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Tendon Regeneration
Understanding Tissue Physiology and Development to Engineer Functional Substitutes
- 2nd Edition - June 1, 2025
- Editors: Manuela E. Gomes, Rui L. Reis, Márcia T. Rodrigues, Ana Gonçalves, Dimitrios Zeugolis, Denitsa Docheva
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 5 9 1 6 - 9
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 3 4 3 0 - 2
Tendon Regeneration: Understanding Tissue Physiology and Development to Engineer Functional Substitutes was the first book to highlight the multi-disciplinary nature of this specia… Read more
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Request a sales quoteTendon Regeneration: Understanding Tissue Physiology and Development to Engineer Functional Substitutes was the first book to highlight the multi-disciplinary nature of this specialized field and the importance of collaboration between medical and engineering laboratories in the development of tissue-oriented products for tissue engineering and regenerative medicine (TERM) strategies.Beginning with a foundation in developmental biology, the book explores physiology, pathology, and surgical reconstruction, providing guidance on biological approaches that enhances tendon regeneration practices. Contributions from scientists, clinicians, and engineers who are the leading figures in their respective field’s present recent findings in tendon stem cells, cell therapies, and scaffold treatments, as well as examples of pre-clinical models for translational therapies and a view of the future of the field.New coverage will include signaling pathways for tendon development, molecular mechanisms of tendinopathy, inflammation contribution to healing and pathology of tendons, tendon aging and degeneration, tendon models, and translational studies for tendon regenerative medicine.
- Provides an updated overview of tendon biology, disease, and tissue engineering approaches
- Presents new subjects, namely experimental models and translational chapters not included in the first edition, due to limited literature on tendon regeneration
- Written by renowned scientists, engineers, and clinicians from around the world
Researchers/Scientists in biology, biomedicine, engineering, or complementary fields, post-graduate level students in developmental biology, human biology, human physiology, biomedical engineering, bioengineering, tissue engineering, material engineering, biomedicine, and biotechnology, clinicians, specifically orthopedic doctors
Section I Biology and Physiology of Tendons
1. Regenerating Tendons: Lessons from Development
2. Mechanobiology of Embryonic and Adult Tendons and Tendon Interfaces
3. Tendon Physiology and Mechanical Behavior Structure-Function Relationships
4. Tendon Resident Cells - Functions and Features
5. Molecular and Biological Mechanisms of Tendon Homeostasis and Repair
Section II Pathologies and Repair of Tendons
6. Tendinopathy Triad - Mechnosenising, ECM, and Inflammation
7. Medical Considerations in Tendinopathy
8. Etiology, Pathology, and Healing of Tendon Injury and Disease
9. Mechanics and Mechanisms of Tendon Disease and Regeneration
10. Tendon Aging and Degeneration
11. The Veterinarian Perspective: Comparative Anatomy, Animal Models and Bioengineering of Tendons
Section III Tendon Tissue Engineering and Regenerative Medicine Approaches
12. Cell-Based Approaches for Tendon Regeneration
13. Engineering Anisotropic 2D and 3D Structures for Tendon Repair and Regeneration
14. Fabrication of Hierarchical and Biomimetic Fibrous Structures to Support the Regeneration of Tendon Tissues
15. Multifactorial Tendon Tissue Engineering Strategies
16. Tendon Interface Engineering Approaches
Section IV Translating Tendon Regenerative Medicine Strategies
17. Transitional Tendinopathy: Are We There Yet?
18. Translational Challenges at the Interfaces
1. Regenerating Tendons: Lessons from Development
2. Mechanobiology of Embryonic and Adult Tendons and Tendon Interfaces
3. Tendon Physiology and Mechanical Behavior Structure-Function Relationships
4. Tendon Resident Cells - Functions and Features
5. Molecular and Biological Mechanisms of Tendon Homeostasis and Repair
Section II Pathologies and Repair of Tendons
6. Tendinopathy Triad - Mechnosenising, ECM, and Inflammation
7. Medical Considerations in Tendinopathy
8. Etiology, Pathology, and Healing of Tendon Injury and Disease
9. Mechanics and Mechanisms of Tendon Disease and Regeneration
10. Tendon Aging and Degeneration
11. The Veterinarian Perspective: Comparative Anatomy, Animal Models and Bioengineering of Tendons
Section III Tendon Tissue Engineering and Regenerative Medicine Approaches
12. Cell-Based Approaches for Tendon Regeneration
13. Engineering Anisotropic 2D and 3D Structures for Tendon Repair and Regeneration
14. Fabrication of Hierarchical and Biomimetic Fibrous Structures to Support the Regeneration of Tendon Tissues
15. Multifactorial Tendon Tissue Engineering Strategies
16. Tendon Interface Engineering Approaches
Section IV Translating Tendon Regenerative Medicine Strategies
17. Transitional Tendinopathy: Are We There Yet?
18. Translational Challenges at the Interfaces
- No. of pages: 470
- Language: English
- Edition: 2
- Published: June 1, 2025
- Imprint: Academic Press
- Paperback ISBN: 9780443159169
- eBook ISBN: 9780443134302
MG
Manuela E. Gomes
Manuela E. Gomes is Associate Professor and Vice-President of the Research Institute for Biomaterials, Biodegradable and Biomimetics at the University of Minho. Dr. Gomes is also on the Board of Directors of the Portuguese Associate Laboratory that gathers the Institute for Life and Health Sciences of the University of Minho and the 3B´s Research Group and was responsible for the implementation of the Quality Management System at the 3B’s. She is a board member of the Doctoral Program on Tissue Engineering Regenerative Medicine and Stem Cells and has been part of numerous European and national/regional projects as PI/member. She was awarded a Consolidator Grant and a PoC from the European Research Council that started in 2018 and 2022, respectively. She has edited 2 books, 1 encyclopedia, and is author of 43 book chapters, 226 scientific papers in journals with international peer-review, 9 patents and over 344 communications in international conferences.
Affiliations and expertise
Associate Professor and Vice President, Research Institute for Biomaterials, Biodegradable and Biomimetics, University of Minho 3B’s Research Group, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Avepark – Parque de Ciência e Tecnologia, Zona Industrial da Gandra, Barco GMR, PortugalRR
Rui L. Reis
Dr. Rui Reis is Vice-President for Research and Innovation of University of Minho, Portugal, Director of 3B’s Research Group and Director of ICVS/3B´s Associate Laboratory, both of UMinho. He’s the CEO of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, the Coordinator of the Discoveries Centre for Regenerative and Precision Medicine, the Global Past-President of the Tissue Engineering and Regenerative Medicine International Society and the Editor-in-chief of the Journal of Tissue Engineering and Regenerative Medicine. He’s edited 18 books, 10 special issue journals, 280 book chapters and has more than 1225 published works listed on ISI Web of Knowledge, being an inventor of around 70 patents. He’s been awarded many important international prizes, including the TERMIS-EU contributions to the literature Award and the TERMIS-EU Career Achievement Award, and recently the UNESCO- International Life Sciences Award and the IET A. F. Harvey Engineering Research Prize.
Affiliations and expertise
President of Institute 3B’s, University of Minho; Director of the Associated Laboratory ICVS/3B’s and of the European Institute of Excellence in Tissue Engineering and Regenerative Medicine (EXPERTISSUES); Full Professor of Tissue Engineering, Regenerative Medicine and Stem Cells, University of Minho, Barco, PortugalMR
Márcia T. Rodrigues
Márcia T. Rodrigues is an Assistant Researcher the Research Institute for Biomaterials, Biodegradable and Biomimetics at the University of Minho. Her research is focused on strategies to study persistent inflammation cues and associated pathways that impair tissue healing and regeneration. Dr. Rodrigues has mentored and supervised several PhD, MSc, and BSc students. Currently, she supervises 1 PhD student and mentors 3 post-doctoral fellows. She has also been part of the scientific committee and organization of 8 international scientific events and acts as a peer reviewer in > 20 major international journals in the field. She is also a member of the Editorial Board of IJMS and editor of 2 special issues for IJMS and Adv Drug Deliv Rev (2022). Dr. Rodrigues co-edited one scientific book Tendon Regeneration (Elsevier), authored 13 book chapters, 1 Encyclopedia chapter, 48 papers in international refereed journals, 3 featured articles, and 4 corresponding author papers.
Affiliations and expertise
Assistant Researcher, Research Institute on Biomaterials, Biodegradables and Biomimetics of University of Minho 3B's Research Group,eadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Avepark – Parque de Ciência e Tecnologia, Zona Industrial da Gandra, Guimarães, Portugal.AG
Ana Gonçalves
Ana Gonçalves is an Individual Fellow (Junior researcher), at the 3Bs Research Group, University of Minho, Portugal. Ana holds a PhD in Tissue Engineering, Regenerative Medicine, and Stem Cells from University of Minho and in collaboration with Keele University, UK (2017). Ana has worked under 5 National financed projects (with fellowship) being actively involved at the start of a research line at her Institution (Tendon Tissue Engineering). She is core team member in 4 ongoing projects and is Co-Chair of the Achilles Conferences organized under the scope of the H2020 Twinning Project Achilles. In addition, Ana has presented her work in the most important conferences of the field such as TERMIS, EORS, and MagMeet, in which she had active participations such as co-chairing sessions, reviewing abstracts, and being involved in the organization of symposia. Ana was recently elected member of the TERMIS-EU Communication and Outreach committee (2021-2024).
Affiliations and expertise
Junior Researcher, Research Institute on Biomaterials, Biodegradables and Biomimetics of University of Minho 3B's Research Group,Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Avepark – Parque de Ciência e Tecnologia, Zona Industrial da Gandra, Barco GMR, PortugalDZ
Dimitrios Zeugolis
Dimitrios Zeugolis is the Director of the Regenerative, Modular & Developmental Engineering Laboratory (REMODEL), Full Professor at the School of Mechanical & Materials Engineering, Principal Investigator at the Charles Institute of Dermatology and Senior Fellow at the Conway Institute of Biomolecular & Biomedical Research, all at University College Dublin (UCD), IE. He is Adjunct Professor at the National University of Ireland Galway (NUI Galway), IE and Co-Director of the Laboratory of Animal Science, Nutrition and Biotechnology, University of Ioannina, Greece. He is Editorial Committee member of the Tissue Engineering and Regenerative Medicine International Society (TERMIS), Irish Ambassador of the European Orthopaedic Research Society (EORS) and Council Member of Matrix Biology Ireland (MBI). He is also Editor-in-Chief of Biomaterials and Biosystems (Elsevier), Senior Editorial Board member of BMC Biomedical Engineering (Springer Nature) and Associate Editor of Frontiers in Bioengineering and Biotechnology.
Affiliations and expertise
Director, Regenerative, Modular & Developmental Engineering Laboratory and Professor Charles Institute of Dermatology, Conway Institute of Biomolecular & Biomedical Research and School of Mechanical & Materials Engineering, University College Dublin.DD
Denitsa Docheva
Denitsa Docheva is the Chair of the Department of Musculoskeletal Tissue Regeneration at the Orthopaedic Hospital König-Ludwig-Haus & the Julius-Maximilians-University of Wuerzburg. Denitsa graduated with two parallel Master’s Degrees (Biology and Chemistry) from the University of Plovdiv, Bulgaria. Afterwards, she obtained a PhD fellowship at the Max-Planck-Institute of Biochemistry, Martinsried, Germany and graduated in 2005. In October 2021, she became Professor and Chair of the Department of Musculoskeletal Tissue Regeneration, University of Wuerzburg, Germany. She has published more than 100 articles and has won multiple grants. She is participating in several EU consortia (MATEGRA, ACHILLES, MEFISTO, OSTEOMET and OSTASKILLS). She has supervised more than 50 research fellows. She has given numerous invited lectures and communications at conferences. She is a reviewer for prestigious biomedical journals and since 2020, Scientific Editor for the eCM Journal. 2018-2020, she was the President of the European Orthopaedic Research Society (EORS).
Affiliations and expertise
Chair, Department of Musculoskeletal Tissue Regeneration, Orthopaedic Hospital König-Ludwig-Haus and Julius-Maximilians-University of Wuerzburg, Germany