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Myeloid-Derived Suppressor Cells
1st Edition - March 15, 2024
Editors: Carlos Jiménez-Cortegana, Lorenzo Galluzzi
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Myeloid-Derived Suppressor Cells, Volume 184 in the Methods in Cell Biology series includes comprehensive and detailed protocols to assess the critical role of myeloid-derived… Read more
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Myeloid-Derived Suppressor Cells, Volume 184 in the Methods in Cell Biology series includes comprehensive and detailed protocols to assess the critical role of myeloid-derived suppressor cells (MDSCs), an immature, heterogenous cell population from the myeloid lineage with a potent immunosuppressive activity in a variety of diseases. This volume presents twelve interesting protocols that address the isolation of MDSCs in murine models, the detection of mouse and human MDSCs by flow cytometry, T-cell proliferation assays, isolation of MDSC-derived exosomes and their immunosuppressive function, characterization of lysosomal lipase in MDSCs, detection of MDSC-derived nitric oxide, and other in vivo and ex vivo assays.
1. Detection of myeloid-derived suppressor cells by flow cytometry Tianju Liu
2. Determination of murine myeloid-derived suppressor cells by flow cytometry Hiroshi Kitamura
3. Isolation of Myeloid-Derived Suppressor Cells (MDSC) from Endometriotic Mice Model and their Immunomodulatory Functions Gene Man
4. Simple protocol for measuring CD11b+ GR-1+ (Ly6C+/Ly6G+) myeloid cells from a minimum volume of mouse peripheral blood Gabriel Cabrera
5. CD4+ T cells proliferation assays to analyze Mo-MDSC suppressive function Marcos López-Hoyos
6. Assessment of myeloid-derived suppressor cell differentiation ex vivo Ester Blanco
7. Single clonal tracking on biomimetic microtextured platforms for real-time guided migration analysis of myeloid-derived suppressor cell dissemination characteristics ex vivo Daniel Gallego-Pérez
8. Isolation and immunosuppressive functions of myeloid-derived suppressor cell-derived exosomes Ali Syed Arbab
9. Characterization of lysosomal acid lipase in Ly6G+ and CD11c+ myeloid-derived suppressor cells Ting Zhao and Hong Du
10. In Vitro Osteoclastogenesis Assessment using Murine Myeloid-derived Suppressor Cells KYU HWAN KWACK and Keith Lough Kirkwood
11. Estimating Nitric Oxide (NO) from MDSCs by Griess Method Saikat Mukherjee
12. In vitro generation of myeloid-derived suppressor cells (MDSCs) from hematopoietic progenitor cells (HPCs) Kevin Alicea-Torres
No. of pages: 318
Published: March 15, 2024
Imprint: Academic Press
Hardback ISBN: 9780443218071
eBook ISBN: 9780443218088
Carlos Jiménez-Cortegana obtained the degree in Chemistry at University of Seville (Spain) in 2014. In July 2020 he got the PhD in Clinical Research at the same University, belonging to the group headed by Dr. Luis de la Cruz-Merino and Dr. Víctor Sánchez-Margalet. Currently, Carlos is a Postdoctoral Researcher at the Department of Radiation Oncology, Weill Cornell Medical College (New York, USA), in the research group headed by Dr. Lorenzo Galluzzi. From 2021, Carlos has published more than 15 articles in recognized, international journals, some of them in high-impact factor journals, mainly focused on the immunosuppressive role of myeloid-derived suppressor cells in a variety of diseases, including breast cancer, diffuse large B-cell lymphoma, and COVID-19.
Affiliations and expertise
Radiation Oncology, Weill Cornell Medical College, New York, NY, USA; Department of Medical Biochemistry, Molecular Biology and Immunology, Faculty of Medicine, University of Seville, Seville, Spain
Lorenzo Galluzzi is Assistant Professor of Cell Biology in Radiation Oncology at the Department of Radiation Oncology of the Weill Cornell Medical College, Honorary Assistant Professor Adjunct with the Department of Dermatology of the Yale School of Medicine, Honorary Associate Professor with the Faculty of Medicine of the University of Paris, and Faculty Member with the Graduate School of Biomedical Sciences and Biotechnology of the University of Ferrara, the Graduate School of Pharmacological Sciences of the University of Padova, and the Graduate School of Network Oncology and Precision Medicine of the University of Rome “La Sapienza”. Moreover, he is Associate Director of the European Academy for Tumor Immunology and Founding Member of the European Research Institute for Integrated Cellular Pathology.
Galluzzi is best known for major experimental and conceptual contributions to the fields of cell death, autophagy, tumor metabolism and tumor immunology. He has published over 450 articles in international peer-reviewed journals and is the Editor-in-Chief of four journals:
OncoImmunology (which he co-founded in 2011), International Review of Cell and Molecular Biology, Methods in Cell biology, and Molecular and Cellular Oncology (which he co-founded in 2013). Additionally, he serves as Founding Editor for Microbial Cell and Cell Stress, and Associate Editor for Cell Death and Disease, Pharmacological Research and iScience.
Affiliations and expertise
Assistant Professor of Cell Biology in Radiation Oncology, Department of Radiation Oncology, Weill Cornell Medical College, NY, USA