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    • Principles of Translational Science in Medicine

      • 3rd Edition
      • July 15, 2021
      • Martin Wehling
      • English
      • Hardback
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      Principles of Translational Science in Medicine: From Bench to Bedside, Third Edition, provides an update on major achievements in the translation of research into medically relevant results and therapeutics. The book presents a thorough discussion of biomarkers, early human trials, and networking models, and includes institutional and industrial support systems. It also covers algorithms that have influenced all major areas of biomedical research in recent years, resulting in an increasing number of new chemical/biological entities (NCEs or NBEs) as shown in FDA statistics. New chapters include: Translation in Oncology, Biologicals, and Orphan Drugs. The book is ideal for use as a guide for biomedical scientists to establish a systematic approach to translational medicine and is written by worldwide experts in their respective fields.

    • Clinical DNA Variant Interpretation

      • 1st Edition
      • February 27, 2021
      • Conxi Lázaro + 2 more
      • English
      • Paperback
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      • eBook
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      Clinical DNA Variant Interpretation: Theory and Practice, a new volume in the Translational and Applied Genomics series, covers foundational aspects, modes of analysis, technology, disease and disorder specific case studies, and clinical integration. This book provides a deep theoretical background, as well as applied case studies and methodology, enabling researchers, clinicians and healthcare providers to effectively classify DNA variants associated with disease and patient phenotypes. Practical chapters discuss genomic variant interpretation, terminology and nomenclature, international consensus guidelines, population allele frequency, functional evidence transcripts for RNA, proteins, and enzymes, somatic mutations, somatic profiling, and much more.

    • Toxicological Evaluation of Electronic Nicotine Delivery Products

      • 1st Edition
      • January 14, 2021
      • Manuel C. Peitsch + 1 more
      • English
      • Paperback
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      Toxicological Evaluation of Electronic Nicotine Delivery Products　(ENDP) discusses the scientific basis for the toxicological assessment and evaluation of ENDPs. The book covers aerosol chemistry, in vitro and in vivo studies as well as clinical studies. It provides the basis for the evaluation of short and long term-effects, along with relative risks. It also examines the potential role of ENDPs in tobacco harm reduction and how they may reduce the risk of disease in smokers who switch to them.　This book is a comprehensive resource for toxicologists, health practitioners and public health professionals who want the scientific information necessary to assess the relative risk of ENDPs when compared with cigarette smoking and cessation.

    • Engineering Technologies and Clinical Translation

      • 1st Edition
      • August 25, 2021
      • Mansoor M. Amiji + 1 more
      • English
      • Paperback
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      Engineering Technologies and Clinical Translation: Volume 3: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy examines the challenges of delivering immuno-oncology therapies, focusing specifically on the development of solutions for drug delivery and its clinical outcomes. Immuno-oncology (IO) is a growing field of medicine at the interface of immunology and cancer biology leading to development of novel therapeutic approaches, such as chimeric antigen receptor T-cell (CAR-T) and immune checkpoint blockade antibodies, that are clinically approved approaches for cancer therapy. Although currently approved IO approaches have shown tremendous promise for select types of cancers, broad application of IO strategies could even further improve the clinical success, especially for diseases such as pancreatic cancer, brain tumors where the success of IO so far has been limited. This volume of Delivery Strategies and Engineering Technologies in Cancer Immunotherapy　discus... biomaterial, microfluidic, and biodegradable devices, engineered microbes, personalized medicine, clinical approval process, and many other IO technologies. Engineering Technologies and Clinical Translation: Volume 3: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy creates a comprehensive treaty that engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side.

    • Nitrogen Assessment

      • 1st Edition
      • November 23, 2021
      • Tariq Aziz + 5 more
      • English
      • Paperback
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      Nitrogen Assessment: Pakistan as a Case-Study provides a detailed overview of issues and challenges related to nitrogen use and overuse, thus serving as a reference for researchers in Pakistan and providing important insights for other geographic regions. Excess and inefficient nitrogen use in crops and livestock sectors is polluting our rivers, seas, atmosphere, and ecosystems, contributing to climate change, hampering biodiversity, and contributing to stratospheric ozone depletion. This book covers the importance of nitrogen in relation to food security, human health, and economic stability in South Asia. It also discusses nitrogen status, sources, sinks, and drivers of nitrogen use in Pakistan, focusing on current nitrogen measures and policies.Nitrogen pollution is one of the biggest challenges of 21st Century, and the international scientific community is beginning to recognize the significance of nitrogen pollution and to explore how to combat it. The editors’ institution, University of Agriculture, Faisalabad, partners with South Asia Nitrogen Hub, which includes about 30 organizations from South Asia and UK working on nitrogen assessment, budgeting, awareness, and policy guidance, as well as possible measures to reduce nitrogen pollution.Nitrogen Assessment: Pakistan as a Case-Study provides an important guide to this work and is written in a way that is accessible to an audience with a wide range of experience from advanced students to seasoned researchers.

    • Zika Virus Biology, Transmission, and Pathways

      • 1st Edition
      • June 25, 2021
      • Colin R. Martin + 3 more
      • English
      • Hardback
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      Zika Virus Biology, Transmission, and Pathways: The Neuroscience of Zika, Volume One provides a detailed introduction to the molecular biology of the Zika virus and its features, transmission, and impact on neurological systems. Designed to better readers’ understanding of the Zika virus, this volume features chapters on the immune response, molecular mechanisms, and other areas to better understand underlying pathways. This book has applicability for neuroscientists, neurologists, virologists and anyone working to better understand the evolution and pathogenesis of Zika virus-related conditions.

    • Lahita's Systemic Lupus Erythematosus

      • 6th Edition
      • July 23, 2021
      • Robert G. Lahita
      • English
      • Hardback
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      Systemic lupus erythematosus (SLE), commonly called lupus, is a chronic autoimmune disorder that can affect virtually any organ of the body. In lupus, the body's immune system, which normally functions to protect against foreign invaders, becomes hyperactive, forming antibodies that attack normal tissues and organs, including the skin, joints, kidneys, brain, heart, lungs, and blood. Lupus is characterized by periods of illness, called flares, and periods of wellness or remission. Because its symptoms come and go and mimic those of other diseases, lupus is difficult to diagnose. There is no single laboratory test that can definitively prove that a person has the complex illness.To date, lupus has no known cause or cure. Early detection and treatment are the key to a better health outcome and can usually lessen the progression and severity of the disease. Anti-inflammatory drugs, antimalarials, and steroids (such as cortisone and others) are often used to treat lupus. Cytotoxic chemotherapies, like those used in the treatment of cancer, are also used to suppress the immune system in lupus patients. A new edition of this established and well-regarded reference combines basic science with clinical science to provide a translational medicine model. Systemic Lupus Erythematosus, Sixth Edition, is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease, and a reference work for hospital libraries.

    • Translational Bioinformatics in Healthcare and Medicine

      • 1st Edition
      • May 13, 2021
      • English
      • Paperback
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      Translational Bioinformatics in Healthcare and Medicine offers an overview of main principles of bioinformatics, biological databases, clinical informatics, health informatics, viroinformatics and real-case applications of translational bioinformatics in healthcare. Written by experts from both technology and clinical sides, the content brings together essential knowledge to make the best of recent advancements of the field. The book discusses topics such as next generation sequence analysis, genomics in clinical care, IoT applications, blockchain technology, patient centered interoperability of EHR, health data mining, and translational bioinformatics methods for drug discovery and drug repurposing. In addition, it discusses the role of bioinformatics in cancer research and viroinformatics approaches to counter viral diseases through informatics. This is a valuable resource for bioinformaticians, clinicians, healthcare professionals, graduate students and several members of biomedical field who are interested in learning more about how bioinformatics can impact in their research and practice.

    • Laboratory Fish in Biomedical Research

      • 1st Edition
      • August 28, 2021
      • Livia D'Angelo + 1 more
      • English
      • Paperback
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      • eBook
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      Fish, and particularly zebrafish, have become the fastest-growing segment of the research population. They offer several advantages, in terms of biology and technologies to apply, and thus are employed in numerous research fields. Laboratory Fish in Biomedical Research: Biology, Husbandry and Research Applications for Zebrafish, Medaka, Killifish, Swordtail Fish, Cavefish, Stickleback, Goldfish and Danionella Translucida addresses the relevant and increasing need to collect cutting-edge knowledge on husbandry, maintenance, welfare and experimental protocols of the most common freshwater species under standard laboratory conditions.

    • Epigenetics in Psychiatry

      • 2nd Edition
      • August 21, 2021
      • Jacob Peedicayil + 2 more
      • English
      • Paperback
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      Epigenetics in Psychiatry, Second Edition covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this growing area of psychiatry. This new edition has been fully revised to address recent advances in epigenetic understanding of psychiatric disorders, evoking data consortia (e.g., CommonMind, ATAC-seq), single cell analysis, and epigenome-wide association studies to empower new research. The book also examines epigenetic effects of the microbiome on psychiatric disorders, and the use of neuroimaging in studying the role of epigenetic mechanisms of gene expression. Ongoing advances in epigenetic therapy are explored in-depth.

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