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Myeloid-Derived Suppressor Cells

1st Edition - March 15, 2024

Editors: Carlos Jiménez-Cortegana, Lorenzo Galluzzi

Hardback ISBN:
9 7 8 - 0 - 4 4 3 - 2 1 8 0 7 - 1
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 2 1 8 0 8 - 8

Myeloid-Derived Suppressor Cells, Volume 184 in the Methods in Cell Biology series includes comprehensive and detailed protocols to assess the critical role of myeloid-derived… Read more

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Myeloid-Derived Suppressor Cells, Volume 184 in the Methods in Cell Biology series includes comprehensive and detailed protocols to assess the critical role of myeloid-derived suppressor cells (MDSCs), an immature, heterogenous cell population from the myeloid lineage with a potent immunosuppressive activity in a variety of diseases. This volume presents twelve interesting protocols that address the isolation of MDSCs in murine models, the detection of mouse and human MDSCs by flow cytometry, T-cell proliferation assays, isolation of MDSC-derived exosomes and their immunosuppressive function, characterization of lysosomal lipase in MDSCs, detection of MDSC-derived nitric oxide, and other in vivo and ex vivo assays.