Chapter 1: Therapeutic nanomaterials: from a drug delivery perspective
C. Ganesh Kumar
- Abstract
- 1. Introduction
- 2. General Methods of Synthesis of Nanomaterials
- 3. Characterization of Nanomaterials
- 4. Applications of Nanomaterials for Drug Delivery
- 5. Conclusions
Chapter 2: Core–shell drug carriers: liposomes, polymersomes, and niosomes
Nily Dan
- Abstract
- 1. Introduction
- 2. Self-Assembled Bilayers
- 3. Liposomes as Drug Carriers
- 4. Polymersomes as Drug Carriers
- 5. Niosomes as Drug Carriers
- 6. Biomedical Applications of Core–Shell Vesicular Drug Carriers
- 7. Discussion
- 8. Conclusions
- Conflict of Interests
Chapter 3: The new nanocarriers based on graphene and graphene oxide for drug delivery applications
Mehrdad Hamidi
- Abstract
- 1. Introduction
- 2. Chemistry of the Graphene Surface
- 3. Modification of Graphene Surface for Drug Delivery Applications
- 4. In Vitro Toxicology and Biosafety of Graphene Derivative
- 5. Conclusions
Chapter 4: Nanostructured nanoparticles for improved drug delivery
Xavier Banquy
- Abstract
- Abbreviations
- 1. Introduction
- 2. The Core–Shell Nanostructure
- 3. The Capsule and Vesicle Nanostructure
- 4. Multicompartment Nanoparticles
- 5. Conclusions and Perspectives
- Acknowledgments
Chapter 5: Design of functionalized materials for use in micronanoscale drug delivery devices and smart patches
James Davis and Ashleigh Anderson
- Abstract
- 1. Introduction
- 2. Traditional Approaches to Drug Delivery
- 3. Compliance
- 4. Evolution of Smart Drug Delivery Devices
- 5. Electrochemical Approaches to Drug Release
- 6. Innovation and Application
- 7. Conclusions
Chapter 6: Niosomes: a novel approach in modern drug delivery systems
Sepideh Khoee
- Abstract
- 1. Introduction
- 2. Factors Affecting the Formation of Niosomes
- 3. Types of Niosomes
- 4. Niosome Preparation
- 5. Characterization
- 6. Advantages of Niosomes
- 7. Limitation of Niosomal Drug Delivery System
- 8. Comparison of Niosomes Versus Liposomes
- 9. In-Vivo Behavior of Niosomes
- 10. Pharmaceutical Applications and Administration of Niosomes
- 11. Final Consideration and Outlook
Chapter 7: Nanofibrous and nanoparticle materials as drug-delivery systems
Masoud Latifi
- Abstract
- 1. Introduction
- 2. Nanoparticle Materials in Drug-Delivery Systems
- 3. Nanofibrous Materials as Drug-Delivery Systems
- 4. Future Directions
Chapter 8: Brush polymer-based nanostructures for drug delivery
Chong Cheng
- Abstract
- 1. Introduction
- 2. Structural Design of BP-Based Drug-Delivery Systems
- 3. BP-Based Encapsulated Drug-Delivery Systems
- 4. BP-Based Conjugated Drug-Delivery Systems
- 5. Multifunctional BP-Based Drug-Delivery Systems
- 6. Summary
- Acknowledgments
Chapter 9: Drug delivery systems based on titania nanostructures
Grzegorz D. Sulka
- Abstract
- 1. Introduction
- 2. Nanostructured TiO2 Used for Drug Delivery Systems
- 3. Drug Loading
- 4. Drug Release
- 5. Functionalization of TiO2 Nanostructures
- 6. Other Types of Nanostructured TiO2 Used as Drug Delivery Systems
- 7. Conclusions
Chapter 10: Redox activated polymeric nanoparticles in tumor therapy
Khaled Greish
- Abstract
- 1. Introduction
- 2. Reactive Chemical Species in Human Physiology
- 3. Origins of Enhanced Free Radical Production in Tumors
- 4. Active and Passive Drug-Delivery Systems
- 5. Redox Responsive Drug-Delivery Systems
- 6. Miscellaneous Systems
- 7. Conclusions
Chapter 11: Polymeric micro- and nanoparticles for controlled and targeted drug delivery
Magdalena Stevanovic
- Abstract
- 1. Introduction
- 2. Polymeric Micro- and Nanoparticles for a Controlled Delivery of Active Substances
- 3. Formulation of Micro- and Nanopolymer Particles
- 4. The Most Widely Used Incorporation Techniques
- 5. Characteristics of Polymeric Micro- and Nanoparticles With an Encapsulated Vitamin as an Active Substance and Their Comparison
- 6. Conclusions
- Acknowledgments
Chapter 12: Novel gels: implications for drug delivery
Swarnali Das Paul
- Abstract
- 1. Introduction
- 2. Hydrogels
- 3. In situ Gel
- 4. Emulsion Gels
- 5. Microgel
- 6. Nanogels
- 7. Vesicular Gel
- 8. Future Prospects
Chapter 13: Nanosuspension drug delivery system: preparation, characterization, postproduction processing, dosage form, and application
Jian Zhong
- Abstract
- 1. Introduction
- 2. Preparation of Liquid Nanosuspension DDS
- 3. Characterization of Nanosuspension DDS
- 4. Postproduction Processing
- 5. Dosage Form of Nanosuspension DDS
- 6. Application of Nanosuspension DDS
- 7. Summary and Outlook
- Acknowledgments
Chapter 14: Polymer-based nanocarriers for therapeutic nucleic acids delivery
Weien Yuan
- Abstract
- 1. Introduction
- 2. Current Challenges and Barriers for Therapeutic Nucleic Acids Delivery
- 3. Advantages and Uniqueness of Polymer-Based Nanocarriers for Addressing Existing Challenges and Barriers
- 4. Recent Examples of Polymer-Based Nanocarriers for Therapeutic Nucleic-Acids Delivery
- 5. Other Considerations for Polymer-Based Nanocarriers for Therapeutic Nucleic Acids Delivery
- 6. Conclusions
- Acknowledgments
Chapter 15: Multifunctional therapeutic hybrid nanocarriers for targeted and triggered drug delivery: recent trends and future prospects
Gokcen Birlik Demirel
- Abstract
- Abbreviations
- 1. Introduction
- 2. Metal Nanoparticles
- 3. Silica Nanoparticles
- 4. Polymeric Nanoparticles
- 5. Core/Shell Nanoparticles
- 6. Conclusion and Future Prospects
Chapter 16: Lipid-based nanocarriers for ocular drug delivery
Ragwa Mohamed Farid
- Abstract
- 1. Introduction
- 2. Routes of Delivery (Thakur and Kashiv, 2011)
- 3. Major Physiological Barriers of the Eye to Topical Ocular Drug Delivery
- 4. Requisites of Controlled Ocular Delivery (Wilson, 2004)
- 5. Lipid-Based Nanocarriers as Topical Ocular Delivery Systems (Gan et al., 2013)
- 6. Conclusions
Chapter 17: Nanoparticulate carrier(s): an emerging paradigm in new generation vaccine development
Suresh P. Vyas
- Abstract
- 1. Introduction
- 2. Advantages of Nanoparticulate-based Vaccine Delivery
- 3. Generation of Immune Response
- 4. Design Aspects in the New Generation of Vaccine Development
- 5. Nanocarrier(s) Properties that Make Suitable Cargo for Vaccine Delivery
- 6. Nanoparticulate Carriers as a Versatile Platform for Vaccine Delivery
- 7. New Generation Vaccines
- 8. Conclusions
Chapter 18: Pathogen-specific nucleic acid aptamers as targeting components of antibiotic and gene delivery systems
Serap Evran
- Abstract
- 1. SELEX for Selection of Specific and High-Affinity Aptamers
- 2. Aptamers for Pathogenic Cells
- 3. Nanoparticle-Based Antimicrobial Gene Delivery
- 4. Functionalization of Nanocarriers
- 5. Conclusions and Future Perspectives
Chapter 19: Multifunctional nanosized emulsions for theragnosis of life threatening diseases
Tamilvanan Shunmugaperumal
- Abstract
- Abbreviations
- 1. Introduction
- 2. O/W-Type Nanosized Emulsions (NE) Generations
- 3. Future Perspectives
- 4. Conclusions
Chapter 20: Therapeutic nanostructures for pulmonary drug delivery
Yousef Javadzadeh
- Abstract
- 1. Introduction
- 2. Nanoparticles
- 3. Pulmonary Drug Delivery
- 4. Drugs Suitable for Pulmonary Drug Delivery
- 5. Nanostructures for Drug Delivery to the Lungs
- 6. Pulmonary Delivery Devices
- 7. Deposition of Inhaled Particles in Respiratory Tract
- 8. Fate of Inhaled Particles
- 9. Evaluation of the Fate of Inhaled Particles
- 10. Conclusions
Chapter 21: Nanostructures in transdermal drug delivery systems
Gul Majid Khan and Naveed Ahmed
- Abstract
- 1. Introduction
- 2. Skin Anatomy
- 3. Permeation Pathways Across Skin
- 4. Advantages of Transdermal Drug Delivery Compared to Other Routes of Administration
- 5. Advantages of Nanostructures in TDDS
- 6. Physicochemical Properties of Nanostructures Required for Good Permeation
- 7. Types of Nanostructures Used in TDDS
- 8. Limitations of Nanostructures in TDDS
- 9. Applications of Nanostructures in TDDS
- 10. Conclusions and Future Perspectives
Chapter 22: Advancement in pulmonary drug delivery systems for treatment of tuberculosis
Amit Kumar Goyal
- Abstract
- 1. Introduction
- 2. Burden of Disease and Progress Toward Global Targets
- 3. Pathogenesis of Tuberculosis
- 4. Current Antitubercular Chemotherapy
- 5. Pulmonary Drug Delivery
- 6. Advanced Dry Powder Inhalers (DPI)
- 7. Carriers Used for Pulmonary Delivery of ATDs
- 8. Conclusions and Future Prospectives
- Acknowledgment
Chapter 23: Nanosized devices as antibiotics and antifungals delivery: past, news, and outlook
Rosario Pignatello
- Abstract
- 1. Introduction
- 2. Liposomes
- 3. Solid Lipid Nanoparticles (SLN)
- 4. Mucoadhesive Drug Delivery Systems
- 5. Chemical Drug Delivery Systems
- 6. Conclusions and Future Outlooks
Chapter 24: Drug delivery mediated by confined nanosystems: structure-activity relations and factors responsible for the efficacy of formulations
Lucia Zakharova
- Abstract
- 1. Introduction
- 2. Surfactant-Based Formulations; Structure-Activity Relations as Criteria for the Choice of Building Blocks
- 3. Cationic Surfactants as Agents for DNA Transfection
- 4. Binding/Release Properties of Self-Assembled Systems
- 5. Biomaterials for Hydrophilic Peptides
- 6. Penetration Through BBB
- 7. Conclusions
- Acknowledgment
Chapter 25: Therapeutic use of monoclonal antibodies: general aspects and challenges for drug delivery
Santiago Daniel Palma
- Abstract
- 1. General Introduction
- 2. Mabs Production
- 3. Antibody–Drug Conjugates
- 4. Nanotechnology’s Potential Impact on Mabs
- 5. Therapeutic Applications of Monoclonal Antibodies
- 6. Future Trends of Monoclonal Antibodies
Chapter 26: Targeted drug delivery via chitosan-coated magnetic nanoparticles
Gozde Unsoy
- Abstract
- 1. Nanotechnology-Based Targeted Drug-Delivery Systems
- 2. Targeting Strategies in Drug Delivery
- 3. Magnetic Nanoparticles
- 4. Chitosan as a Surface Coating Material for Magnetic Nanoparticles
- 5. Synthesis Methods for Chitosan-Coated Magnetic Nanoparticles
- 6. Magnetically Targeted Drug Delivery via Chitosan-Coated Magnetic Nanoparticles
- 7. Cellular Internalization of Chitosan-Coated Magnetic Nanoparticles
- 8. Drug Release From Chitosan-Coated Magnetic Nanoparticles
- 9. Toxicity of Chitosan-Coated Magnetic Nanoparticles
- 10. Administration Routes of Chitosan-Coated Magnetic Nanoparticles
- 11. Concluding Remarks
Chapter 27: Drug delivery: advancements and challenges
Gaurav Verma
- Abstract
- 1. Introduction
- 2. Drug Delivery into the Brain
- 3. Oral Drug Delivery Systems
- 4. Targeted Drug Delivery
- 5. Nanomaterials for Drug Delivery
- 6. Modern Drug Delivery: Challenges
- 7. Conclusions
Chapter 28: Stimuli-responsive liposome and control release drug
Xue Qin An
- Abstract
- 1. Introduction
- 2. Liposomes
- 3. Stimuli-Responsive Liposome
- 4. Conclusions
- Acknowledgments
Chapter 29: Nanotechnology to enhance transdermal delivery of hydrophilic humectants for improved skin care: a model for therapeutic applications
Marek K. Dobke
- Abstract
- 1. Basic Concepts
- 2. Transdermal Agents Delivery and Nanotechnology
- 3. Humectants for Improved Skin Care: A Model for Therapeutic Applications
- 4. Conclusions and Lessons From Humectants for Skin Care Modeling Therapeutic Applications of Nanotechnologies
Chapter 30: Nanostructures for drug delivery: pharmacokinetic and toxicological aspects
Alexandru Mihai Grumezescu
- Abstract
- 1. Introduction
- 2. Nanoparticles and Drug Delivery
- 3. Main Applications
- 4. Pharmacokinetic Characteristics of Nanoparticles in Drug Delivery Systems
- 5. Toxicological Effects of Nanoparticles
- 6. Determination of Toxicity
- 7. Toxicity
- 8. Conclusions
- Acknowledgments