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751-760 of 14739 results in All results

HIV-Associated Neurocognitive Disorders

  • 1st Edition
  • February 21, 2024
  • Guoku Hu + 2 more
  • English
  • Paperback
    9 7 8 - 0 - 3 2 3 - 9 9 7 4 4 - 7
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 9 7 4 5 - 4
HIV-Associated Neurocognitive Disorders (HAND) presents a complex and evolving challenge in the context of HIV-1 infection and treatment. This comprehensive volume dives into the clinical manifestations, molecular and cellular mechanisms, and therapeutic strategies underlying HAND and its associated comorbidities. This book brings together cutting-edge research and clinical insights, making it an essential resource for researchers, clinicians, and students engaged in HIV-related studies and neurocognitive research. This resource also aims to advance our understanding of HAND to contribute to the development of novel diagnostic tools and therapeutic interventions for improved patient outcomes.

Concepts and Models for Drug Permeability Studies

  • 2nd Edition
  • February 20, 2024
  • Bruno Sarmento + 2 more
  • English
  • Hardback
    9 7 8 - 0 - 4 4 3 - 1 5 5 1 0 - 9
  • eBook
    9 7 8 - 0 - 4 4 3 - 1 5 5 1 1 - 6
Concepts and Models for Drug Permeability Studies: Cell and Tissue Based in Vitro Culture Models, Second Edition, summarizes the most important developments in in vitro models for predicting the permeability of drugs.This book is structured around three different approaches, summarizing the most recent achievements regarding models comprising (i) immortalized cells with an intrinsic ability to grow as monolayers when seeded in permeable supports, (ii) primary cells isolated from living organisms and directly cultured as barrier monolayers, and (iii) tissue-based models constructed with cell lines and extracellular matrix that resembles the tridimensional structure of mucosae and other biological membranes, or animal/patient-derived tissues. Each model is covered in detail, including the protocol of generation and application for specific drugs/drug delivery systems. The equivalence between in vitro cell and tissue models and in vivo conditions is discussed, highlighting how each model may provisionally resemble different drug absorption route.Chapters included in the first edition were updated with relevant data published in recent years, while four new chapters were included to reflect new emerging directions and trends in drug permeability models.Concepts and Models for Drug Permeability Studies: Cell and Tissue Based in Vitro Culture Models, Second Edition, is a critical reference for drug discovery and drug formulation scientists interested in delivery systems intended for the administration of drugs through mucosal routes and other important tissue barriers (e.g. the BBB). Researchers studying mucosal biology can use this book to familiarize themselves and exploit the synergic effect of mucosal delivery systems and biomolecules.

Biocontrol Agents for Improved Agriculture

  • 1st Edition
  • February 17, 2024
  • Ajay Kumar + 3 more
  • English
  • Paperback
    9 7 8 - 0 - 4 4 3 - 1 5 1 9 9 - 6
  • eBook
    9 7 8 - 0 - 4 4 3 - 1 5 3 0 3 - 7
Biocontrol Agents for Improved Agriculture, a volume in the Plant and Soil Microbiome series, presents both an advanced and current description of the important role of plant and soil microbiome in plant disease management. Including the latest biotechnological interventions for harnessing plant and soil microbiome and their potential in controlling plant pathogen/ disease, as well as the commercialization of biocontrol products and exploration of microbial derived bioactive compounds, this book provides an important reference on the challenges of biocontrol products. Sections explore the bacterial and fungal species successfully applied as plant and soil inoculant for the effective management of plant diseases. As these microbial biocontrol agents not only suppress the plant disease, but also enhance the growth or agricultural production in sustainable ways, the book focuses on the molecular aspect of plant- pathogen interactions and their biocontrol strategies via the use of plant and soil microbiome. This book is an important reference for those seeking sustainable, safe options for protecting against microbial agricultural loss and environmental damage.

Ureases

  • 1st Edition
  • February 16, 2024
  • Rodrigo Ligabu Braun + 1 more
  • English
  • Paperback
    9 7 8 - 0 - 3 2 3 - 9 1 8 0 0 - 8
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 7 2 0 0 - 0
Ureases: Foundations, Classes, and Applications provides a thorough, practical analysis of ureases—enzymes of growing relevance across a range of biotechnological applications and drug discovery. Unique in many aspects, ureases are one of the few enzymes to have nickel in their active sites. This book covers all aspects of this enzymatic class starting with foundational overview and then providing historical urease research and current state, from basic biochemistry to the use of ureases as hallmarks in enzymology, crystallography, and bioinorganic chemistry. The different classes of ureases, structurally diverse but chemically equivalent, are individually discussed.The multi-protein, multi-step activation of ureases (with chemical modification of residues, transport, and transfer of nickel ions) are examined in-depth, along with the catalytic mechanisms of ureolysis and its inhibitors. The final two sections of the book address multiple applications of ureases in health and biotechnology, respectively, going from gastric ulcer treatment to architectural uses in buildings and engineering. Future applications and next steps in research are also considered.

Adrenal Gland

  • 1st Edition
  • Volume 124
  • February 15, 2024
  • Gerald Litwack
  • English
  • Hardback
    9 7 8 - 0 - 4 4 3 - 1 9 4 0 0 - 9
  • eBook
    9 7 8 - 0 - 4 4 3 - 1 9 4 0 1 - 6
Adrenal Gland, Volume 124 in the Vitamins and Hormones series, highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

Fundamentals of Weed Science

  • 6th Edition
  • February 14, 2024
  • Robert L Zimdahl + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 4 4 3 - 1 5 7 2 3 - 3
  • eBook
    9 7 8 - 0 - 4 4 3 - 1 5 7 2 4 - 0
Fundamentals of Weed Science, Sixth Edition, places weed management in the context of weed research and science, presenting the latest advances in the role, control, and potential uses of weed plants. This book uses an ecological framework to explore the role of responsible and effective weed control in agriculture from the emergence and genetic foundation of weeds to the latest means of control and environmental effects.Fully revised, updated, and expanded, Fundamentals of Weed Science now includes insights into international trad eand consumer preferences, weed seedbanks, advancements in robotic weeding, weed flaming, and the potential of precision agriculture in weed science.

Proteomics Mass Spectrometry Methods

  • 1st Edition
  • February 13, 2024
  • Paula Meleady
  • English
  • Paperback
    9 7 8 - 0 - 3 2 3 - 9 0 3 9 5 - 0
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 0 6 5 2 - 4
Proteomics Mass Spectrometry Methods: Sample Preparation, Protein Digestion, and Research Protocols shares best practices collected across key laboratories and core facilities, taking the reader through key tactics for executing the most usual mass spectrometry experiments. Sections review research making use of MS proteomics experiments, focus on critical sample preparation, cover mammalian cell lines and samples from clinical tissue and biological fluids, discuss subcellular fractionation, provide methods for protein digestion both for in gel and in solution, and delve into key MS proteomics analysis protocols, including label-free LC-MS, TMT and iTRAQ labelled LC-MS, phosphorylation enrichment, ubiquination enrichment, and more. This book is the perfect lab manual for research teams or for use as a new staff training material. Core facility managers may also find it useful for sharing best practices with their staff and researchers.

Epigenetic Regulation of Cancer - Part B

  • 1st Edition
  • Volume 383
  • February 13, 2024
  • Sheila Spada + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 4 4 3 - 1 3 6 5 3 - 5
  • eBook
    9 7 8 - 0 - 4 4 3 - 1 3 6 5 4 - 2
Epigenetic Regulation of Cancer, Part B, Volume 383 in the International Review of Cell and Molecular Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of hot topics, including Epigenetic control of cell signaling in cancer stem cells, Genetic and epigenetic features of neuroendocrine prostate cancer and their emerging applications, Epigenetic regulation in pancreatic cancer, Epigenome Editing in Cancer: Advances and Challenges for Potential Therapeutic Options, Inhibition of epigenetic mechanisms in cancer, and Epigenetics as a determinant of radiation response in cancer.

RNA Therapeutics Part A

  • 1st Edition
  • Volume 203
  • February 13, 2024
  • Dinh-Toi Chu + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 4 4 3 - 2 2 3 1 4 - 3
  • eBook
    9 7 8 - 0 - 4 4 3 - 2 2 3 1 5 - 0
RNA Therapeutics, Part A, Volume 203 presents the latest on a new class of medication based on RNA molecules. The book includes timely chapters that focus on An introduction to RNA therapeutics and potentials, The development and technologies of RNA therapeutics, Types of RNA therapeutics, Molecular mechanisms of RNA therapeutics, IT, and AI applications in RNA therapeutics, The application of data sciences and bioinformatics in RNA therapeutics, RNA therapeutics history and future perspectives, Recent applications of RNA therapeutic in clinics, Advantages and disadvantages of RNA therapeutics, RNA therapeutics for neurological disease, RNA therapeutics for metabolic disorders, and RNA therapeutics for metabolic disorders.

Systems Biology Approaches for Host-Pathogen Interaction Analysis

  • 1st Edition
  • February 12, 2024
  • Mohd. Tashfeen Ashraf + 2 more
  • English
  • Paperback
    9 7 8 - 0 - 3 2 3 - 9 5 8 9 0 - 5
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 5 8 9 1 - 2
Application and utilization of data science approaches has revolutionized scientific research including host–pathogen interaction analyses. Host–pathogen interactions are generally considered highly specific interactions, resulting in a variety of consequences. Data science approaches coupled with network biology has taken host–pathogen interaction analysis from specific interaction to a new paradigm of understanding the consequences of these interactions within a biological network. Unfortunately, basic biological researchers are mostly unaware of these advancements. Conversely, data scientists are not familiar with biological aspects of such data. Systems Biology Approaches for Host–Pathogen Interaction Analyses benefits biological researchers by expanding the scope of their research and utilization of their accumulated data using recent technological advancements. In addition, the book also opens avenues for bioinformatics and computer science researchers to utilize their expertise in biologically meaningful ways.

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