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Books in Life sciences

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    • Mechanism of the Anticancer Effect of Phytochemicals

      • 1st Edition
      • Volume 37
      • August 21, 2015
      • English
      • Hardback
        9 7 8 0 1 2 8 0 3 8 7 6 5
      • eBook
        9 7 8 0 1 2 8 0 3 8 7 7 2
      Volume 37 will provide details on the major chemical constituents of medicinal plants and their mechanism of action as the anticancer compounds. This special issue, in addition to the previous volume (volume 36 of The Enzyme series was on Natural Products and Cancer Signaling Targets: Isoprenoids, Polyphenols and Flavonoids), will highlight the significant advance made in the field in elucidating mechanisms of anticancer effect of the major phytochemicals.

    • Concepts and Models for Drug Permeability Studies

      • 1st Edition
      • September 30, 2015
      • Bruno Sarmento
      • English
      • Hardback
        9 7 8 0 0 8 1 0 0 0 9 4 6
      • eBook
        9 7 8 0 0 8 1 0 0 1 1 4 1
      This book intends to be an updated compilation of the most important buccal, gastric, intestinal, pulmonary, nasal, vaginal, ocular, skin and blood-brain barrier in vitro models for predicting the permeability of drugs. Concepts and Models for Drug Permeability Studies focuses on different approaches and comprises of various models. Each model describes the protocol of seeding and conservation, the application for specific drugs, and takes into account the maintenance of physiologic characteristics and functionality of epithelium, from the simplest immortalized cell-based monoculture to the most complex engineered-tissue models. Chapters also discuss the equivalence between in vitro cell and tissue models and in vivo conditions, highlighting how each model may provisionally resemble a different drug absorption route.

    • Drug-Like Properties

      • 2nd Edition
      • December 17, 2015
      • Li Di + 1 more
      • English
      • Hardback
        9 7 8 0 1 2 8 0 1 0 7 6 1
      • eBook
        9 7 8 0 1 2 8 0 1 3 2 2 9
      Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including solubility and permeability, before exploring how compounds are absorbed, distributed, and metabolized safely and stably. Review chapters provide context and underscore the importance of key concepts such as pharmacokinetics, toxicity, the blood-brain barrier, diagnosing drug limitations, prodrugs, and formulation. Building on those foundations, this thoroughly updated revision covers a wide variety of current methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties for process and product improvement. From conducting key assays for interpretation and structural analysis, the reader learns to implement modification methods and improve each ADME property. Through valuable case studies, structure-property relationship descriptions, and structure modification strategies, Drug-Like Properties, Second Edition, offers tools and methods for ADME/Tox scientists through all aspects of drug research, discovery, design, development, and optimization.

    • Sketches of Nature

      • 1st Edition
      • September 9, 2015
      • John C. Avise
      • English
      • Hardback
        9 7 8 0 1 2 8 0 1 9 4 5 0
      • eBook
        9 7 8 0 1 2 8 0 1 9 6 0 3
      This visually appealing book recounts the history of molecular ecology and evolution as seen through the personal lens of one of its most prolific practitioners, who has studied a panorama of creatures ranging from corals, sponges, and other invertebrates to a wide variety of vertebrate animals including numerous birds, mammals, herps, and fishes. The sketches are of two types: evocative drawings of the animals themselves, and more than 230 written abstracts summarizing the author’s eclectic research on ecological-genetic topics spanning the microevolutionary to macroevolutionary. With the abstracts arranged by organismal group and placed in chronological order, the chapters in this book lead readers on a fascinating historical journey into the realm of molecular genetics as applied across the past four decades to intriguing questions in ecology, evolution, animal behavior, and natural history.

    • Mucosal Immunology

      • 4th Edition
      • March 6, 2015
      • Jiri Mestecky + 5 more
      • English
      • Hardback
        9 7 8 0 1 2 4 1 5 8 4 7 4
      • Hardback
        9 7 8 0 1 2 3 9 4 3 0 1 9
      • Hardback
        9 7 8 0 1 2 3 9 4 3 0 2 6
      • eBook
        9 7 8 0 1 2 4 1 5 9 7 5 4
      Mucosal Immunology, now in its fourth edition, is the only comprehensive reference covering the basic science and clinical manifestations of mucosal immunology. Most infectious agents enter the body through the various mucous membranes, and many common infections take place in or on mucous membranes, making this subject an area of singular importance in the field of immunology. This book contains new research data, exceptional illustrations, original theory, a new perspective, and excellent organization. It covers immune system topics, such as inductive and effector tissues and cells, and development and physiology of the mucosal barrier; diseases in the digestive system, respiratory tract, and genitourinary tract; and immunodeficiency.

    • ABC Transporters and Cancer

      • 1st Edition
      • Volume 125
      • January 27, 2015
      • English
      • Hardback
        9 7 8 0 1 2 8 0 1 2 5 1 2
      • eBook
        9 7 8 0 1 2 8 0 1 3 6 1 8
      ABC Transporters and Cancer provides invaluable information on the exciting and fast-moving field of cancer research. Here, outstanding and original reviews are presented on a variety of topics. This volume covers ABC transporters and cancer, and is suitable for researchers and students alike.

    • The Neuropsychiatric Complications of Stimulant Abuse

      • 1st Edition
      • Volume 120
      • May 26, 2015
      • English
      • Hardback
        9 7 8 0 1 2 8 0 2 9 7 8 7
      • eBook
        9 7 8 0 1 2 8 0 3 0 0 3 5
      This well-established international series examines major areas of basic and clinical research within neuroscience, as well as emerging and promising subfields. This volume concentrates on the neuropsychiatric complications of stimulant abuse.

    • 250 examens de laboratoire

      • 12th Edition
      • April 9, 2015
      • René Caquet
      • French
      • Paperback
        9 7 8 2 2 9 4 7 4 9 6 2 9
      • eBook
        9 7 8 2 2 9 4 7 4 5 1 6 4
      Chaque année apparaissent de nouveaux moyens de diagnostic et de traitement modifiant notre manière de comprendre et de guérir. Cette 12e édition, totalement actualisée, donne au praticien tout ce qu'il faut savoir pour prescrire les analyses médicales et en interpréter les résultats. L'ouvrage place chaque examen dans une démarche diagnostique, décrivant les examens les plus performants ou les plus adaptés aux données de la clinique. Entièrement revu, ce livre présente de manière simple plus de 250 examens de laboratoire sous forme de fiches classées par ordre alphabétique. Chaque fiche en précise les indications, les précautions éventuelles de prélèvement, les valeurs normales et guide l'interprétation des valeurs pathologiques. Cette 12e édition intègre les avancées récentes de la biologie médicale dans de nombreux domaines tels les examens de biologie moléculaire qui désormais font partie de la pratique quotidienne. Un index très fourni facilite l'usage du livre par le praticien qui dispose ainsi d'un outil de travail indispensable et efficace.

    • Breeding Oilseed Crops for Sustainable Production

      • 1st Edition
      • September 25, 2015
      • Surinder Kumar Gupta
      • English
      • Hardback
        9 7 8 0 1 2 8 0 1 3 0 9 0
      • eBook
        9 7 8 0 1 2 8 0 1 4 6 9 1
      Breeding Oilseed Crops for Sustainable Production: Opportunities and Constraints presents key insights into accelerating the breeding of sustainable and superior varieties. The book explores the genetic engineering/biotechn... that has played a vital role in transforming economically important traits from distant/wild species to cultivated varieties, enhancing the quality and quantity of oil and seed yield production. Integrated nutrient management, efficient water management, and forecasting models for pests diseases outbreaks and integrated pest and pest management have also added new dimensions in breeding for sustainable production. With the rise in demand, the scientific community has responded positively by directing a greater amount of research towards sustainable production both for edible and industrial uses. Covering the latest information on various major world oil crops including rapeseed mustard, sunflower, groundnut, sesame, oilpalm, cotton, linseed/flax, castor and olive, this book brings the latest advances together in a single volume for researchers and advanced level students.

    • Economic Evaluation in Genomic Medicine

      • 1st Edition
      • March 20, 2015
      • Vasilios Fragoulakis + 3 more
      • English
      • Paperback
        9 7 8 0 1 2 8 0 1 4 9 7 4
      • eBook
        9 7 8 0 1 2 8 0 1 6 1 1 4
      Economic Evaluation in Genomic Medicine introduces health economics and economic evaluation to genomic clinicians and researchers, while also introducing the topic to health economists. Each chapter includes an executive summary, questions, and case studies, along with supplementary online materials, including process guides, maps, flow charts, diagrams, and economic evaluation spreadsheets to enhance the learning process. The text can easily be used as course material for related graduate and undergraduate courses, providing a succinct overview of the existing, state-of-the-art application of economic evaluation to genomic healthcare and precision medicine.

Related subjects

Agricultural and biological sciences

Drug discovery

Immunology

Microbiology and virology

Neuroscience

Pharmaceutical sciences

Pharmacology

Toxicology