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Elsevier

Books in Life sciences

  • Monitoring Vesicular Trafficking in Cellular Responses to Stress

    • 1st Edition
    • Volume 164
    • English
    Monitoring Vesicular Trafficking in Cellular Responses to Stress, Volume 164 in the Methods in Cell Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics. Each chapter is written by an international board of authors.

  • Neuromuscular Disorders

    Treatment and Management
    • 2nd Edition
    • Tulio E. Bertorini
    • English
    Offering an authoritative, multidisciplinary approach to the complex issues associated with neuromuscular disease, Neuromuscular Disorders, 2nd Edition, provides the latest tools and strategies for minimizing disability and maximizing quality of life. Dr. Tulio Bertorini, an expert in clinical neuromuscular care, and a team of world-renowned contributors cover all management and therapeutic considerations regarding the full range of neuromuscular disorders and resulting complications.

  • Principles and Labs for Deep Learning

    • 1st Edition
    • Shih-Chia Huang + 1 more
    • English
    Principles and Labs for Deep Learning provides the knowledge and techniques needed to help readers design and develop deep learning models. Deep Learning techniques are introduced through theory, comprehensively illustrated, explained through the TensorFlow source code examples, and analyzed through the visualization of results. The structured methods and labs provided by Dr. Huang and Dr. Le enable readers to become proficient in TensorFlow to build deep Convolutional Neural Networks (CNNs) through custom APIs, high-level Keras APIs, Keras Applications, and TensorFlow Hub. Each chapter has one corresponding Lab with step-by-step instruction to help the reader practice and accomplish a specific learning outcome. Deep Learning has been successfully applied in diverse fields such as computer vision, audio processing, robotics, natural language processing, bioinformatics and chemistry. Because of the huge scope of knowledge in Deep Learning, a lot of time is required to understand and deploy useful, working applications, hence the importance of this new resource. Both theory lessons and experiments are included in each chapter to introduce the techniques and provide source code examples to practice using them. All Labs for this book are placed on GitHub to facilitate the download. The book is written based on the assumption that the reader knows basic Python for programming and basic Machine Learning.

  • Zika Virus Impact, Diagnosis, Control, and Models

    Volume 2: The Neuroscience of Zika Virus
    • 1st Edition
    • Colin R. Martin + 3 more
    • English
    Zika Virus Impact, Diagnosis, Control, and Models: Volume Two: The Neuroscience of Zika examines diagnosis, vaccines, and potential therapy methods for Zika virus syndrome. The book also details the neuroscience of Guillain-Barré syndrome, its effects and neuromuscular rehabilitation. It is designed to help readers better understand detection, therapies for Zika virus, preventative vaccines, diagnosis and associated microcephaly. Chapters on models enable further research and understanding. This book has applicability for neuroscientists, neurologists, virologists and anyone working to better understand the evolution and pathogenesis of Zika virus-related conditions.

  • The Neuroscience of Aging

    • 1st Edition
    • Colin R. Martin + 2 more
    • English
    Assessments, Treatments and Modeling in Aging and Neurological Disease: The Neuroscience of Aging is a comprehensive reference on the diagnosis and management of neurological aging and associated disorders. This book discusses the mechanisms underlying neurological aging and provides readers with a detailed introduction to the aging of neural connections and complexities in biological circuitries, as well as the interactions between genetics, epigenetics and other micro-environmental processes. It also examines pharmacological and non-pharmacological interventions of age-related conditions that affect the brain including Alzheimer’s, stroke, and multiple sclerosis. Factors Affecting Neurological Aging: Genetics, Neurology, Behavior, and Diet is a comprehensive reference on the genetic and behavioral features associated with neurological aging and associated disorders. This book discusses the mechanisms underlying neurological aging and provides readers with a detailed introduction to the aging of neural connections and complexities in biological circuitries, as well as the physiological, behavioral, molecular, and cellular features of neurological aging. It also examines the use of animal modelling of aging and neurological disease.

  • Zika Virus Biology, Transmission, and Pathways

    Volume 1: The Neuroscience of Zika Virus
    • 1st Edition
    • Colin R. Martin + 3 more
    • English
    Zika Virus Biology, Transmission, and Pathways: The Neuroscience of Zika, Volume One provides a detailed introduction to the molecular biology of the Zika virus and its features, transmission, and impact on neurological systems. Designed to better readers’ understanding of the Zika virus, this volume features chapters on the immune response, molecular mechanisms, and other areas to better understand underlying pathways. This book has applicability for neuroscientists, neurologists, virologists and anyone working to better understand the evolution and pathogenesis of Zika virus-related conditions.

  • Epigenetic Regulation in Overcoming Chemoresistance

    • 1st Edition
    • Volume 16
    • Chunfu Wu + 1 more
    • English
    Epigenetic Regulation in Overcoming Chemoresistance, Volume 19, explains how epigenetic agents can enhance the chemotherapy sensitivity of diverse types of cancers. The book provides a comprehensive delineation and the recent development of the scientific studies on the epigenetic regulation in enhancing chemo-sensitivity. In addition, it discusses several topics such as DNA methyltransferase inhibitors (DNMTi), Histone deacetylases inhibitors (HDACi), Histone lysine demethylases inhibitors (HDMi), Histone lysine methyltransferases inhibitors (HMTi) and drugs regulating the microRNA, long non-coding RNA (lncRNA) or RNA methylation. Finally, recent and future developments of the field of epigenetic regulation are explored. This is a valuable resource for cancer researchers, clinicians, graduate students and several members of biomedical field who are interested in learning about epigenetic regulation methods to reverse chemo-resistance in cancers.

  • Environmental and Health Management of Novel Coronavirus Disease (COVID-19)

    • 1st Edition
    • Mohammad Hadi Dehghani + 2 more
    • English
    Environmental and Health Management of Novel Coronavirus Disease (COVID-19) examines mitigation measures that can be adopted at the time of a novel coronavirus outbreak to lessen environmental contamination and impacts on human health. The book discusses origin, structure and pathogenesis, epidemiology, environmental transmission and the potential spread routes of COVID-19 via surfaces, air, water, wastewater, medical waste and food products. It also covers guidelines and protocols for setting safety conditions to provide adequate health care and reduce the risk of infection in health and non-healthcare settings, along with preventative measures and disinfection technologies. In addition, the book discusses challenges, opportunities and future perspectives, the global crisis, and global consequences on the environment and health. With contributions from experts, this book presents a multidisciplinary reference resource for virologists, microbiologists, public health professionals, environmental health managers and others engaged in the study and mitigation of the environmental and health impacts of the virus.

  • Advances in Immunology

    • 1st Edition
    • Volume 150
    • Frederick W. Alt
    • English
    Advances in Immunology, Volume 150, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology.

  • Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies

    • 1st Edition
    • Volume 15
    • Ramasamy Paulmurugan + 1 more
    • English
    Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies brings current knowledge from an international team of experts on the science and clinical management of glioblastoma chemoresistance. The book discusses topics such as molecular mechanisms of chemoresistance, experimental models to study chemoresistance, chemoresistance to drugs other than Temozolomide, and specific strategies to reverse chemoresistance. Additionally, it encompasses information on how to mitigate chemoresistance by targeted enhancement of p53 function. This book is a valuable resource for cancer researchers, oncologists, neuro-oncologists and other members of the biomedical field. Glioblastoma (GBM) is the most invasive and malignant primary brain tumor in humans with poor survival after diagnosis, therefore it is imperative that molecular and cellular mechanisms behind therapy resistant GBM cells, as well as the therapeutic strategies available to counter the resistance are comprehensively understood.

  • mRNA 3’ End Processing and Metabolism

    • 1st Edition
    • Volume 655
    • English
    mRNA 3’ End Processing and Stability, Volume 655 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics. Each chapter is written by an international board of authors.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 103
    • Gregory S. Makowski
    • English
    Advances in Clinical Chemistry, Volume 103, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry. It is the benchmark publication for novel analytical approaches in the clinical laboratory.

  • Foodborne Infections and Intoxications

    • 5th Edition
    • J. Glenn Morris Jr. + 1 more
    • English
    Foodborne Infections and Intoxications, Fifth Edition brings together up-to-date, relevant interdisciplinary expertise of 70 authors presenting foodborne disease pathogens and toxins, microbiology, disease diagnosis and treatment, epidemiology, and disease prevention in the context of public health and food safety regulation. Beginning with the estimation of foodborne disease burden at the international scale, this book dives deep in foodborne disease outbreak investigation, food safety risk assessment, and molecular analysis, together with detailed descriptions of the major bacteria, viruses, parasites, and toxins associated with foodborne illness. This new edition also emphasizes development of risk-based approaches to food safety and safety regulation implementation. This book is a valuable scientific resource for understanding causes and management of foodborne diseases. The new edition offers the latest knowledge and updates on foodborne infections and intoxications and food safety for multiple generations of students, investigators, public health workers, food scientists, and food safety practitioners.

  • Inoculating Cities

    Case Studies of Urban Pandemic Preparedness
    • 1st Edition
    • Rebecca Katz + 1 more
    • English
    Inoculating Cities: Case Studies of Urban Pandemic Preparedness begins with a brief historical description of infectious disease outbreaks in cities as well as an overview of infectious disease outbreaks since 2000 that hold profound implications for cities and urban environments – such as severe acute respiratory syndrome (SARS) in 2003, H1N1 influenza in 2009, Ebola virus in 2014, Zika virus in 2015, and more recently, COVID-19 in 2020. Each of these outbreaks affected different geographies of the world and underscored the importance of urban pandemic preparedness or urban health security as a means of mitigating the threats posed by infectious diseases. This book describes several of the characteristics of cities that make them uniquely vulnerable to infectious disease threats which include, but are not limited to, their population density, population diversity, internal and external population movements, and inequalities in cities. Finally, the book discusses frameworks and capacities that are essential for preparing cities to prevent, detect, and respond to infectious disease outbreaks. With contributions from experts and researchers with first-hand experiences with infectious disease outbreaks, their impact on the management of disease, and pandemic preparedness in progressively urban societies, Inoculating Cities addresses the unique threats infectious diseases pose to urban environments and surveys innovative models that cities are using to combat these threats.

  • Biomedical Signal Analysis for Connected Healthcare

    • 1st Edition
    • Sridhar Krishnan
    • English
    Biomedical Signal Analysis for Connected Healthcare provides rigorous coverage on several generations of techniques, including time domain approaches for event detection, spectral analysis for interpretation of clinical events of interest, time-varying signal processing for understanding dynamical aspects of complex biomedical systems, the application of machine learning principles in enhanced clinical decision-making, the application of sparse techniques and compressive sensing in providing low-power applications that are essential for wearable designs, the emerging paradigms of the Internet of Things, and connected healthcare.

  • Advanced Drug Delivery Systems in the Management of Cancer

    • 1st Edition
    • Kamal Dua + 5 more
    • English
    Advanced Drug Delivery Systems in the Management of Cancer discusses recent developments in nanomedicine and nano-based drug delivery systems used in the treatment of cancers affecting the blood, lungs, brain, and kidneys. The research presented in this book includes international collaborations in the area of novel drug delivery for the treatment of cancer. Cancer therapy remains one of the greatest challenges in modern medicine, as successful treatment requires the elimination of malignant cells that are closely related to normal cells within the body. Advanced drug delivery systems are carriers for a wide range of pharmacotherapies used in many applications, including cancer treatment. The use of such carrier systems in cancer treatment is growing rapidly as they help overcome the limitations associated with conventional drug delivery systems. Some of the conventional limitations that these advanced drug delivery systems help overcome include nonspecific targeting, systemic toxicity, poor oral bioavailability, reduced efficacy, and low therapeutic index. This book begins with a brief introduction to cancer biology. This is followed by an overview of the current landscape in pharmacotherapy for the cancer management. The need for advanced drug delivery systems in oncology and cancer treatment is established, and the systems that can be used for several specific cancers are discussed. Several chapters of the book are devoted to discussing the latest technologies and advances in nanotechnology. These include practical solutions on how to design a more effective nanocarrier for the drugs used in cancer therapeutics. Each chapter is written with the goal of informing readers about the latest advancements in drug delivery system technologies while reinforcing understanding through various detailed tables, figures, and illustrations. Advanced Drug Delivery Systems in the Management of Cancer is a valuable resource for anyone working in the fields of cancer biology and drug delivery, whether in academia, research, or industry. The book will be especially useful for researchers in drug formulation and drug delivery as well as for biological and translational researchers working in the field of cancer.

  • Successes and Challenges of NK Immunotherapy

    Breaking Tolerance to Cancer Resistance
    • 1st Edition
    • Benjamin Bonavida + 1 more
    • English
    Successes and Challenges of NK Immunotherapy: Increasing Anti-tumor Efficacy describes the unique therapeutic applications of NK cells to fight cancers and eliminate the bulk and subset of cancer stem cells responsible for metastasis, relapse and recurrences. The book provides information on the development, engineering, mechanisms of action, response to various preclinical models, and applications in various clinical trials. Sections cover the development of highly engineered cytotoxic NK cells, their mechanisms of action, preclinical and clinical applications, the development and application of CAR-NK cells, and new NK-drug conjugates, also emphasizing that activated NK cells can target and kill highly resistant cancer stem cells. Written by the leading experts on NK immunotherapy worldwide, this is a valuable resource for researchers, clinicians and members of the biomedical field who are interested in understanding novel and efficient therapies to fight cancers.

  • Curing Genetic Diseases through Genome Reprogramming

    • 1st Edition
    • Volume 182
    • English
    Curing Genetic Diseases through Genome Reprogramming, Volume 182 captures an historic moment in the field of gene therapy—the dawn of a new age in which the dream of curing genetic diseases has become realizable. The volume presents the most clinically advanced gene therapy and genome editing approaches for the treatment of genetic diseases in specific organs, including difficult therapeutic targets, futuristic ideas of genetic interventions, and large scale human genome repair. An initial chapter addresses the complex ethical aspects involved in the very idea of modifying the human genome.

  • Biostimulants for Crops from Seed Germination to Plant Development

    A Practical Approach
    • 1st Edition
    • Shubhpriya Gupta + 1 more
    • English
    Biostimulants for crops from seed germination to plant development focuses on the effects and roles of natural biostimulants in every aspect of plant growth development to reduce the use of harmful chemical fertilizers and pesticides. Biostimulants are a group of substances of natural origin that offer a potential to reduce the dependency on harmful chemical fertilizers causing environmental degradation. While there is extensive literature on biostimulants, there remains a gap in understanding how natural biostimulants work and their practical application. This book fills that gap, presenting the ways in which biostimulants enhance seed vigor and plant productivity by looking into their mode of action, an area still being researched for deeper understanding. Exploring the roles of seed germination, pollen tube formation, pollen-pistil interaction, flower and fruit setting, to plant pigments, rhizospheric and soil microorganisms, the book also sheds light on the challenges and realistic opportunities for the use of natural biostimulants.

  • Polymeric Supports for Enzyme Immobilization

    Opportunities and Applications
    • 1st Edition
    • Alka Dwevedi
    • English
    Enzyme immobilization has been approached for finding solutions for various critical problems associated with industries, medicine, environment, agriculture, etc. Especially since last decades, several innovative researches have come up to look for enhancing catalytic efficiency, reusability of immobilized enzyme and longer stability by introducing range of immobilizing supports, supports modifiers through introduction of several chemical agents (non-toxic) and adopting innovative enzyme immobilization methods. In the present book, polymeric supports have been focussed for enzyme immobilization, especially due to their versatility in immobilizing different enzymes for different large scale enzyme reactors to be used for several applications. Especially, polymers can be modified according to applications and enzyme properties which have made it supports of choice for all several enzyme based applications. Polymeric Supports for Enzyme Immobilization: Opportunities and Applications offers in-depth discussions of known polymeric enzyme support materials, reaction processes, and optimized methods to enhance enzyme immobilization. Case-based chapters examine methods of enzyme immobilization onto various polymeric supports, their surface chemistry and physical morphology followed by implementation of polymers based immobilized enzymes in various applications, viz. medicine, environment, industries, clean energy, disease diagnosis, drug delivery etc. This book has prime focus to allow several researchers across the world to provide updated technological details and incite to contribute more innovative work in coming years to find solutions to several critical problems.

  • Engineering Principles of Unit Operations in Food Processing

    Unit Operations and Processing Equipment in the Food Industry
    • 1st Edition
    • Seid Mahdi Jafari
    • English
    Engineering Principles of Unit Operations in Food Processing, volume 1 in the Woodhead Publishing Series, In Unit Operations and Processing Equipment in the Food Industry series, presents basic principles of food engineering with an emphasis on unit operations, such as heat transfer, mass transfer and fluid mechanics.

  • Non-invasive Brain Stimulation (NIBS) in Neurodevelopmental Disorders

    • 1st Edition
    • Volume 264
    • English
    Non-invasive Brain Stimulation (NIBS) in Neurodevelopmental Disorders, Volume 264 presents the latest updates on recent techniques used to examine the potential treatment of psychiatric and neurological disorders in adults. In this special issue, the book's authors and contributors provide a unique focus on the potential effects of non-invasive brain stimulation. Topics cover a range of reviews, opinions, methodologies, original research articles, and suggestions on how to better translate scientific knowledge into practice. This new release will help guide basic research and the development of therapeutic interventions for children and adolescents who suffer from neurodevelopmental disorders.

  • The Inductive Brain in Development and Evolution

    • 1st Edition
    • Nelson R Cabej
    • English
    The Inductive Brain in Development and Evolution provides readers with a substantial biological education on animal nervous systems and their role in the development, adaptation, homeostasis, and evolution of species. The book begins by delving into the embryonic development of the brain and then discusses epigenetic information and neural activity post-birth. It then analyzes the inductive brain’s neural and brain control of such factors like myogenesis, bone development, sensory organs, metamorphosis in vertebrates and invertebrates, and wing development in insects. The book closes with an examination of phenotypic evolution in neural control, mechanisms, and drivers of animal brains. The Inductive Brain in Development and Evolution will offer evolutionary biologists, specifically those researching development, adaptation, and evolution of animals, a comprehensive text that covers a variety of valuable topics.

  • Volatiles and Metabolites of Microbes

    • 1st Edition
    • Joginder Singh Panwar + 2 more
    • English
    Volatiles and Metabolites of Microbes compiles the latest research and advancement in the field of volatiles, metabolites synthesized from the microbial strains such as actinomycetes, bacteria, cyanobacteria, and fungal species and their potential applications in the field of healthcare issue and sustainable agriculture. There is an urgent need to explore new and advanced biological methods for health industries and sustainable agriculture and to protect the environment from environmental pollution or contaminates, global warming, and also control the health of human beings from the side effects of various pharmaceuticals products. Focusing all these factors, Volatiles and Metabolites of Microbes explores new aspects of microorganism in terms of volatiles, enzymes, bioactive compounds synthesized from the microbes and their potential applications in the field of sustainable agriculture and health-related issues

  • Generative Adversarial Networks for Image-to-Image Translation

    • 1st Edition
    • Arun Solanki + 2 more
    • English
    Generative Adversarial Networks (GAN) have started a revolution in Deep Learning, and today GAN is one of the most researched topics in Artificial Intelligence. Generative Adversarial Networks for Image-to-Image Translation provides a comprehensive overview of the GAN (Generative Adversarial Network) concept starting from the original GAN network to various GAN-based systems such as Deep Convolutional GANs (DCGANs), Conditional GANs (cGANs), StackGAN, Wasserstein GANs (WGAN), cyclical GANs, and many more. The book also provides readers with detailed real-world applications and common projects built using the GAN system with respective Python code. A typical GAN system consists of two neural networks, i.e., generator and discriminator. Both of these networks contest with each other, similar to game theory. The generator is responsible for generating quality images that should resemble ground truth, and the discriminator is accountable for identifying whether the generated image is a real image or a fake image generated by the generator. Being one of the unsupervised learning-based architectures, GAN is a preferred method in cases where labeled data is not available. GAN can generate high-quality images, images of human faces developed from several sketches, convert images from one domain to another, enhance images, combine an image with the style of another image, change the appearance of a human face image to show the effects in the progression of aging, generate images from text, and many more applications. GAN is helpful in generating output very close to the output generated by humans in a fraction of second, and it can efficiently produce high-quality music, speech, and images.

  • Aquacultural Facilities and Equipment

    • 1st Edition
    • Bimal Chandra Mal
    • English
    Aquaculture Facilities and Equipment is a practical resource on the technical aspects needed for experts in the field to understand a high-performance aquaculture facility, its design and form, and the materials and systems used within the facility. The book is written at a level suitable for both field experts and students alike. It includes topics such as pond construction machinery, pumps for aquaculture, aeration for aquaculture, fish feeders, filtration systems in aquaculture, hatchery, raceways and tanks, and cage and pen culture. This book is based on 30 years of research that is presented as a useful reference to enhance efficient aquaculture production. It will be very helpful for experts working in related fields of fishery development and for those teaching fishery science and engineering courses.

  • Tissue Barriers in Disease, Injury and Regeneration

    • 1st Edition
    • Nikolai V. Gorbunov
    • English
    Tissue Barriers in Disease, Injury and Regeneration focuses on the molecular and cellular fundamentals of homeostatic and defense responses of tissue barriers, covering the damaging impacts and exposure to pathogens and engineered nanomaterials. Sections emphasize the role of mesenchymal stoma, vascular, epithelial, telocyte, myofibroblast, lymphoid and reticuloendothelial cells, along with reactions that bridge the effects of ambient factors, medical treatments, drag delivery systems with alterations in barrier integrity, tissue/organ functions, and metabolic status. Other sections cover the role of progenitor cells of different origins in the remodeling and regeneration of tissue stroma, vasculature of blood-tissue barriers, and more.

  • Novel Approaches to Colorectal Cancer

    • 1st Edition
    • Volume 151
    • English
    Novel Approaches to Colorectal Cancer, Volume 151 in the Advances in Cancer Research series, is composed of 11 reviews covering state-of-the-art research relating to the etiology, diagnosis, prevention and treatment of colorectal cancer. The book's chapters were written by recognized experts in the field, and include sections on molecular biomarkers in diagnosis and therapy, the interplay of diet, lifestyle, and the microbiome, early-age onset disease, mutational signature analysis, challenges in early detection, immunotherapy, organoid technology, the role of epigenetic alterations, disparities in minority populations, field carcinogenesis, and cancer as an evolutionary process. Each of these topics provides novel insights and concepts on various aspects of the nature of colorectal cancer, offering new opportunities for the management of a major source of cancer incidence and mortality.

  • Progress in Medicinal Chemistry

    • 1st Edition
    • Volume 60
    • Brian Cox + 1 more
    • English
    Progress in Medicinal Chemistry, Volume 60 provides a review of eclectic developments in medicinal chemistry. Each chapter is written by an international board of authors who cover topics including Venoms in Drug Discovery, Designing Protacs as a Drugs, Automated synthesis and enabling tools for Medicinal Chemistry, Use of Molecular Docking Computational Tools in Drug Discovery, and An industrial perspective on co-crystals: screening, identification and development of the less utilized solid form in drug discovery and development.

  • The Atlantic Walrus

    Multidisciplinary Insights into Human-Animal Interactions
    • 1st Edition
    • Xénia Keighley + 3 more
    • English
    The Atlantic Walrus: Multidisciplinary insights into human-animal interactions addresses the key dimensions of long-term human walrus interactions across the Atlantic Arctic and subarctic regions, over the past millennia. This book brings together research from across the social and natural sciences to explore walrus biology, human culture, environmental conditions and their reciprocal effects. Together, 13 chapters of this book reconstruct the early evolution of walruses, walrus biology, the cultural significance and ecological impact of prehistoric and indigenous hunting practices, as well as the effects of commercial hunting and international trade. This book also examines historic and ongoing management strategies and, the importance of new research methodologies in revealing hitherto unknown details of the past, and concludes by discussing the future for Atlantic walruses in the face of climate change and increased human activities in the Arctic. This volume is an ideal resource for those who are seeking to understand an iconic Arctic species and its long and complex relationship with humans. This includes individuals and researchers with a personal or professional connection to walruses or the Arctic, as well as marine biologists, zoologists, conservationists, paleontologists, archaeologists, anthropologists, historians, indigenous communities, natural resource managers and government agencies.

  • Biologically Active Peptides

    From Basic Science to Applications for Human Health
    • 1st Edition
    • Fidel Toldra + 1 more
    • English
    Biologically Active Peptides: From Basic Science to Applications for Human Health stands as a comprehensive resource on bioactive peptide science and applications. With contributions from more than thirty global experts, topics discussed include bioactive peptide science, structure-activity relationships, best practices for their study and production, and their applications. In the interdisciplinary field of bioactive peptides, this book bridges the gap between basic peptide chemistry and human physiology, while reviewing recent advances in peptide analysis and characterization. Methods and technology-driven chapters offer step-by-step guidance in peptide preparation from different source materials, bioactivity assays, analysis and identification of bioactive peptides, encoding bioactive peptides. Later, applications across disease areas and medical specialties are examined in-depth, including the use of bioactive peptides in treating obesity, diabetes, osteoporosis, mental health disorders, food allergies, and joint health, among other disorders, as well as bioactive peptides for sensory enhancement, sports and clinical nutrition, lowering cholesterol, improving cardiovascular health, and driving advances in biotechnology.

  • Direct Nose-to-Brain Drug Delivery

    Mechanism, Technological Advances, Applications, and Regulatory Updates
    • 1st Edition
    • Chandrakantsing Pardeshi + 1 more
    • English
    Direct Nose-to-Brain Drug Delivery provides the reader with precise knowledge about the strategies and approaches for enhanced nose-to-brain drug delivery. It highlights the development of novel nanocarrier-based drug delivery systems for targeted drug delivery to the brain microenvironments with a focus on the technological advances in the development of the novel drug delivery devices for intranasal administration, including special emphasis on brain targeting through nose. This book explores the various quantification parameters to assess the brain targeting efficiency following intranasal administration and includes an overview on the toxicity aspects of the various materials used to develop the direct nose-to-brain drug delivery vehicles and of the regulatory aspects including patents and current clinical status of the potential neurotherapeutics for the effective management of neuro-ailments. Technological advances in new drug delivery systems with diverse applications in pharmaceutical, biomedical, biomaterials, and biotechnological fields are also explained. This book is a crucial source that will assist the veteran scientists, industrial technologists, and clinical research professionals to develop new drug delivery systems and novel drug administration devices for the treatment of neuro-ailments.

  • Transporters and Plant Osmotic Stress

    • 1st Edition
    • Aryadeep Roychoudhury + 2 more
    • English
    Transporters and Plant Osmotic Stress focuses on the potential negative impact of abiotic stresses on plant health and crop yield. The book focuses on the current state of knowledge of the biochemical and molecular regulation of several classes of membrane transporters during different osmotic stresses and their probable mechanisms of operation in plant stress tolerance. The comprehensive discussion presented in this book highlights steps appropriate for mitigating multiple forms of abiotic stresses utilizing transporter proteins. Edited by leading experts and authored by top researchers from around the world, Transporters and Plant Osmotic Stress will be valuable to researchers, academicians, and scientists to enhance their knowledge and inspire further research in the field of transporters with respect to abiotic stress responses. It is complimented by its companion book titled Metal and Nutrient Transporters in Abiotic Stress.

  • The Human Hypothalamus

    Anterior Region
    • 1st Edition
    • Volume 179
    • Dick F. Swaab + 4 more
    • English
    The Hypothalamus is an important area of the brain for understanding a variety of neurological disorders. This volume summarizes for readers the anatomy and physiology of the anterior hypothalamus, to better understand pathology and treatment of hypothalamus related disorders. In addition to anatomy and physiology in humans, cytoarchitecture and chemoarchitecture in rodents is provided. The volume explores the role of the hypothalamus in disorders of eating, sleeping, anxiety, and mood, as well as its role in sexual behavior and gender identity. Coverage includes how Parkinson’s, Alzheimer’s and other neurological disorders relate to the hypothalamus.

  • Advances in Agronomy

    • 1st Edition
    • Volume 169
    • English
    Advances in Agronomy, Volume 169, the latest release in this leading reference on agronomy, contains a variety of updates and highlights new advances in the field. Each chapter is written by an international board of authors.

  • Advances in Applied Microbiology

    • 1st Edition
    • Volume 115
    • English
    Advances in Applied Microbiology, Volume 115 continues the comprehensive reach of this widely read and authoritative review source in microbiology. Users will find invaluable references and information on a variety of areas relating to the topic of microbiology, with this release focusing on the preparation of functional oligosaccharides using microbial coupling fermentation.

  • Advances in Microbial Physiology

    • 1st Edition
    • Volume 78
    • Robert K. Poole + 1 more
    • English
    Advances in Microbial Physiology, Volume 78, the latest release in this ongoing series, continues the long tradition of topical, important, cutting-edge reviews in microbiology. This updated release contains the latest information in the field, with comprehensive chapters covering Microbubble Intensification of Bioprocessing, Bacterial cellulose: biosynthesis, production, and applications, Microbial energy management – a product of three broad tradeoffs, and more.

  • The Intestine

    • 1st Edition
    • Ahmed El-Hashash + 1 more
    • English
    The intestine is among the leading organs, in which several cutting edge in vitro and in vivo research tools and approaches have recently been developed and used to investigate stem cell biology/function, and the potential applications of stem cells in the treatment of intestinal diseases. These cutting-edge research tools and approaches involve human and murine organoid cultures, genetic editing in vitro and in vivo, human induced pluripotent cell (iPS cell) models of disease, haploid cells for genetic as well as compound screening paradigms, genetically engineered mice, and stem cell transplantation to cure diseases. Stem Cell Innovation in Health and Disease: Volume 1: The Intestine contains two major sections describing cutting edge research for understanding stem cell functions in the intestine, and for developing methods to bring stem cells from bench to bedside; respectively. Each section includes insights ranging from using mouse and human organoid cultures, genetic editing in vitro and in vivo, and human induced pluripotent cells (iPSCs) to study stem cell functions and model intestinal diseases, through the cutting-edge research, including the potential application of iPSCs, ESCs and blood stem cells (stem cell transplants) in the treatment of intestinal diseases/disorders. This volume, therefore, discusses the fact-based promise of stem cells and regenerative medicine in the intestine in the real world.

  • Real-Time Data Acquisition in Human Physiology

    Real-Time Acquisition, Processing, and Interpretation—A MATLAB-Based Approach
    • 1st Edition
    • Dipali Bansal
    • English
    Real-Time Data Acquisition in Human Physiology: Real-Time Acquisition, Processing, and Interpretation—A MATLAB-Based Approach focuses on the design and development of a computer-based system to detect and digitally process human ECG, EMG, and carotid pulse waveforms in real time. The indigenous system developed and described in this book allows for an easy-to-interface, simple hardware arrangement for bio-signal detection. The computational functionality of MATLAB is verified for viewing, digital filtration, and feature extraction of acquired bio-signals. This book demonstrates a method of providing a relatively cost-effective solution to human physiology real-time monitoring, processing, and interpretation that is more realizable and would directly benefit a larger population of patients.

  • Cognitive and Behavioral Dysfunction in Schizophrenia

    • 1st Edition
    • Ahmed Moustafa
    • English
    According to the World Health Organization, schizophrenia affects more than 21 million people worldwide, causing distortions in thinking, perception, emotions, language, sense of self, behavior, and hallucinations. Cognitive and Behavioral Dysfunction in Schizophrenia provides an overview of topics and theories related to cognitive dysfunction in schizophrenia. This book discusses what schizophrenia is and its relationship with the cognitive domains including, but not limited to, learning, working memory, attention, and both deductive and inductive reasoning. This book also reviews theories as to why some individuals develop schizophrenia following cannabis and amphetamine abuse and how these relate to additional cognitive problems. The book further discusses recent topics related to religious delusions in psychotic patients, impact of sleep on psychosis, how urban life increases the likelihood of developing schizophrenia, as well as sexual dysfunction in schizophrenia patients. Unlike other books, Cognitive and Behavioral Dysfunction in Schizophrenia covers many cognitive domains related to the occurrence and development of positive and negative symptoms of schizophrenia. Advanced students and researchers in cognitive and behavioral neuroscience, psychology, psychiatry, and psychotherapy will find it useful for a well-rounded understanding of the subject.

  • Genomics of Rare Diseases

    Understanding Disease Genetics Using Genomic Approaches
    • 1st Edition
    • Claudia Gonzaga-Jauregui + 1 more
    • English
    Genomics of Rare Diseases: Understanding Disease Genetics Using Genomic Approaches, a new volume in the Translational and Applied Genomics series, offers readers a broad understanding of current knowledge on rare diseases through a genomics lens. This clear understanding of the latest molecular and genomic technologies used to elucidate the molecular causes of more than 5,000 genetic disorders brings readers closer to unraveling many more that remain undefined and undiscovered. The challenges associated with performing rare disease research are also discussed, as well as the opportunities that the study of these disorders provides for improving our understanding of disease architecture and pathophysiology. Leading chapter authors in the field discuss approaches such as karyotyping and genomic sequencing for the better diagnosis and treatment of conditions including recessive diseases, dominant and X-linked disorders, de novo mutations, sporadic disorders and mosaicism.

  • Regenerative Nephrology

    • 2nd Edition
    • Michael S. Goligorsky
    • English
    Since the publication of the first edition of this book in 2010, an explosion of spectacular discoveries in the field of regeneration has compelled the current revisit of the field of Regenerative Nephrology. This second edition features subjects as diverse as age and gender influencing regenerative processes; mechanisms and pathways of premature cell senescence affecting kidney regeneration; the ways intrinsic regenerative processes can become subverted by noxious stressors eventuating in disease progression; novel mechanistic and engineering efforts to recreate functional kidney or its component parts; cell reprogramming and reconditioning as emerging tools of future regenerative efforts; and effects of various biologicals on kidney regeneration. These newer additions to the armamentarium of Regenerative Medicine and Nephrology have become an integral part of the second edition of the book. Cutting-edge investigations are summarized by the constellation of the most experienced contributing authors coming together from around the world under the umbrella of the second edition.

  • Ion Channels: Channel Chemical Biology, Engineering, and Physiological Function

    • 1st Edition
    • Volume 654
    • English
    Ion Channels, Part C, Volume 653 in the Methods in Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on a variety of topics, including Nonsense suppression in ion channels, Engineering Ion Channels Using Protein Trans-splicing, Probing Ion Channel Neighborhoods Using APEX, STX based probes for NaVs, ANAP: a versatile, fluorescent probe of ion channel gating and regulation, High Throughput Screens for Small Molecule Ion Channel Modulators, Using toxins to study ion channels, Re/de-constructing ubiquitin regulation of ion channels, Tethered Peptide Toxins for Ion Channels, Voltage-Sensing Phosphatase Molecular Engineering, and more. Additional chapters cover Engineering excitable cells, Stretch and Poke Stimulation of Mechanically-Activat... Ion Channels, Optical Control of STIM Channels, High Throughput Electrophysiological Evaluation of Mutant Ion Channels, Evaluating BEST1 Mutations in RPE Stem Cells, Long Read Transcript Profiling of Ion Channel Splice Variants, Permeation of Connexin Channels, Ratiometric pH indicator for melanosomes and lysosomes, and Ion channels in the epithelial cells of the choroid plexus.

  • Hydrogen Sulfide in Plant Biology

    Past and Present
    • 1st Edition
    • Samiksha Singh + 5 more
    • English
    Hydrogen Sulfide in Plant Biology: Past and Present includes 17 chapters, with topics from cross-talk and lateral root development under stress, to post-translational modifications and disease resistance. With emerging research on the different roles and applications of H2S, this title compiles the latest advances of this key signaling molecule. The development of a plant requires complex signaling of various molecules like H2S in order to achieve regulated and proper development, hence hydrogen sulfide (H2S) has emerged as an important signaling molecule that regulates nearly each and every stage of a plant’s lifecycle. Edited by leading experts in the field, this is a must-read for scientists and researchers interested in plant physiology, biochemistry and ecology.

  • Reprogramming the Genome: CRISPR-Cas-based Human Disease Therapy

    • 1st Edition
    • Volume 181
    • English
    Reprogramming the Genome: CRISPR-Cas-based Human Disease Therapy, presents the collation of chapters written by eminent scientists worldwide. CRISPR-Cas9 is a key technology for targeted genome editing and regulation in a number of organisms including mammalian cells. It is a rapid, simple, and cost-effective solution. CRISPR-Cas system has recently gained much scientific and public attention. This volume covers CRISPR-Cas9 based mammalian genome editing, creating disease models, cancer therapy, neurological, heredity, blood disorders, defective gene correction, stem cells therapy, epigenetic modifications, patents, ethics, biosafety and regulatory issues challenges and opportunities. This book is a key source of information on mammalian genome editing available in a single volume. This book will be useful for beginners in mammalian genome editing and also students, researchers, scientists, policymakers, clinicians and stakeholders interested in genome editing in several areas.

  • Ultrasound Guided Musculoskeletal Procedures in Sports Medicine

    A Practical Atlas
    • 1st Edition
    • Dinesh Sirisena
    • English
    Ultrasound Guided Musculoskeletal Procedures in Sports Medicine: A Practical Atlas provides the support practitioners need based on practical, first-hand experience of a Sports and Exercise Medicine Physician who trained in musculoskeletal sonography. Over the years, and with much practice, the lessons learned and techniques developed are summarized with relevant pictures that guide those undertaking the procedure. As musculoskeletal ultrasound forms an important tool for physicians working in this field of medicine, this book helps physicians provide increasing expectation for patients who want a safe, guided procedure when clinically warranted. While an understanding of ultrasound imaging is essential prior to ultrasound guided procedures, there are few practical guides that provide practicing clinicians with a quick reference when faced with a procedure. This book fills that void.

  • Clinical Studies and Therapies in Parkinson's Disease

    Translations from Preclinical Models
    • 1st Edition
    • Juan Segura-Aguilar
    • English
    More than 50 years have passed since the use of L-dopa in the palliative treatment of Parkinson’s disease, but it remains the most common treatment despite inducing severe side effects such as dyskinesia after 4–6 years of use. Numerous preclinical investigations based on endogenous neurotoxin models have promised various therapies for Parkinson’s disease, but these efforts have failed　when attempting to transfer these successful results to preclinical studies. Although several publications have warned of these failures, the scientific community remains mostly unaware, and there is a need to focus their efforts on potential therapeutics that can slow or halt development of the disease.Clinical Studies and Therapies in Parkinson’s Disease: Translations from Preclinical Models analyzes preclinical models based on exogenous neurotoxins and why they have failed. Neuroscientists, neurologists, and neuropharmacologists will benefit greatly from the book’s discussion of these newer models, their benefits, and the need for their implementation. This book also provides the basic concepts of dopamine metabolism for students taking courses in neurochemistry, neuroscience, neuropharmacology, biochemistry, and medicine.

  • Advances in Agronomy

    • 1st Edition
    • Volume 168
    • English
    Advances in Agronomy, Volume 168, the latest release in this leading reference on agronomy, contains a variety of updates and highlights new advances in the field. Each chapter is written by an international board of authors.

  • Roselle (Hibiscus sabdariffa)

    Chemistry, Production, Products, and Utilization
    • 1st Edition
    • Abdalbasit Adam Mariod + 2 more
    • English
    Roselle (Hibiscus sabdariffa) Chemistry, Production, Products, and Utilization assesses the Hibiscus sabdariffa plant for food and nonfood uses, as well as for its use as fixed or essential oils. The chapters explore Hibiscus sabdariffa breeding, production, composition, storage, and quality related to the chemistry, nutrition, antioxidant activity, and traditional uses of its bioactive components. This book also includes coverage of medicinal, pharmacological, therapeutic, and cosmetic uses of Hibiscus sabdariffa. This book will be of interest to nutritionists, food scientists, chemists, ethnobotanists, pharmacists, academics, undergraduate and graduate students, and professionals working with medicinal plants.

  • The Lung

    • 1st Edition
    • Ahmed El-Hashash
    • English
    In the lung, more recent data have been accumulated on lung stem cell biology/function and the potential applications of stem cells in pulmonary diseases that are facilitated by the recent development of a broad range of cutting edge in vitro and in vivo research tools and approaches, including mouse and human organoid cultures, genetic editing in vitro and in vivo, human induced pluripotent cell (iPS cell) models of disease, haploid cells for genetic as well as compound screening paradigms, genetically engineered mice, and stem cell transplantation to cure diseases. Stem Cell Innovation in Health and Disease: Volume 2: The Lung, contains two major sections describing cutting edge research for understanding stem cell functions in the lung and respiratory system, and for developing methods to bring stem cells from bench to bedside; respectively. Each section includes insights ranging from using mouse and human organoid cultures, genetic editing in vitro and in vivo, and human induced pluripotent cells (iPSCs) to study stem cell functions and model lung diseases, through the cutting-edge research aiming to bring stem cells from bench to bedside, including the potential application of iPSCs, ESCs and blood stem cells (stem cell transplants) in the treatment of lung diseases/disorders. This book, therefore, discusses the fact-based promise of stem cells and regenerative medicine in the lung in the real world.

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