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    • Emerging Model Systems in Developmental Biology

      • 1st Edition
      • Volume 147
      • March 23, 2022
      • English
      • Hardback
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      • eBook
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      An ever-growing roster of model organisms is a hallmark of 21st century Developmental Biology. Emerging model organisms are well suited to asking some fascinating and important questions that cannot be addressed using established model systems. And new methods are increasingly facilitating the adoption of new research organisms in laboratories. This volume is written by some of the scientists who have played pivotal roles in developing new models or in significantly advancing tools in emerging systems.

    • Advances in Clinical Chemistry

      • 1st Edition
      • Volume 108
      • June 2, 2022
      • Gregory S. Makowski
      • English
      • Hardback
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      • eBook
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      Advances in Clinical Chemistry, Volume 108, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry, with this new release focusing on Nephrinuria and podocytopathies, Extracellular vesicles in respiratory disease, Diabetes and cognitive decline, Testosterone analysis in prostate cancer, Mono/polyclonal free light chains as challenging biomarkers for immunological abnormalities, and more.

    • Recapitulating the Stem Cell Niche ex Vivo

      • 1st Edition
      • July 1, 2022
      • Susie Nilsson
      • English
      • Paperback
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      • eBook
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      Recapitulating The Stem Cell Niche Ex Vivo, Volume Six in the Advances in Stem Cells and their Niches series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Recapitulating the bone marrow stem cell niche ex vivo, The generation of the liver ex vivo, Recapitulating the thymic stem cell niche ex vivo, Recapitulating the intestinal epithelium stem cell niche ex vivo, Recapitulating the lung stem cell niche in vitro, Recapitulating mammary tissue in vitro, and Recapitulating muscle in vitro.

    • New Targets for the Treatment of Hypertension and Associated Diseases

      • 1st Edition
      • Volume 94
      • June 2, 2022
      • English
      • Hardback
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      • eBook
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      New Targets for the Treatment of Hypertension and Associated Diseases, Volume 94 in the Advances in Pharmacology serial, highlights new advances in the field, with this new volume presenting interesting chapters on Cytochrome P450, 20-hydroxyeicosatetr... acid and GPR75 pathway in hypertension, Treatment of hypertension with soluble epoxide hydrolase inhibitors, Effects of allosteric modifiers of adenosine receptors in the heart, Orally active epoxyeicosatrienoic acid analogs in hypertension and renal injury, Drugs affecting the nitric oxide- cyclic GMP pathway in hypertension, Relaxin-2 and Serelaxin in renal and cardiac dysfunction in hypertension, and more.

    • Recent Advances and Controversies in Gamma Knife Neurosurgery

      • 1st Edition
      • Volume 268
      • January 20, 2022
      • English
      • Hardback
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      • eBook
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      Recent Advances and Controversies in Gamma Knife Neurosurgery, Volume 268, the latest release in the Progress in Brain Research series, highlights new advances in the field with this new volume presenting interesting chapters on the latest in Dosimetry, Radiobiology, Evolving Gamma Knife Technology, Imaging, Arteriovenous Malformations, Dural A-V Fistulae, Cavernous Malformations, Vestibular Schwannoma, Other Schwannoma, Meningiomas, Pituitary Adenomas, Craniopharyngiomas, Metastases, Glioma Low Grade, Glioma High Grade, Glomus Tumors, Less Common Tumors, Orbital Indications, Trigeminal Neuralgia, Epilepsy, Movement, Psychosurgery, and Future Trends.

    • Chemical Microbiology Part B

      • 1st Edition
      • Volume 665
      • April 2, 2022
      • English
      • Hardback
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      • eBook
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      Chemical Microbiology, Part B, Volume 665, the latest release in the Methods of Enzymology series, highlights new advances in the field, including comprehensive chapters on the Application of Antibiotic-derived Fluorescent Probes to Bacterial Studies, Metabolomic approaches for enzyme function and pathway discovery in bacteria, Adding a diazo-transfer reagent to culture to generate secondary metabolite probes for click chemistry, Customized Peptidoglycan Surfaces to Investigate Innate Immune Recognition via Surface Plasmon Resonance, Development and application of highly sensitive labeling reagents for amino acids, Bacterial Cell Wall Modification with a Glycolipid Substrate, and much more.

    • Conservation Physiology for the Anthropocene - A Systems Approach

      • 1st Edition
      • Volume 39A
      • October 17, 2022
      • English
      • Hardback
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      • eBook
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      Conservation Physiology for the Anthropocene: A Systems Approach, Volume 39A in the Fish Physiology series, is a comprehensive synthesis on the physiology of fish in the Anthropocene. This volume closes the knowledge gap by considering the many ways in which different physiological systems (e.g., sensory physiology, endocrine, cardio-respiratory, bioenergetics, water and ionic balance and homeostasis, locomotion/biomechan... gene function) and physiological diversity are relevant to management and conservation. As the world is changing, with a dire need to identify solutions to the many environmental problems facing wild fish populations, this book comprehensively covers conservation physiology and its future techniques. Conservation physiology reveals the many ways in which environmental change and human activities can negatively influence wild fish populations. These tactics inform new management and conservation activities and help create the necessary conditions for fish to thrive.

    • Hepatobiliary Cancers: Translational Advances and Molecular Medicine

      • 1st Edition
      • Volume 156
      • August 10, 2022
      • English
      • Hardback
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      Hepatobiliary cancer refers to primary malignant tumors originating in cells of the liver, bile ducts, and gallbladder. Globally, primary liver cancer, which includes hepatocellular carcinoma (~75 % of all cases) and intrahepatic biliary cancer or cholangiocarcinoma (~10-15 % 0f all cases) is the 6th most commonly diagnosed cancer and 3rd leading cause of cancer deaths worldwide. The vast majority of these highly malignant cancers are diagnosed at an advanced stage where treatment options are limited and patient survival outcomes are poor. The biological and therapeutic challenges posed by hepatobililiary cancers such as hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) are daunting, emphasizing a critical need to review and assess current and evolving basic, translational, and clinical research focused on addressing the critical obstacles that continue to limit progress towards achieving significant improvements in HCC and CCA clinical management and patient survival outcomes. Towards this goal, this special edition of Advances in Cancer Research is focused on providing a comprehensive, timely and authoritative reviews covering such topics of significant scientific and clinical relevance, including hepatobiliary cancer risk mechanisms and risk-predictive molecular biomarkers; causes and functional intricacies of inter- and intratumor heterogeneity; novel insights into the role of tumor microenvironment and key signaling pathways in promoting hepatobiliary cancer progression, therapeutic resistance and immunosuppression; emerging biomarkers of HCC and CCA prognosis; advances in molecular genomics for personalizing tumor classification and targeted therapies; innovative preclinical cell culture modeling for hepatobiliary cancer drug discovery; and current and emerging trends in hepatobiliary cancer molecular therapeutic targeting and immunotherapies.

    • Advances in Genetics

      • 1st Edition
      • Volume 110
      • October 13, 2022
      • English
      • Hardback
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      • eBook
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      Advances in Genetics serial, Volume 110 highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, all written by an international board of authors.

    • Pharmacology and Toxicology of Cytochrome P450 - 60th Anniversary

      • 1st Edition
      • Volume 95
      • August 9, 2022
      • English
      • Hardback
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      • eBook
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      Pharmacology and Toxicology of Cytochrome P450 - 60th Anniversary, Volume 95 highlights the extensive contributions by worldwide researchers in the cytochrome P450 (P450) field over the past six decades, and since the first article on P450 was published in 1962. Chapters in this new release include Multiple conformations of cytochromes P450 and the relevance to predicting SAR, Pharmacogenetics of the cytochromes P450 and relevance to drug metabolism, Cytochromes P450 drug metabolism within the brain, Mammalian cytochrome P450 biodiversity: Physiological importance, function, and protein and genomic structures of cytochromes P4502B in multiple species of woodrats with different dietary preferences, and more. Additional section cover Atypical kinetics of cytochrome P450 enzymes in drug metabolism, Biosynthesis using cytochrome P450 Enzymes: focus on synthesis of drug metabolites, Use of engineered cytochrome P450s for accelerating drug discovery and development, Assessing cytochrome P450 function using genetically engineered mouse models, Use of the biologicals with sustainable reproducibility for phenotyping study of cytochrome P450 enzymes involved in the biotransformation of test compounds and calculating the fraction unbound parameter, for anticipating drug Interactions, and much more. Research on many forms of P450s has been extended into different fields, from molecules to in vivo situations because pharmacologists and toxicologists appreciate and are attracted to the potential therapeutics. The purpose of this volume is to collect a comprehensive description of major progress to date, to discuss possible future directions, and to invite young researchers to join this important and exciting world of P450.

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Agricultural and biological sciences

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Neuroscience

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