, senior graduate students, and research workers.

  • Antigen-Antibody Reactions In Vivo

    Methods in Immunology and Immunochemistry, Vol. 5
    • 1st Edition
    • Curtis A. Williams + 1 more
    • English
    Methods in Immunology and Immunochemistry, Volume V: Antigen-Antibody Reactions In Vivo deals primarily with immune phenomena in tissues or in cell preparations. This book covers a variety of topics, including anaphylaxis, tolerance, immune suppression with chemical agents, radiation effects, antibody synthesis in vitro, immunological methods, and applied electron microscopy. Organized into 10 chapters, this volume begins with an overview of systemic anaphylaxis investigations in other more resistant species. This text then presents the analysis of mechanisms involved in the pathogenesis of the Arthus phenomenon, which shed light on the understanding of other lesions of hypersensitivity. Other chapters consider the effects of antigen–antibody interaction on connective tissue. This book discusses as well the degree and duration of acquired tolerance. The final chapter deals with the application of electron microscopy in the elucidation of the mechanisms of immune reactions. This book is a valuable resource for immunologists, students, and research workers.

  • Penicillins and Cephalosporins

    • 1st Edition
    • Robert B. Morin + 1 more
    • English
    Chemistry and Biology of ?-Lactam Antibiotics, Volume 1: Penicillins and Cephalosporins provides information pertinent to the study of antibiotics containing the ?-lactam moiety. This book discusses the occurrence of a group of ?-lactam antibiotics structurally related to cephalosporin C. Organized into five chapters, this volume begins with an overview of the mechanism of action of ?-lactam antibiotics that caused many microbiologists to develop screening tools for the detection of the ?-lactam moiety. This text then discusses the discovery of the nocardicins, the thienamycins, and olivanic acids. Other chapters provide a summary of the essential penicillin sulfoxide chemistry that gave rise to many compounds. This book discusses as well the ability of chemists to predict the level of biological activity of a compound from knowledge of its structure through theoretical and physicochemical studies. The final chapter deals with quantitative structure–activity relationships. This book is a valuable resource for microbiologists, chemists, and scientists.

  • The Antigens

    Volume II
    • 1st Edition
    • Michael Sela
    • English
    The Antigens, Volume II is a comprehensive treatise covering all aspects of antigens, including their chemistry and biology as well as their immunologic role and expression. Topics covered range from protein antigens and blood group antigens to low molecular weight antigens and immunoglobulin A. The idiotypy of antibodies is also explored, along with the application of antibodies to the measurement of substances of physiological and pharmacological interest. Comprised of six chapters, this volume begins with a discussion on the molecular bases of antigenicity and immunogenicity of proteins, followed by a chapter dealing with blood group antigens. The immunologic effects of low molecular weight antigens are then considered, together with their elicitation of allergic reactions and their tolerance and specific inhibition of the immune response. The next chapter focuses on the use of antibodies to measure substances of physiological and pharmacological interest, with emphasis on the general principle of quantitative immunoassay. The book also analyzes the idiotypy of antibodies before concluding with a description of the antibody functions of immunoglobulin A. This monograph will be of interest to practitioners and researchers in immunology, experimental and clinical medicine, biochemistry, and other disciplines.

  • The Antigens

    Volume IV
    • 1st Edition
    • Michael Sela
    • English
    The Antigens, Volume IV is a comprehensive treatise covering all aspects of antigens, including their chemistry and biology as well as their immunologic role and expression. Topics covered range from the immune reactions of lipids and lipid model membranes to the immunology of antibiotics and protective antigens of bacteria. Antigens of pathogenic fungi are also explored, along with adjuvants and antigenic competition. Comprised of seven chapters, this volume begins with a review of lipids as antigens, followed by a discussion on the immunological aspects of antibiotics. The next two chapters are concerned with more complex antigens, namely, bacteria and fungi, as well as the relationship between immunity and infection. The last three chapters deal with three important areas of immunology: antigenic competition, adjuvants, and lectins. In particular, the chemistry of lectins and their application to immunology are examined. This monograph will be of interest to practitioners and researchers in immunology, experimental and clinical medicine, biochemistry, and other disciplines.

  • The Cell: Supplementary Volume

    Biochemistry, Physiology, Morphology
    • 1st Edition
    • Jean Brachet + 1 more
    • English
    The Cell: Biochemistry, Physiology, Morphology, Volume VI: Supplementary Volume focuses on the advancements of processes, technologies, and approaches employed in studies on the structure and functions of cells. The selection first offers information on the cytoplasm of Protozoa, fungi, and the aspects of the form and function of plant cells. Topics include special structures, basic genetics, physiology, life cycles and sexuality, special fungal genetics, basal bodies or kinetosomes, mitochondria, and symbiotes in Protozoa. The text then elaborates on sensory and connective tissue cells.Discussions focus on some catabolic processes of connective tissues, formation and cytology of connective tissues, nature of the extracellular constituents, and pseudosensory, neurosensory, and true sensory cells. The selection is a vital reference for researchers interested in the biochemistry, physiology, and morphology of cells.

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