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Elsevier

Books in Life sciences

  • Food Microstructures

    Microscopy, Measurement and Modelling
    • 1st Edition
    • Vic Morris + 1 more
    • English
    The development of high-quality foods with desirable properties for both consumers and the food industry requires a comprehensive understanding of food systems and the control and rational design of food microstructures. Food microstructures reviews best practice and new developments in the determination of food microstructure.After a general introduction, chapters in part one review the principles and applications of various spectroscopy, tomography and microscopy techniques for revealing food microstructure, including nuclear magnetic resonance (NMR) methods, environmental scanning electron, probe, photonic force, acoustic, light, confocal and infrared microscopies. Part two explores the measurement, analysis and modelling of food microstructures. Chapters focus on rheology, tribology and methods for modelling and simulating the molecular, cellular and granular microstructure of foods, and for developing relationships between microstructure and mechanical and rheological properties of food structures. The book concludes with a useful case study on electron microscopy.Written by leading professionals and academics in the field, Food microstructures is an essential reference work for researchers and professionals in the processed foods and nutraceutical industries concerned with complex structures, the delivery and controlled release of nutrients, and the generation of improved foods. The book will also be of value to academics working in food science and the emerging field of soft matter.

  • Biotextiles as Medical Implants

    • 1st Edition
    • M W King + 2 more
    • English
    Textiles play a vital role in the manufacture of various medical devices, including the replacement of diseased, injured or non-functioning organs within the body. Biotextiles as medical implants provides an invaluable single source of information on the main types of textile materials and products used for medical implants. The first part of the book focuses on polymers, fibers and textile technologies, and these chapters discuss the manufacture, sterilization, properties and types of biotextiles used for medical applications, including nanofibers, resorbable polymers and shaped biotextiles. The chapters in part two provide a comprehensive discussion of a range of different clinical applications of biotextiles, including surgical sutures, arterial prostheses, stent grafts, percutaneous heart valves and drug delivery systems.This book provides a concise review of the technologies, properties and types of biotextiles used as medical devices. In addition, it addresses the biological dimension of how to design devices for different clinical applications, providing an invaluable reference for biomedical engineers of medical textiles, quality control and risk assessment specialists, as well as managers of regulatory affairs. The subject matter will also be of interest to professionals within the healthcare system including surgeons, nurses, therapists, sourcing and purchasing agents, researchers and students in different disciplines.

  • Metabolomics in Food and Nutrition

    • 1st Edition
    • Bart C Weimer + 1 more
    • English
    Metabolomics enables valuable information about the biochemical composition of foods to be rapidly obtained. Since the biochemical profile of food largely determines key food properties such as flavour and shelf life, the information gained using metabolomics-based methods will enable greater control of food quality and also help to determine the relationship between diet and health. Metabolomics in food and nutrition provides an overview of their current and potential use in the food industry.Part one reviews equipment, methods and data interpretation in metabolomics including the use of nuclear magnetic resonance (NMR), statistical methods in metabolomics, and metabolic reconstruction databases and their application to metabolomics research. Part two explores applications of metabolomics in humans, plants and food. Chapters discuss metabolomics in nutrition, human samples for health assessments, and current methods for the analysis of human milk oligosaccharides (HMOs) and their novel applications. Further chapters highlight metabolomic analysis of plants and crops, metabolomics for the safety assessment of genetically modified (GM) crops, and applications of metabolomics in food science including food composition and quality, sensory and nutritional attributes.With its distinguished editors and team of expert contributors, Metabolomics in food and nutrition is a technical resource for industrial researchers in the food and nutrition sectors interested in the potential of metabolomics methods and academics and postgraduate students working in the area.

  • Drug-Biomembrane Interaction Studies

    The Application of Calorimetric Techniques
    • 1st Edition
    • Rosario Pignatello
    • English
    The design and development of drugs and new pharmaceutical formulations require a full characterization of the chemical and physicochemical events occurring at the level of the single active ingredients or excipients, as well as their reciprocal interaction. Thermal analysis techniques are among the most widely used methods to achieve this; among them, the Differential Scanning Calorimetry (DSC) technique, in which the thermotropic behaviour of a single substance or mixtures is analyzed as a function of a controlled temperature program. DSC is an accurate and rapid thermo-analytical technique, widely used by the pharmaceutical industry and in drug research to investigate several physico-chemical phenomena, such as polymorphism, melting and crystallization, purity, and drug-excipient interaction; as well as characterizing biomolecules such as genetic material.Drug-biomem... interaction studies is written by scientists renowned for their work in the field of DSC applications to drug development and delivery, and especially to drug-biomembrane interaction studies. The book combines insights from biochemistry and physiology with those from structural biology, nanotechnology and biothermodynamics, to obtain a complete depiction of cell membranes and their functions.

  • Gene therapy

    Potential Applications of Nanotechnology
    • 1st Edition
    • Surendra Nimesh
    • English
    Gene therapy is emerging as a new class of therapeutics for the treatment of inherited and acquired diseases. However, poor cellular uptake and instability of DNA in the physiological milieu limits its therapeutic potential, hence a vector which can protect and efficiently transport DNA to the target cells must be developed. Nanotechnology-based non-viral vectors have been proposed as potential candidates. Various polymeric nanoparticles have been shown to be suitable, with high cellular uptake efficiencies and reduced cytotoxicity. These delivery vectors form condensed complexes with DNA which result in shielding against enzymatic degradation and enhanced cellular targeting. Advantages including easy manipulatibility, high stability, low cost and high payload, mean that nanoparticles from various polymers have been exploited. Gene therapy gives a systematic account of the many aspects of nanotechnology mediated gene therapy, from the preparation of nanoparticles to physicochemical characterization, and follows with applications in in vitro and in vivo models. This book emphasizes the various aspects of nanotechnology-based gene therapy, with initial chapters detailing the tools and techniques available for preparation and in vitro and in vivo characterization of nanoparticles. Later chapters provide exhaustive details on polymeric systems employed for gene therapy.

  • The Funding of Biopharmaceutical Research and Development

    • 1st Edition
    • David R Williams
    • English
    The funding of biopharmaceutical research and development provides a comprehensive critical review of the funding of research and development (R&D) in the human biopharmaceutical market sector. It addresses both private and public funding sources available in the US and internationally. The biopharmaceutical market is among the most research-intensive market sectors globally. Clinical researchers face a multitude of public and private funding options with respect to bringing their idea or innovation to market. These funding options are continually changing and complex, and are expected to decrease in the near future. A lack of understanding of the scale, scope, and inner workings of the funding aspects of R&D can, at times, act as a barrier for all involved, and can slow down or even eliminate the R&D process. The book lessens these barriers by describing the theoretical underpinnings, present practice, and trends in R&D funding in this market sector, both in the US and internationally. This includes a review and discussion of public-private partnership activity and their inner-workings, noting the complementary relationship between public and private funding. The book also contains an overview of the inner-workings of strategic alliance activity, including the advantages and disadvantages for each party. It goes on to provide an outline of venture capital activity, detailing the methods by which venture capital firms raise capital and are organized, a description of the venture capital-entrepreneur arrangement, and the effects of this arrangement. The book also presents an overview of the IPO process and the various fates of firms going public.

  • Orphan Drugs

    Understanding the Rare Disease Market and its Dynamics
    • 1st Edition
    • Elizabeth Hernberg-Ståhl + 1 more
    • English
    This authoritative and comprehensive book makes the reader familiar with the processes of bringing orphan drugs to the global market. There are between 5,000 and 7,000 rare diseases and the number of patients suffering from them is estimated to be more than 50 million in the US and Europe. Before the orphan drug legislation enacted in the US in 1983, there was a limited interest from industry to develop treatment for very small patient groups. One of the difficulties is, of course, that similar levels of investment are needed from a pharmaceutical company to bring a drug to the market for both small and large patient groups.The journey from application of an orphan drug designation to a reimbursed market- approved drug is long and many obstacles occur during the journey.After reading the book, readers will: Understand who the players/stakeholders are in the rare orphan disease field and their specific needs and concerns: patients and patient organizations, researchers and treating physicians within the field, industry, regulatory and reimbursement bodies* Understand the strong partnership between the different players and the various initiatives to improve and increase access to treatment for patients; minimizing the gap between numbers of known diseases, orphan designations, approved drugs and paid drugs.The book also provides short practical case stories from patients and researchers, as well as representatives from industry and authorities on the challenges they came across in developing orphan drugs or getting access to orphan drugs.

  • Stem Cell Bioprocessing

    For Cellular Therapy, Diagnostics and Drug Development
    • 1st Edition
    • Tiago G. Fernandes + 2 more
    • English
    Stem cell bioprocessing describes the main large-scale bioprocessing strategies for both stem cell culture and purification, envisaging the application of these cells for regenerative medicine and drug screening. Bioreactor configurations are described, including their applications for stem cell expansion, and stem cell separation techniques such as isolation and purification are discussed. Basic definitions are provided concerning the different types of stem cells, from adult stem cells to the more recent induced pluripotent stem cells. The main characteristics of these different stem cell types are described, alongside the molecular mechanisms underlying their self-renewal and differentiation. The book also focuses on methodologies currently used for in vitro stem cell culture under static conditions, including the challenge of xeno-free culture conditions, as well as culture parameters that influence stem cell culture. Approaches for both stem cell culture and separation in micro-scale conditions are presented, including the use of cellular microarrays for high-throughput screening of the effect of both soluble and extracellular matrix molecules. A further section is dedicated to application of stem cells for regenerative medicine.

  • Ocular Transporters and Receptors

    Their Role in Drug Delivery
    • 1st Edition
    • Ashim K Mitra
    • English
    Ocular transporters and receptors contains detailed descriptions of major transporters and receptors expressed in the eye, with special emphasis on their role in drug delivery. The complex anatomy and the existence of multiple barriers in the eye pose a considerable challenge to successful drug delivery to the eye. Hence ocular transporters and receptors are important targets for drug delivery. A significant advancement has been made in the field of ocular transport research and their role in drug delivery. In this book the cutting edge research being carried out in this field is compiled and summarized. The book focuses on key areas, including the anatomy and physiology of the eye, biology of ocular transporters and receptors, techniques in characterization of transporters and receptors, transporters and receptors in the anterior and posterior segment in the eye, the role of ocular transporters and receptors in drug delivery, and transporter-metaboli... interplay in the eye.

  • Sterility, Sterilisation and Sterility Assurance for Pharmaceuticals

    Technology, Validation and Current Regulations
    • 1st Edition
    • Tim Sandle
    • English
    Failure to adequately control any microbial challenge associated within process or product by robust sterilisation will result in a contaminated marketed product, with potential harm to the patient. Sterilisation is therefore of great importance to healthcare and the manufacturers of medical devices and pharmaceuticals. Sterility, sterilisation and sterility assurance for pharmaceuticals examines different means of rendering a product sterile by providing an overview of sterilisation methods including heat, radiation and filtration. The book outlines and discusses sterilisation technology and the biopharmaceutical manufacturing process, including aseptic filling, as well as aspects of the design of containers and packaging, as well as addressing the cleanroom environments in which products are prepared. Consisting of 18 chapters, the book comprehensively covers sterility, sterilisation and microorganisms; pyrogenicity and bacterial endotoxins; regulatory requirements and good manufacturing practices; and gamma radiation. Later chapters discuss e-beam; dry heat sterilisation; steam sterilisation; sterilisation by gas; vapour sterilisation; and sterile filtration, before final chapters analyse depyrogenation; cleanrooms; aseptic processing; media simulation; biological indicators; sterility testing; auditing; and new sterilisation techniques.

  • Improving the Safety and Quality of Nuts

    • 1st Edition
    • Linda J Harris
    • English
    As tree nuts and peanuts become increasingly recognised for their health-promoting properties, the provision of safe, high quality nuts is a growing concern. Improving the safety and quality of nuts reviews key aspects of nut safety and quality management.Part one explores production and processing practices and their influence on nut contaminants. Chapters discuss agricultural practices to reduce microbial contamination of nuts, pest control in postharvest nuts, and the impact of nut postharvest handling, de-shelling, drying and storage on quality. Further chapters review the validation of processes for reducing the microbial load on nuts and integrating Hazard Analysis Critical Control Point (HACCP) and Statistical Process Control (SPC) for safer nut processing. Chapters in part two focus on improving nut quality and safety and highlight oxidative rancidity in nuts, the impact of roasting on nut quality, and advances in automated nut sorting. Final chapters explore the safety and quality of a variety of nuts including almonds, macadamia nuts, pecans, peanuts, pistachios and walnuts.Improving the safety and quality of nuts is a comprehensive resource for food safety, product development and QA professionals using nuts in foods, those involved in nut growing, nut handling and nut processing, and researchers in food science and horticulture departments interested in the area.

  • Catalogue of the Cicadoidea (Hemiptera: Auchenorrhyncha)

    • 1st Edition
    • Allen F. Sanborn
    • English
    This is the third in a series of catalogs and bibliographies of the Cicadoidea covering 1981-2010. The work summarizes the cicada literature, providing a means for easy access to information previously published on a particular species or to allow researchers the ability to locate similar work that has been published on other species. A total of 2,591 references are included in the bibliography. The book is a source of biological and systematic information that could be used by zoologists, entomologists, individuals interested in crop protection, and students studying entomology as well as anyone interested in cicadas or who require specific information on the insects. Each genus/species is identified with the reference, the page number, any figures (if applicable), the topics covered by the reference, any synonymies, and any biogeographic information mentioned for the species in the individual reference. An added benefit to the catalog is that it is the first complete species list for the Cicadoidea, including all synonymies and new combinations through 2012.

  • Managing Burnout in the Workplace

    A Guide for Information Professionals
    • 1st Edition
    • Nancy McCormack + 1 more
    • English
    Information professionals are under constant stress. Libraries are ushering in sweeping changes that involve the closing of branches and reference desks, wholesale dumping of print, disappearing space, and employment of non-professional staff to fill what have traditionally been the roles of librarians. Increasing workloads, constant interruptions, ceaseless change, continual downsizing, budget cuts, repetitive work, and the pressures of public services have caused burnout in many information professionals.Managi... Burnout in the Workplace concentrates on the problem of burnout, what it is and how it differs from chronic stress, low morale, and depression. The book addresses burnout from psychological, legal, and human resources perspectives. Chapters also cover how burnout is defined, symptom recognition, managing and overcoming burnout, and how to avoid career derailment while coping with burnout.

  • Plant Virology

    • 5th Edition
    • Roger Hull
    • English
    The seminal text Plant Virology is now in its fifth edition. It has been 10 years since the publication of the fourth edition, during which there has been an explosion of conceptual and factual advances. The fifth edition of Plant Virology updates and revises many details of the previous edition while retaining the important earlier results that constitute the field's conceptual foundation. Revamped art, along with fully updated references and increased focus on molecular biology, transgenic resistance, aphid transmission, and new, cutting-edge topics, bring the volume up to date and maintain its value as an essential reference for researchers and students in the field.

  • Transporters in Drug Discovery and Development

    Detailed Concepts and Best Practice
    • 1st Edition
    • Yurong Lai
    • English
    Written by a leading researcher in the field, Transporters in Drug Discovery and Development provides a comprehensive and practical guide to drug transporter families that are the most important for drug discovery and development. It covers: an overview of transporter families and organ distribution; clinical relevant drug-drug interaction; clinical relevant polymorphism; drug transporter related pharmacokinetic, pharmacodynamics and toxicity; in vitro/in vivo probes of drug transport studies; the practical methodologies of industrial transporter screening and translational aspect in drug discovery and developments.

  • Research Methods in Biomineralization Science

    • 1st Edition
    • Volume 532
    • English
    This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in biomineralization science, and includes sections on such topics as determining solution chemistry, structure and nucleation; probing structure and dynamics at surfaces; and interfaces mapping biomineral and morphology and ultrastructure.

  • Biological DNA Sensor

    The Impact of Nucleic Acids on Diseases and Vaccinology
    • 1st Edition
    • Ken Ishii + 1 more
    • English
    Biological DNA Sensor defines the meaning of DNA sensing pathways and demonstrates the importance of the innate immune responses induced by double stranded DNA (dsDNA) through its influencing functions in disease pathology and immune activity of adjuvants for vaccines. Though discussed in specific subsections of existing books, dsDNA and its immunogenic properties has never received the complete treatment given in this book. Biological DNA Sensor approaches the impact of dsDNA's immunogenicity on disease and vaccinology holistically. It paints a complete and concise picture on the topic so you can understand this area of study and make more informed choices for your respective research needs. Chapters are authored by researchers who are renowned for their research focus, ensuring that this book provides the most complete views on the topics.

  • Laboratory Methods in Enzymology: Cell, Lipid and Carbohydrate

    • 1st Edition
    • Volume 533
    • English
    Methods in Enzymology volumes provide an indispensable tool for the researcher. Each volume is carefully written and edited by experts to contain state-of-the-art reviews and step-by-step protocols. In this volume, we have brought together a number of core protocols concentrating on Cell, Lipid and Carbohydrate, complementing the traditional content that is found in past, present and future Methods in Enzymology volumes.

  • Diabetes

    Oxidative Stress and Dietary Antioxidants
    • 1st Edition
    • Victor R. Preedy
    • English
    Diabetes: Oxidative Stress and Dietary Antioxidants bridges the trans-disciplinary divide among diabetologists, endocrinologists, and nutritionists in understanding and treating diabetes. The book covers, in a single volume, the science of oxidative stress in diabetes and the potentially therapeutic use of natural antioxidants in the diet or food matrix. The processes within the science of oxidative stress are described in concert with other processes such as apoptosis, cell signaling, receptor-mediated responses and more. This approach recognizes that diseases are usually multifactorial and that oxidative stress is a single component of this.Pharmacological treatments for diabetes are commonly marked by unwanted side effects, leading to treatment efforts using naturally occurring substances. But a plant-based approach alone is not sufficient; understanding the processes inherent in the oxidative stress of diabetes is vital for clinical workers, dietitians, and nutritionists.This translational work provides that understanding. The book begins by covering the basic biology of oxidative stress from molecular biology to imaging in relation to diabetes. There are chapters on neuropathy, nephropathy, atherosclerosis, cardiomyopathy, and retinopathy. The book then moves on to antioxidants in foods, including plants, components of the diet, and their relevance to diabetes.

  • Advances in Marine Biology

    • 1st Edition
    • Volume 66
    • English
    Advances in Marine Biology has been providing in-depth and up-to-date reviews on all aspects of marine biology since 1963--over 40 years of outstanding coverage! The series is well known for its excellent reviews and editing. Now edited by Michael Lesser (University of New Hampshire, USA) with an internationally renowned Editorial Board, the serial publishes in-depth and up-to-date content on many topics that will appeal to postgraduates and researchers in marine biology, fisheries science, ecology, zoology, and biological oceanography.

  • Neuroanatomy of Language Regions of the Human Brain

    • 1st Edition
    • Michael Petrides
    • English
    Many studies of the neural bases of language processes are now conducted with functional and structural neuroimaging. Research is often compromised because of difficulties in identifying the core structures in the face of the complex morphology of these regions of the brain. Although there are many books on the cognitive aspects of language and also on neurolinguistics and aphasiology, Neuroanatomy of Language Regions of the Human Brain is the first anatomical atlas that focuses on the core regions of the cerebral cortex involved in language processing. This atlas is a richly illustrated guide for scientists interested in the gross morphology of the sulci and gyri of the core language regions, in the cytoarchitecture of the relevant cortical areas, and in the connectivity of these areas. Data from diffusion MRI and resting-state connectivity are integrated iwth critical experimental anatomical data about homologous areas in the macaque monkey to provide the latest information on the connectivity of the language-relevant cortical areas of the brain. Although the anatomical connectivity data from studies on the macaque monkey provide the most detailed information, they are often neglected because of difficulties in interpreting the terminology used and in making the monkey-to-human comparison. This atlas helps investigators interpret this important source of information. Neuroanatomy of Language Regions of the Human Brain will assist investigators of the neural bases of language in increasing the anatomical sophistication of their research adn in evaluating studies of language and the brain.

  • Polyphenols in Human Health and Disease

    • 1st Edition
    • Ronald Ross Watson + 2 more
    • English
    Polyphenols in Human Health and Disease documents antioxidant actions of polyphenols in protection of cells and cell organelles, critical for understanding their health-promoting actions to help the dietary supplement industry. The book begins by describing the fundamentals of absorption, metabolism and bioavailability of polyphenols, as well as the effect of microbes on polyphenol structure and function and toxicity. It then examines the role of polyphenols in the treatment of chronic disease, including vascular and cardiac health, obesity and diabetes therapy, cancer treatment and prevention, and more.

  • Platelets and Aspirin-Induced Asthma

    Pathogenesis and Melatonin
    • 1st Edition
    • Helen Evsyukova
    • English
    Platelets and Aspirin-Induced Asthma is the first book to be published that reflects research conducted on aspirin-induced asthma pathogenesis. It is examined through positions of neuroimmunoendocrine interactions in organism. The Melatonin hormone plays a key role, being the regulator and coordinator of complicated and interrelated biological processes. This new concept of aspirin-induced asthma pathogenesis suggests new methods for treatment of this disease by means of correcting the melatonin content in the patient’s organism. Investigations into the mechanisms of aspirin-induced asthma as a pathology of melatonin producing cells of platelets helps to determine high-risk groups and develop preventive measures and adequate therapy.

  • Techniques in Protein Chemistry

    • 1st Edition
    • Choh Hao Li
    • English
    Hormonal Proteins and Peptides: Techniques in Protein Chemistry, Volume IX presents the various methods in protein chemistry and discusses their use for hormonal protein investigations. This book examines the approach to investigating biologically active peptides, which is based on a combination of chromatographic and fluorometric procedures. Organized into five chapters, this volume starts with an overview of the fluorometric methods for analysis of peptides and proteins with focus on their use in high performance liquid chromatography. This text then presents a thorough discussion on partition chromatography of proteins and peptides. Other chapters consider a comprehensive account of absorption and fluorescence techniques for the structural analysis of proteins. This book presents as well a comprehensive discussion on optical rotatory dispersion and circular dichroism methods and their application for the study of protein conformation. The final chapter deals with the historical aspects of fetuin and ultracentrifuge. This book is a valuable resource for chemists, biologists, endocrinologists, and physicians.

  • The Rat Brain in Stereotaxic Coordinates

    • 7th Edition
    • George Paxinos + 1 more
    • English
    Since its first edition in 1982, the Paxinos and Watson rat brain atlas has become the most trusted source of accurate coordinates and anatomical information in laboratories throughout the world. It has been cited over 60,000 times, making it the most cited publication in neuroscience. The seventh edition incorporates new findings on developmental gene expression and presents the boundaries of neuromeres in sagittal sections.

  • The Physiology of Growth

    • 1st Edition
    • I.C. Gunsalus
    • English
    The Bacteria, Volume IV: The Physiology of Growth focuses on the biochemical phenomena that are expressed at the level of the intact microbial cell and of the growing cell. This book explores the structure, metabolism, and biosynthesis of bacteria. Organized into nine chapters, this volume starts with an overview of the growth requirements, metabolic pathways, individual enzymes, and a variety of other components and functions of the bacterial cell. This text then analyzes the genetic organization of bacteria and explains the nuclear division in bacteria. Other chapters consider the effects of physical environment upon the growth of microorganisms. This book discusses as well the methods for obtaining bacterial cultures by manipulating environmental factors. The final chapter deals with chemotherapeutic drugs, which are valuable tools in the investigation of bacterial organization and function. Bacteriologists, microbiologists, biochemists, microbial physiologists, and cell physiologists interested in the study of bacteria will find this book extremely useful.

  • Physiology of Metabolism

    • 1st Edition
    • David D. Davies
    • English
    The Biochemistry of Plants, Volume 12: Physiology of Metabolism focuses on plant biochemistry, with emphasis on the metabolism of plants. This book discusses the organizational resistance to account for changes in the rate of respiration that both cells and organs undertake. Organized into two parts encompassing eight chapters, this volume starts with an overview of the microtubule structure and function in plant cell biology. This book then discusses the presence of microtubular structures in the cytoplasm of eukaryotic cells. Other chapters consider the characteristics of plant cells, which possess the highest degree of subcellular compartmentation of metabolism. This text discusses as well the various transport reactions that are involved in primary metabolic pathways in plants. The final chapter explores the several changes that fruits undergo to reach maturity, including the development of color and aroma, as well as improvements in texture and flavor. This book is a valuable resource for biologists, plant scientists, and agriculturists.

  • Presynaptic Receptors and Neuronal Transporters

    Official Satellite Symposium to the IUPHAR 1990 Congress Held in Rouen, France, on 26–29 June 1990
    • 1st Edition
    • S.Z. Langer + 2 more
    • English
    Advances in the Biosciences, Volume 82: Presynaptic Receptors and Neuronal Transporters documents the proceedings of the Official Satellite Symposium to the IUPHAR 1990 Congress held in Rouen, France on June 26-29, 1990. The first part of this book deals with the extensive and still increasing list of presynaptic release-modulating auto and heteroreceptors, emphasizing the various subtypes of presynaptic receptors that are characterized by functional studies, both in vitro and in vivo, using a number of experimental approaches. The next chapters are devoted to the molecular pharmacology of presynaptic receptors, of which can interfere with G proteins and modify the activity of adenylate cyclase, guanylate cyclase, or protein kinase C. The purification and molecular biology of transporter systems, including cloning and sequencing of the neuronal sodium-ion coupled GABA transporter are also discussed. This compilation concludes with insights on the function of presynaptic receptors and neuronal transporters both in the periphery and in the CNS, as well as their ubiquitous locations and physiological roles. This publication is a good reference for students and individuals researching on the presynaptic autoreceptors and neurotransmitters.

  • The Saccharine Disease

    Conditions Caused by the Taking of Refined Carbohydrates, Such as Sugar and White Flour
    • 1st Edition
    • T. L. Cleave
    • English
    The Saccharine Disease, Conditions Caused by the Taking of Refined Carbohydrates, such as Sugar and White Flour contends that the causation of these conditions has been obscured through confusing distinctions between unnatural, refined carbohydrates and that of natural, unrefined carbohydrates like fruits and whole meal flour. The author notes that all the foregoing conditions are really the manifestations of a single master-disease—that many of the major diseases of modern societies are caused by consuming unreasonable amounts of refined carbohydrate foods. The author discusses that in the short time that man has changed his diet, evolutionary adaptation is left behind. He gives two rules to prevent and arrest all saccharine disease manifestations: Do not eat any food unless you definitely want it, and avoid eating white flour or white sugar. These two rules will prevent gastric or duodenal ulcer, diabetes, coronary disease, constipation, complications of varicose veins, hemorrhoids, E. coli infections, obesity, and some skin conditions, As a retired Surgeon-General of the Royal Navy, the author bases his assumptions on evolutionary, epidemiological, and other scientific or historical work. This book can give insights to dieticians, food researchers, nutritionists, people on diet, and general medicine practioners.

  • Theory and Practice of Blood Flow Measurement

    • 1st Edition
    • John P. Woodcock
    • English
    Theory and Practice of Blood Flow Measurement presents the methods for determining the metrics of blood flow in the major vessels. This book is organized into two sections encompassing 16 chapters that discuss the theories behind the different techniques of flow measurement and the performance of flowmeters and their practical application to determining blood flow volume in the tissues and organs. Considerable chapters are devoted to various methods of blood measurement, including dilution, transport, and thermal techniques, as well as the effect of catheter sampling on the shape of indicator dilution curves. Other chapters are concerned with the possible errors in the application of indicator dilution techniques and the types of dilution indicator, and measurement of indicator concentration. A chapter is devoted to the advantages and disadvantages of thermistor flowmeter. The last chapter focuses on the design of a thermal dilution catheter. The book can provide useful information to physicists, bioengineers, surgeons, students, and researchers.

  • General Botany

    • 1st Edition
    • Wilhelm Nultsch
    • English
    General Botany covers certain aspects of general botany, such as morphology, anatomy, and histology. The book discusses the molecular constitution of plants; the structural constitution of the protoplasm, the cell, and the cytoplasm; and the differentiation of the cell. The text also describes the types of organization in plants; the internal and external structure of the stem, the leaf, and the root; and water and salt balance, with regard to the translocation of materials. The energy procurement and the synthetic processes in autotrophic plants; the respiration and energy transformations; and nitrogen metabolism are also considered. The book further tackles heterotrophy; reproduction; heredity; development; and the movement of plants. Botanists, cytologists, plant physiologists, and students taking related courses will find the text invaluable.

  • Routes of Drug Administration

    Topics in Pharmacy
    • 1st Edition
    • A. T. Florence + 1 more
    • English
    Routes of Drug Administration covers topics about parenteral and enteral routes of drug administration. The book discusses the anatomy and physiology of administration sites; the formulation and design of delivery systems; and other relevant aspects of biopharmaceutics. The text describes pulmonary delivery, nasal, buccal, and transdermal routes of administration for systemic delivery, as well as a number of systems for more localized therapy with antibiotics. Innovative methods of antibiotic administration, such as continuous and intermittent infusion, endotracheal installation, aerosol delivery, antibiotic-impregnat... catheters, antibiotic-containin... bone cement, and beads, are also considered. Senior undergraduate and postgraduate students in pharmacy, medicine, nursing and allied health sciences and practitioners in these fields, as well as other professionals concerned with the preparation and administration of medicines and the monitoring of drug therapy will find the book useful.

  • A Synopsis of Infectious and Tropical Diseases

    • 3rd Edition
    • A. W. Woodruff + 1 more
    • English
    A Synopsis of Infectious and Tropical Diseases provides a summary of information on the diagnosis and management of infectious and tropical diseases. It contains essential information required by general practitioners, specialists, medical students and graduates preparing for higher examinations, the nursing profession, and health workers in the proper management of infective and tropical diseases. This book is organized into nine chapters that describe the signs and symptoms, clinical forms and manifestations, incubation period, stages of invasion, mode of transmission, epidemiology, and treatment of different tropical and infectious diseases such as those caused by viruses, protozoans, and metazoan parasites. These diseases include herpesvirus infections, blackwater fever, and trematode or fluke infections. This book will be of interest to travelers and people in the medical profession.

  • Case Presentations in Heart Disease

    • 2nd Edition
    • Alan Mackintosh
    • English
    Case Presentations in Heart Disease: Second Edition presents cases dealing with the diagnosis and treatment of patients with a heart related problem. This book addresses the need for a sample of real life cardiologic problems. Some of the topics covered in the book are the case of the 63-year-old brewery worker with severe pain between the shoulder blades; a case of a 54 years old woman with pain in her right loin; a case of a man applying for insurance; and a case of a married man who experienced loss of consciousness lasting 5 minutes. Other topics discussed include the causes of dissecting aortic aneurysm, the diagnosis made on the female with pain in her right loin, and the development of atrial myxomas. The acute phase of a myocardial infarction is presented. The concluding part is devoted to the analysis of a case of coughing symptom with no smoking history. The book can provide useful information to doctors, cardiologists, students, and researchers.

  • Forensic Toxicology

    Proceedings of a Symposium Held at the Chemical Defence Establishment, Porton Down, 29-30 June 1972
    • 1st Edition
    • Bryan Ballantyne
    • English
    Forensic Toxicology presents the legal and medical aspects of the detrimental effects of chemicals on humans. This book discusses the immediate and long-term consequences of accident or deliberate poisoning, the detection of such poisoning, and the interpretation of the possible importance of demonstrating exogenous substances in biological fluids and tissues. Organized into 14 chapters, this compilation of papers begins with an overview of the fundamental procedure and interpretation in forensic toxicology. This text then examines the ways in which enzymes may be used in the analysis of drugs. Other chapters consider the equipment and reagents required in the rapid tests for drugs in urine. This book presents as well barbiturate poisoning from the viewpoint of the forensic pathologist performing the post mortem over the cause of death. The final chapter deals with further advances in forensic toxicology. This book is a valuable resource for general practitioners, forensic toxicologists, forensic pathologists, and police officers.

  • Mycobacteria

    Institute of Medical Laboratory Sciences Monographs
    • 1st Edition
    • Maureen V. Chadwick
    • F. J. Baker
    • English
    Mycobacteria covers some aspects of mycobacterial identification. The book starts by describing a historical review of tuberculosis, including topics about searching for its causes and cure and about the use of chemotherapy for treating tuberculosis. The text describes the different species of Mycobacteriaceae, including Mycobacterium tuberculosis, M. africanum, M. bovis, M. microti, and M. ulcerans. Safety precautions in pathology laboratories; the preparation of good culture media and sensitivity test media; and the treatment of specimens are also considered. The book further tackles sensitivity testing of Mycobacteria using the resistance ratio method, the proportional method and the absolute concentration method, and methods of identifying mycobacteria. The text also describes assay methods for anti-tuberculosis drugs. Pathologists, medical technologists, and other people working in pathology laboratories will find the book useful.

  • Essays in Toxicology

    Volume 1
    • 1st Edition
    • Frank R. Blood
    • English
    Essays in Toxicology, Volume 1 covers essays in toxicology and related topics. The book presents essays on the use of poisons as tools in studying the nervous system as well as teratology. The text also includes essays on the significance of methemoglobinemia in toxicology and lead poisoning. Biochemists, plant and animal physiologists, pharmacologists, pathologists, microbiologists, entomologists, food technologist, and people involved in forensic medicine and industrial medicine.

  • Fruit and Vegetables

    • 1st Edition
    • R. B. Duckworth
    • English
    Fruit and Vegetables provides comprehensive information on fruits and vegetables, which are deemed to be an important part of diets in every part of the world. The book is intended to be a primary source of information for advanced food science students and readers interested in the deep appreciation and understanding of food. The text illustrates the wide range of background material on the study of fruits and vegetables. Subjects on the chemical constitution and structure of fruits and vegetables are covered in Part I, Concerning the Nature of Fruit and Vegetables. Part II deals with the utilization, production, processing and trade of fruits and vegetables. Food technologists, food scientists, chefs, nutritionists, students and those in the food industry will find this book a good reference material.

  • The Molecular Fabric of Cells

    • 1st Edition
    • BIOTOL + 2 more
    • English
    Knowledge of the molecules which make up cells not only provides the basis upon which an understanding of cell function may be developed, but also provides the knowledge needed to manipulate and purify chemicals. The text therefore holds an importantand key position in both applied biology and biotechnology.

  • Discovery of Novel Natural Products with Therapeutic Potential

    • 1st Edition
    • Vincent P. Gullo
    • English
    Although science has discovered effective drugs for many of the diseases that afflict mankind, many human health problems remain untreatable. The search for novel therapeutic agents is always ongoing. This book will describe some of the diverse sourcesof natural products, such as terrestrial and marine environments; and will review how research has increased knowledge of biological systems and human disease, leading to the design of targeted asssays, amenable to high volume screening.

  • Comprehensive Insect Physiology, Volume 4

    Regulation: Digestion, Nutrition, Excretion
    • 1st Edition
    • G. A. Kerkut
    • English
    In this volume, seven of the chapters deal with feeding and diet, which is reasonable since insects consume an estimated l5-20% of all the world's planted crops. Many insects even have a specialized larval feeding stage that usually occupies a different ecological niche to the adult and so does not compete for the adult's food stock. Other chapters describe the means by which insects maintain their water balance, nitrogen balance and temperature balance under a range of conditions. These involve regulation by hormonal and behavioural systems that are also described here. The l4 chapters are all extensively illustrated and referenced and therefore provide excellent summaries of current knowledge. They will be of great value to entomologists, zoologists and biologists in general.

  • Interleukin-1 in the Brain

    • 1st Edition
    • Nancy J. Rothwell
    • English
    Interest in interleukin-1 (IL-1) has increased dramatically over the last decade, but has been largely restricted to immunologists, cell biologists and those studying inflammation and cancer. However, it has recently been recognized that the brain directly controls or modulates many aspects of immune function, while molecules classically associated with the immune system, such as interleukin-1, are synthesised within the brain and act directly on the central nervous system to modify local and systemic functions. Thus, this topic is relatively new to neurobiologists, and this book is the first comprehensive description of current knowledge on interleukin-1 in the brain, including its location, synthesis and receptors, actions on behaviour, fever, metabolism, neuroendocrine function, electrical activity of the brain, nerve growth factor, and relationship to clinical indications. The book is organised into three sections. The first reviews the data available on the neural localisation of IL-1 and the nature of its central receptors. The main part of the book examines the different neural effects of IL-1 and the mechanisms which are involved in these actions, comparing IL-1 where possible to other inflammatory cytokines which also have neurotrophic effects. The final section evaluates the possible role of IL-1 in neural plasticity and neuronal degeneration.

  • Neurology for Nurses

    • 1st Edition
    • J Bickerton + 1 more
    • English
    Neurology for Nurses is an attempt to make neurology as clear as possible, using the nursing model. The first portion of this book provides a diagram of the planes of the body that considers the nervous system anatomically, which is referenced throughout the book. The different orientations and planes of the body include the anterior (ventral) surface, posterior (dorsal) surface, lateral, medial, sagittal (median) section, Coronal (frontal) section, and transverse. Other than detailed descriptions of the anatomy and functions of nerves and the nervous system, this book provides diagnostic evaluation of diseases and clinical conditions, such as multiple sclerosis, cerebrovascular accidents, brain tumors, head injury, epilepsy, Parkinson's disease, and meningitis. This book includes as well discussions on neurological examinations, investigations, and observations. The topic on nursing care for unconscious patients is also provided. This text is aimed primarily at nursing students in training, but will also benefits those taking a post-basic nursing course in neurology.

  • A Synopsis of Biology

    • 1st Edition
    • W. B. Crow
    • English
    A Synopsis of Biology summarizes the entire field of biology using a telegraphic style. The discussions are organized around seven themes: form and structure (morphology); functions (physiology); organism and environment (ecology); evolution and heredity (genetics); plant classification (systematic botany); animal classification (systematic zoology); and applications of biology (applied biology). Comprised of seven sections, this book begins with a detailed account of the morphology of living and non-living things, followed by an assessment of the origin of life. The reader is then introduced to reproduction (vegetative, sexual, and asexual); plant and animal tissues; seeds and seedlings; and metameric segmentation. Subsequent chapters explore matter and energy; organic and inorganic compounds; dermal excretion and thermo-regulation; periodicity and seasonal phenomena; and the life of rivers and lakes. The book also examines parasitism; mating and courtship; natural, artificial, and sexual selection; cultivation of plants; and domestication of animals. This monograph will be useful to research workers, degree students, and others interested in biology.

  • Handbook of the Biology of Aging

    • 3rd Edition
    • Edward L. Schneider + 1 more
    • English
    Handbook of The Biology of Aging, Third Edition provides a general overview to a wide scientific audience of some of the most important topics in biomedical gerontology. The book discusses methodologies for biological aging studies and on animal models. Protein modifications with aging, special senses, circadian rhythms, and the adrenocortical axis are tacked in the book as well. Gerontologists, psychologists, health care professionals, and graduate students will find the book useful.

  • Study Guide for Houston, Bee, Hatfield, and Rimm's Invitation to Psychology

    • 1st Edition
    • Victor Benassi
    • English
    Study Guide for Houston, Bee, Hatfield, and Rimm's Invitation to Psychology seeks to aid students in their study of psychology. Each chapter in the Study Guide corresponds to the chapter of the same number in Invitation to Psychology and is broken down into component sections: Learning Objectives, Key Terms, Study Questions, Optional Exercises, and Practice Quizzes. The topics covered in these chapters include the following: the definition of psychology; the psychological basis of behavior; sensation and perception; states of awareness; learning, memory, and cognition; motivation and emotion; abnormal psychology and social behavior. Proper use of the Study Guide will help students get the most from what could be their only formal course in psychology. To maximize their learning, all of the components of each chapter must be completed. While no single approach to learning is the best, many students benefit greatly from the use of a study guide.

  • Poulsson's Text-Book of Pharmacology and Therapeutics

    • 1st Edition
    • Stanley Alstead
    • English
    Poulsson’s Text-Book of Pharmacology and Therapeutics, Second English Edition covers the considerable progress in understanding the basic principles, applications, and classifications of drugs and other organic compounds of therapeutic interest. This text is divided into six chapters, each dealing with a specific classification of drugs. The first chapter describes the so-called protoplasmic poisons, which are organic substances that are characterized by their specific effects after absorption on the nervous and muscular systems, while local effects are altogether absent or insignificant. The second chapter examines the organic remedies that principally act locally, such as at the point of application, while the action after absorption is unimportant or is not utilized in medicine. The third and fourth chapters explore the main groups containing the inorganic bodies. These chapters demonstrate that the inorganic compounds differ from the organic, whose activity is due to the unchanged entire molecules, and they are subjected to dissociation. The fifth chapter considers the digestive ferments and foodstuffs, while the sixth chapter is concerned with antitoxins and bacterial products. This book will be of value to pharmacologists, pharmacists, researchers, and pharmacology and pharmacy students.

  • Neurocutaneous Diseases

    A Practical Approach
    • 1st Edition
    • Manuel Rodriguez Gomez
    • English
    Neurocutaneous Diseases is a systematic presentation limited to diseases that affect both of the nervous system and skin of humans. Neurologists and dermatologist will find knowledge of these diseases of real clinical value. Many of the diseases described in these pages do not affect the skin and nervous system simultaneously. Many of these diseases, mostly not well understood, may stimulate new lines of scientific inquiry, for understanding of a pathologic change in easily accessible dermal cells that promises to clarify a more recondite brain disease. This book is organized into five main parts. The chapters describe different types of diseases including those with autosomal dominant inheritance, those with autosomal recessive inheritance, those with x-linked inheritance, those with unknown or multiple inheritance and congenital and vascular anomalies. These diseases include neurofibromatosis, Cockayne's Syndrome, adrenoleukodystrophy... albinism and neurocutaneous melanosis. This book will be of interest to dermatologists and neurologists.

  • Biotechnological Innovations in Animal Productivity

    • 1st Edition
    • BIOTOL + 2 more
    • English
    Biotechnological Innovations in Animal Productivity examines the application of biotechnology to animal production. The book focuses on the use of contemporary biotechnology procedures on the different facets of animal production such as the reproductive capabilities of animals, their growth rates, and the ability of the farmer and veterinary services to prevent and cure infection. The text contains chapters that discuss topics on the manipulation of reproductive processes, endocrine regulation of the oestrous cycle, in vitro embryo production and manipulation, vaccines, and the production of transgenic (livestock) animals. Biotechnologists, biologists, and livestock producers will find the book very insightful.

  • Peripheral Neuropathies

    Proceedings of the International Symposium on Peripheral Neuropathies Held in Milan, Italy, on June 26–28, 1978
    • 1st Edition
    • N. Canal + 1 more
    • English
    Peripheral Neuropathies compiles lectures presented at the Symposium on Peripheral Neuropathies held in Milan, Italy on June 26-28, 1978. This book covers the basic problems in peripheral nerve pathology; axonal transport; neuropathies in chronic renal failure; peripheral neuropathies in diabetes; compression neuropathies; and metabolic, genetic, and inflammatory neuropathies. This text also discusses topics such as filamentous inclusions in Schwann cell nuclei; autonomie dysfunction and myokymia in gold neuropathy; study of the effect of gangliosides on experimental carbon disulfide neuropathy; and peripheral nerve changes in Refsum's disease before and after treatment. This compilation is a useful source of information for students and researchers conducting investigative work on peripheral neuropathy.

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