Life sciences print books and ebooks | Elsevier

Reproducibility in Biomedical Research

2nd Edition
April 26, 2024
Erwin B. Montgomery Jr.
English
Paperback
9 7 8 0 4 4 3 1 3 8 2 9 4
eBook
9 7 8 0 4 4 3 1 3 8 3 0 0

Reproducibility in Biomedical Research: Epistemological and Statistical Problems, Second Edition explores the ideas and conundrums inherent in scientific research. This second edition addresses new challenges to reproducibility in biosciences, namely reproducibility of machine learning Artificial Intelligence (AI), reproducibility of translation from research to medical care, and the fundamental challenges to reproducibility. All current chapters are expanded to cover advances in the topics previously addressed. This book provides biomedical researchers with a framework to better understand the reproducibility challenges in the area. Newly introduced interactive exercises and updated case studies help students understand the fundamental concepts involved in the area.

Neurogenetics for the Practitioner

1st Edition
April 24, 2024
Gregory M. Pastores
English
Paperback
9 7 8 0 3 2 3 9 9 4 1 7 0
eBook
9 7 8 0 3 2 3 9 5 8 5 9 2

Neurogenetics for the Practitioner provides clinicians with a navigation tool to help diagnose and treat patients with neurological disorders using neurogenetics. Sections introduce the reader to an overview of genetic principles, including practical applications in relation to diagnosis and current limitations. Additional chapters highlight how to workup patients presenting with certain features, including cerebral palsy/intellectual disability, congenital muscular dystrophy, cognitive decline/dementia, peripheral neuropathy, and paroxysmal disorder. The final section explores therapeutic strategies based on genetic interventions and genetic counselling options. This internationally contributed book will become the essential reference guide for neurologists.

Neurological and Neurosurgical Emergencies

1st Edition
April 20, 2024
Indu Kapoor + 2 more
English
Paperback
9 7 8 0 4 4 3 1 9 1 3 2 9
eBook
9 7 8 0 4 4 3 1 5 6 6 2 5

Neurological and Neurosurgical Emergencies addresses emergencies in all fields of neuroscience, including disciplines like Neurology, Neurosurgery, Neuroanaesthesia, and Neuroradiology. This volume covers neurosurgical emergencies, like hydrocephalus, brain edema, intracranial bleed, intracranial hematoma, infection, and trauma, alongside neurovascular emergencies like acute ischemic stroke, non-traumatic, aneurysmal subarachnoid hemorrhage, carotid cavernous fistula, and arteriovenous malformation.In addition, the book discusses common emergencies in neurology, including status epilepticus, refractory epilepsy, super-refractory epilepsy, and neuromuscular disorders. Beginning with neurological examination of patients through to anesthetic management of various emergencies, this book features clear images that accompany each emergency with learner-friendly features such as flow-charts, figures, text boxes, and algorithms. This book provides insights into all possible aspects of emergency management and the anesthetic management of such patients.

Fatty Acid-Binding Proteins and Their Roles in Human Health and Disease

1st Edition
August 6, 2024
Asim K. Duttaroy
English
Paperback
9 7 8 0 3 2 3 9 5 7 0 0 7
eBook
9 7 8 0 3 2 3 9 5 7 0 1 4

Fatty Acid-Binding Proteins and Their Roles in Human Health and Disease: From Basic Science to Clinical Application presents the latest information on the contributions of different FABPs in physiology and pathophysiology, along with their importance in clinical outcomes. The book is divided into six main sections that cover FABP biology and their role in inflammation and diseases, such as cardiovascular, neurological, and liver diseases, to FABPs and their clinical applications.Each chapter thoroughly reviews current literature, primary research data and clinical cases, providing readers with an overview of the latest information in the expanded field of FABPs. This is an invaluable resource for both researchers and clinicians familiar with and those new to the exciting and everchanging world of fatty acid-binding proteins and clinical disorders.

Translational Models of Parkinson’s Disease and related Movement Disorders

1st Edition
November 26, 2024
Wael Mohamed
English
Paperback
9 7 8 0 4 4 3 1 6 1 2 8 5
eBook
9 7 8 0 4 4 3 1 6 1 2 9 2

Translational Models of Parkinson’s Disease and Related Movement Disorders focuses on cutting-edge techniques for creating and validating current Parkinson’s Disease translational experimental models. Various characteristics of these models are examined, including the prion-like properties of -synuclein, mitochondrial functions connected to the PINK1-Parkin pathway/CHCHD2, the endolysosome pathway connected to LRRK2, VPS35, and ATP13A2 using cultured cells (including patient iPS cells). This book also highlights the future possibilities of introducing new models for Parkinson’s Disease and related movements disorders, underscoring current advancements, pre-clinical and clinical developments, and future scope related to numerous models.

Artificial Intelligence in Biomedical and Modern Healthcare Informatics

1st Edition
September 27, 2024
M. A. Ansari + 4 more
English
Paperback
9 7 8 0 4 4 3 2 1 8 7 0 5
eBook
9 7 8 0 4 4 3 2 1 8 7 1 2

Artificial Intelligence in Biomedical and Modern Healthcare Informatics provides a deeper understanding of the current trends in AI and machine learning within healthcare diagnosis, its practical approach in healthcare, and gives insight into different wearable sensors and its device module to help doctors and their patients in enhanced healthcare system.The primary goal of this book is to detect difficulties and their solutions to medical practitioners for the early detection and prediction of any disease.The 56 chapters in the volume provide beginners and experts in the medical science field with general pictures and detailed descriptions of imaging and signal processing principles and clinical applications.With forefront applications and up-to-date analytical methods, this book captures the interests of colleagues in the medical imaging research field and is a valuable resource for healthcare professionals who wish to understand the principles and applications of signal and image processing and its related technologies in healthcare.

Concepts and Models for Drug Permeability Studies

2nd Edition
February 23, 2024
Bruno Sarmento + 2 more
English
Hardback
9 7 8 0 4 4 3 1 5 5 1 0 9
eBook
9 7 8 0 4 4 3 1 5 5 1 1 6

Concepts and Models for Drug Permeability Studies: Cell and Tissue Based in Vitro Culture Models, Second Edition, summarizes the most important developments in in vitro models for predicting the permeability of drugs.This book is structured around three different approaches, summarizing the most recent achievements regarding models comprising (i) immortalized cells with an intrinsic ability to grow as monolayers when seeded in permeable supports, (ii) primary cells isolated from living organisms and directly cultured as barrier monolayers, and (iii) tissue-based models constructed with cell lines and extracellular matrix that resembles the tridimensional structure of mucosae and other biological membranes, or animal/patient-deriv... tissues. Each model is covered in detail, including the protocol of generation and application for specific drugs/drug delivery systems. The equivalence between in vitro cell and tissue models and in vivo conditions is discussed, highlighting how each model may provisionally resemble different drug absorption route.Chapters included in the first edition were updated with relevant data published in recent years, while four new chapters were included to reflect new emerging directions and trends in drug permeability models.Concepts and Models for Drug Permeability Studies: Cell and Tissue Based in Vitro Culture Models, Second Edition, is a critical reference for drug discovery and drug formulation scientists interested in delivery systems intended for the administration of drugs through mucosal routes and other important tissue barriers (e.g. the BBB). Researchers studying mucosal biology can use this book to familiarize themselves and exploit the synergic effect of mucosal delivery systems and biomolecules.

From Anatomy to Function of the Central Nervous System

1st Edition
August 25, 2024
Brandon Matteo Ascenzi
English
Hardback
9 7 8 0 1 2 8 2 2 4 0 4 5
eBook
9 7 8 0 1 2 8 2 2 4 3 4 2

From Anatomy to Function of the Central Nervous System: Clinical and Neurosurgical Applications features neuroradiologic images that represent today, one of the most effective resources able to detect the anatomy of the nerve structures. Simultaneously featuring neuroimages, readers can study the functional aspects of the entire central nervous system with detailed captions that describe in detail how to use and interpret them. This book includes images of the brain dissected with the Klingler’s method and white matter fiber dissection. By integrating the anatomo-functional description with the synaptic organization of the CNS, this reference is useful for anyone who wants to understand how the activity of a nerve structure arises, describing its microstructure, neurotransmitter phenotype, and neural activity. It also features descriptions of pathologic conditions which result from neuroanatomical and/or neurofunctional alterations and includes neurosurgical aspects.

Childhood Obesity

1st Edition
September 13, 2024
Luis Moreno
English
Paperback
9 7 8 0 4 4 3 2 1 9 7 5 7
eBook
9 7 8 0 4 4 3 2 1 9 7 4 0

Childhood Obesity: From Basic Knowledge to Effective Prevention brings together field experts, taking a multifactorial approach to understand the scope and various causes of the issue and offer the latest in treatment and prevention strategies and resources. Beginning with basic concepts and definitions, chapters progress to cover worldwide prevalence and trends, genetic and epigenetic origins, metabolic programming, and neuroendocrine control of appetite and satiety. Further, this book examines social determinants and lifestyle behaviors contributing to risk factors as well as complications associated with childhood obesity.Final chapters discuss multidisciplinary treatment, strategies for prevention, and current worldwide policies aimed to address obesity in children. This fundamental reference is a vital resource for both researchers and practicing clinicians in pediatric medicine.

Diagnostic, Prognostic, and Therapeutic Role of MicroRNAs in Head and Neck Cancer

1st Edition
July 25, 2024
Ashok Kumar + 3 more
English
Paperback
9 7 8 0 4 4 3 1 5 9 6 8 8
eBook
9 7 8 0 4 4 3 1 5 9 6 9 5

Diagnostic, Prognostic and Therapeutic Role of MicroRNAs in Head and Neck Cancer provides detailed information on various miRNA-based approaches for the diagnosis, prognosis, and treatment of HNSCC. The book encompasses various miRNA-based point-of-care diagnostics and drug delivery systems for HNSCC, along with information on clinical trials for improved clinical outcomes in HNSCC patients. In addition, it provides a comprehensive overview of currently available miRNAs associated with HNSCC and their extensive application for early diagnosis, prognosis, and treatment. Scientists and clinicians looking to win the battle against HNSCC will benefit from the book's sections on early diagnosis to improve treatment, increase treatment response rates, and reduce mortality rates. Recently, miRNA-based diagnostics and therapeutics have gained considerable attention among the scientific community. MiRNAs are known to have great potential as biomarkers for early diagnosis, prediction, and prognosis of HNSCC, and play a role in development of targeted gene therapy.

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