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Elsevier

Books in Life sciences

  • Overcoming Resistance to EGFR Inhibitors in EGFR-Mutant NSCLC

    • 1st Edition
    • Volume 19
    • Anthony Faber
    • English
    Overcoming Resistance to EGFR Inhibitors in EGFR Mutant NSCLC presents updated information on how EGFR mutant lung cancers evolve to evade EGFR inhibitors, clinical strategies that identify these mechanisms, and how to implement newer therapeutic strategies to combat resistance and improve patient survival. As resistance to EGFR inhibitors is often through re-activation of MEK/ERK and PI3K pathways, or through loss of cell death responses, there is much overlap with resistance to targeted therapies in other paradigms, such as BRAF inhibitors in BRAF mutant melanoma, and HER2 inhibitors in HER2 amplified breast cancer. This book is a valuable resource for cancer researchers, clinicians, graduate students and other members of the biomedical field who are interested in promising treatments for lung cancer.

  • Transcription and Translation in Health and Disease

    • 1st Edition
    • Manoj Garg + 2 more
    • English
    Transcription and Translation in Health and Disease provides a detailed overview of the regulators underlying transcription and translation in relation to a variety of human diseases and disorders. Beginning with an introduction into the current perspectives relating to these processes in human disease, the book expands to focus on specific mechanisms underlying conditions such as arthritis, cancer, neurological disorders, diabetes and cardiovascular disease. This book considers RNA processing and related mechanisms in eukaryotes including RNA splicing, RNA binding proteins, RNA interference, microRNAs, RNA editing, transcription factors, RNAi screening, CRISPR activation, CRISPR-Cas9 interference, and post-translational modifications. It provides a structured and detailed overview of the various regulators underlying molecular processes and their impact on health and disease, equipping readers with the necessary knowledge for further investigation in the areas of treatment and therapeutic intervention.

  • Joint and Bone

    From Bench to Bedside
    • 1st Edition
    • Deming Jiang + 1 more
    • English
    Joint and Bone: From Bench to Bedside, Volume Three, the latest release in the Stem Cell Innovation in Health and Disease series, is a timely and fascinating collection of information and new discoveries that provides a contemporary snapshot album from the fast-moving field of regenerative medicine and stem cell therapeutics. This new volume addresses the molecular players underlying iPSC formation, maintenance, and expansion and differentiation, bringing chapters that describe cutting-edge research for understanding stem cell functions in joint and bone diseases, and for developing methods to bring stem cells from bench to bedside. Each chapter includes insights ranging from the use of mouse and human organoid cultures, genetic editing in vitro and in vivo, and human iPSCs to study stem cell functions and model joint and bone diseases.

  • Human Histology

    A Text and Atlas for Physicians and Scientists
    • 1st Edition
    • Bertalan Dudas
    • English
    Visually engaging and easy to use, Human Histology: A Text and Atlas for Physicians and Scientists covers the normal histology of every organ in the human body. This book presents full-page high-definition photomicrographs for organs and tissues, followed by a compact and simple-to-read description of the structures identified on the micrographs, offering a clear, visual understanding of this complex subject. With over 300 outstanding images, this reference is an invaluable resource for every clinical researcher and pathologist in need of easily accessible, relatively simple but detailed enough information on normal histology of different organs systems. Due to its compact, but detailed layout, the volume is an excellent tool for medical board review and can be recommended for medical students and histology course directors.

  • Advanced Microbial Techniques in Agriculture, Environment, and Health Management

    • 1st Edition
    • Satish Chandra Pandey + 3 more
    • English
    Advanced Microbial Techniques in Agriculture, Environment, and Health Management provides current perspectives on the fields of agriculture, the environment and health. This important reference presents recent advancements in applied microbial technology, compiling it in a comprehensive manner and transferring applied microbial technology from laboratory conditions to field level. In 20 chapters, the book focuses on microbial interventions for all-inclusive, cost-effective environmental management tactics while also linking the cumulative microbial services involved in the up-gradation of agriculture, environment and health. In addition, the book offers detailed information on emerging environmental issues and proposes ways of controlling their consequences using different approaches to treatment.

  • Specialty Thermoplastics

    • 1st Edition
    • Prakash Trivedi
    • English

  • Recycling of Plastics

    • 1st Edition
    • Norbert Niessner
    • English
    Plastics have a very important role to play in energy-efficient and low-carbon technologies of the present and future, but for them to be classified as sustainable materials, there is a great need for practical and economic recycling methods and infrastructure. This book fills the gap for a modern comprehensive technical guide to recycling of plastics, covering the whole value chain from raw materials to recycled materials. All important recycling technologies (mechanical, chemical/feedstock, dissolution) are discussed and compared to each other and alternative disposal methods such as energy recovery and gasification. Collecting, sorting, and purification methods are also covered, as are economic and regulatory aspects. A strong emphasis is placed on data comparability, e.g. by standardized methods in measuring data. Although this is a challenge to implement, comparing data across technologies, regions, and stakeholders along the value chain yields important benefits. Key instruments for such a target are lifecycle assessments (LCAs), which are calculated in a standardized way across the chapters.

  • Biochemical Pathways and Environmental Responses in Plants: Part B

    • 1st Edition
    • Volume 680
    • English
    Biochemical Pathways and Environmental Responses in Plants, Part B, Volume 682 in the Methods in Enzymology series, highlights advances in the field with this new volume presenting chapters on MIE 681/682: Biochemical pathways and environmental responses in plants, Structure, function, and engineering of plant polyketide synthases, A sensitive LC-MS/MS assay for enzymatic characterization of methylthioalkylmalat... synthase involved in glucosinolate side-chain elongation, Assaying formate-tetrahydrofo... ligase with monoglutamylated and polyglutamylated substrates using a fluorescence-HPLC based assay, An Approach to Nearest Neighbor Analysis of Pigmented Protein Complexes by Using Chemical Crosslinking in Combination with Mass Spectrometry, Biochemical characterization of plant aromatic aminotransferases, and much more. Other chapters focus on Functional Analysis of Phosphoethanolamine N-methyltransferase (PMT) in Plants and Parasites, A structure-guided computational screening approach for predicting plant enzyme-metabolite interactions, Plant metacaspase: an example of microcrystal structure determination and analysis, Biocatalytic system for comparative assessment of functional association of cytochrome P450 monooxygenases with their redox partners, Dirigent Protein Family Function and Structure, and more.

  • Problem-Based Learning Approach in Microbiology

    • 1st Edition
    • Khalid Mubarak Bindayna + 1 more
    • English
    Problem-based Learning Approach in Microbiology, is an organ-based study of microbiology and infectious diseases using real patient problems (cases) and cases edited for educational purposes. This approach uses case studies to stimulate interactive learning and to facilitate basic knowledge for clinical training. In seven sections, each problem in each section begins with a clinical case scenario and is followed by the learning objectives of the case. The “Question-and-answer... section facilitates student-tutor interaction, thereby resulting in a problem-solving approach. The etiological agent is then described in complete detail comprising the epidemiology and pathogenicity of the agent, and the host immune response, clinical manifestations, diagnostic, and therapeutic measures. This book includes a wide-spectrum of commonly encountered infectious diseases, emerging infectious diseases, and immunological diseases. This book caters to the need for fundamental knowledge through an alternative approach achieved by dividing the book into sections. This book facilitates a more effective learning process thereby ensuring better information retention, correlation with real-life scenarios, and better applicability of the concepts.

  • Computational Approaches in Drug Discovery, Development and Systems Pharmacology

    • 1st Edition
    • Rupesh Kumar Gautam + 2 more
    • English
    Computational Approaches in Drug Discovery, Development and Systems Pharmacology provides detailed information on the use of computers in advancing pharmacology. Drug discovery and development is an expensive and time-consuming practice, and computer-assisted drug design (CADD) approaches are increasing in popularity in the pharmaceutical industry to accelerate the process. With the help of CADD, scientists can focus on the most capable compounds so that they can minimize the synthetic and biological testing pains. This book examines success stories of CADD in drug discovery, drug development and role of CADD in system pharmacology, additionally including a focus on the role of artificial intelligence (AI) and deep machine learning in pharmacology. Computational Approaches in Drug Discovery, Development and Systems Pharmacology will be useful to researchers and academics working in the area of CADD, pharmacology and Bioinformatics.

  • Enzymes Beyond Traditional Applications in Dairy Science and Technology

    • 1st Edition
    • Y.S. Rajput + 1 more
    • English
    A volume in the series on Foundations and Frontiers of Enzymology, Enzymes Beyond Traditional Applications in Dairy Science and Technology presents the applications of enzymes in dairy science and technology. Broken into four sections, this book provides a brief account of traditional applications of indigenous milk enzymes, the actions of exogenous enzymes on milk proteins for generating bioactive peptides and lactose for value addition, and methods and approaches for ensuring milk quality or cleaning milk plants.　 This book is an excellent resource for postgraduate students, academics, food scientists, and dairy professionals engaged in milk processing.

  • Gene-Environment Interactions in Birth Defects and Developmental Disorders

    • 1st Edition
    • Volume 152
    • English
    Gene-Environment Interactions in Birth Defects and Developmental Disorders, Volume 152, covers the multifactorial etiology of a variety of developmental disorders, including orofacial clefts, fetal alcohol spectrum disorders, autism, and others. The causes of individual cases of most common birth defects are unknown but likely involve a combination of genetic predisposition and environmental exposures. How these risk factors interact in the genesis of these conditions is still largely unknown and readers will find the latest information and ideas on these disorders, along with discussion of the challenges and opportunities for furthering knowledge in this area.

  • Principles of Genomics and Proteomics

    • 1st Edition
    • Rakeeb Ahmad Mir + 2 more
    • English
    Principles of Genomics and Proteomics is the perfect reference for graduate students and researchers in these areas to understand its principles and execute precise and reproducible experiments. Following an introductory chapter, the book dives into proper research, including genome mapping. Experiments covered in the book span from Sangers Sequencing, Shotgun sequencing, SAGE analysis, DNA footprinting, Gel retardation, ChIP, and protein resolution methods, including PAGE, 2D gel electrophoresis and isoelectric focusing. Biophysical techniques are also described in detail, including ultraviolet and visible light spectroscopy, fluorescence spectroscopy, NMR and X-ray diffraction.A final proteome analysis is dedicated to functional analysis. Other chapters cover applications of omics technologies broadly. This book is the perfect reference for genetics labs around the world. Graduate students will benefit from the structured and detailed coverage of methods and established researchers will benefit from the book for staff training in research and may find it particularly helpful in enhancing reproducibility of experiments.

  • Microbiome Metabolome Brain Vagus Nerve Circuit in Disease and Recovery

    • 1st Edition
    • Elena L. Paley
    • English
    Microbiome Metabolome Brain Vagus Nerve Circuit in Disease and Recovery focuses on the emerging hypothesis of a dysfunctional microbiome metabolome vagus nerve brain circuit in Alzheimer’s disease and associated diseases and medical conditions, including dementia, aging, COVID-19, autoimmune conditions, and inflammatory skin condition rosacea, which may increase the risk of other conditions. This book also discusses the vagus nerve-related conditions, including Arnold’s reflex, laryngopharyngeal reflux, duodenogastric reflux, gastroesophageal reflux, and related pulmonary diseases. The subjects covered in the book also address an important question of which one is more important for human health and intellectual abilities: the human genome or the human microbiome? The conceptual model of food and gut microbial tryptamine vagus nerve circuit is also presented in this book.

  • Antioxidants

    • 1st Edition
    • Volume 121
    • Gerald Litwack
    • English
    Antioxidants, Volume 121 in the Vitamins and Hormones series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors.

  • G Protein-Coupled Receptors - Part B

    • 1st Edition
    • Volume 195
    • English
    G Protein-Coupled Receptors, Part B, Volume 195 represents the largest class of cell H103 surface proteins that have intricate involvement in nearly every physiological process in our body. Approximately one third of the clinically prescribed medicines target GPCRs and the quest to improve the exiting GPCR-targeting therapeutics continues. Sections in this volume include Adhesion G protein-coupled receptors: Structure and functions, Molecular and cellular mechanisms underlying brain region-specific cannabinoid receptor modulation by estradiol across the rodent estrus cycle, Probing the orphan receptors: Tools and directions, Asymmetric activation of Class C GPCRs, Common and selective signal transduction mechanisms of GPCRs, and much more.

  • Advances in Parasitology

    • 1st Edition
    • Volume 119
    • English
    Hybridisation in Parasites: Disease Evolution by Saltation, Volume 119 in the Advances in Parasitology: Disease Evolution by Saltation, the latest release in this ongoing series, includes medical studies of parasites of major influence, along with reviews of more traditional areas, such as zoology, taxonomy and life history.

  • Healthcare Systems Design of Intelligent Testing Centers

    Latest Technologies to Battle Pandemics such as Covid-19
    • 1st Edition
    • Tawanda Mushiri + 1 more
    • English
    Healthcare Systems Design of Intelligent Testing Centers: Latest Technologies to Battle Pandemics such as Covid-19 highlights the importance of designing intelligent testing centers requiring no human intervention during sample collection and testing of the Covid-19 virus and all similar viruses. This book introduces the background, medical requirements, and new research on medical robotics applications, including general Covid-19 testing techniques, development considerations for intelligent testing booths, kinematic and dynamic modeling, design specifications and optimization, numerical verifications, actuators, and sensors in medical applications of artificial intelligence and robotics systems.

  • Developments and Applications of Enzymes From Thermophilic Microorganisms

    • 1st Edition
    • Pratima Bajpai
    • English
    Developments and Applications of Enzymes from Thermophilic Microorganisms extensively presents the industrial application of thermophilic/hyperth... enzymes. The book brings thorough and in-depth coverage on the role of these enzymes in a broad range of industries, focusing on present scenarios of these enzymes in biofuel industries, including recent advancements. The use of thermophilic enzymes in 2G biorefineries may enable the whole production process to take place at high temperatures, allowing increased reaction rate and reduced costs. Researchers in biochemistry, microbiology, microbial technology, biotechnology, molecular biology and bioresource technology will benefit from the new insights given on potential applications of hyperthermophiles. Hyperthermophilic enzymes, many of which survive at temperatures at or above 100C, contain novel macromolecules and metabolic systems which represent a vast resource for fundamental molecular and physiological studies, and for potential exploitation in biotechnology.

  • Indigenous Fermented Foods for the Tropics

    • 1st Edition
    • Oluwafemi Ayodeji Adebo + 5 more
    • English
    Indigenous Fermented Foods for the Tropics provides insights on fermented foods of the Tropics, particularly Africa, Asia and South America, highlighting key aspects and potential developments for these food products. Sections provide an overview on the production and composition (nutritional, physicochemical, health beneficial and microbiota) of these indigenous fermented foods in the tropics,　 innovative techniques for investigating the composition of these fermented food products and improvement of the fermentation process to yield better nutritional constituents, health beneficial components and sensory qualities, and safety aspects to be considered in fermented foods. Other sections provide insights into the packaging and marketing of these food products as well as future prospects of fermented foods in the tropics. This book provides new perspectives and recent information to complement existing texts on indigenous fermented foods serving as a valuable reference text for detailed insights into indigenous fermented foods of the tropics.

  • Biotechnology of Microbial Enzymes

    Production, Biocatalysis, and Industrial Applications
    • 2nd Edition
    • Goutam Brahmachari
    • English
    Biotechnology of Microbial Enzymes: Production, Biocatalysis, and Industrial Applications, Second Edition provides a complete survey of the latest innovations on microbial enzymes, highlighting biotechnological advances in their production and purification along with information on successful applications as biocatalysts in several chemical and industrial processes under mild and green conditions. The application of recombinant DNA technology within industrial fermentation and the production of enzymes over the last three decades have produced a host of useful chemical and biochemical substances. The power of these technologies results in novel transformations, better enzymes, a wide variety of applications, and the unprecedented development of biocatalysts through the ongoing integration of molecular biology methodology, all of which is covered insightfully and in-depth within the book. This fully revised, second edition is updated to address the latest research developments and applications in the field, from microbial enzymes recently applied in drug discovery to penicillin biosynthetic enzymes and penicillin acylase, xylose reductase, and microbial enzymes used in antitubercular drug design. Across the chapters, the use of microbial enzymes in sustainable development and production processes is fully considered, with recent successes and ongoing challenges highlighted.

  • Anticandidal Therapeutics

    Discovery and Development
    • 1st Edition
    • Awanish Kumar + 1 more
    • English
    Developments of antifungal agents have declined as compared to other antibiotics that have displayed a potent development with time. There is an urgent need for both prophylactic and therapeutic treatments worldwide to control the severity of infections caused by Candida. Anticandidal Therapeutics: Discovery and Development provides the readers with a compiled knowledge of the fungal human infection Candida and the development of anticandidal drugs. Anticandidal Therapeutics helps researchers form the basis for the discovery and development of novel anticandidal therapies. In 14 chapters this book provides collective information on anticandidal agents and their discovery and development with respect to major drug transporter families, different stages of anticandidal agent development, recent trends and progress in antifungal translational research, clinical studies status of anticandidal therapeutic agents, and drug repurposing for development of novel anticandidal agents.

  • Nanometal Oxides in Horticulture and Agronomy

    • 1st Edition
    • Li Xinghui + 3 more
    • English
    Nanometal Oxides in Horticulture and Agronomy, a volume in the Nanomaterial-Plant Interactions series, summarizes the physiological, morphological, biochemical, and molecular regulation of metal oxide nanoparticles in plants under normal conditions as well as during different stresses. With a focus on impact and applications, it presents the latest advances in the roles of metal oxide nanoparticles in both horticulture and agriculture. Metal oxide nanoparticles have been reported as beneficial inorganic materials for the growth and development of plants, playing a protective role against the abiotic and biotic stresses. Researchers need to understand the different regulatory pathways of metal oxide nanoparticles, including their mechanisms of operation under different stressful conditions. This volume presents the physiological, morphological, biochemical, and molecular regulation of metal oxide nanoparticles in plants in normal conditions as well as during different stresses. It also discusses tolerance mechanisms and the variety of roles and applications that metal oxide nanoparticles have within plant biology. Beginning with an introductory overview to metal oxide nanomaterials, chapters discuss the effect of metal oxide nanomaterials on biochemical pathways within the plant, highlighting key applications such as fertilizers, weed control systems and pest control systems. It describes the impact of metal oxide nanoparticles in different challenging environmental conditions. Concluding with a discussion of the strengths and weaknesses of metal oxide nanoparticles in agriculture, Nanometal Oxides in Horticulture and Agronomy provides inspiration for further research and advancement. This book is an essential read for researchers and students interested in horticulture, agronomy, and plant nanomaterials.

  • Board Review in Preventive Medicine and Public Health

    • 2nd Edition
    • Gregory M. Schwaid
    • English
    Board Review in Preventive Medicine and Public Health, Second Edition provides an ideal resource for physicians preparing to take the board exams in both preventive medicine and occupational medicine or for those preparing to take the examination to become certified in Public Health. In this new edition, topics have been added to fill any potential gaps in important key concepts. Topics include clinical preventive medicine, health administration, epidemiology, biostatistics, occupational medicine, correctional medicine, aerospace medicine, and much more. This second edition uses the board exam outline supplied by the American Board of Preventive Medicine to help test-takers understand exam topics and components. The primary audience for the book is physicians preparing to take board exams in preventive medicine or occupational medicine. This includes resident physicians taking the exam for the first time, as well as those that are preparing to take the recertifying exam. Similar to physicians, this book can be used by nurse practitioners preparing for their occupational medicine certification exams.

  • Clinical Case Studies on Medication Safety

    • 1st Edition
    • Yaser Mohammed Al-Worafi
    • English
    Clinical Case Studies on Medication Safety provides real and simulated scenarios about safety issues related to medication, including Adverse Drug Reactions (ADRs), medication errors, and Drug Related Problems (DRPs). The book explains real-life case management, including details about adverse drug reactions, mistakes during drug administration, drug avoidance, and drug-drug interactions with a goal of improving patient care. With over 150 case studies, including cases from alternative medicine and traditional medicine, this book will help medical and health sciences educators, students, healthcare professionals, and other readers apply their knowledge and skills to solve cases for better patient care.

  • Coastal Habitat Conservation

    New Perspectives and Sustainable Development of Biodiversity in the Anthropocene
    • 1st Edition
    • Free Espinosa
    • English
    Coastal Habitat Conservation: New Perspectives and Sustainable Development of Biodiversity in the Anthropocene offers the latest research and approaches to biodiversity conservation in coastal areas. The book synthesizes the background of foundational conservation views and provides new perspectives and recent strategies within a sustainable development context for coastal species and organic life. Written by a team of international authors with expertise in wide-ranging issues of biodiversity conservation, this book analyzes the challenges of conserving marine habitats and species that humanity faces in the Anthropocene era. Sections explore emerging and unforeseen impacts within a changing world, specifically, the marine-based conservation in the context of global change, coastal urbanization and mitigation of its environmental impacts, marine bioinvasions, conservation strategies for of out-of-sight communities like caves, habitat restoration, and the citizen science and its challenging role in monitoring conservation.

  • Integrated Methods in Protein Biochemistry: Part B

    • 1st Edition
    • Volume 679
    • English
    Integrated Methods in Protein Biochemistry: Part B, Volume 678 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Precise modification of native proteins, purification, and analysis of bioconjugates, NanoBiT-based methods to monitor the activation and modulation of RTKs, The interplay of G-protein βγ subunit and PLC-β enzyme in PIP2 hydrolysis and downstream signaling, Structure and function of bacterial secretion system, Tools and protocols for probing protein sumoylation, Spectroscopic analysis of cysteine dioxygenase: a mammalian thiol-dioxygenase, DeGlyPHER: MS-based analysis of viral spike N-glycoforms, and more. Additional sections cover Covalent protein painting: MS-based protein footprinting, Characterization of GPCR signaling complexes using negative-staining electron microscopy, Probing protein misfolding and dissociation with free electron laser, Optimized protocol for the characterization of Cas12a activities, Proximity proteomics for the identification and characterization of extracellular vesicles, Structural and Functional characterization of lytic polysaccharide monooxygenases, and much more.

  • Magnetic Resonance Imaging of The Pelvis

    A Practical Approach
    • 1st Edition
    • Neeraj Lalwani
    • English
    Magnetic Resonance Imaging of The Pelvis: A Practical Approach presents comprehensive information to deal withcommonly encountered pelvic pathologies. The content is developed by disease-focused experts aiming to share theirexperience to make the information easily applicable to clinical setting and research. The book covers a wide range of pelvic pathologies, and each chapter focuses on problem-solving approaches andincludes tips and advice for multiple real-world scenarios. It also provides comprehensive-yet-ta... protocols, clearguidelines for indications, a detailed discussion of pathologies, descriptions of important differential diagnoses, and pitfalls and their solutions. It is a valuable resource for radiologists, researchers, clinicians, and members of medical and biomedical fields who needto understand better how to use MRI to base their diagnosis or advance their research work.

  • Antimicrobial Resistance in Wastewater and Human Health

    • 1st Edition
    • Dharm Pal + 1 more
    • English
    Antimicrobial Resistance in Wastewater and Human Health provides updated knowledge on the human health risks associated with antimicrobial resistance of wastewater. The book's chapters address commonly found bacteria and drug resistant genes in wastewater, treatment plant problems and challenges, human health hazards, and gaps in current literature. Written for researchers, scientists, graduate and PhD students in the areas of Public Health, Biotechnology, Chemical Engineering, and Environmental Science, this will be an ideal resource.

  • Biscuit Baking Technology

    Processing and Engineering Manual
    • 3rd Edition
    • Iain Davidson
    • English
    Biscuit Baking Technology: Processing and Engineering Manual, Third Edition shares over 50 years of experience in the biscuit baking industry worldwide, and is the most updated reference book for senior managers and staff involved in industrial-scale biscuit baking. This volume covers the biscuit industry process, ingredients, and formulations, as well as the design, manufacture, installation, operation, and maintenance of baking ovens. This third edition is fully updated and covers topics, such as baking by infrared radiation, NIR, FIR and dielectric heating, new innovations from leading oven manufacturers, new products for baking cookies, filled cookies, and snack cakes, and 3D and puzzle biscuit design.

  • Secretory Proteins

    • 1st Edition
    • Volume 133
    • Rossen Donev
    • English
    Secretory Proteins, Volume 133 in the Advances in Protein Chemistry and Structural Biology series highlights new advances in the field, including chapters on Proprotein Convertases regulate trafficking and maturation of key proteins within the secretory pathway, Secretory Proteins in Cancer Diagnosis, Senescent Cells and SASP in Cancer Microenvironment: new approaches in cancer therapy, Autophagy for secretory protein: Therapeutic targets in cancer, Secretory proteins and pathways of secretion of osteosarcoma, Monocyte secretory proteins as drug targets for arresting progression of atherosclerosis, The secretory phenotypes of envenomed cells: insights into venom cytotoxicity, Macromolecules for secretory pathway in SARS-CoV-2 infection, and much more. Other sections cover Exploring the role of secretory proteins in the human infectious diseases diagnosis and therapeutics, Secretory proteins in orchestration of microbial pathogenesis- the curious case of Staphylococcus aureus, Influence of pathological mutations in Aspartylglucosylamin... Deaspartylase causing Aspartylglucosaminur... an in silico approach, and Change in conformational dynamics of Lipase A secretory protein upon mutation causing Wolman disease.

  • Biotechnology for Beginners

    • 3rd Edition
    • Reinhard Renneberg
    • English
    Biotechnology for Beginners, Third Edition presents the latest developments in the evolving field of biotechnology which has grown to such an extent over the past few years that increasing numbers of professional’s work in areas that are directly impacted by the science. This book offers an exciting and colorful overview of biotechnology for professionals and students in a wide array of the life sciences, including genetics, immunology, biochemistry, agronomy and animal science. This book will also appeals to lay readers who do not have a scientific background but are interested in an entertaining and informative introduction to the key aspects of biotechnology. Authors Renneberg and Loroch discuss the opportunities and risks of individual technologies and provide historical data in easy-to-reference boxes, highlighting key topics. The book covers all major aspects of the field, from food biotechnology to enzymes, genetic engineering, viruses, antibodies, and vaccines, to environmental biotechnology, transgenic animals, analytical biotechnology, and the human genome.

  • Hospitalization, Diagnosis, Treatment, and Surgery in Iran

    The Lifecycle of Medical Sciences
    • 1st Edition
    • Ali Akbar Velayati
    • English
    Hospitalization, Diagnosis, Treatment, and Surgery: The Lifecycle of Medical Sciences in Iran provides a complete understanding of the lifecycle of medicine in the underserved area of Iran. Coverage will elucidate the importance of communication between scientists in different countries for the further development of research to advance hospitalization infrastructure, diagnosis and treatment of diseases, and surgery techniques and availability. Using a systematic timeline approach, coverage includes early medical sciences to present day of Iran. Each chapter highlights important research, techniques, and procedures throughout the lifecycle of medical sciences and includes topics from bloodletting and setting bones, to anesthesia and vaccines. The content in each chapter emphasizes standard protocols based on international recognition to help developing countries adopt newer technologies.

  • Green Sustainable Process for Chemical and Environmental Engineering and Science

    Methods for Producing Smart Packaging
    • 1st Edition
    • Tariq Altalhi + 2 more
    • English
    Green Sustainable Process for Chemical and Environmental Engineering and Science: Methods for Producing Smart Packaging covers the latest advances in the development and production of smart packaging. The book addresses issues related to the production of smart packaging, including marketing and environmental impacts of these new products. The book demonstrates how modern packaging goes beyond protecting food against physical, chemical, and biological damage, and that scientific advances now enable producing functional packaging that prolongs product quality, preserves physical and chemical properties, produces greater protection against transportation shocks, and makes food more compact and easily recycled.

  • Venous Ulcers

    • 2nd Edition
    • Cynthia K. Shortell + 1 more
    • English
    Venous Ulcers, Second Edition, provides a comprehensive synthesis of evidence-based recommendations and the highest level of expertise from a leading group of doctors, which is a fundamental constituent for the appropriate management of nonhealing venous wounds in everyday practice. This book offers a fertile environment for a complete understanding of genetics and molecular and biochemical mechanisms that lead to the development and progression of venous ulcers, which is essential for elucidating the underlying pathophysiology and can be utilized for developing novel therapies and accessing previously inaccessible areas of research. Socioeconomic impact, impact on health-related quality of life, the clinical course of the disease, and diagnostic algorithms are elaborated in detail. All currently available treatment modalities are explained in a clinically applicable approach with particular emphasis on operative technique, technical feasibility, success rates (both clinical and technical), and side effects. Lastly, this book elaborates on special diagnostic considerations and management of the most complex patients, often requiring the highest level of expertise for successful treatment.

  • Tratamiento integral del ictus

    • 7th Edition
    • James C. Grotta + 7 more
    • Spanish
    Título derivado del libro de referencia internacional sobre el abordaje integral del ictus, Grotta, que recoge todos los temas relacionados con el tratamiento clínico de esta patología excluyendo así toda la parte vinculada al tratamiento quirúrgico. Esta obra incluiría los diferentes enfoques terapéuticos de esta patología recogiendo en su índice un total de 12 capítulos. Considerando que el abordaje del ictus tiene un enfoque totalmente transversal, el objetivo que se persigue con este derivado es que cualquier profesional NO neurólogo tenga a su disposición el contenido esencial para la asistencia de un paciente que ha sufrido un accidente cerebrovascular. Este derivado, al igual que la obra de referencia, está escrito por los mayores expertos de mundo en la materia e incorpora los resultados de las investigaciones más recientes realizadas en cuanto al manejo de la patología. Igualmente, la parte de terapia farmacológica está completamente actualizada incluyendo los últimos hallazgos en esta área.

  • Clinical Management of Pediatric COVID-19

    An International Perspective and Practical Guide
    • 1st Edition
    • Char Leung
    • English
    Clinical Management of Pediatric COVID-19: An International Perspective and Practical Guide provides the most current international research and clinical characteristics of pediatric patients with SARS-CoV-2 infection. Coverage ranges from epidemiology including origin, route of transmission, incubation period, mortality and susceptibility risk factors; to pathogenesis, including difference between the adult and pediatric populations. Diagnosis is covered with special attention to the difference between adult and pediatric patients as well as the differences between newborns, children and adolescents. The book presents current complications, including multisystemic inflammatory syndrome as well as treatment therapies including antiviral and immunomodulatory therapies for this age group. Finally, immunization efficacy and safety are examined. This is the perfect reference to provide guidance to pediatricians on the diagnosis and treatment of SARS-CoV-2, as well as a valuable source of the latest research about the pediatric population for further study.

  • Urgencias en endocrinología

    • 1st Edition
    • Alexander L. Shifrin
    • Spanish
    Las urgencias en endocrinología son potencialmente mortales y pueden pasarse por alto con facilidad en pacientes sin antecedentes de enfermedades endocrinas. Urgencias en endocrinología es una imprescindible guía práctica de diagnóstico y tratamiento dirigida a los profesionales de la medicina, que cubre las urgencias frecuentes y graves relacionadas con los trastornos metabólicos endocrinos de la tiroides, las paratiroides, la hipófisis, las glándulas suprarrenales, el páncreas y los tumores neuroendocrinos gastrointestinales.

  • FAQ Kinder- und Jugendgynäkologie

    • 1st Edition
    • Patricia G. Oppelt + 1 more
    • German
    Das klar formulierte Kompendium mit knapp 300 Fragen und Antworten bereitet Ärzt*innen darauf vor, kleine und heranwachsende Mädchen sowie Jugendliche mit ihren spezifischen Problemstellungen gynäkologisch kompetent und sicher zu betreuen. Auf dem aktuellem wissenschaftlichem Stand werden u.a. dargestellt: die Besonderheiten der kinder- und jugendgynäkologische... Sprechstunde Erkrankungen des äußeren Genitals, der Ovarien, genitale Fehlbildungen Brustentwicklungsstö... Blutungsstörungen Kontrazeption Infektionen Sexueller Kindesmissbrauch Expert*innen aus ihrem Fach beantworten umfassend die wichtigsten und dringendsten Fragen. Das Buch eignet sich für: Weiterbildungsassist... und Fachärzt*innen Frauenheilkunde Geburtsmedizin, Kinder- und Jugendmedizin Kidnerchirurg*innen Endokrinolog*innen

  • Handbook of Obesity in Obstetrics and Gynecology

    • 1st Edition
    • Tahir A. Mahmood + 1 more
    • English
    **Selected for 2026 Doody's Core Titles in Obstetrics & Gynecology**Handbook of Obesity in Obstetrics and Gynecology addresses all aspects of general obstetrics and gynecology in obese patients, providing evidence-based guidance for the treatment and management of gynecological problems and pregnancy-related care in obese women. The book is a valuable resource for junior doctors, residents and obstetricians and gynecologists looking for a comprehensive guide that addresses the most relevant aspects of obstetric and gynecologic care that are impacted by obesity, an increasingly prevalent condition. The rising prevalence of global obesity is of public health concern, hence obese women suffer from a higher incidence of menstrual disorders, polycystic ovaries, infertility issues, and more.In pregnancy, obesity is associated with an increased risk of early pregnancy loss, recurrent pregnancy loss, fetal developmental abnormalities, thrombo-embolic disease, gestational diabetes, dysfunctional labor, post-partum hemorrhage and difficult operative deliveries.

  • The Immunological Synapse Part A

    • 1st Edition
    • Volume 173
    • English
    The Immunological Synapse, Part A, Volume 173 in the Methods in Cell Biology series provides state-of-the-art methods for the study of the immunological synapse. Sections cover Imaging polarized granule release at the cytotoxic T cell immunological synapse using TIRF microscopy: control by polarity regulators, Analysis of centrosomal area actin reorganization and centrosome polarization upon lymphocyte activation at the immunological synapse, P815-based redirected degranulation assay to study human NK cell effector functions, Cytotoxic and Chemotactic Dynamics of Natural Killer Cells Quantified by Live-cell Imaging, Quantification of interaction frequency between antigen-presenting cells and T cells by conjugation assay, and more. Other chapters focus on the Study of the Effects of NK-Tumor Cell Interaction by Proteomic Analysis and Imaging, Quantification of lymphocytic choriomeningitis virus specific T cells and LCMV viral titers, Quantification of lymphocytic choriomeningitis virus specific T cells and LCMV viral titers, An in vitro model to monitor natural killer cell effector functions against primary breast cancer, and Standardized Protocol for the Evaluation of Chimeric Antigen Receptor (CAR)-modified Cell Immunological Synapse Quality using the Glass-supported Planar L.

  • Abiotic Stresses in Wheat

    Unfolding the Challenges
    • 1st Edition
    • Mohd. Kamran Khan + 4 more
    • English
    Approx.434 pages

  • Metabolomics

    A Path Towards Personalized Medicine
    • 1st Edition
    • Mahbuba Rahman
    • English
    Metabolomics: A Path Towards Personalized Medicine integrates environmental factors of genomics, transcriptomics and proteomics, providing a bridge to resolve gaps between fundamental science and applications in clinical medicine and population health. The concept of personalized medicine or precision medicine is of great interest in biomedical research as it helps bring about new drug discovery and biomarker identification. In addition, it helps clinicians prescribe the right medicine to the right person with maximum efficacy and minimum toxicity, allowing clinicians to further predict the susceptibility to disease onset of vulnerable populations.The book is ideally suited for researchers and postgraduate students who are interested in clinical and non-clinical studies where metabolites are used for the identification of disease and therapeutic targets.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 112
    • Gregory S. Makowski
    • English
    Advances in Clinical Chemistry, Volume 112 highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Heterogeneity in Major Depressive Disorder: The need for Biomarker-based and Personalized Treatments, Advances in exosome analysis, Translational Proteomics and Phosphoproteomics: Tissue to Extracellular Vesicles, Immune Checkpoint Therapy, Tumor Immunology, and Biomarkers in Non-Small-Cell Lung Cancer, Advances in Congestive Heart Failure Biomarkers, Fluid biomarkers in Alzheimer’s disease, and more.

  • Scattering Methods in Structural Biology Part B

    • 1st Edition
    • Volume 678
    • English
    Scattering Methods in Structural Biology, Part B, Volume 676 in the Methods in Enzymology serial, highlights advances in the field, presenting chapters on Quality controls, Refining biomolecular structures and ensembles by SAXS-driven molecular dynamics simulations, Data analysis and modelling of small-angle scattering data with contrast variation, Observing protein degradation in solution by the PAN-20S proteasome complex: state-of-the-art and future perspectives of TR-SANS as a complementary tool to NMR, crystallography and Cryo-EM, Extracting structural insights from chemically-specific soft X-ray scattering, Reconstruction of 3D density of biological macromolecules from solution scattering, ATSAS- present state and new developments in computational methods, and much more. Additional chapters cover Modeling Structure and Dynamics of Protein Complexes with SAXS Profiles (FoXSDock and MultiFoXS), Validation of macromolecular flexibility in solution by SAXS, Combining NMR, SAXS and SANS to characterize the structure and dynamics of protein complexes, Application of Molecular Simulation Methods to Analyze SAS Data, and more.

  • Meiosis in Development and Disease

    • 1st Edition
    • Volume 151
    • English
    Meiosis in Development and Disease, Volume 151 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as The initiation stages of meiosis, The molecular basis and dynamics of meiotic cohesions, and their significance in human infertility, Chromatin, recombination, and the centromeres, Sites and structures that mediate segregation when crossing over calls out sick/Life (or at Least Meiosis) Without Crossing Over, Crossover maturation inefficiency, Non coding RNA mediated gene regulation in meiosis, Short chromosomes in meiotic recombination, Chromatin level changes during meiosis initiation vs. oncogenesis, and much more. Other sections of note include Chromosomal speciation revisited: Meiotic recombination and synapsis of evolutionary diverged homologs, Recombination suppression at specific chromosome regions, Unwinding during stressful times - mechanisms of helicases in meiotic recombination, Meiotic functions of PCH-2/TRIP13 and HORMADs, Crossover interference, Checkpoint control in meiotic prophase: Idiosyncratic demands require unique characteristics, The breadth of meiotic drive genes and mechanisms across the tree of life, and many more interesting topics.

  • Nanobiotechnology for the Livestock Industry

    Animal Health and Nutrition
    • 1st Edition
    • Ravindra Pratap Singh + 5 more
    • English
    Nanobiotechnology for the Livestock Industry: Animal Health and Nutrition delivers a multidisciplinary reference of nanobiotechnology applications in various sectors, including farming practices, healthcare and breeding practices, market and economic analysis/benefits, biosafety, regulation, and more. The book explores nanobiotechnology's role in livestock handling, including hygiene maintenance and feed/nutrient delivery. The book also examines nanobiotechnology's role in maintaining nutrient quality in food products, and covers healthcare practices utilizing nanobiotechnology, such as maintaining and monitoring livestock health, diagnosis and treatment of disease, monitoring drug delivery, optimizing breeding patterns, and cryopreservation of sperm and eggs.

  • Biomarkers of Hip Implant Function

    • 1st Edition
    • Ilona Swiatkowska
    • English
    Nearly all orthopaedic surgeons have implanted a cobalt-chromium hip, and most general practitioners have at least one patient with a cobalt-chromium prosthesis on their books. The recent worldwide controversy surrounding metal-on-metal bearings – and increasing concern over the use of metallic biomaterials in general – means that advice on how to manage patients with metal implants is of great interest to these professionals. Specifically, they want to know if there are any diagnostic tests that could be performed to gain clues about implant performance and the risk of local or systemic toxicity. Biomarkers of Hip Implant Function aims to bring together all established and promising new biomarkers and critically evaluate their clinical usefulness. Researchers will benefit from an updated, comprehensive view of the topic to identify underexplored areas. Orthopaedic surgeons and general practitioners will use the book to monitor implant performance and manage their patients. The work may also benefit engineers and joint implant manufacturers by guiding improvements in implant design, and be of interest to regulators and policymakers to inform guidelines on the follow-up of hip implant recipients.

  • Nanotechnology for Drug Delivery and Pharmaceuticals

    • 1st Edition
    • Ravindra Pratap Singh + 3 more
    • English
    Nanotechnology for Drug Delivery and Pharmaceutical Sciences presents various drug-delivery techniques that utilize nanotechnology for the biomedical domain, highlighting both therapeutic and diagnostic applications. The book provides important facts and detailed studies on different promising nanocarriers like liposomes, exosomes and virus-based nanocarriers. Moreover, it explores these nanocarriers' utilization in the therapeutic applications of various diseases such as cancer, inflammation, neurodegenerative disorders like Huntington’s disease, Alzheimer's disease, human immunodeficiency virus (HIV), and inflammatory bowel disease. In addition, the book describes how nanotechnology has efficiently overtaken conventional dosage forms and provided comfort and ease to patients. Relevant information regarding market trends, patents and social-economic factors are also provided, making this the perfect reference for doctors, researchers and scientists working in the fields of medicine, biochemistry, biotechnology, nanobiotechnology and the pharmaceutical sciences.

  • Advances in Agronomy

    • 1st Edition
    • Volume 177
    • Donald L. Sparks
    • English
    Advances in Agronomy, Volume 117, the latest release in this leading reference on agronomy, contains a variety of updates and highlights new advances in the field. Chapters in this new release include Farming Systems Research: Concepts, Design and Methodology, Soil Potassium Fertility and Management Strategies in South Asian Agriculture, Sensing for Characterizing and Monitoring Soil Functions – A Review, Isolation and Fractionation of Organic Matter from Soils and Waters, Tolerance Mechanism and Management Concepts of Iron Toxicity in Rice: A Critical Review, and Smart Sensing and Automated Irrigation for Sustainable Rice Systems: A State of the Art Review.

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