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    • Immunological Tolerance

      • 1st Edition
      • June 28, 2014
      • David H. Katz + 1 more
      • English
      • Paperback
        9 7 8 1 4 8 3 2 4 1 4 1 8
      • eBook
        9 7 8 1 4 8 3 2 7 3 4 3 3
      Immunological Tolerance: Mechanisms and Potential Therapeutic Applications documents the proceedings of a conference held at Brook Lodge, Michigan, April 27-May 1, 1974. The conference brought together many of the investigators who have actively contributed to furthering knowledge and understanding of immunological tolerance. It will be immediately clear to the reader that the conference was structured in a way to consider phenomena of tolerance and immune suppression as interrelated entities with a certain degree of emphasis on the possible common cellular mechanisms involved. The volume contains 36 contributions presented during the seven sessions of the conference. The papers presented in Session I examined T-cell tolerance. The presentations in Session II focused on B cell tolerance. The papers in Sessions III and IV focused on the mechanisms of B cell and T cell tolerance, respectively. Session V dealt with the activity of suppressor cells as a mechanism of tolerance. The papers in Session VI investigated the suppressive activity of antibody and antigen-antibody complexes. In Session VII a final General Discussion was held in order to identify what has been established concerning the phenomenology and mechanisms of specific immunological tolerance, what are the major unresolved issues, and what approaches appear most promising to answer these questions.

    • Techniques in Protein Chemistry III

      • 1st Edition
      • June 28, 2014
      • Ruth Hogue Angeletti
      • English
      • Paperback
        9 7 8 1 4 8 3 2 3 5 5 3 0
      • eBook
        9 7 8 1 4 8 3 2 5 9 4 6 8
      Techniques in Protein Chemistry III compiles papers presented at the Fifth Protein Society Symposium in Baltimore on June 22-26, 1991. This book discusses the protein and peptide recovery from PVDF membranes; high-sensitivity peptide mapping utilizing reversed-phase microbore and microcolumn liquid chromatography; and capillary electrophoresis for preparation of peptides and direct determination of amino acids. The TFMSA/TFA cleavage in t-Boc peptide synthesis; applications of automatic PTC amino acid analysis; and identification of O-glycosylation sites with a gas phase sequencer are also elaborated. This text likewise covers the conformational stability of the molten globule of cytochrome c and role of aqueous solvation in protein folding. This publication is useful to students and researchers interested in methods and research approaches on protein chemistry.

    • Centrifugation in Density Gradients

      • 1st Edition
      • June 28, 2014
      • C. A. Price
      • English
      • Paperback
        9 7 8 1 4 8 3 2 4 4 9 7 6
      • eBook
        9 7 8 1 4 8 3 2 8 2 0 6 0
      Centrifugation in Density Gradients provides information pertinent to the fundamental aspects of density gradient centrifugation. This book discusses the benefits of density gradient centrifugation to membrane-bound particles. Organized into nine chapters, this book begins with an overview of the method of differential or fractional centrifugation. This text then explores the physical basis of density gradient centrifugation. Other chapters deal with the nuts and bolts of density gradient centrifugation, the construction and composition of gradients, the properties and operation of centrifuge systems, and certain arcane but highly useful procedures. This book discusses as well density gradient centrifugation in the analytical ultracentrifuge. The final chapter deals with a collection of protocols for separating particles ranging in size from whole cells to macromolecules. This book is intended to be suitable for readers who need to separate biological particles. Biologists, chemists, biochemists, cytologists, physiologists, scientists, and research workers will also find this book useful.

    • Hormones

      • 1st Edition
      • June 28, 2014
      • Anthony W. Norman + 1 more
      • English
      • Paperback
        9 7 8 1 4 8 3 2 4 4 1 8 1
      • eBook
        9 7 8 1 4 8 3 2 5 8 1 0 2
      Hormones provides a comprehensive treatment of human hormones viewed in the light of modern theories of hormone action and in the context of current understanding of subcellular and cellular architecture and classical organ physiology. The book begins with discussions of the first principles of hormone action and the seven classes of steroid hormones and their chemistry, biosynthesis, and metabolism. These are followed by separate chapters that address either a classical endocrine system, e.g., hypothalamic hormones, posterior pituitary hormones, anterior pituitary hormones, ,thyroid hormones, pancreatic hormones, gastrointestinal hormones, calcium regulating hormones, adrenal corticoids, hormones of the adrenal medulla, androgens, estrogens and progestins, and pregnancy and lactation hormones; or newer domains of hormone action which are essential to a comprehensive understanding of hormone action, including prostaglandins, thymus hormones, and pineal hormones. The book concludes with a presentation of hormones of the future, i.e., cell growth factors. This book is intended for use by first-year medical students, graduate students, and advanced undergraduates in the biological sciences. It is also hoped that this book will fill the void that exists for resource materials for teaching cellular and molecular endocrinology and that it will be employed as an equal partner with most standard biochemistry textbooks to provide a comprehensive and balanced coverage of this realm of biology.

    • Bacterial Metabolism

      • 2nd Edition
      • June 28, 2014
      • H. W. Doelle
      • English
      • Paperback
        9 7 8 1 4 8 3 2 3 8 2 1 0
      • eBook
        9 7 8 1 4 8 3 2 7 2 3 7 5
      Bacterial Metabolism, Second Edition describes microbial systematics and microbial chemistry and focuses on catabolic events. This book deals with the progress made in bacterial metabolism that includes data on regulatory mechanisms; comparison of bacterial growth kinetics with enzyme kinetics; aerobic amino acid catabolism; and the glucose transport mechanism. This text also emphasizes the development of photosynthetic phosphorylation in the different bacterial families. This book explains anaerobic respiration and carbohydrate metabolism—glucose, fructose, lactose, mannose, allose, and sorbitol. This text then describes aerobic respiration including the "Nitroso" and "Nitro" groups of genera, and the Knallgas bacteria, which use the reaction between molecular hydrogen and molecular oxygen as their source of energy. This book also explains the microbial transformation of iron as caused by either specific organisms (e.g. Ferrobacillus ferrooxidans) or nonspecific organisms. This selection also explains the process of fermentation by Enterobacteriaceae, lactic acid bacteria, and proteolytic clostridia. This text can be valuable for microchemists, microbiologists, students, and academicians whose disciplines are in biological chemistry and cellular biology.

    • Antimetabolites in Biochemistry, Biology and Medicine

      • 1st Edition
      • May 19, 2014
      • J. Skoda + 1 more
      • English
      • eBook
        9 7 8 1 4 8 3 1 8 9 0 9 3
      FEBS: Federation of European Biochemical Societies, Volume 57: Antimetabolites in Biochemistry, Biology, and Medicine is a collection of papers that presents that advancement in the field of antimetabolites research. The title first covers the use of antimetabolites in enzymology, and then proceeds to tackling the consequences of analog incorporation into nucleic acids. Next, the selection discusses the rational approach to the use of antimetabolite in commination cancer chemotherapy an in immunosuppression. The text also covers the aspects of selective antiviral action. In the last part, the selection details various compounds, along with their synthesis and mechanisms of action. The book will be of great use to researchers and practitioners of biochemistry, biology, and medicine.

    • Ultrasmall Lanthanide Oxide Nanoparticles for Biomedical Imaging and Therapy

      • 1st Edition
      • October 24, 2014
      • Gang Ho Lee + 1 more
      • English
      • Paperback
        9 7 8 0 0 8 1 0 1 5 4 5 2
      • Hardback
        9 7 8 0 0 8 1 0 0 0 6 6 3
      • eBook
        9 7 8 0 0 8 1 0 0 0 6 9 4
      Most books discuss general and broad topics regarding molecular imagings. However, Ultrasmall Lanthanide Oxide Nanoparticles for Biomedical Imaging and Therapy, will mainly focus on lanthanide oxide nanoparticles for molecular imaging and therapeutics. Multi-modal imaging capabilities will discussed, along with up-converting FI by using lanthanide oxide nanoparticles. The synthesis will cover polyol synthesis of lanthanide oxide nanoparticles, Surface coatings with biocompatible and hydrophilic ligands will be discussed and TEM images and dynamic light scattering (DLS) patterns will be provided. Various techniques which are generally used in analyzing the synthesized surface coated nanoparticles will be explored and this section will also cover FT­, IR analysis, XRD analysis, SQUID analysis, cytotoxicity measurements and proton relaxivity measurements. In vivo MR images, CT images, fluorescence images will be provided and Therapeutic application of gadolinium oxide nanoparticles will be discussed. Finally, future perpectives will be discussed. That is, present status and future works needed for clinical applications of lanthanide oxide nanoparticles to molecular imagings will be discussed.

    • Translating Gene Therapy to the Clinic

      • 1st Edition
      • November 14, 2014
      • Jeffrey Laurence + 1 more
      • English
      • Hardback
        9 7 8 0 1 2 8 0 0 5 6 3 7
      • eBook
        9 7 8 0 1 2 8 0 0 5 6 4 4
      Translating Gene Therapy to the Clinic, edited by Dr. Jeffrey Laurence and Michael Franklin, follows the recent, much-lauded special issue of Translational Research in emphasizing clinical milestones and critical barriers to further progress in the clinic. This comprehensive text provides a background for understanding the techniques involved in human gene therapy trials, and expands upon the disease-specific situations in which these new approaches currently have the greatest therapeutic application or potential, and those areas most in need of future research. It emphasizes methods, tools, and experimental approaches used by leaders in the field of translational gene therapy. The book promotes cross-disciplinary communication between the sub-specialties of medicine, and remains unified in theme.

    • The Retinoids: v. 2

      • 1st Edition
      • June 28, 2014
      • BAERT ET BAERT ET AL
      • English
      • Paperback
        9 7 8 1 4 9 3 3 0 4 5 9 2
      • eBook
        9 7 8 1 4 8 3 2 9 6 3 7 1
      The Retinoids is a collection of papers that deals with the biochemistry and metabolism of the retinoids and of specific retinoid-binding proteins that are found in plasma and in cells. Some papers describes the biosynthesis and metabolism of retinol, with plasma retinol-binding protein, with intracellular retinoid-binding proteins, as well as with the metabolism and role of retinoids in the eye. Other papers review the metabolism of retinoic acid and synthetic retinoids, the cellular and molecular mechanisms of action of the retinoids, and applied biology of the retinoids. Several papers discuss toxicology, teratology, immunology, and the applications of retinoids in the fields of cancer and dermatology. One paper describes the transport of retinoic acid and other acidic retinoids in plasma in association with serum albumin. Another paper hypothesizes that vitamin A affects differentiation at the cellular level and addresses how tissue specificity of this action can arise. One paper examines the role of retinoid-binding proteins in vertebrate visual system, particularly how these proteins transport retinoids in the serum, cell sap, and interstitial spaces of the eye. The collection can prove useful for biologists, microbiologists, cellular biologists, students and professors of biology, oncology, ophthalmology or dermatology.

    • Cord Blood Stem Cells Medicine

      • 1st Edition
      • December 3, 2014
      • Catherine Stavropoulos-Giokas + 2 more
      • English
      • Paperback
        9 7 8 0 1 2 8 1 0 3 4 4 9
      • Hardback
        9 7 8 0 1 2 4 0 7 7 8 5 0
      • eBook
        9 7 8 0 1 2 4 0 7 8 3 6 9
      Cord Blood Stem Cells and Regenerative Medicine discusses the current applications for cord blood stem cells and techniques for banking cord blood. Cord blood, blood from the umbilical cord and placenta of an infant, represents an alternate source of stem cells that can be used to treat a myriad of disorders. Cord blood stem cells are being used more frequently and studied more seriously, as evidenced by the explosion of scientific literature on the topic. Currently, clinical and pre-clinical trials are being done in the field, treating conditions as severe as heart failure. Coupled with regenerative medicine, cord blood stem cells potentially carry the future of research and medicine in treating tissue damage, genetic disorders, and degenerative diseases. Read about new applications for cord blood stem cells and new techniques for banking cord blood — the future of regenerative medicine therapy.

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