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Elsevier

Books in Life sciences

  • Cellular and Molecular Immunology

    • 8th Edition
    • Abul K. Abbas + 2 more
    • English
    Popular for its highly visual, straightforward approach, Cellular and Molecular Immunology delivers an accessible yet thorough understanding of this active and fast-changing field. Drs. Abul K. Abbas, Andrew H. Lichtman, and Shiv Pillai present key updates in this new edition to cover the latest developments in antigen receptors and signal transduction in immune cells, mucosal and skin immunity, cytokines, leukocyte-endothelia... interaction, and more. With additional online features, this is an ideal resource for medical, graduate and undergraduate students of immunology who need a clear, introductory text for immunology courses.

  • Biased Signaling in Physiology, Pharmacology and Therapeutics

    • 1st Edition
    • Brian J Arey
    • English
    Biased Signaling in Physiology, Pharmacology and Therapeutics is a unique and essential reference for the scientific community concerning how conformational-depen... activation is a common phenomenon across many classes of receptors or signaling molecules. It discusses the role of conformational dynamics in leading to signaling bias across different classes of receptors and signaling molecules. By providing a broader view of signaling bias, this resource helps to explain common mechanisms shared across receptor classes and how this can be utilized to elucidate their cellular activity and better understand their therapeutic potential. Written for both new and established scientists in pharmacology, cell biology, biochemistry, and signal transduction, as well as physicians, this book clearly illustrates how biased receptor signaling can be utilized to develop and understand complex pharmacology. Chapters are each focused on a specific class of receptor or other important topic and make use of real-world examples illustrating how the latest research in signal transduction has led to a better understanding of pharmacology and cell biology. This structure creates a basis for understanding that physiological signalling bias has been selected by nature in order to provide complex and tissue- specific biological responses in the face of limited receptors and signaling pathways. This book provides a framework to reveal that these physiological mechanisms are not restricted to one receptor type or family and thus presents receptor signaling from a newer, more global perspective.

  • The Role of Chromosomes in Development

    • 1st Edition
    • Michael Locke
    • English
    The Role of Chromosomes in Development is a collection of papers that deals with structural patterns and functional organization of chromosomes. Some papers discuss chromosomal proteins, DNA replication sequences in higher animals, and the implications of localized DNA synthesis in polytene chromosomes. Several papers describe chromosomal RNA, nuclear RNA fractions, genetic control, and the regulation of developmental pathways. One paper concerns the "bithorax" series that controls the development of certain body segments of the fly in a polarized and coordinated manner reminiscent of the genes in the operons of microorganisms. The bithorax genes evidently exploit and amplify a gradient arising from an anteroposterior gradient during mitotic division rates. The bithorax genes produces a whole set of new substances that repress certain systems of cellular differentiation, letting other systems to emerge and develop. Another paper investigates the hypothesis of diploid subnuclei as the architectural subunit of the ciliate macronucleus, as well as the hypothesis of "allelic repression" as the basis for certain examples of subnuclear differentiation. The collection can prove beneficial for biochemists, micro-biologists, bio-physicists, cellular researchers, and academicians involved in the study of cellular biology.

  • A Text-Book of Bacteriology

    • 9th Edition
    • R. W. Fairbrother + 1 more
    • English
    Fairbrother's Textbook of Bacteriology, Tenth Edition provides an outline of the medical aspects of bacteriology. This book emphasizes the biological relationship of allied organisms. This edition begins with an overview of the various elements of the bacterial cell in detail, starting with external features such as flagella and capsules, and working inwards to the cytoplasm. This text then describes the principal toxic effects of the different groups of anti-bacterial substances. Other chapters consider the relationship of the different types of hypersensitivity to classical immune responses. This book discusses as well the earliest application of a specific chemical substance to the treatment of microbial disease. This book is a valuable resource for medical students. Bacteriologists, chemists, pathologists, and microbiologists will also find this book useful.

  • Celiac Disease and Gluten

    Multidisciplinary Challenges and Opportunities
    • 1st Edition
    • Peter Koehler + 2 more
    • English
    Celiac Disease and Gluten: Multidisciplinary Challenges and Opportunities is a unique reference work—the first to integrate the insights of the causes and effects of celiac disease from the chemistry of reaction-causing foods to the diagnosis, pathogenesis, and symptoms that lead to proper diagnoses and treatment. With an estimated three million people in the United States alone affected by celiac disease, an autoimmune digestive disease, only five percent are properly diagnosed. Drawing on the connection between foods containing gluten and the resulting symptoms, this resource offers distinctive information that directly explores and links food science, medical diagnostics, and treatment information. A helpful tool for researchers and medical practitioners alike, Celiac Disease and Gluten: Multidisciplinary Challenges and Opportunities helps refine research targets, and provides a comprehensive overview on the multidisciplinary approaches to all crucial aspects related to celiac disease.

  • The Composition, Structure and Reactivity of Proteins

    A Laboratory Manual of Analytical Methods of Protein Chemistry (Including Polypeptides)
    • 1st Edition
    • P. Alexander + 1 more
    • English

  • Enzymes

    • 2nd Edition
    • Malcolm Dixon + 1 more
    • English
    Enzymes, Second Edition provides information pertinent to the developments in the field of enzymology. This book presents the properties of enzymes as chemical catalysts or simply as chemical substances. Organized into 13 chapters, this edition begins with an overview of the range of action or specificity of enzymes. This text then discusses the special techniques employed in the isolation of enzymes and explores the considerable progress in the study of the properties and functions of enzymes. Other chapters consider the mechanism of enzyme catalysis by more direct methods, including the use of isotopes. This book discusses as well the mechanism of the biosynthesis of enzymes and the means by which their chemical structure is determined by the genetic material of the chromosomes. The final chapter deals with the essential aspects of the enzymatic system linking energy-producing processes with energy-utilizing processes. This book is a valuable resource for biochemists, physical chemists, and research workers.

  • Lipid Analysis

    Isolation, Separation, Identification and Structural Analysis of Lipids
    • 1st Edition
    • William W. Christie
    • English
    Lipid Analysis: Isolation, Separation, Identification, and Structural Analysis of Lipids focuses on the methods, principles, and approaches involved in the isolation, identification, separation, and structural analysis of lipids. The publication first elaborates on the structure, chemistry and occurrence of lipids, isolation of lipids from tissues, and chromatographic and spectroscopic analysis of lipids. Discussions focus on equipping a laboratory for lipid analysis, spectroscopy, chromatographic procedures, general principles of solvent extraction procedures, structural features of lipids important in analyses, simple and complex lipids, and fatty acids. The text then examines the preparation of volatile derivatives of lipids and analysis of fatty acids and simple lipid classes. Topics include alkyl diglycerides and neutral plasmalogens, analysis of the hydrolysis products of simple lipids, preparation of large quantities of pure fatty acids, physical characterization of fatty acids, location of double bonds in fatty acid chains, and saponification of lipids. The manuscript covers the analysis and radioassay of isotopically-labelle... lipids, enzymatic hydrolysis of lipids, and analysis of molecular species of lipids. The publication is a primary reference for researchers interested in lipid analysis.

  • Biomechanics and Related Bio-Engineering Topics

    Proceedings of a Symposium Held in Glasgow, September 1964
    • 1st Edition
    • R. M. Kenedi
    • English

  • Lymphokines

    A Forum for Immunoregulatory Cell Products
    • 1st Edition
    • Edgar Pick
    • English
    Lymphokines: A Forum for Immunoregulatory Cell Products deals with immunoregulatory cell products that produce lymphokines. Topics covered include the purification and characterization of transfer factor; activation of cytotoxicity and/or suppressor activity in murine macrophages by lymphokines, lipopolysaccharide, and polyinosinic-polycyt... acid; and the role of clotting processes in the action of lymphokines on macrophages. A comparison of the immune-modulating effects of interferon and interferon inducers is also presented. Comprised of 13 chapters, this volume begins with a discussion on transfer factor and its ability to react specifically with antigens. The clinical uses of transfer factor are considered with special emphasis on its value as a prophylactic agent. The reader is then introduced to the subject of T cell regulation of the immunoglobulin E (IgE) response via potentiating and suppressor lymphokines, together with the possible clinical application of IgE suppressive factors in the treatment of atopic diseases. Subsequent chapters examine the evidence in favor of the existence of T cell-derived polyclonal B cell activator (PBA) playing a role in both normal antibody responses and autoimmune diseases; the role of suppressor T cells and the associated lymphokines in contact sensitivity in mice; and lymphokine action on macrophages. The book also analyzes the genetics of the response of human and mouse cells to interferons. This monograph will be helpful to practitioners and researchers in the fields of microbiology and immunology.

  • Tissue Engineering Using Ceramics and Polymers

    • 2nd Edition
    • Aldo R. Boccaccini + 1 more
    • English
    The second edition of Tissue Engineering Using Ceramics and Polymers comprehensively reviews the latest advances in this area rapidly evolving area of biomaterials science. Part one considers the biomaterials used for tissue engineering. It introduces the properties and processing of bioactive ceramics and glasses, as well as polymeric biomaterials, particularly biodegradable polymer phase nanocomposites. Part two reviews the advances in techniques for processing, characterization, and modeling of materials. The topics covered range from nanoscale design in biomineralization strategies for bone tissue engineering to microscopy techniques for characterizing cells to materials for perfusion bioreactors. Further, carrier systems and biosensors in biomedical applications are considered. Finally, part three looks at the specific types of tissue and organ regeneration, with chapters concerning kidney, bladder, peripheral nerve, small intestine, skeletal muscle, cartilage, liver, and myocardial tissue engineering. Important developments in collagen-based tubular constructs, bioceramic nanoparticles, and multifunctional scaffolds for tissue engineering and drug delivery are also explained. Tissue Engineering Using Ceramics and Polymers is a valuable reference tool for both academic researchers and scientists involved in biomaterials or tissue engineering, including the areas of bone and soft-tissue reconstruction and repair, and organ regeneration.

  • Biomaterials for Bone Regeneration

    Novel Techniques and Applications
    • 1st Edition
    • P. Dubruel + 1 more
    • English
    Novel Biomaterials for Bone Regeneration provides a comprehensive review of currently available biomaterials and how they can be applied in bone regeneration. In recent decades, there has been a shift from the idea of using biomaterials as passive substitutes for damaged bones towards the concept of biomaterials as aids for the regeneration of a host's own bone tissue. This has generated an important field of research and a range of technological developments. Part one of this book discusses a wide range of materials, including calcium phosphate cements, hydrogels, biopolymers, synthetic polymers, and shape memory polymers. Part two then turns to the processing and surface modification of biomaterials, as well as how biomaterials can be evaluated both for their mechanical properties and for immunocompatibility with the host. Finally, part three covers a variety of cellular approaches, and production and delivery of biomaterials for bone regeneration. Chapters also consider the potential of electromagnetic and ultrasonic stimulation of biomaterials to aid in the regenerative process. Novel Biomaterials for Bone Regeneration represents an important resource for academics, clinicians, and industry professionals working in the area of biomedical materials, providing them with both an overview of the current state-of-the-art, and an indication of potential future developments.

  • Mouse Models of the Nuclear Envelopathies and Related Diseases

    • 1st Edition
    • Volume 109
    • English
    Volume 109 of Current Topics in Developmental Biology covers mouse models of the nuclear envelopathies and related diseases, with contributions from an international board of authors. The chapters provide a comprehensive set of reviews covering such topics as mouse models neurodegenerative diseases including Parkinson’s and dystonia, muscle ageing and sarcopenia, cardiac failure and repair, ageing and prospects lifespan extension, lipodystrophy and the significance in fat regulation, also identifying developmental mutations in mammals and nuclear envelope and LINC complex in disease.

  • Joint Replacement Technology

    • 2nd Edition
    • Peter A. Revell
    • English
    This second edition of Joint Replacement Technology provides a thoroughly updated review of recent developments in joint replacement technology. Joint replacement is a standard treatment for joint degradation and has improved the quality of life of millions of patients. Collaboration between clinicians and researchers is critical to its continued success and to meet the rising expectations of patients and surgeons. Part one introduces the advances in joint replacement technology, tribological considerations and experiments, and immune and regenerative responses to joint replacements. Part two covers the materials and techniques used in joint replacement. The advantages and disadvantages of different metals are explained here, as well as the use of ceramics. This section also addresses challenges in joint bearing surfaces, design, and cementless fixation techniques. Biological and mechanical issues are considered in part three, including healing responses to implants and biological causes of prosthetic joint failure, and a new chapter on imaging of joint prostheses. Each chapter in part four describes the clinical challenges of replacing specific joints, with specific focus on hip, knee, intervertebral disc joint, shoulder arthroplasty, elbow arthroplasty, and pyrocarbon small joint arthroplasty. Thanks to its widespread collaboration and international contributors, Joint Replacement Technology is useful for materials scientists and engineers in both academia and biomedical industry. Chemists, clinicians, and other researchers in this area will also find it invaluable.

  • The Stimulated Brain

    Cognitive Enhancement Using Non-Invasive Brain Stimulation
    • 1st Edition
    • Roi Cohen Kadosh
    • English
    The Stimulated Brain—which garnered an Honorable Mention for Biomedicine & Neuroscience at the 2015 PROSE Awards from the Association of American Publishers—presents the first integration of findings on brain stimulation from different research fields with a primary focus on Transcranial Electrical Stimulation (tES), one of the most frequently used noninvasive stimulation methods. The last decade has witnessed a significant increase in the amount of research exploring how noninvasive brain stimulation can not only modulate but also enhance cognition and brain functions. However, although Transcranial Magnetic Stimulation (TMS) and particularly tES have the potential to become more widely applicable techniques (as they come with none of the risks associated with deep brain stimulation) the reference literature on these neurotechnologies has been sparse. This resource provides a broad survey of current knowledge, and also marks future directions in cognitive and neuro-enhancement. It expands our understanding of basic research findings from animals and humans, including clear translational benefits for applied research and the therapeutic use of noninvasive brain stimulation methods. The book's coverage includes a primer that paves the way to a more advanced knowledge of tES and its physiological basis; current research findings on cognitive and neuro-enhancement in animals and typical and atypical human populations, such as neurological patients; and discussions of future directions, including specific neuroethical issues and pathways for collaboration and entrepreneurialism. The Stimulated Brain is the first book to provide a comprehensive understanding of different aspects of noninvasive brain stimulation that are critical for scientists, clinicians, and those who are interested in “stimulating their minds” by exploring this fascinating field of research.

  • Wine Science

    Principles and Applications
    • 4th Edition
    • Ronald S. Jackson
    • English
    Wine Science, Fourth Edition, covers the three pillars of wine science: grape culture, wine production, and sensory evaluation. It discusses grape anatomy, physiology and evolution, wine geography, wine and health, and the scientific basis of food and wine combinations. It also covers topics not found in other enology or viticulture texts, including details on cork and oak, specialized wine making procedures, and historical origins of procedures. New to this edition are expanded coverage on micro-oxidation and the cool prefermentative maceration of red grapes; the nature of the weak fixation of aromatic compounds in wine – and the significance of their release upon bottle opening; new insights into flavor modification post bottle; the shelf-life of wine as part of wine aging; and winery wastewater management. Updated topics include precision viticulture, including GPS potentialities, organic matter in soil, grapevine pests and disease, and the history of wine production technology. This book is a valuable resource for grape growers, fermentation technologists; students of enology and viticulture, enologists, and viticulturalists.

  • Toxicological Survey of African Medicinal Plants

    • 1st Edition
    • Victor Kuete
    • English
    Toxicological Survey of African Medicinal Plants provides a detailed overview of toxicological studies relating to traditionally used medicinal plants in Africa, with special emphasis on the methodologies and tools used for data collection and interpretation. The book considers the physical parameters of these plants and their effect upon various areas of the body and human health, including chapters dedicated to genotoxicity, hepatotoxicity, nephrotoxicity, cardiotoxicity, neurotoxicity, and specific organs and systems.Following this discussion of the effects of medicinal plants is a critical review of the guidelines and methods in use for toxicological research as well as the state of toxicology studies in Africa. With up-to-date research provided by a team of experts, Toxicological Survey of African Medicinal Plants is an invaluable resource for researchers and students involved in pharmacology, toxicology, phytochemistry, medicine, pharmacognosy, and pharmaceutical biology.

  • Advances in Cancer Research

    • 1st Edition
    • Volume 121
    • Kenneth D. Tew + 1 more
    • English
    Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics.

  • Processing and Impact on Active Components in Food

    • 1st Edition
    • Victor R. Preedy
    • English
    From beef to baked goods, fish to flour, antioxidants are added to preserve the shelf life of foods and ensure consumer acceptability. These production-added components may also contribute to the overall availability of essential nutrients for intake as well as the prevention of the development of unwelcome product characteristics such as off-flavours or colours. However, there are processes that reduce the amount of naturally occurring antioxidants and awareness of that potential is just as important for those in product research and development. There is a practical need to understand not only the physiological importance of antioxidants in terms of consumer health benefit, but how they may be damaged or enhanced through the processing and packaging phases. This book presents information key to understanding how antioxidants change during production of a wide variety of food products, with a focus toward how this understanding may be translated effectively to other foods as well.

  • Rodents

    A Compilation from the GenBank® and EMBL data libraries
    • 1st Edition
    • Edwin J. Atencio + 2 more
    • English

  • Advances in Cephalopod Science: Biology, Ecology, Cultivation and Fisheries

    • 1st Edition
    • Volume 67
    • English
    Advances in Cephalopod Science: Biology, Ecology, Cultivation and Fisheries—volume 67 in the Advances in Marine Biology series—addresses major themes of growing research interest in the field of cephalopod research. The book is composed of four chapters incorporating the latest advances in biology, ecology, life cycles, cultivation, and fisheries of cephalopods. Each chapter is written by a team of internationally recognized authorities to reflect recent findings and understanding. The book represents a breakthrough contribution to the field of cephalopod science. Advances in Marine Biology was first published in 1963 under the founding editorship of Sir Frederick S. Russell, FRS. Now edited by Michael P. Lesser, with an internationally renowned editorial board, the serial publishes in-depth and up-to-date reviews on a wide range of topics that appeal to postgraduates and researchers in marine biology, fisheries science, ecology, zoology, and biological oceanography. Eclectic volumes in the series are supplemented by thematic volumes on such topics as the biology of calanoid copepods.

  • Rare Diseases and Orphan Drugs

    Keys to Understanding and Treating the Common Diseases
    • 1st Edition
    • Jules J. Berman
    • English
    Rare Diseases and Orphan Drugs shows that much of what we now know about common diseases has been achieved by studying rare diseases. It proposes that future advances in the prevention, diagnosis, and treatment of common diseases will come as a consequence of our accelerating progress in the field of rare diseases. Understanding the complex steps in the development of common diseases, such as cancer, cardiovascular disease, and metabolic diseases, has proven a difficult problem. Rare diseases, however, are often caused by aberrations of a single gene. In rare diseases, we may study how specific genetic defects can trigger a series of events that lead to the expression of a particular disease. Often, the disease process manifested in a certain rare disease is strikingly similar to the disease process observed in a common disease. This work ties the lessons learned about rare diseases to our understanding of common ones. Chapters covering the number of common diseases are minimized, while rare diseases are introduced as single diseases or as members of diseases classes. After reading this book, readers will appreciate how further research into the rare diseases may lead to new methods for preventing, diagnosing, and treating all diseases, rare or common.

  • Conceptual Background and Bioenergetic/Mitochondrial Aspects of Oncometabolism

    • 1st Edition
    • Volume 542
    • English
    Volume 542 of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This new volume covers research methods providing a theoretical overview on metabolic alterations of cancer cells and a series of protocols that can be employed to study oncometabolism, in vitro, ex vivo and in vivo. Malignant cells exhibit metabolic changes when compared to their normal counterparts, owing to both genetic and epigenetic alterations. Although such a metabolic rewiring has recently been indicated as "yet another" general hallmark of cancer, accumulating evidence suggests that the metabolic alterations of each neoplasm rather represent a molecular signature that intimately accompanies, and hence cannot be severed from, all facets of malignant transformation.

  • Advances in Genetics

    • 1st Edition
    • Volume 85
    • English
    The field of genetics is rapidly evolving, and new medical breakthroughs are occurring as a result of advances in our knowledge of genetics. Advances in Genetics continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines. Volume 85 presents an eclectic mix of articles of use to all human and molecular geneticists on topics including: association mapping in crop plants; miRNA-mediated crosstalk between transcripts; unisexual reproduction; and more.

  • From Molecules to Networks

    An Introduction to Cellular and Molecular Neuroscience
    • 3rd Edition
    • John H. Byrne + 2 more
    • English
    An understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. The third edition of From Molecules to Networks provides the solid foundation of the morphological, biochemical, and biophysical properties of nerve cells. In keeping with previous editions, the unique content focus on cellular and molecular neurobiology and related computational neuroscience is maintained and enhanced. All chapters have been thoroughly revised for this third edition to reflect the significant advances of the past five years. The new edition expands on the network aspects of cellular neurobiology by adding new coverage of specific research methods (e.g., patch-clamp electrophysiology, including applications for ion channel function and transmitter release; ligand binding; structural methods such as x-ray crystallography). Written and edited by leading experts in the field, the third edition completely and comprehensively updates all chapters of this unique textbook and insures that all references to primary research represent the latest results.

  • Development of Auditory and Vestibular Systems

    • 1st Edition
    • Raymond Romand + 1 more
    • English
    Development of Auditory and Vestibular Systems fourth edition presents a global and synthetic view of the main aspects of the development of the stato-acoustic system. Unique to this volume is the joint discussion of two sensory systems that, although close at the embryological stage, present divergences during development and later reveal conspicuous functional differences at the adult stage. This work covers the development of auditory receptors up to the central auditory system from several animal models, including humans. Coverage of the vestibular system, spanning amphibians to effects of altered gravity during development in different species, offers examples of the diversity and complexity of life at all levels, from genes through anatomical form and function to, ultimately, behavior. The new edition of Development of Auditory and Vestibular Systems will continue to be an indispensable resource for beginning scientists in this area and experienced researchers alike.

  • Current Advances in Immunology

    • 1st Edition
    • H. Smith
    • English
    Current Advances in Immunology presents the advances in immunology in an easy-to-use format. The book is split into 51 main areas that are further classified into sections. Where appropriate, cross-referencing to other sections is given. The text also provides a guide on how to use the book. Papers included in the book focus on a variety of topics ranging from immunoglobulins and antigens to interferons, lymphocytes, leukocytes, and macrophages as well as natural killer cells, Langerhans cells, dendritic cells, lymphoid tissue, and humoral mediators of immune responses and immunomodulators. Other papers discuss blood groups, transplantation, anti-bacterial immunity, chronic inflammation, delayed hypersensitivity, and contact sensitivity. Immunodeficiency, immune complexes, tumor immunity, immunopharmacology and immunotoxicology, and the link between nutrition and immunity are also explored. A section devoted to psychoneuroimmunolog... focuses on the effect of stress on graft-versus-host reaction; immunological response to stress in agoraphobia and panic attacks; and anti-beta-endorphin immunoglobulin G in humans. This book will be of interest to working scientists in the field of immunology.

  • Stem Cells

    Scientific Facts and Fiction
    • 2nd Edition
    • Christine L. Mummery + 3 more
    • English
    The second edition of Stem Cells: Scientific Facts and Fiction provides the non-stem cell expert with an understandable review of the history, current state of affairs, and facts and fiction of the promises of stem cells. Building on success of its award-winning preceding edition, the second edition features new chapters on embryonic and iPS cells and stem cells in veterinary science and medicine. It contains major revisions on cancer stem cells to include new culture models, additional interviews with leaders in progenitor cells, engineered eye tissue, and xeno organs from stem cells, as well as new information on "organs on chips" and adult progenitor cells. In the past decades our understanding of stem cell biology has increased tremendously. Many types of stem cells have been discovered in tissues that everyone presumed were unable to regenerate in adults, the heart and the brain in particular. There is vast interest in stem cells from biologists and clinicians who see the potential for regenerative medicine and future treatments for chronic diseases like Parkinson's, diabetes, and spinal cord lesions, based on the use of stem cells; and from entrepreneurs in biotechnology who expect new commercial applications ranging from drug discovery to transplantation therapies.

  • Proteinases and Their Inhibitors

    Structure, Function and Applied Aspects
    • 1st Edition
    • V. Turk + 1 more
    • English
    Proteinases and their Inhibitors: Structure, Function, and Applied Aspects documents the proceedings of an international symposium organized by the Department of Biochemistry, Jozef Stefan Institute, E. Kardelj University, Ljubljana, and the Department of Organic Chemistry and Biochemistry, Rudjer Boskovic Institute, Zagreb, held in Portoroz, Yugoslavia, September 29-October 3, 1980. The volume contains 34 papers that are organized into four parts. Part I on biological functions includes studies such as muscle protein breakdown in human catabolic state and age-dependent changes in intracellular protein turnover. The papers in Part II, which deals with properties and structure of enzymes, cover topics such as structures and biological functions of cathepsin B and L; and human erythrocytes peptidases. Part III is devoted to industrial applications, such as exogenous proteinases in dairy technology and the application of immobilized proteinases. Part IV on proteinase inhibitors includes papers on thiol inhibitors of proteases and and intracellular neutral proteinases and inhibitors. The papers in this volume provide new data, concepts, and visions which will not only prove useful, but will also stimulate further investigations of proteinases and their inhibitors.

  • Biotechnology and Nutrition

    Proceedings of the Third International Symposium
    • 1st Edition
    • Donald Bills + 1 more
    • English
    Biotechnology and Nutrition documents the proceedings of the Third International Symposium Biotechnology and Nutrition jointly sponsored by the University of Maryland, the United States Department of Agriculture, and E. I. du Pont de Nemours & Co. The symposium was organized to provide a forum for nutritionists, molecular biologists, animal and plant biochemists, food scientists, policymakers, and others who will influence the improvement of nutrition through the application of biotechnology. The contributions made by researchers at the symposium are organized into five parts. Part I provides a broad consideration of human nutrition and the ability of biotechnology to improve nutrition. Part II presents studies on carbohydrate nutrition, including industry trends and nutritional issues for food uses of starch and human physiological responses to dietary fiber. Part III focuses on proteins, including studies on improving the nutritional quality of legume seed proteins and increasing the lysine content of maize. The studies in Part IV deal with vitamins and minerals, such as genetic improvement of vegetable carotene content and iron uptake and translocation in plants. Part V examines molecular approaches in the modification and production of edible oils.

  • Prostaglandins, Platelets, Lipids

    New Developments in Atherosclerosis
    • 1st Edition
    • Hadley L. Conn + 2 more
    • English
    Prostaglandins, Platelets, Lipids: New Developments in Atherosclerosis focuses on developments pertaining to atherosclerosis and suggested novel approaches for its prevention, treatment, and complications. The selection first underscores the biological importance and therapeutic potential of prostacyclin and rationale for the suppression of platelet aggregation and thrombosis by dietary manipulation of fatty acids. Discussions focus on eicosapentaenoic acid as a potential antithrombotic substance, vascular effects of prostacyclin, antithrombotic and hemostatic effects of prostacyclin, fatty acids, prostacyclin, and thrombosis, and therapeutic uses of prostacyclin. The text then examines prostaglandins and hypertension, role of platelets in stroke and transient ischemic attack, and antiplatelet agents in the prevention of acute coronary events. Topics include thrombosis and clinical complications of atherosclerosis, mechanisms in thrombosis, vascular prostaglandins and antihypertensive mechanisms, and renal prostaglandins and antihypertensive mechanisms. The book ponders on a specific inhibitor of thrombin and cardiovascular actions of prostacyclin in man, including prostacyclin and angina pectoris, prostacyclin therapy for peripheral arterial disease, and hemodynamic changes induced by prostacyclin. The selection is a dependable source of data for researchers interested in atherosclerosis.

  • History of Toxicology and Environmental Health

    Toxicology in Antiquity Volume I
    • 1st Edition
    • English
    Toxicology in Antiquity is the first in a series of short format works covering key accomplishments, scientists, and events in the broad field of toxicology, including environmental health and chemical safety. This first volume sets the tone for the series and starts at the very beginning, historically speaking, with a look at toxicology in ancient times. The book explains that before scientific research methods were developed, toxicology thrived as a very practical discipline. People living in ancient civilizations readily learned to distinguish safe substances from hazardous ones, how to avoid these hazardous substances, and how to use them to inflict harm on enemies. It also describes scholars who compiled compendia of toxic agents.

  • Sea Plants

    • 1st Edition
    • Volume 71
    • English
    Advances in Botanical Research publishes in-depth and up-to-date reviews on a wide range of topics in plant sciences. The series features several reviews by recognized experts on all aspects of plant genetics, biochemistry, cell biology, molecular biology, physiology and ecology. This thematic volume, number 71, features reviews on sea plants. Its chapters cover topics such as the role of algae in sustainability; the status of kelp exploitation and marine agronomy; potential applications for enzymatic recovery of metabolites from seaweeds; and many more.

  • Development and Differentiation in the Cellular Slime Moulds

    Proceedings of the International Workshop Held at Porto Conte, Sardinia on 12—16 April, 1977
    • 1st Edition
    • P. Cappuccinelli + 1 more
    • English
    Developments in Cell Biology, Volume 1: Development and Differentiation in the Cellular Slime Moulds is a collection of papers from the proceedings of the International Workshop held at Porto Conte, Sardinia on April 12-16, 1977. This collection of papers deals with a single group of organisms, the cellular slime molds, particularly with Dictyostelium discoideum. Dictyostelium is dealt, firstly, according to cell differentiation and pattern formation common in this type of organism. These examples are further explored in the Dictyostelium discoideum slug, through the control of morphogenesis. Further research shows that two compounds, 3'5' cyclic AMP and NH3, can affect the course of morphogenesis in D. discoideum. Techniques for cell fusion and mutation induction in D. discoideum, especially as a result of DNA damage following radiation and chemicals, are analyzed. Other studies show that formation and maintenance of stable contacts between cells appear to be necessary for the normal cell cycle involved in the growth of D. discoideum. The changes in plasma membrane protein analyzed using SDS-polyacrylamide gel electrophoresis are examined. Results show that detection and quantitation of tubulin in Dictyostelium discoideum is important when studying the differentiation processes of a wide range of cellular activities. Because many D. discoideum mutants fail to reach proper development, the method for selecting the aggregation of defective mutants of D. discoideum is emphasized. This book is of interest to those whose work involves these organisms and to researchers, professors, and students whose disciplines are in Developmental Biology or Mycology.

  • The Quality Control of Medicines

    Proceedings of the 35th International Congress of Pharmaceutical Sciences, Dublin, 1975
    • 1st Edition
    • P.B. Deasy + 1 more
    • English
    The Quality Control of Medicines documents the proceedings of the 35th International Congress of Pharmaceutical Sciences, organized by the Pharmaceutical Society of Ireland on behalf of the Federation Internationale Pharmaceutique, held in Dublin, on 1-5 September 1975. The theme chosen for the Congress was ""the basis for the quality control of medicines"", because of the importance and relevance of quality control in the production and distribution of medicines at national and international levels. This volume is arranged according to the manner in which the theme of the Congress was developed by the eminent invited speakers. Following the inaugural address a main symposium was held where five speakers presented a review of the quality control of medicines under the general headings of (i) chemical and physical aspects; (ii) biological aspects; (iii) control of drug delivery systems; (iv) storage problems; and (v) problems of international control. Certain aspects of the content of the main symposium were then developed in greater depth in parallel symposia. In the first parallel symposium some novel physicochemical aspects of the quality control of medicines were treated under the headings of spectrofluorimetry, mass spectrometry, detection in gas chromatography, and automation in pharmaceutical analysis. The second parallel symposium developed certain microbiological aspects of quality control under the headings of sterility testing and microbiological control of non-sterile products and ophthalmic preparations. The final symposium on submissions to regulatory bodies and international aspects of drug control covered aspects of politics in submissions, regulatory problems in small countries, and various pharmacopoeial problems.

  • Structure and Function of Membrane Proteins

    Proceedings of the International Symposium on Structure and Function of Membrane Proteins Held in Selva Di Fasano (Italy), May 23-26, 1983
    • 1st Edition
    • E. Quagliariello + 1 more
    • English
    Structure and Function of Membrane Proteins documents the proceedings of the International Symposium on Structure and Function of Membrane Proteins held in Selva di Fasano on May 23-26, 1983. This compilation makes it possible to obtain more information on the structure of membrane proteins, determining the structure in order to understand the function, and mechanism of action that is only understood by knowledge of the atomic structure. The gathering of data on the function of membrane proteins prior to knowledge of their structure is valuable for characterizing and defining the proteins. Once the structure is known, another stage of research will penetrate to the functional assignments of the structure. Other topics covered include the physical methods for the structure-function relationship; identification and mapping of sites in membrane proteins; and primary structure of transport proteins. Tertiary structure and molecular shape of membrane proteins and structure-function relationship in membrane proteins are also examined. This book is a good source of information for students and individuals conducting research on biochemistry, specifically on membrane proteins.

  • Fairbrother's Textbook of Bacteriology

    • 10th Edition
    • R. L. Vollum + 2 more
    • English
    Fairbrother's Textbook of Bacteriology, Tenth Edition provides an outline of the medical aspects of bacteriology. This book emphasizes the biological relationship of allied organisms. Organized into three parts encompassing 38 chapters, this edition begins with an overview of the various elements of the bacterial cell in detail, starting with external features such as flagella and capsules, and working inwards to the cytoplasm. This text then describes the principal toxic effects of the different groups of anti-bacterial substances. Other chapters consider the relationship of the different types of hypersensitivity to classical immune responses. This book discusses as well the earliest application of a specific chemical substance to the treatment of microbial disease. The final chapter deals with the various methods used to determine the sensitivity of bacteria to the different sulphonamides. This book is a valuable resource for medical students. Bacteriologists, chemists, pathologists, and microbiologists will also find this book useful.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 65
    • English
    Volume 65 in the internationally acclaimed Advances in Clinical Chemistry contains chapters authored by world renowned clinical laboratory scientists, physicians and research scientists. The serial provides the latest and most up-to-date technologies related to the field of Clinical Chemistry and is the benchmark for novel analytical approaches in the clinical laboratory.

  • Human Biology

    A Text Book of Human Anatomy, Physiology and Hygiene
    • 2nd Edition
    • C. J. Wallis
    • English
    Human Biology is a textbook on human biology and presents facts and details about a number of diseases as well as organ transplants, antibiotics, and anesthetics. Other topics include world food, drug addiction, smoking, and lung cancer and the effects of radioactivity. The important subject of environmental pollution is also discussed. Some of the common disorders and diseases of the various systems are mentioned at the end of the chapters in addition to the characteristics of certain specified diseases. Comprised of 34 chapters, this book begins with an overview of man and his origins, as well as human biology and the human body. The discussion then turns to cell structure and tissues; the skin; the skeletal system; and joints. The biochemistry of foodstuffs is also examined, along with digestion and the alimentary system; the cardiovascular system; maintenance of body temperature; the genital system and reproduction; and hormones and the endocrine system. In addition, the book considers antibiotics, drugs, and anesthetics, as well as vectors and other parasites affecting humans. This monograph is intended for student nurses and potential medical students, as well as for non-science students and general readers who wish to learn something about the human body and its health.

  • Organizing Schools to Encourage Self-Direction in Learners

    • 1st Edition
    • R. Skager
    • English
    Summarizes and synthesizes four case studies of schools organized to develop self-direction in students. A theoretical perspective on the origins of self-direction is presented and integrated with the findings. The schools, located in the Federal Republic of Germany, Hungary, the Philippines and the USA were studied by local research teams operating under criteria developed for the research. The book seeks to develop a more accurate perspective on the psychological and behavioral characteristics of self-directed learners and to analyze how schools in four different national contexts are organized for the purpose of promoting self-direction in learners.

  • Guide des analyses en immunologie

    Indications, critères de réalisation et limites
    • 1st Edition
    • Collège des Enseignants d'Immunologie
    • French
    Ce guide, rédigé par l'ASSIM recense les principales analyses en immunologie prises en charge par la Sécurité sociale dans le cadre de la Nomenclature des Actes de Biologie Médicale (NABM).L'ouvrage développe en 6 grandes parties l'exploration : - de l'auto-immunité ; - de l'immunité humorale ; - de l'immunité cellulaire ; - en histocompatibilité et l'étude des associations HLA-maladies ; - des traitements par biomédicaments immunologiques. Chacune de ces parties est détaillée de façon pratique et synthétique sous forme de fiches, étayées de synopsis d'aide à l'exploration de la pathologie. Les points suivants sont systématiquement abordés : - la signification biologique du paramètre ; - les objectifs de l'analyse ; - la place de cette analyse dans un bilan d'exploration ; - la nature du prélèvement ; - les recommandations particulières ; - les contraintes d'acheminement ; - le mode de conservation ; - le principe méthodologique ; - le type de méthode et de mesure ; - le contrôle interne et l'évaluation externe de la qualité ; - les performances du test ; - les causes d'erreur et les limites du test.

  • Mammalian Cell Membranes

    Responses of Plasma Membranes
    • 1st Edition
    • G. A. Jamieson + 1 more
    • English
    Mammalian Cell Membranes, Volume 5: Responses of Plasma Membranes compiles broadly based reviews of specific areas of plasma membranes and introduces concepts and techniques from non-mammalian systems that may be useful in the application to eukaryotic cells. This book discusses about the turnover of mammalian surface membranes; influence of the solute environment on membrane; effects of hydrostatic pressure and radiation on cell membranes; and stimulation by hormones and regulation by nucleotides of adenylyl cyclases. Other topics include endocytosis; cell surface and growth in vitro; membranes and aging; host cell membranes in animal virus reproduction; and cytoplasmic membranes in somatic cell interaction and hybridization. This volume aims to provide a background of information and stimulation of interest to specialists and generalists working on mammalian cell membranes.

  • Steroid–Cell Interactions

    • 1st Edition
    • R. J. B. King + 1 more
    • English
    Steroid–Cell Interactions describes the processes involved in the intracellular binding of steroids (and related compounds) in mammalian cells. Serum binding proteins and steroid-immunoglobul... interaction are also discussed, along with the relationship of these binding processes to the biological action of the steroid. This book consists of 10 chapters and begins by presenting an elementary account of the factors contributing to the interaction between a steroid hormone and another molecule. The discussion then turns to the three types of methods used to study the interaction between steroids and tissue receptors: cell fractionation, autoradiography, and the separation of specifically and non-specifically bound steroids. The next chapter deals with the metabolism of steroid hormones in relation to their binding and mechanism of action, focusing on testosterone and progesterone. The reader is also introduced to the intracellular binding of androgens, glucocorticoids, mineralocorticoids, and estrogens and to how binding is related to biological activity. The final chapter reviews the clinical and immunological data relevant to steroid-protein binding. This text will be of interest to students and practitioners of biology, biochemistry, and physiology.

  • Parenteral Products

    The Preparation and Quality Control of Products for Injection
    • 1st Edition
    • M. J. Groves
    • English
    Parenteral Products: The Preparation and Quality Control of Products for Injection deals with modern pharmaceutical practice in the preparation, quality control, and storage of injectable drug solutions. The book gives a basic background of parenteral solutions, the routes of administration, the effects of the different administrations of injection solutions, and the formulation of these products. The text discusses the theories of filtration, the different methods used, such as screen filters, depth filters, and the possible choices of filtration to capture any preselected unwanted particle size. Developments on sterilization of the product are given attention, citing techniques and equipment. The working and preparation conditions are discussed, since the sterile intravenous solutions, whether in large or small quantities, are done in quite the same procedures, with the similar equipment, and same organization. Equally important in the discussion are the monitoring and control of contamination by particulates through the application of standards known as the Coulter principle and the light-blockage method. The pharmaceutical problems encountered during the administration of large volume drip solutions are analyzed. This book is helpful for pharmacists, pharmaceutical students and professors, and those working in the pharmaceutical industry and hospital/health sector.

  • Chemical Microbiology

    An Introduction to Microbial Physiology
    • 3rd Edition
    • A. H. Rose
    • English
    Chemical Microbiology: An Introduction to Microbial Physiology, Third Edition covers aspects of the chemical activities of microorganisms. The book describes the molecular architecture of microorganisms, the methods used in studying this molecular architecture; and the ways by which microorganisms can respond to and modify their environment. The text also discusses the various environmental factors that influence microbial activity. The book tackles the principles, the strategies employed, and the methods used in the studies of microbial metabolism. The transport of compounds into and out of microorganisms by the solute-transport processes and endocytosis; the principles of bioenergetics and biosynthesis; and the regulation of metabolism are also considered. The book tackles as well the growth, survival and differentiation of microorganisms. Biologists, microbiologists, chemical microbiologists, geneticists, and biochemists will find this book invaluable.

  • Nuclear Pore Complexes and Nucleocytoplasmic Transport - Methods

    • 1st Edition
    • Volume 122
    • English
    Volume 122 of Methods in Cell Biology describes modern tools and techniques used to study nuclear pore complexes and nucleocytoplasmic transport in diverse eukaryotic model systems (including mammalian cells, Xenopus, C. elegans, yeast). The volume enables investigators to analyze nuclear pore complex structure, assembly, and dynamics; to evaluate protein and RNA trafficking through the nuclear envelope; and to design in vivo or in vitro assays appropriate to their research needs. Beyond the study of nuclear pores and transport as such, these protocols will also be helpful to scientists characterizing gene regulation, signal transduction, cell cycle, viral infections, or aging. The NPC being one of the largest multiprotein complexes in the cell, some protocols will also be of interest for people currently characterizing other macromolecular assemblies. This book is thus designed for laboratory use by graduate students, technicians, and researchers in many molecular and cellular disciplines.

  • Fish Aquaculture

    Technology and Experiments
    • 1st Edition
    • C.P.B. Meske + 1 more
    • English
    Aquaculture has gained a momentum throughout the world during recent decades which is unparalleled in other branches of food production. This book describes methods currently used for the production of those warm water table fish which are of major importance. Included are experiments and procedures which will help to combat the growing food problem through new production methods for animal protein. The aim of the work presented here is to promote the continuous production of warm water table fish independently of climate or environment within the least necessary space and even in regions with unsuitable weather or topography.

  • Subcellular Components

    Preparation and Fractionation
    • 2nd Edition
    • G. D. Birnie
    • English
    Subcellular Components: Preparation and Fractionation talks about cells and particles' components, including their preparation and fractionation. The book includes theories and answers to questions that are relevant to the study. The first chapter of the book details various facts about homogenization of mammalian cells. This chapter presents the results of studies on solid tissues and single-cell suspensions; the author then offers his conclusion of the study. The next two chapters highlight the methods on isolating nuclei, including the guides for standard assessment and the procedure of isolation, along with analysis of nuclei biochemical properties. The main topics in Chapter 4 are mitochondria from animal tissues and yeasts; this chapter also discusses the preparation for a rat-liver, blowfly flight-muscle, yeast, and brain mitochondria. The chapter that follows widely talks about lysosomes, including its historical background, centrifugal method, and related topics. In the next several chapters, the topics covered include purification, isolation, preparation, and separation of cells including plasma-membrane, polysomes, ribosomes, microsomes, and microvilli. The book serves as a great reference for undergraduates and postgraduates in the field, as it contains a thorough discussion of various relevant studies.

  • Leanness in Domestic Birds

    Genetic, Metabolic and Hormonal Aspects
    • 1st Edition
    • B. Leclercq + 1 more
    • English
    Leanness in Domestic Birds: Genetic, Metabolic, and Hormonal Aspects is a proceeding of a symposium held in Tours, France, from 4 to 6 August 1987. Said symposium was concerned with genetic and metabolic factors associated with leanness of poultry and accounts of research in these areas. The book is divided into six parts. Part I covers studies that involve genetics in the selection of meat leanness. Part II deals with the relationship of feed intake and metabolism to the leanness of poultry. Part III discusses the lipid metabolism in birds and its related factors and effects. Part IV talks about the use of hormones such as insulin, thyroid hormones, and corticosteroids in the control of fatness in birds. Part V covers studies involving amino acid metabolism and its relation to leanness in poultry, and Part VI talks about the applications of the studies in commercial use. The text is recommended for zoologists, agriculturists, and poultry farmers who would like to know more about the different factors that affect the leanness of domestic birds and its implications.

  • Mammalian Cell Membranes

    General Concepts
    • 1st Edition
    • G. A. Jamieson + 1 more
    • English
    Mammalian Cell Membranes, Volume 1: General Concepts is a collection of papers that deals on the physical and chemical studies focusing on membrane structure and function. This collection reviews the interpretation of the anatomy of the mammalian cell, including its separation and cultivation. The different methods of isolation of its surface membrane are then evaluated to bring some understanding of the subject. More descriptions of the various physical techniques adopted to membrane constituents and to cell membrane research, such as nuclear magnetic resonance, electron spin resonance, fluorescence, and flash photolysis spectroscopy are given. Discoveries of mitochondrial DNA and other techniques have increased investigation of the synthesis and components of functional mitochondria, leading to different perspectives on models of membrane structure. This book can serve the needs of biochemists and microbiologists in advancing their work, research, and understanding of mammalian cell membranes.

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