Life sciences print books and ebooks | Elsevier

Advances in Applied Microbiology

1st Edition
Volume 101
October 18, 2017
English
Hardback
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eBook
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Addictive Substances and Neurological Disease

1st Edition
February 18, 2017
Ronald Ross Watson + 1 more
English
Hardback
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eBook
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Addictive Substances and Neurological Disease: Alcohol, Tobacco, Caffeine, and Drugs of Abuse in Everyday Lifestyles is a complete guide to the manifold effects of addictive substances on the brain, providing readers with the latest developing research on how these substances are implicated in neurological development and dysfunction. Cannabis, cocaine, and other illicit drugs can have substantial negative effects on the structure and functioning of the brain. However, other common habituating and addictive substances often used as part of an individual’s lifestyle, i.e., alcohol, tobacco, caffeine, painkillers can also compromise brain health and effect or accentuate neurological disease. This book provides broad coverage of the effects of addictive substances on the brain, beginning with an overview of how the substances lead to dysfunction before examining each substance in depth. It discusses the pathology of addiction, the structural damage resulting from abuse of various substances, and covers the neurobiological, neurodegenerative, behavioral, and cognitive implications of use across the lifespan, from prenatal exposure, to adolescence and old age. This book aids researchers seeking an understanding of the neurological changes that these substances induce, and is also extremely useful for those seeking potential treatments and therapies for individuals suffering from chronic abuse of these substances.

DNA Repair Enzymes: Cell, Molecular, and Chemical Biology

1st Edition
Volume 591
June 20, 2017
English
Hardback
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eBook
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DNA Repair Enzymes, Part A, Volume 591 is the latest volume in the Methods in Enzymology series and the first part of a thematic that focuses on DNA repair enzymes. Topics in this new release include chapters on the Optimization of Native and Formaldehyde iPOND Techniques for Use in Suspension Cells, the Proteomic Analyses of the Eukaryotic Replication Machinery, DNA Fiber Analysis: Mind the Gap!, Comet-FISH for Ultrasensitive Strand-Specific Detection of DNA Damage in Single Cells, Examining DNA Double-Strand Break Repair in a Cell Cycle-Dependent Manner, Base Excision Repair Variants in Cancer, and Fluorescence-Based Reporters for Detection of Mutagenesis in E. coli.

Neuromonitoring Techniques

1st Edition
November 13, 2017
Hemanshu Prabhakar
English
Paperback
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Paperback
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Paperback
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eBook
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Neuromonitoring Techniques: Quick Guide for Clinicians and Residents provides a quick and easy guide to understanding various neuromonitoring equipment. Chapters include intracranial pressure monitoring, EEG-based monitors, evoked potentials and transcranial doppler. This book is written for trainees, clinicians and researchers in the fields of neurosurgery, neurocritical care, neuroradiology, neuroanesthesia and neurology. As specialized neuromonitoring is now routinely done in neurosurgical cases, it provides an important resource for neurologists, neurophysiologists, anesthesiologists and residents who are expected to have theoretical and practical knowledge on different systems. Each monitoring system is discussed separately, with examples, images, reference values and their interpretations.

Multi-Scale Approaches in Drug Discovery

1st Edition
February 14, 2017
Alejandro Speck-Planche
English
Paperback
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eBook
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Drug discovery is an expensive, time-consuming process and the modern drug discovery community is constantly challenged not only with discovering novel bioactive agents to combat resistance from known diseases and fight against new ones, but to do so in a way that is economically effective. Advances in both experimental and theoretical/computat... methods envisage that the greatest challenges in drug discovery can be most successfully addressed by using a multi-scale approach, drawing on the specialties of a whole host of different disciplines. Multi-Scale Approaches to Drug Discovery furnishes chemists with the detail they need to identify drug leads with the highest potential before isolating and synthesizing them to produce effective drugs with greater swiftness than classical methods may allow. This significantly speeds up the search for more efficient therapeutic agents. After an introduction to multi-scale approaches outlining the need for and benefits of their use, the book goes on to explore a range of useful techniques and research areas, and their potential applications to this process. Profiling drug binding by thermodynamics, machine learning for predicting enzyme sub-classes, and multitasking models for computer-aided design and virtual compound screening are discussed, before the book goes on to review Alkaloid Menispermaceae leads, natural chemotherapeutic agents and methods for speeding up the design and virtual screening of therapeutic peptides. Flavonoids as multi-target compounds are then explored, before the book concludes with a review of Quasi-SMILES as a novel tool. Collecting together reviews and original research contributions written by leading experts in the field, Multi-Scale Approaches to Drug Discovery highlights cutting-edge approaches and practical examples of their implementation for those involved in the drug discovery process at many different levels. Using the combined knowledge of medicinal, computational, pharmaceutical and bio- chemists, it aims to support growth in the multi-scale approach to promote greater success in the development of new drugs.

Social and Administrative Aspects of Pharmacy in Low- and Middle-Income Countries

1st Edition
October 24, 2017
Mohamed Izham Mohamed Ibrahim + 2 more
English
Paperback
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eBook
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Social and Administrative Aspects of Pharmacy in Low- and Middle-Income Countries: Present Challenges and Future Solutions examines the particularities of low- and middle-income countries and offers solutions based on their needs, culture and available resources. Drawing from the firsthand experience of researchers and practitioners working in these countries, this book addresses the socio-behavioral aspects of pharmacy and health, pharmacoeconomics, pharmaceutical policy, supply management and marketing, pharmacoepidemiology and public health pharmacy specific to low- and middle-income countries. While some practices may be applied appropriately in disparate places, too often pharmacy practice in low- and middle-income countries is directly copied from successes in developed countries, despite the unique needs and challenges low- and middle-income countries face.

Nanostructures for Drug Delivery

1st Edition
March 24, 2017
Ecaterina Andronescu + 1 more
English
Hardback
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eBook
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Nanostructures for Drug Delivery extensively covers the various nanostructured products that have been tested as carriers in target drug delivery systems. In addition, the book analyses the advantages of, and issues related to, using nanostructured materials in drug delivery systems, also detailing various nanocarrier preparation techniques. As delivering the drug to the target site is a major problem in providing effective treatment for many diseases, this book covers the latest advancements in numerous nanotechnological products that are being used in disease detection, controlled drug delivery, as biosensors, and in tissue engineering that have been developed for more efficient patient healthcare. Due to the versatility of nanostructured materials, it is now possible to deliver a drug at its target site in a more accurate and efficient way. This volume is an up-to-date, state-of-the-art work that highlights the principal mechanistic aspects related to the delivery of active nanoscale therapeutic agents (natural or synthetic) and their release profile in different environmental media. It highlights nanoscale encapsulation strategies and discusses both organic and inorganic nanomaterials as carriers and delivery platforms.

Advances in Virus Research

1st Edition
Volume 98
April 19, 2017
English
Hardback
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eBook
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Advances in Virus Research, Volume 98, the latest in a series first published in 1953, covers a diverse range of in-depth reviews, providing a valuable overview of the current field of virology. Topics in this new release include Zoonotic Potential of Emerging Paramyxoviruses: Knowns and Unknowns, Metabolomics: Strategies to Define the Role of Metabolism in Virus Infection and Pathogenesis, The Envelope Proteins of the Bunyavirales, and Insect-Specific Viruses: A Historical Overview and Recent Developments. The series is a valuable resource for information on all topics of virus research, from bacteriophages, to human viruses.

Mutagenicity: Assays and Applications

1st Edition
September 26, 2017
Ashutosh Kumar + 3 more
English
Paperback
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eBook
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Mutagenicity: Assays and Applications presents an extensive examination of the detection, assessment and future of mutagenicity, particularly as it concerns human health and the environment. Chapters focused on specific types of mutagens or testing methods for their detection collectively explore the current state of human and environmental mutagenesis, future perspectives and regulatory needs. The test procedures for measuring mutagenicity, their advantages and limitations are described with practical and procedural detail, along with their presentation and data processing aspects. It is an essential reference covering the breadth and depth of the field of mutagenicity studies and regulation. By providing both important introductory material and practical assays and applications, this book is useful to graduate students, academic and industry researchers and regulators at various stages of their careers, leading to improved risk assessment and regulation.

Handbook of Coffee Processing By-Products

1st Edition
May 5, 2017
Charis M. Galanakis
English
Paperback
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eBook
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Handbook of Coffee Processing By-Products: Sustainable Applications presents alternative and sustainable solutions for coffee processing by-products and specifies their industrial potential, both as a source for the recovery of bioactive compounds and their reutilization in the pharmaceutical, biotechnological, food, biotechnology, and cosmetic industries, also covering environmental and agronomic applications. This book addresses key topics specific to sustainable management in the coffee industry, placing an emphasis on integrated solutions for the valorization and upgrade of coffee processing by-products, biorefinery, and different techniques for the separation, extraction, recovery and formulation of polyphenols.

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